Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

Biochemical Pharmacology

Volumn 92, Issue 2, 2014, Pages 220-234

  Xu, Xuefen ^a   Zhang, Yi ^a   Li, Wei ^a   Miao, Hanchi ^a   Zhang, Haiwei ^a   Zhou, Yuxin ^a   Li, Zhiyu ^a   You, Qidong ^a   Zhao, Li ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

DNA PKcs; MRP1; Nrf2 ARE; Reversal effect; Wogonin

Indexed keywords

CISPLATIN; DNA DEPENDENT PROTEIN KINASE; DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; WOGONIN; FLAVANONE DERIVATIVE; HERBACEOUS AGENT; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; NFE2L2 PROTEIN, HUMAN;

ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IC50; K562 CELL LINE; MODULATION; MULTIDRUG RESISTANCE; MYELOID LEUKEMIA; MYELOID LEUKEMIA CELL LINE; PLANT ROOT; PROTEIN EXPRESSION; REDUCTION; RNA DEGRADATION; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY;

ANTIOXIDANT RESPONSE ELEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; FLAVANONES; GENE EXPRESSION REGULATION; HUMANS; K562 CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NF-E2-RELATED FACTOR 2; RNA, MESSENGER; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION;

EID: 84908353712     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.09.008     Document Type: Article

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