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Volumn 7, Issue 5, 2015, Pages 825-840

Efficacy of aliskiren, compared with angiotensin ii blockade, in slowing the progression of diabetic nephropathy in db/db mice: Should the combination therapy be a focus?

Author keywords

Albuminuria; Angiotensin converting enzyme inhibitor (ACEI); Angiotensin II receptor blocker (ARB); Direct renin inhibitor (DRI); Podocyte; Renal fibrosis

Indexed keywords

ALBUMIN; ALDOSTERONE; ALISKIREN; B7 ANTIGEN; COLLAGEN TYPE 4; DESMIN; ENALAPRIL; FIBRONECTIN; HEMOGLOBIN A1C; MALONALDEHYDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHRIN; P47PHOX PROTEIN; PEPTIDES AND PROTEINS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PODOCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; RENIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALSARTAN; WILMS TUMOR PROTEIN 1;

EID: 84936752828     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (43)
  • 1
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collab orative Study Group
    • [1] Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collab orative Study Group. N Engl J Med 1993; 329: 1456-1462.
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 2
    • 3543019104 scopus 로고    scopus 로고
    • Effect of candesartan and lisinopril alone and in combination on blood pressure and mi-croalbuminuria
    • [2] Morgan T, Anderson A, Bertram D, MacInnis RJ. Effect of candesartan and lisinopril alone and in combination on blood pressure and mi-croalbuminuria. J Renin Angiotensin Aldoste-rone Syst 2004; 5: 64-71.
    • (2004) J Renin Angiotensin Aldoste-Rone Syst , vol.5 , pp. 64-71
    • Morgan, T.1    Erson, A.2    Bertram, D.3    Macinnis, R.J.4
  • 3
    • 0037219665 scopus 로고    scopus 로고
    • Angiotensin II receptor blockade: Is there truly a beneft of adding an ACE inhibitor?
    • [3] Forclaz A, Maillard M, Nussberger J, Brunner HR, Burnier M. Angiotensin II receptor blockade: is there truly a beneft of adding an ACE inhibitor? Hypertension 2003; 41: 31-36.
    • (2003) Hypertension , vol.41 , pp. 31-36
    • Forclaz, A.1    Maillard, M.2    Nussberger, J.3    Brunner, H.R.4    Burnier, M.5
  • 4
    • 33646580336 scopus 로고    scopus 로고
    • ACE inhibitor-angiotensin receptor blocker combinations: A clinician’s perspective
    • [4] Doulton TW. ACE inhibitor-angiotensin receptor blocker combinations: a clinician’s perspective. Mini Rev Med Chem 2006; 6: 491-497.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 491-497
    • Doulton, T.W.1
  • 5
    • 1642542430 scopus 로고    scopus 로고
    • Integrating drug pharmacokinetics for phe-notyping individual renin response to angioten-sin II blockade in humans
    • [5] Azizi M, Bissery A, Lamarre-Cliche M, Menard J. Integrating drug pharmacokinetics for phe-notyping individual renin response to angioten-sin II blockade in humans. Hypertension 2004; 43: 785-790.
    • (2004) Hypertension , vol.43 , pp. 785-790
    • Azizi, M.1    Bissery, A.2    Lamarre-Cliche, M.3    Menard, J.4
  • 6
    • 0345267112 scopus 로고    scopus 로고
    • Effects of the angiotensin II type-1 receptor antagonist ZD7155 on angiotensin II-mediated regulation of renin secretion and renal renin gene expression, renal vasoconstriction, and blood pressure in rats
    • [6] Kramer BK, Ritthaler T, Schweda F, Ittner KP, Scholz H, Riegger GA and Kurtz A. Effects of the angiotensin II type-1 receptor antagonist ZD7155 on angiotensin II-mediated regulation of renin secretion and renal renin gene expression, renal vasoconstriction, and blood pressure in rats. J Cardiovasc Pharmacol 1998; 31: 700-705.
    • (1998) J Cardiovasc Pharmacol , vol.31 , pp. 700-705
    • Kramer, B.K.1    Ritthaler, T.2    Schweda, F.3    Ittner, K.P.4    Scholz, H.5    Riegger, G.A.6    Kurtz, A.7
  • 7
    • 42949109643 scopus 로고    scopus 로고
    • Aliskiren: The frst renin inhibitor for clinical treatment
    • [7] Jensen C, Herold P, Brunner HR. Aliskiren: the frst renin inhibitor for clinical treatment. Nat Rev Drug Discov 2008; 7: 399-410.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 399-410
