Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: A genome-wide interaction analysis

Environmental Health Perspectives

Volumn 123, Issue 1, 2015, Pages 72-79

  Imboden, Medea ^a,b   Kumar, Ashish ^a,b,c   Curjuric, Ivan ^a,b   Adam, Martin ^a,b   Thun, Gian Andri ^a,b   Haun, Margot ^d   Tsai, Ming Yi ^a,b   Pons, Marco ^e   Bettschart, Robert ^f   Turk, Alexander ^g   Rochat, Thierry ^h   Künzli, Nino ^a,b   Schindler, Christian ^a,b   Kronenberg, Florian ^d   Probst Hensch, Nicole M ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^f KLINIK HIRSLANDEN   (Switzerland)

^g Zurcher Hohenklinik Clavadel   (Switzerland)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AIR POLLUTANT; CADHERIN; H-CADHERIN; PARTICULATE MATTER;

ADOLESCENT; ADULT; ADVERSE EFFECTS; AIR POLLUTANT; AIR POLLUTION; COHORT ANALYSIS; DRUG EFFECTS; FEMALE; GENETICS; GENOME; GENOTYPE; HUMAN; LUNG VENTILATION; MALE; METABOLISM; MIDDLE AGED; PARTICLE SIZE; PARTICULATE MATTER; RESPIRATORY FUNCTION; TOXICITY;

ADOLESCENT; ADULT; AIR POLLUTANTS; AIR POLLUTION; CADHERINS; COHORT STUDIES; FEMALE; GENOME; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PARTICLE SIZE; PARTICULATE MATTER; PULMONARY VENTILATION; RESPIRATORY PHYSIOLOGICAL PHENOMENA;

EID: 84964693777     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1307398     Document Type: Article

References (62)

