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Volumn 8, Issue 3, 2016, Pages 1339-1354

An additive effect of eplerenone to ACE inhibitor on slowing the progression of diabetic nephropathy in the db/db mice

Author keywords

ACEI; Albuminuria; Aldosterone; Podocyte; Renal fibrosis

Indexed keywords

ALDOSTERONE; CREATININE; ENALAPRIL; EPLERENONE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PODOCIN; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84964461864     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (31)

References (49)
  • 1
    • 0028362076 scopus 로고
    • Angiotensin II Stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells
    • Kagami S, Border WA, Miller DE, Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 1994; 93: 2431-2437.
    • (1994) J Clin Invest , vol.93 , pp. 2431-2437
    • Kagami, S.1    Border, W.A.2    Miller, D.E.3    Noble, N.A.4
  • 2
    • 3543019104 scopus 로고    scopus 로고
    • Effect of candesartan and lisinopril alone and in combination on blood pressure and microalbuminuria
    • Morgan T, Anderson A, Bertram D, MacInnis, RJ. Effect of candesartan and lisinopril alone and in combination on blood pressure and microalbuminuria. J Renin Angiotensin Aldosterone Syst 2004; 5: 64-71.
    • (2004) J Renin Angiotensin Aldosterone Syst , vol.5 , pp. 64-71
    • Morgan, T.1    Anderson, A.2    Bertram, D.3    Macinnis, R.J.4
  • 3
    • 0037219665 scopus 로고    scopus 로고
    • Angiotensin ii receptor blockade: Is there truly a benefit of adding an ace inhibitor?
    • Forclaz A, Maillard M, Nussberger J, Brunner HR, Burnier M. Angiotensin II receptor blockade: is there truly a benefit of adding an ACE inhibitor? Hypertension 2003; 41: 31-36.
    • (2003) Hypertension , vol.41 , pp. 31-36
    • Forclaz, A.1    Maillard, M.2    Nussberger, J.3    Brunner, H.R.4    Burnier, M.5
  • 4
    • 33646580336 scopus 로고    scopus 로고
    • Ace inhibitor-angiotensin receptor blocker combinations: A clinician’s perspective
    • Doulton TW. ACE inhibitor-angiotensin receptor blocker combinations: a clinician’s perspective. Mini Rev Med Chem 2006; 6: 491-497.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 491-497
    • Doulton, T.W.1
  • 5
    • 0031727915 scopus 로고    scopus 로고
    • Targeting tgfbeta overexpression in renal disease: Maximizing the antifibrotic action of angiotensin ii blockade
    • Peters H, Border WA, Noble NA. Targeting TGFbeta overexpression in renal disease: maximizing the antifibrotic action of angiotensin II blockade. Kidney Int 1998; 54: 1570-1580.
    • (1998) Kidney Int , vol.54 , pp. 1570-1580
    • Peters, H.1    Border, W.A.2    Noble, N.A.3
  • 6
    • 12144252958 scopus 로고    scopus 로고
    • Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate
    • Schjoedt KJ, Andersen S, Rossing P, Tarnow L, Parving HH. Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate. Diabetologia 2004; 47: 1936-1939.
    • (2004) Diabetologia , vol.47 , pp. 1936-1939
    • Schjoedt, K.J.1    Andersen, S.2    Rossing, P.3    Tarnow, L.4    Parving, H.H.5
  • 8
    • 18244402213 scopus 로고    scopus 로고
    • Effects of long-term enalapril and losartan therapy of hypertension on cardiovascular aldosterone
    • Li S, Wu P, Zhong S, Guo Z, Lai W, Zhang Y, Liang X, Xiu J, Li J, Liu Y. Effects of long-term enalapril and losartan therapy of hypertension on cardiovascular aldosterone. Horm Res 2001; 55: 293-297.
    • (2001) Horm Res , vol.55 , pp. 293-297
    • Li, S.1    Wu, P.2    Zhong, S.3    Guo, Z.4    Lai, W.5    Zhang, Y.6    Liang, X.7    Xiu, J.8    Li, J.9    Liu, Y.10
  • 9
    • 0035818917 scopus 로고    scopus 로고
    • Aldosterone in congestive heart failure
    • Weber KT. Aldosterone in congestive heart failure. N Engl J Med 2001; 345: 1689-1697.
    • (2001) N Engl J Med , vol.345 , pp. 1689-1697
