Columbianadin inhibits cell proliferation by inducing apoptosis and necroptosis in HCT116 colon cancer cells

Biomolecules and Therapeutics

Volumn 24, Issue 3, 2016, Pages 320-327

  Kang, Ji In ^a   Hong, Ji Young ^a   Choi, Jae Sue ^b   Lee, Sang Kook ^a  

^a Seoul National University   (South Korea)

^b Pukyong National University   (South Korea)

Author keywords

Apoptosis; Colon cancer; Columbianadin; Necroptosis; Oxidative stress

Indexed keywords

BIM PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; COLUMBIANADIN; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE 1; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE; PROTEIN RIP 3; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; HCT116 CELL LINE; HUMAN; HUMAN CELL; NECROPTOSIS; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

EID: 84964959970     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2015.145     Document Type: Article

References (49)

1. Ames, B. N. (1983) Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221, 1256-1264.
2. Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S. and Kalayci, O. (2012) Oxidative stress and antioxidant defense. World Allergy Organ. J. 5, 9-19.
3. Cerutti, P., Krupitza, G., Larsson, R., Muehlematter, D., Crawford, D. and Amstad, P. (1988) Physiological and pathologic effects of oxidants in mouse epidermal cells. Ann. N. Y. Acad. Sci. 551, 75-81.
4. Cerutti, P. A. (1985) Prooxidant states and tumor promotion. Science 227, 375-381.
5. Chen, Y. F., Tsai, H. Y. and Wu, T. S. (1995) Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med. 61, 2-8.
6. Christofferson, D. E. and Yuan, J. (2010) Necroptosis as an alternative form of programmed cell death. Curr. Opin. Cell Biol. 22, 263-268.
7. Church, S. L., Grant, J. W., Meese, E. U. and Trent, J. M. (1992) Sublocalization of the gene encoding manganese superoxide dismutase (MnSOD/SOD2) to 6q25 by fluorescence in situ hybridization and somatic cell hybrid mapping. Genomics 14, 823-825.
8. Clerkin, J. S., Naughton, R., Quiney, C. and Cotter, T. G. (2008) Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett. 266, 30-36.
9. D'Autréaux, B. and Toledano, M. B. (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 8, 813-824.
10. Denning, T. L., Takaishi, H., Crowe, S. E., Boldogh, I., Jevnikar, A. and Ernst, P. B. (2002) Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radic. Biol. Med. 33, 1641-1650.
11. Dunai, Z. A., Imre, G., Barna, G., Korcsmaros, T., Petak, I., Bauer, P. I. and Mihalik, R. (2012) Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. PLoS ONE 7, e41945.
12. Fiers, W., Beyaert, R., Declercq, W. and Vandenabeele, P. (1999) More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 18, 7719-7730.
13. Galluzzi, L., Joza, N., Tasdemir, E., Maiuri, M. C., Hengartner, M., Abrams, J. M., Tavernarakis, N., Penninger, J., Madeo, F. and Kroemer, G. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15, 1113-1123.
14. Huang, C., Luo, Y., Zhao, J., Yang, F., Zhao, H., Fan, W. and Ge, P. (2013) Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS ONE 8, e66326.
15. Hyoudou, K., Nishikawa, M., Kobayashi, Y., Umeyama, Y., Yamashita, F. and Hashida, M. (2006) PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal. Free Radic. Biol. Med. 41, 1449-1458.
16. Hyoudou, K., Nishikawa, M., Kobayashi, Y., Ikemura, M., Yamashita, F. and Hashida, M. (2008) SOD derivatives prevent metastatic tumor growth aggravated by tumor removal. Clin. Exp. Metastasis 25, 531-536.
17. Jacob, C., Cottrell, G. S., Gehringer, D., Schmidlin, F., Grady, E. F. and Bunnett, N. W. (2005) c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J. Biol. Chem. 280, 16076-16087.
18. Kerr, J. F., Wyllie, A. H. and Currie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
19. Khan, M. A., Tania, M., Zhang, D. Z. and Chen, H. C. (2010) Antioxidant enzymes and cancer. Chin. J. Cancer Res. 22, 87-92.
20. Kim, Y. S., Morgan, M. J., Choksi, S. and Liu, Z. G. (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol. Cell 26, 675-687.
21. Kong, Q. and Lillehei, K. O. (1998) Antioxidant inhibitors for cancer therapy. Med. Hypotheses 51, 405-409.