1. Ackermann-Liebrich U, Kuna-Dibbert B, Probst-Hensch N, Schindler C, Felber Dietrich D, Zemp Stutz E, et al. 2005. Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants. Soz Praventivmed 50:245-263.
2. American Thoracic Society. 1995. Standardization of Spirometry, 1994 update. Am J Respir Crit Care Med 152(3):1107-1136.
3. Andreau K, Leroux M, Bouharrour A. 2012. Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity. Biochem Res Int 2012:493894; doi:10.1155/2012/493894.
4. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83.
5. Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al. 2011. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 43:1082-1090.
6. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
7. Breton CV, Salam MT, Vora H, Gauderman WJ, Gilliland FD. 2011. Genetic variation in the glutathione synthesis pathway, air pollution, and children’s lung function growth. Am J Respir Crit Care Med 183:243-248.
8. Brook RD, Rajagopalan S, Pope CA III, Brook JR, Bhatnagar A, Diez-Roux AV, et al. 2010. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121:2331-2378.
9. Chung CM, Lin TH, Chen JW, Leu HB, Yang HC, Ho HY, et al. 2011. A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes 60:2417-2423.
10. Curjuric I, Imboden M, Nadif R, Kumar A, Schindler C, Haun M, et al. 2012. Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population. PLoS One 7:e40175; doi:10.1371/journal.pone.0040175.
11. Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SL, et al. 2010. HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. Eur Respir J 35:505-514.
12. Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, et al. 2012. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 8:e1002607; doi:10.1371/journal.pgen.1002607.
13. Downs SH, Schindler C, Liu LJ, Keidel D, Bayer-Oglesby L, Brutsche MH, et al. 2007. Reduced exposure to PM10 and attenuated age-related decline in lung function. N Engl J Med 357:2338-2347.
14. Ege MJ, Strachan DP, Cookson WO, Moffatt MF, Gut I, Lathrop M, et al. 2011. Gene-environment inter action for childhood asthma and exposure to farming in Central Europe. J Allergy Clin Immunol 127:138-144.e4; doi:10.1016/j.jaci.2010.09.041.
15. Gauderman WJ, Zhang P, Morrison JL, Lewinger JP. 2013. Finding novel genes by testing G × E inter-actions in a genome-wide association study. Genet Epidemiol 37:603-613.
16. Hancock DB, Artigas MS, Gharib SA, Henry A, Manichaikul A, Ramasamy A, et al. 2012. Genome-wide joint meta-analysis of SNP and SNP-by-smoking inter action identifies novel loci for pulmonary function. PLoS Genet 8:e1003098; doi:10.1371/journal.pgen.1003098.
17. Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, et al. 2010. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 42:45-52.
18. Hansel NN, Ruczinski I, Rafaels N, Sin DD, Daley D, Malinina A, et al. 2013. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. Hum Genet 132:79-90.
19. Heath SC, Gut IG, Brennan P, McKay JD, Bencko V, Fabianova E, et al. 2008. Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet 16:1413-1429.
20. Huang W, Wang G, Lu SE, Kipen H, Wang Y, Hu M, et al. 2012. Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics. Am J Respir Crit Care Med 186:1150-1159.
21. Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. 2004. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 101:10308-10313.
22. Hutter CM, Mechanic LE, Chatterjee N, Kraft P, Gillanders EM, NCI Gene-Environment Think Tank. 2013. Gene-environment inter actions in cancer epidemiology: a National Cancer Institute Think Tank report. Genet Epidemiol 37:643-657.
23. Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, et al. 2012. Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol 129:1218-1228.
24. Imboden M, Nieters A, Bircher AJ, Brutsche M, Becker N, Wjst M, et al. 2006. Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Clin Mol Allergy 4:9; doi:10.1186/1476-7961-4-9.
25. Imboden M, Schwartz J, Schindler C, Curjuric I, Berger W, Liu SL, et al. 2009.
26. Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect 117:1420-1427; doi:10.1289/ehp.0800430.
27. Jee SH, Sull JW, Lee JE, Shin C, Park J, Kimm H, et al. 2010. Adiponectin concentrations: a genome-wide association study. Am J Hum Genet 87:545-552.
28. Katanoda K, Sobue T, Satoh H, Tajima K, Suzuki T, Nakatsuka H, et al. 2011. An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan. J Epidemiol 21:132-143.
29. Kraft P, Yen YC, Stram DO, Morrison J, Gauderman WJ. 2007. Exploiting gene-environment inter action to detect genetic associations. Hum Hered 63:111-119.
30. Künzli N, Kuna-Dibbert B, Keidel D, Keller R, Brändli O, Schindler C, et al. 2005. Longitudinal validity of spirometers—a challenge in lung function follow-up studies. Swiss Med Wkly 135(33-34):503-508.
31. Li Y, Rittenhouse-Olson K, Scheider WL, Mu L. 2012. Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies. Rev Environ Health 27:133-149.
32. Liao SY, Lin X, Christiani DC. 2013. Gene-environment inter action effects on lung function-a genome-wide association study within the Framingham heart study. Environ Health 12:101; doi:10.1186/1476-069X-12-101.
33. Liu LJ, Curjuric I, Keidel D, Heldstab J, Künzli N, Bayer-Oglesby L, et al. 2007. Characterization of source-specific air pollution exposure for a large population-based Swiss cohort (SAPALDIA). Environ Health Perspect 115:1638-1645; doi:10.1289/ehp.10177.