    • Weber, K.T.1
  • 10
    • 0034896157 scopus 로고    scopus 로고
    • Aldosterone as a determinant of cardiovascular and renal dysfunction
    • Epstein M. 2001. Aldosterone as a determinant of cardiovascular and renal dysfunction. J R Soc Med 94:378-383.
    • (2001) J R Soc Med , vol.94 , pp. 378-383
    • Epstein, M.1
  • 11
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne, A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 12
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin i/angiotensin ii conversion in patients with chronic heart failure
    • Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 2000; 101: 594-597.
    • (2000) Circulation , vol.101 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 15
    • 0035922443 scopus 로고    scopus 로고
    • Spironolactone in addition to ace inhibition to reduce proteinuria in patients with chronic renal disease
    • Chrysostomou A, Becker G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N Engl J Med 2001; 345: 925-926.
    • (2001) N Engl J Med , vol.345 , pp. 925-926
    • Chrysostomou, A.1    Becker, G.2
  • 16
    • 2342559832 scopus 로고    scopus 로고
    • The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: A randomized controlled study
    • Rachmani R, Slavachevsky I, Amit M, Levi Z, Kedar Y, Berla M, Ravid M. The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study. Diabet Med 2004; 21: 471-475.
    • (2004) Diabet Med , vol.21 , pp. 471-475
    • Rachmani, R.1    Slavachevsky, I.2    Amit, M.3    Levi, Z.4    Kedar, Y.5    Berla, M.6    Ravid, M.7
  • 19
    • 0031600240 scopus 로고    scopus 로고
    • Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats
    • Rocha R, Chander PN, Khanna K, Zuckerman A, Stier CT Jr. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 1998; 31: 451-458.
    • (1998) Hypertension , vol.31 , pp. 451-458
    • Rocha, R.1    Chander, P.N.2    Khanna, K.3    Zuckerman, A.4    Stier, C.T.5
  • 20
    • 33744981628 scopus 로고    scopus 로고
    • Podocyte injury underlies the glomerulopathy of dahl salt-hypertensive rats and is reversed by aldosterone blocker
    • Nagase M, Shibata S, Yoshida S, Nagase T, Gotoda T, Fujita T. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006; 47: 1084-1093.
    • (2006) Hypertension , vol.47 , pp. 1084-1093
    • Nagase, M.1    Shibata, S.2    Yoshida, S.3    Nagase, T.4    Gotoda, T.5    Fujita, T.6
  • 22
    • 33745683630 scopus 로고    scopus 로고
    • Spironolactone ameliorates renal injury and connective tissue growth factor expression in type ii diabetic rats
    • Han KH, Kang YS, Han SY, Jee YH, Lee MH, Han JY, Kim HK, Kim YS, Cha DR. Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney Int 2006; 70: 111-120.
    • (2006) Kidney Int , vol.70 , pp. 111-120
    • Han, K.H.1    Kang, Y.S.2    Han, S.Y.3    Jee, Y.H.4    Lee, M.H.5    Han, J.Y.6    Kim, H.K.7    Kim, Y.S.8    Cha, D.R.9
  • 23
    • 33747804321 scopus 로고    scopus 로고
    • Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well
    • Gullulu M, Akdag I, Kahvecioglu S, Filiz G, Savci V. Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well. Ren Fail 2006; 8: 509-514.
    • (2006) Ren Fail , vol.8 , pp. 509-514
    • Gullulu, M.1    Akdag, I.2    Kahvecioglu, S.3    Filiz, G.4    Savci, V.5
  • 27
    • 84902165229 scopus 로고    scopus 로고
    • Targeting reduction of proteinuria in glomerulonephritis: Maximizing the antifibrotic effect of valsartan by protecting podocytes
    • Gu C, Zhou G, Noble NA, Border WA, Cheung AK, Huang Y. Targeting reduction of proteinuria in glomerulonephritis: Maximizing the antifibrotic effect of valsartan by protecting podocytes. J Renin Angiotensin Aldosterone Syst 2014; 15: 177-189.
    • (2014) J Renin Angiotensin Aldosterone Syst , vol.15 , pp. 177-189
    • Gu, C.1    Zhou, G.2    Noble, N.A.3    Border, W.A.4    Cheung, A.K.5    Huang, Y.6