22. Lim, H. J., Lee, J. H., Choi, J. S., Lee, S. K., Kim, Y. S. and Kim, H. P. (2014) Inhibition of airway inflammation by the roots of Angelica decursiva and its constituent, columbianadin. J. Ethnopharmacol. 155, 1353-1361.
23. Mann, J. (2002) Natural products in cancer chemotherapy: past, present and future. Nat. Rev. Cancer 2, 143-148.
24. Medan, D., Wang, L., Toledo, D., Lu, B., Stehlik, C., Jiang, B. H., Shi, X. and Rojanasakul, Y. (2005) Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages. J. Cell. Physiol. 203, 78-84.
25. Millikin, D., Meese, E., Vogelstein, B., Witkowski, C. and Trent, J. (1991) Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. Cancer Res. 51, 5449-5453.
26. Morgan, M. J., Kim, Y. S. and Liu, Z. (2007) Lipid rafts and oxidative stress-induced cell death. Antioxid. Redox Signal. 9, 1471-1483.
27. Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S. and Green, D. R. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3dependent necrosis. Nature 471, 363-367.
28. Ouyang, Z., Zhu, S., Jin, J., Li, J., Qiu, Y., Huang, M. and Huang, Z. (2012) Necroptosis contributes to the cyclosporin A-induced cytotoxicity in NRK-52E cells. Pharmazie 67, 725-732.
29. Ozben, T. (2007) Oxidative stress and apoptosis: impact on cancer therapy. J. Pharm. Sci. 96, 2181-2196.
30. Pelicano, H., Carney, D. and Huang, P. (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist. Updat. 7, 97-110.
31. Pozarowski, P. and Darzynkiewicz, Z. (2004) Analysis of cell cycle by flow cytometry. Methods Mol. Biol. 281, 301-311.
32. Ramsey, M. R. and Sharpless, N. E. (2006) ROS as a tumour suppressor? Nat. Cell Biol. 8, 1213-1215.
33. Reinehr, R., Becker, S., Eberle, A., Grether-Beck, S. and Häussinger, D. (2005) Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J. Biol. Chem. 280, 27179-27194.
34. Renschler, M. F. (2004) The emerging role of reactive oxygen species in cancer therapy. Eur. J. Cancer 40, 1934-1940.
35. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S. and Boyd, M. R. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82, 1107-1112.
36. Stewart, B. W. and Wild, C. P. (2014) World cancer report 2014. International Agency for Research on Cancer, World Health Organiza tion.
37. Szychowski, J., Truchon, J. F. and Bennani, Y. L. (2014) Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry. J. Med. Chem. 57, 9292-9308.
38. Tammela, P., Wennberg, T., Vuorela, H. and Vuorela, P. (2004) HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal. Bioanal. Chem. 380, 614-618.
39. Toler, S. M., Noe, D. and Sharma, A. (2006) Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme. Neurosurg. Focus 21, E10.
40. Uchikura, K., Wada, T., Hoshino, S., Nagakawa, Y., Aiko, T., Bulkley, G. B., Klein, A. S. and Sun, Z. (2004) Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G620-G626.
41. Upton, J. W., Kaiser, W. J. and Mocarski, E. S. (2012) DAI/ZBP1/DLM 1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe. 11, 290-297.
42. Ushio-Fukai, M. and Nakamura, Y. (2008) Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett. 266, 37-52.
43. Vandenabeele, P., Galluzzi, L., Vanden Berghe, T. and Kroemer, G. (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700-714.
44. Wang, X. F., Zhang, J. S. and Xu, T. W. (2007) Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol. Appl. Pharmacol. 218, 88-95.
45. Wu, W., Liu, P. and Li, J. (2012) Necroptosis: an emerging form of programmed cell death. Crit. Rev. Oncol. Hematol. 82, 249-258.
46. Yang, X. W., Guo, Q. M. and Wang, Y. (2008) Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model. Zhong Xi Yi Jie He Xue Bao. 6, 392-398.
47. Yang, X. W., Xu, B., Ran, F. X., Wang, R. Q., Wu, J. and Cui, J. R. (2007) Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro. Zhong Xi Yi Jie He Xue Bao 5, 56-60.
48. Zhang, D. W., Shao, J., Lin, J., Zhang, N., Lu, B. J., Lin, S. C., Dong, M. Q. and Han, J. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336.
49. Zhang, Y. B., Li, W. and Yang, X. W. (2012) Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro. Phytochemistry 81, 109-116.