    • Jensen, C.1    Herold, P.2    Brunner, H.R.3
  • 8
    • 84874698281 scopus 로고    scopus 로고
    • Renin inhibition in the treatment of diabetic kidney disease
    • [8] Komers R. Renin inhibition in the treatment of diabetic kidney disease. Clin Sci (Lond) 2013; 124: 553-566.
    • (2013) Clin Sci (Lond) , vol.124 , pp. 553-566
    • Komers, R.1
  • 12
    • 0031727915 scopus 로고    scopus 로고
    • Targeting TGF-beta overexpression in renal disease: Maximizing the antifbrotic action of angiotensin II blockade
    • [12] Peters H, Border WA, Noble NA. Targeting TGF-beta overexpression in renal disease: maximizing the antifbrotic action of angiotensin II blockade. Kidney Int 1998; 54: 1570-1580.
    • (1998) Kidney Int , vol.54 , pp. 1570-1580
    • Peters, H.1    Border, W.A.2    Noble, N.A.3
  • 13
    • 84902165229 scopus 로고    scopus 로고
    • Targeting reduction of pro-teinuria in glomerulonephritis: Maximizing the antifbrotic effect of valsartan by protecting podocytes
    • [13] Gu C, Zhou G, Noble NA, Border WA, Cheung AK and Huang Y. Targeting reduction of pro-teinuria in glomerulonephritis: Maximizing the antifbrotic effect of valsartan by protecting podocytes. J Renin Angiotensin Aldosterone Syst 2012; 15: 177-189.
    • (2012) J Renin Angiotensin Aldosterone Syst , vol.15 , pp. 177-189
    • Gu, C.1    Zhou, G.2    Noble, N.A.3    Border, W.A.4    Cheung, A.K.5    Huang, Y.6
  • 14
    • 84893958447 scopus 로고    scopus 로고
    • Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury and renal oxidative stress and inflammation
    • [14] Zhou G, Cheung AK, Liu X, Huang Y. Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury and renal oxidative stress and inflammation. Clin Sci (Lond) 2014; 126: 707-720.
    • (2014) Clin Sci (Lond) , vol.126 , pp. 707-720
    • Zhou, G.1    Cheung, A.K.2    Liu, X.3    Huang, Y.4
  • 15
    • 84899928632 scopus 로고    scopus 로고
    • A PAI-1 mutant retards diabetic ne-phropathy in db/db mice through protecting podocytes
    • [15] Zhang J, Gu C, Lawrence DA, Cheung AK, Huang Y. A PAI-1 mutant retards diabetic ne-phropathy in db/db mice through protecting podocytes. Exp Physiol 2014; 99: 802-815.
    • (2014) Exp Physiol , vol.99 , pp. 802-815
    • Zhang, J.1    Gu, C.2    Lawrence, D.A.3    Cheung, A.K.4    Huang, Y.5
  • 16
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte’s response to injury: Role in proteinuria and glomerulosclerosis
    • [16] Shankland SJ. The podocyte’s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006; 69: 2131-2147.
    • (2006) Kidney Int , vol.69 , pp. 2131-2147
    • Shankland, S.J.1
  • 17
    • 38949151661 scopus 로고    scopus 로고
    • Pathogenesis of the podo-cytopathy and proteinuria in diabetic glomeru-lopathy
    • [17] Ziyadeh FN, Wolf G. Pathogenesis of the podo-cytopathy and proteinuria in diabetic glomeru-lopathy. Curr Diabetes Rev 2008; 4: 39-45.
    • (2008) Curr Diabetes Rev , vol.4 , pp. 39-45
    • Ziyadeh, F.N.1    Wolf, G.2
  • 18
    • 21344446946 scopus 로고    scopus 로고
    • Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    • [18] Yu D, Petermann A, Kunter U, Rong S, Shank-land SJ and Floege J. Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J Am Soc Nephrol 2005; 16: 1733-1741.
    • (2005) J am Soc Nephrol , vol.16 , pp. 1733-1741
    • Yu, D.1    Petermann, A.2    Kunter, U.3    Rong, S.4    Shank-Land, S.J.5    Floege, J.6
  • 19
    • 0141790220 scopus 로고    scopus 로고
    • Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker
    • [19] Sanden SK, Wiggins JE, Goyal M, Riggs LK, Wiggins RC. Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 2003; 14: 2484-2493.
    • (2003) J am Soc Nephrol , vol.14 , pp. 2484-2493
    • Sanden, S.K.1    Wiggins, J.E.2    Goyal, M.3    Riggs, L.K.4    Wiggins, R.C.5
  • 20
    • 0037087593 scopus 로고    scopus 로고
    • WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    • [20] Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND and Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 2002; 11: 651-659.
    • (2002) Hum Mol Genet , vol.11 , pp. 651-659