  • 29
    • 84894106381 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: An emerging paradigm in diabetic nephropathy: A systematic review
    • Mavrakanas TA, Gariani K, Martin PY. Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: an emerging paradigm in diabetic nephropathy: a systematic review. Eur J Intern Med 2014; 25: 173-176.
    • (2014) Eur J Intern Med , vol.25 , pp. 173-176
    • Mavrakanas, T.A.1    Gariani, K.2    Martin, P.Y.3
  • 30
    • 84860531024 scopus 로고    scopus 로고
    • Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease
    • Lian M, Hewitson TD, Wigg B, Samuel CS, Chow F, Becker GJ. Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease. Nephrol Dial Transplant 2012; 27: 906-912.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 906-912
    • Lian, M.1    Hewitson, T.D.2    Wigg, B.3    Samuel, C.S.4    Chow, F.5    Becker, G.J.6
  • 32
    • 15844402989 scopus 로고    scopus 로고
    • Combining TGF-β inhibition and angiotensin II blockade results in enhanced anti-fibrotic effect
    • Yu L, Border WA, Anderson I, McCourt M, Huang Y, Noble NA. Combining TGF-β inhibition and Angiotensin II blockade results in enhanced anti-fibrotic effect. Kidney Int 2004; 66: 1774-1784.
    • (2004) Kidney Int , vol.66 , pp. 1774-1784
    • Yu, L.1    Border, W.A.2    Anderson, I.3    McCourt, M.4    Huang, Y.5    Noble, N.A.6
  • 33
    • 84893958447 scopus 로고    scopus 로고
    • Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation
    • Zhou G, Cheung AK, Liu X, Huang Y. Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation. Clin Sci (Lond) 2014; 126: D707-720.
    • (2014) Clin Sci (Lond) , vol.126 , pp. D707-D720
    • Zhou, G.1    Cheung, A.K.2    Liu, X.3    Huang, Y.4
  • 34
    • 84933529443 scopus 로고    scopus 로고
    • Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: A double-blind, randomised, placebo-controlled trial
    • Ando K, Ohtsu H, Uchida S, Kaname S, Arakawa Y, Fujita T. Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 2014; 2: 944-953.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 944-953
    • Ando, K.1    Ohtsu, H.2    Uchida, S.3    Kaname, S.4    Arakawa, Y.5    Fujita, T.6
  • 35
    • 0141790220 scopus 로고    scopus 로고
    • Evaluation of a thick and thin sec tion method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with wilms’ tumor-1 protein used as a podocyte nuclear marker
    • Sanden SK, Wiggins JE, Goyal M, Riggs LK, Wiggins RC. Evaluation of a thick and thin sec tion method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 2003; 14: 2484-2493.
    • (2003) J am Soc Nephrol , vol.14 , pp. 2484-2493
    • Sanden, S.K.1    Wiggins, J.E.2    Goyal, M.3    Riggs, L.K.4    Wiggins, R.C.5
  • 36
    • 0037087593 scopus 로고    scopus 로고
    • Wt1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    • Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 2002; 11: 651-659.
    • (2002) Hum Mol Genet , vol.11 , pp. 651-659
    • Guo, J.K.1    Menke, A.L.2    Gubler, M.C.3    Clarke, A.R.4    Harrison, D.5    Hammes, A.6    Hastie, N.D.7    Schedl, A.8
  • 37
    • 84872041647 scopus 로고    scopus 로고
    • Inflammation and the pathogenesis of diabetic nephropathy
    • Wada J, Makino H. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (Lond) 2013; 124: 139-152.
    • (2013) Clin Sci (Lond) , vol.124 , pp. 139-152
    • Wada, J.1    Makino, H.2
  • 38
    • 34547788748 scopus 로고    scopus 로고
    • Suppressing renal nadph oxidase to treat diabetic nephropathy
    • Tojo A, Asaba K, Onozato ML. Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin Ther Targets 2007; 11: 1011-1018.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 1011-1018
    • Tojo, A.1    Asaba, K.2    Onozato, M.L.3
  • 39
    • 51849122365 scopus 로고    scopus 로고
