Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21335-21345

  Tiaden, André N ^a   Klawitter, Marina ^a   Lux, Vanda ^b   Mirsaidi, Ali ^a   Bahrenberg, Gregor ^a   Glanz, Stephan ^a   Quero, Lilian ^a   Liebscher, Thomas ^c   Wuertz, Karin ^a,d   Ehrmann, Michael ^b   Richards, Peter J ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c Klinikum Karlsbad Langensteinbach   (Germany)

^d AOSpine Research Network   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACELLULAR MATRIX PROTEIN; FIBRONECTIN FRAGMENTS; HEPARIN BINDING; HIGH TEMPERATURE; INACTIVE MUTANTS; INTERVERTEBRAL DISCS; MATRIX METALLOPROTEINASES; MRNA EXPRESSION; PROMOTER REGION; PROTEIN LEVEL; PROTEOLYTIC CLEAVAGE; SERINE PROTEASE; SINGLE NUCLEOTIDE POLYMORPHISMS;

AMINO ACIDS; CELL CULTURE; GENES; PATIENT TREATMENT; TISSUE;

VOLTAGE DIVIDERS;

FIBRIN; FIBRONECTIN; HIGH TEMPERATURE REQUIREMENT SERINE PROTEASE A1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MESSENGER RNA; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HIGH TEMPERATURE REQUIREMENT SERINE PROTEASE A1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION;

CELL LINE; COLLAGENASES; EXTRACELLULAR MATRIX; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MAP KINASE KINASE 1; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEOLYSIS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES;

EID: 84862273432     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.341032     Document Type: Article

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