Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

PLoS Pathogens

Volumn 12, Issue 4, 2016, Pages

  Arai, Yasuha ^a,b   Kawashita, Norihito ^a,c   Daidoji, Tomo ^b   Ibrahim, Madiha S ^b,d   El Gendy, Emad M ^b,d   Takagi, Tatsuya ^a,c   Takahashi, Kazuo ^e   Suzuki, Yasuo ^f   Ikuta, Kazuyoshi ^a   Nakaya, Takaaki ^b   Shioda, Tatsuo ^a   Watanabe, Yohei ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Damanhour University   (Egypt)

^e International University of Health and Welfare   (Japan)

^f CHUBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENOME ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLUENZA A VIRUS (H5N1); MOUSE; NONHUMAN; PHYLOGENY; POLYMERASE GENE MUTATION; RESPIRATORY EPITHELIUM; SEQUENCE HOMOLOGY; VIRAL GENETICS; VIRUS ISOLATION; VIRUS MUTANT; VIRUS REPLICATION; ADAPTATION; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; GENETIC TRANSFECTION; GENETICS; INFLUENZA; MUTATION; REAL TIME POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

DNA DIRECTED RNA POLYMERASE; PB2 PROTEIN, INFLUENZA VIRUS; VIRAL PROTEIN;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DNA-DIRECTED RNA POLYMERASES; FEMALE; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFECTION; VIRAL PROTEINS;

EID: 84964877614     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005583     Document Type: Article

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