Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

Journal of the American College of Cardiology

Volumn 67, Issue 17, 2016, Pages 2018-2028

  Meyer, Kathleen ^a,b   Hodwin, Bettina ^a   Ramanujam, Deepak ^a,b   Engelhardt, Stefan ^a,b   Sarikas, Antonio ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

antifibrotic therapy; cardiac fibroblasts; extracellular matrix; gene therapy; transverse aortic constriction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYSTEINE RICH PROTEIN 61; PLATELET DERIVED GROWTH FACTOR A; SENESCENCE ASSOCIATED BETA GALACTOSIDASE; UNCLASSIFIED DRUG; VIMENTIN; ACTIN; CDKN1A PROTEIN, RAT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN P53; SMOOTH MUSCLE ACTIN, RAT;

ADENO ASSOCIATED VIRUS 9; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CELL AGING; CONTROLLED STUDY; DRUG TARGETING; GAIN OF FUNCTION MUTATION; GENE TRANSFER; HEART MUSCLE BIOPSY; HEART MUSCLE FIBROSIS; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MALE; MOUSE; MURINE MODEL; MYOFIBROBLAST; NONHUMAN; PATHOPHYSIOLOGY; PREMATURE SENESCENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SENESCENCE; TISSUE SPECIFICITY; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CARDIAC MUSCLE; DEFICIENCY; DEPENDOPARVOVIRUS; FIBROSIS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ACTINS; ANIMALS; BETA-GALACTOSIDASE; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYSTEINE-RICH PROTEIN 61; DEPENDOVIRUS; FIBROSIS; GENE TRANSFER TECHNIQUES; HUMANS; MICE, KNOCKOUT; MYOCARDIUM; MYOFIBROBLASTS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN P53; VIMENTIN;

EID: 84964986306     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.02.047     Document Type: Article

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