Role of N terminus-truncated NS1 proteins of influenza A virus in inhibiting IRF3 activation

Journal of Virology

Volumn 90, Issue 9, 2016, Pages 4696-4705

  Kuo, Rei Lin ^a   Li, Li Hsin ^a   Lin, Sue Jane ^a   Li, Zong Hua ^a   Chen, Guang Wu ^a,b   Chang, Cheng Kai ^a   Wang, Yi Ren ^a   Tam, Ee Hong ^a   Gong, Yu Nong ^a,d   Krug, Robert M ^c   Shih, Shin Ru ^a,d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; INTERFERON REGULATORY FACTOR 3; MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; INS1 PROTEIN, INFLUENZA VIRUS; START CODON; VIRAL PROTEIN;

A549 CELL LINE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE ACTIVATION; IMMUNE RESPONSE; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)); INFLUENZA A VIRUS (H3N2); NONHUMAN; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA BINDING; VIRAL CLEARANCE; VIRUS CELL INTERACTION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSCRIPTION; ANIMAL; CELL CULTURE; CELL LINE; CHEMISTRY; DISEASE MODEL; GENETIC TRANSCRIPTION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; INFLUENZA; METABOLISM; MOUSE; MUTATION; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; START CODON; VIROLOGY;

ANIMALS; CELL LINE; CELLS, CULTURED; CODON, INITIATOR; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MICE; MUTATION; OPEN READING FRAMES; PROTEIN BIOSYNTHESIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN TRANSPORT; TRANSCRIPTION, GENETIC; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84964959547     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02843-15     Document Type: Article

References (26)

1. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW. 2001. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 7:1306-1312. http://dx.doi.org/10.1038/nm1201-1306.
2. Wise HM, Foeglein A, Sun J, Dalton RM, Patel S, Howard W, Anderson EC, Barclay WS, Digard P. 2009. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J Virol 83:8021-8031. http://dx.doi.org/10.1128/JVI.00826-09.
3. Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P. 2012. An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 337:199-204. http://dx.doi.org/10.1126/science.1222213.
4. Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y. 2013. Identification of novel influenza A virus proteins translated from PA mRNA. J Virol 87:2455-2462. http://dx.doi.org/10.1128/JVI.02656-12.
5. Shih SR, Suen PC, Chen YS, Chang SC. 1998. A novel spliced transcript of influenza A/WSN/33 virus. Virus Genes 17:179-183. http://dx.doi.org/10.1023/A:1008024909222.
6. Wise HM, Hutchinson EC, Jagger BW, Stuart AD, Kang ZH, Robb N, Schwartzman LM, Kash JC, Fodor E, Firth AE, Gog JR, Taubenberger JK, Digard P. 2012. Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain. PLoS Pathog 8:e1002998. http://dx.doi.org/10.1371/journal.ppat.1002998.
7. Selman M, Dankar SK, Forbes NE, Jia J-J, Brown EG. 2012. Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing. Emerg Microbes Infect 1:1-10.
8. Qian XY, Alonso-Caplen F, Krug RM. 1994. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA. J Virol 68:2433-2441.
9. Min JY, Krug RM. 2006. The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: inhibiting the 2'-5' oligo( A) synthetase/RNase L pathway. Proc Natl Acad Sci U S A 103:7100-7105. http://dx.doi.org/10.1073/pnas.0602184103.
10. Krug RM, Garcia-Sastre A. 2013. The NS1 protein: a master regulator of host and viral functions, p 114-132. In Webster RG, Monto AS, Braciale TJ, Lamb RA (ed), Textbook of influenza, 2nd ed. John Wiley & Sons, Ltd, New York, NY.
11. Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM. 1998. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell 1:991-1000. http://dx.doi.org/10.1016/S1097-2765(00)80099-4.
12. Noah DL, Twu KY, Krug RM. 2003. Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAs. Virology 307:386-395. http://dx.doi.org/10.1016/S0042-6822(02)00127-7.
13. Twu KY, Kuo RL, Marklund J, Krug RM. 2007. The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells. J Virol 81:8112-8121. http://dx.doi.org/10.1128/JVI.00006-07.
14. Hale BG, Steel J, Medina RA, Manicassamy B, Ye J, Hickman D, Hai R, Schmolke M, Lowen AC, Perez DR, Garcia-Sastre A. 2010. Inefficient control of host gene expression by the 2009 pandemicH1N1influenzaAvirus NS1 protein. J Virol 84:6909-6922. http://dx.doi.org/10.1128/JVI.00081-10.
15. Steidle S, Martinez-Sobrido L, Mordstein M, Lienenklaus S, Garcia-Sastre A, Staheli P, Kochs G. 2010. Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response. J Virol 84:12761-12770. http://dx.doi.org/10.1128/JVI.00701-10.
16. Kuo RL, Zhao C, Malur M, Krug RM. 2010. Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-beta transcription. Virology 408:146-158. http://dx.doi.org/10.1016/j.virol.2010.09.012.
17. Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, Garcia-Sastre A. 2009. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5:439-449. http://dx.doi.org/10.1016/j.chom.2009.04.006.
18. Neumann G, Watanabe T, Ito H, Watanabe S, Goto H, Gao P, Hughes M, Perez DR, Donis R, Hoffmann E, Hobom G, Kawaoka Y. 1999. Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96:9345-9350. http://dx.doi.org/10.1073/pnas.96.16.9345.
19. Takeda M, Pekosz A, Shuck K, Pinto LH, Lamb RA. 2002. Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture. J Virol 76:1391-1399. http://dx.doi.org/10.1128/JVI.76.3.1391-1399.2002.
20. Kuo RL, Kao LT, Lin SJ, Wang RY, Shih SR. 2013. MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation. PLoS One 8:e63431. http://dx.doi.org/10.1371/journal.pone.0063431.
21. Lin SJ, Lo M, Kuo RL, Shih SR, Ojcius DM, Lu J, Lee CK, Chen HC, Lin MY, Leu CM, Lin CN, Tsai CH. 2014. The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection. J Biomed Sci 21:99. http://dx.doi.org/10.1186/s12929-014-0099-6.
22. Gong YN, Chen GW, Chen CJ, Kuo RL, Shih SR. 2014. Computational analysis and mapping of novel open reading frames in influenza A viruses. PLoS One 9:e115016. http://dx.doi.org/10.1371/journal.pone.0115016.
23. Melen K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I. 2007. Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. J Virol 81:5995-6006. http://dx.doi.org/10.1128/JVI.01714-06.
24. Vasin AV, Temkina OA, Egorov VV, Klotchenko SA, Plotnikova MA, Kiselev OI. 2014. Molecular mechanisms enhancing the proteome of influenzaAviruses: an overview of recently discovered proteins. Virus Res 185:53-63. http://dx.doi.org/10.1016/j.virusres.2014.03.015.
25. Kochs G, Garcia-Sastre A, Martinez-Sobrido L. 2007. Multiple antiinterferon actions of the influenza A virus NS1 protein. J Virol 81:7011-7021. http://dx.doi.org/10.1128/JVI.02581-06.
26. Quinlivan M, Zamarin D, Garcia-Sastre A, Cullinane A, Chambers T, Palese P. 2005. Attenuation of equine influenza viruses through truncations of the NS1 protein. J Virol 79:8431-8439. http://dx.doi.org/10.1128/JVI.79.13.8431-8439.2005.