Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19280-19287

  Akhatib, Bashar ^a   Önnerfjord, Patrik ^b   Gawri, Rahul ^a   Ouellet, Jean ^a,b   Jarzem, Peter ^a,b   Heinegård, Dick ^b   Mort, John ^c   Roughley, Peter ^c   Haglund, Lisbet ^a  

^a MCGILL UNIVERSITY   (Canada)

^b LUND UNIVERSITY   (Sweden)

^c SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE SITES; DISC DEGENERATION; IDIOPATHIC SCOLIOSIS; IMMUNOBLOT ANALYSIS; IMMUNOBLOTTING; IMMUNOBLOTTING ANALYSIS; INTER-VERTEBRAL DISC DEGENERATION; LEUCINE-RICH REPEATS;

AMINO ACIDS; ANTIBODIES;

TISSUE;

AGGRECANASE 1; AGGRECANASE 2; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CELL PROTEIN; CHONDROADHERIN; COLLAGENASE 3; HTRA1; ISOLEUCINE; MACROPHAGE ELASTASE; MATRILYSIN; SERINE PROTEINASE; STROMELYSIN; TYROSINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGING; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE SEVERITY; DNA FRAGMENTATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INTERVERTEBRAL DISK DEGENERATION; NUCLEUS PULPOSUS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PUNCH BIOPSY; SCOLIOSIS; TANDEM MASS SPECTROMETRY; UPREGULATION;

CHONDROADHERIN; EXTRACELLULAR MATRIX; HTRA1; INTERVERTEBRAL DISC DEGENERATION; IVD; PROTEASE; PROTEIN DEGRADATION; PROTEIN TURNOVER; PROTEOLYTIC ENZYMES;

ADOLESCENT; AGE FACTORS; AGING; BINDING SITES; DIAGNOSIS, DIFFERENTIAL; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; HUMANS; INFLAMMATION; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MIDDLE AGED; PEPTIDE HYDROLASES; SERINE ENDOPEPTIDASES;

EID: 84879570167     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.443010     Document Type: Article

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