A mitochondrial-targeted coenzyme Q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 3, 2014, Pages 699-708

  Fink, Brian D ^a   Herlein, Judith A ^a   Guo, Deng Fu ^b   Kulkarni, Chaitanya ^a   Weidemann, Benjamin J ^b   Yu, Liping ^b   Grobe, Justin L ^b   Rahmouni, Kamal ^b   Kerns, Robert J ^a   Sivitz, William I ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGOUTI RELATED PROTEIN; ALANINE AMINOTRANSFERASE; ALCOHOL; ANTIOXIDANT; LEPTIN RECEPTOR; LIPID HYDROPEROXIDE; MESSENGER RNA; MITOQUINONE; NEUROPEPTIDE Y; REACTIVE OXYGEN METABOLITE; SODIUM; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FAT INTAKE; ORGANOPHOSPHORUS COMPOUND; UBIQUINONE;

AGRP GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENERGY EXPENDITURE; FAT CONTENT; FAT MASS; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION; KIDNEY FUNCTION; LEPRB GENE; LIPID PEROXIDATION; LIVER DYSFUNCTION; LIVER FUNCTION; MALE; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NPY GENE; OBESITY; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WEIGHT GAIN; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; FAT INTAKE; LIPID DIET; LIVER DISEASES; LIVER MITOCHONDRION; PHYSIOLOGY;

ANIMALS; DIET, HIGH-FAT; DIETARY FATS; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; ORGANOPHOSPHORUS COMPOUNDS; UBIQUINONE; WEIGHT GAIN;

EID: 84964698143     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.219329     Document Type: Article

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