    • Normalizing NADPH Oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats
    • Xu M, Dai DZ, Dai Y. Normalizing NADPH oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats. Am J Nephrol 2009; 29: 252-256.
    • (2009) Am J Nephrol , vol.29 , pp. 252-256
    • Xu, M.1    Dai, D.Z.2    Dai, Y.3
  • 40
    • 47549114629 scopus 로고    scopus 로고
    • Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats
    • Taira, M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, Nakata T. Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Eur J Pharmacol 2008; 589: 264-271.
    • (2008) Eur J Pharmacol , vol.589 , pp. 264-271
    • Taira, M.1    Toba, H.2    Murakami, M.3    Iga, I.4    Serizawa, R.5    Murata, S.6    Kobara, M.7    Nakata, T.8
  • 42
    • 0042333495 scopus 로고    scopus 로고
    • Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: Effects of raas stimulation
    • Luik PT, Kerstens MN, Hoogenberg K, Navis GJ, Dullaart RP. Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: effects of RAAS stimulation. Eur J Clin Invest 2003; 233: 787-793.
    • (2003) Eur J Clin Invest , vol.233 , pp. 787-793
    • Luik, P.T.1    Kerstens, M.N.2    Hoogenberg, K.3    Navis, G.J.4    Dullaart, R.P.5
  • 43
    • 84936752828 scopus 로고    scopus 로고
    • Efficacy of aliskiren, compared with angiotensin II blockade, in slowing the progression of diabetic nephropathy in db/db mice: Should the combination therapy be a focus?
    • Zhou G, Liu X, Cheung AK, Huang Y. Efficacy of aliskiren, compared with angiotensin II blockade, in slowing the progression of diabetic nephropathy in db/db mice: should the combination therapy be a focus? Am J Transl Res 2015; 7: 825-840.
    • (2015) Am J Transl Res , vol.7 , pp. 825-840
    • Zhou, G.1    Liu, X.2    Cheung, A.K.3    Huang, Y.4
  • 44
    • 84930915402 scopus 로고    scopus 로고
    • Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine a nephrotoxicity
    • Sun QL, Li M, Rui HL, Chen YP. Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity. J Renin Angiotensin Aldosterone Syst 2015; 16: 301-310.
    • (2015) J Renin Angiotensin Aldosterone Syst , vol.16 , pp. 301-310
    • Sun, Q.L.1    Li, M.2    Rui, H.L.3    Chen, Y.P.4
  • 45
    • 46149104414 scopus 로고    scopus 로고
    • Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats
    • Siragy HM, Xue C. Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats. Exp Physiol 2018; 93: 817-824.
    • (2018) Exp Physiol , vol.93 , pp. 817-824
    • Siragy, H.M.1    Xue, C.2
  • 46
    • 84893869723 scopus 로고    scopus 로고
    • Aldosterone synthase inhibitors in cardiovascular and renal diseases
    • Namsolleck P, Unger T. Aldosterone synthase inhibitors in cardiovascular and renal diseases. Nephrol Dial Transplant 2014; 29 Suppl 1: i62-i68.
    • Nephrol Dial Transplant 2014; 29 Suppl , vol.1 , pp. 162-168
    • Namsolleck, P.1    Unger, T.2
  • 47
    • 48249139468 scopus 로고    scopus 로고
    • Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells
    • Huang W, Xu C, Kahng KW, Noble NA, Border WA, Huang Y. Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells. Am J Physiol Renal Physiol 2008; 294: F1287-1295.
    • (2008) Am J Physiol Renal Physiol , vol.294 , pp. F1287-F1295
    • Huang, W.1    Xu, C.2    Kahng, K.W.3    Noble, N.A.4    Border, W.A.5    Huang, Y.6
  • 49
    • 84858997658 scopus 로고    scopus 로고
    • The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: Systematic review and meta-analysis
    • Harel Z, Gilbert C, Wald R, Bell C, Perl J, Juurlink D, Beyene J, Shah PS. The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis. BMJ 2012; 344: e42.
    • (2012) BMJ , vol.344
    • Harel, Z.1    Gilbert, C.2    Wald, R.3    Bell, C.4    Perl, J.5    Juurlink, D.6    Beyene, J.7    Shah, P.S.8


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