Thermostabilization of the human serotonin transporter in an antidepressant-bound conformation

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Green, Evan M ^a,b   Coleman, Jonathan A ^a   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PAROXETINE; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN; TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LIGAND BINDING; MELTING POINT; MUTATIONAL ANALYSIS; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; WILD TYPE; ACTIVE TRANSPORT; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PROTEIN STABILITY;

AMINO ACID SUBSTITUTION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOLOGICAL TRANSPORT, ACTIVE; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; PROTEIN STABILITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84964468208     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0145688     Document Type: Article

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