34. Manzo ND, LaGier AJ, Slade R, Ledbetter AD, Richards JH, Dye JA. 2012. Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells—implications for susceptibility to traffic-related air pollution. Part Fibre Toxicol 9:43; doi:10.1186/1743-8977-9-43.
35. Martin BW, Ackermann-Liebrich U, Leuenberger P, Künzli N, Stutz EZ, Keller R, et al. 1997. SAPALDIA: methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults. Soz Praventivmed 42:67-84.
36. Mehta AJ, Adam M, Schaffner E, Barthélémy JC, Carballo D, Gaspoz JM, et al. 2012. Heart rate variability in association with frequent use of household sprays and scented products in SAPALDIA. Environ Health Perspect 120:958-964; doi:10.1289/ehp.1104567.
37. Melén E, Nyberg F, Lindgren CM, Berglind N, Zucchelli M, Nordling E, et al. 2008. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect 116:1077-1084; doi:10.1289/ehp.11117.
38. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. 2010. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363:1211-1221.
39. Morisaki H, Yamanaka I, Iwai N, Miyamoto Y, Kokubo Y, Okamura T, et al. 2012. CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population. Hum Mutat 33:402-410.
40. Obeidat M, Wain LV, Shrine N, Kalsheker N, Soler Artigas M, Repapi E, et al. 2011. A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLoS One 6:e19382; doi:10.1371/journal.pone.0019382.
41. Ohashi K, Ouchi N, Matsuzawa Y. 2012. Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie 94:2137-2142.
42. Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, et al. 2010. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet 19:2303-2312.
43. Peters KE, Beilby J, Cadby G, Warrington NM, Bruce DG, Davis WA, et al. 2013. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. BMC Med Genet 14:15; doi:10.1186/1471-2350-14-15.
44. Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP, et al. 2010. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26:2336-2337.
45. Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, et al. 2010. Genome-wide association study identifies five loci associated with lung function. Nat Genet 42:36-44.
46. Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, Moreno-Macías H, del Rio-Navarro BE, David G, et al. 2006. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J 28:953-959.
47. Romieu I, Riojas-Rodríguez H, Marrón-Mares AT, Schilmann A, Perez-Padilla R, Masera O. 2009. Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women. Am J Respir Crit Care Med 180:649-656.
48. Rossi AP, Watson NL, Newman AB, Harris TB, Kritchevsky SB, Bauer DC, et al. 2011. Effects of body composition and adipose tissue distribution on respiratory function in elderly men and women: the health, aging, and body composition study. J Gerontol A Biol Sci Med Sci 66:801-808.
49. Schikowski T, Ranft U, Sugiri D, Vierkötter A, Brüning T, Harth V, et al. 2010. Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women. Respir Res 11:113; doi:10.1186/1465-9921-11-113.
50. Schikowski T, Schaffner E, Meier F, Phuleria HC, Vierkötter A, Schindler C, et al. 2013. Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort. Environ Health Perspect 121:1034-1039; doi:10.1289/ehp.1206145.
51. Sohns M, Viktorova E, Amos CI, Brennan P, Fehringer G, Gaborieau V, et al. 2013. Empirical hierarchical Bayes approach to gene-environment inter actions: development and application to genome-wide association studies of lung cancer in TRICL. Genet Epidemiol 37:551-559.
52. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, et al. 2007. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 117:375-386.
53. Thun GA, Ferrarotti I, Imboden M, Rochat T, Gerbase M, Kronenberg F, et al. 2012. SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort. PLoS One 7:e42728; doi:10.1371/journal.pone.0042728.
54. Thyagarajan B, Jacobs DR Jr, Smith LJ, Kalhan R, Gross MD, Sood A. 2010. Serum adiponectin is positively associated with lung function in young adults, independent of obesity: the CARDIA study. Respir Res 11:176; doi:10.1186/1465-9921-11-176.
55. Trasande L, Thurston GD. 2005. The role of air pollution in asthma and other pediatric morbidities. J Allergy Clin Immunol 115:689-699.
56. Uski OJ, Happo MS, Jalava PI, Brunner T, Kelz J, Obernberger I, et al. 2012. Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies. Inhal Toxicol 24:952-965.
57. Wehrmeister FC, Menezes AM, Muniz LC, Martínez-Mesa J, Domingues MR, Horta BL. 2012. Waist circumference and pulmonary function: a systematic review and meta-analysis. Syst Rev 1:55; doi:10.1186/2046-4053-1-55.
58. Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, et al. 2009. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet 5:e1000429; doi:10.1371/journal.pgen.1000429.
59. Williams AS, Kasahara DI, Verbout NG, Fedulov AV, Zhu M, Si H, et al. 2012. Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice. PLoS One 7:e41088; doi:10.1371/journal.pone.0041088.
60. Wu Y, Li Y, Lange EM, Croteau-Chonka DC, Kuzawa CW, McDade TW, et al. 2010. Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet 19:4955-4964.
61. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. 2003. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769.
62. Yang IA, Holz O, Jörres RA, Magnussen H, Barton SJ, Rodríguez S, et al. 2005. Association of tumor necrosis factor-α polymorphisms and ozone-induced change in lung function. Am J Respir Crit Care Med 171:171-176.