Structural basis for action by diverse antidepressants on biogenic amine transporters

Nature

Volumn 503, Issue 7474, 2013, Pages 141-145

  Wang, Hui ^a   Goehring, April ^a   Wang, Kevin H ^a   Penmatsa, Aravind ^a   Ressler, Ryan ^a   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BIOGENIC AMINE TRANSPORTER; CHLORIDE; DESVENLAFAXINE; DULOXETINE; FLUOXETINE; LEUCINE; MAZINDOL; MEMBRANE PROTEIN; NEUROTRANSMITTER; PAROXETINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SODIUM; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

AMINO ACID; BIOGENIC MATERIAL; CRYSTAL STRUCTURE;

ARTICLE; BINDING SITE; CLINICAL PHARMACOLOGY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; MOLECULAR BIOLOGY; MUTANT; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BACTERIAL PROTEINS; BINDING, COMPETITIVE; BIOGENIC AMINES; CHLORIDES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MAZINDOL; MODELS, MOLECULAR; MUTATION; NOREPINEPHRINE; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 84887403382     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12648     Document Type: Article

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