    • Guo, J.K.1    Menke, A.L.2    Gubler, M.C.3    Clarke, A.R.4    Harrison, D.5    Hammes, A.6    Hastie, N.D.7    Schedl, A.8
  • 22
    • 84872041647 scopus 로고    scopus 로고
    • Inflammation and the pathogenesis of diabetic nephropathy
    • [22] Wada J, Makino H. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (Lond) 2013; 124: 139-152.
    • (2013) Clin Sci (Lond) , vol.124 , pp. 139-152
    • Wada, J.1    Makino, H.2
  • 23
    • 34547788748 scopus 로고    scopus 로고
    • Suppressing renal NADPH oxidase to treat diabetic nephropa-thy
    • [23] Tojo A, Asaba K, Onozato ML. Suppressing renal NADPH oxidase to treat diabetic nephropa-thy. Expert Opin Ther Targets 2007; 11: 1011-1018.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 1018
    • Tojo, A.1    Asaba, K.2    Onozato, M.L.3
  • 24
    • 51849122365 scopus 로고    scopus 로고
    • Normalizing NADPH oxi-dase contributes to attenuating diabetic ne-phropathy by the dual endothelin receptor antagonist CPU0213 in rats
    • [24] Xu M, Dai DZ, Dai Y. Normalizing NADPH oxi-dase contributes to attenuating diabetic ne-phropathy by the dual endothelin receptor antagonist CPU0213 in rats. Am J Nephrol 2009; 29: 252-256.
    • (2009) Am J Nephrol , vol.29 , pp. 252-256
    • Xu, M.1    Dai, D.Z.2    Dai, Y.3
  • 27
    • 34848907212 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, is renoprotec-tive in a model of advanced diabetic nephropa-thy in rats
    • [27] Kelly DJ, Zhang Y, Moe G, Naik G, Gilbert RE. Aliskiren, a novel renin inhibitor, is renoprotec-tive in a model of advanced diabetic nephropa-thy in rats. Diabetologia 2007; 50: 2398-2404.
    • (2007) Diabetologia , vol.50 , pp. 2398-2404
    • Kelly, D.J.1    Zhang, Y.2    Moe, G.3    Naik, G.4    Gilbert, R.E.5
  • 29
    • 79951677184 scopus 로고    scopus 로고
    • Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fbrosis
    • [29] Gross O, Girgert R, Rubel D, Temme J, Theissen S and Muller GA. Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fbrosis. Am J Hypertens 2011; 24: 355-361.
    • (2011) Am J Hypertens , vol.24 , pp. 355-361
    • Gross, O.1    Girgert, R.2    Rubel, D.3    Temme, J.4    Theissen, S.5    Muller, G.A.6
  • 30
    • 84898458065 scopus 로고    scopus 로고
    • The synergistic effect of mizoribine and a direct Renin inhibitor, aliskiren, on unilateral ure-teral obstruction induced renal fbrosis in rats
    • [30] Sakuraya K, Endo A, Someya T, Hirano D, Mu-rano Y, Fujinaga S, Ohtomo Y and Shimizu T. The synergistic effect of mizoribine and a direct Renin inhibitor, aliskiren, on unilateral ure-teral obstruction induced renal fbrosis in rats. J Urol 2014; 191: 1139-1146.
    • (2014) J Urol , vol.191 , pp. 1139-1146
    • Sakuraya, K.1    Endo, A.2    Someya, T.3    Hirano, D.4    Mu-Rano, Y.5    Fujinaga, S.6    Ohtomo, Y.7    Shimizu, T.8
  • 32
    • 78649929199 scopus 로고    scopus 로고
    • Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
    • [32] Persson F, Lewis JB, Lewis EJ, Rossing P, Hol-lenberg NK and Parving HH. Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy. Diabetes Care 2010; 33: 2304-2309.
    • (2010) Diabetes Care , vol.33 , pp. 2304-2309
    • Persson, F.1    Lewis, J.B.2    Lewis, E.J.3    Rossing, P.4    Hol-Lenberg, N.K.5    Parving, H.H.6
  • 33
    • 84865206169 scopus 로고    scopus 로고
    • Effect of add-on direct re-nin inhibitor aliskiren in patients with non-diabetes related chronic kidney disease
    • [33] Li SY, Chen YT, Yang WC, Tarng DC, Lin CC, Yang CY and Liu WS. Effect of add-on direct re-nin inhibitor aliskiren in patients with non-diabetes related chronic kidney disease. BMC Nephrol 2012; 13: 89.
    • (2012) BMC Nephrol , vol.13 , pp. 89
    • Li, S.Y.1    Chen, Y.T.2    Yang, W.C.3    Tarng, D.C.4    Lin, C.C.5    Yang, C.Y.6    Liu, W.S.7
  • 35
    • 84859212040 scopus 로고    scopus 로고
    • Effectiveblockade of RAAS by combination of aliskiren and olmesartan improves glucose homeosta-sis, glomerular fltration rate along with renal variables in streptozotocin induced diabetic rats
    • [35] Gandhi S, Srinivasan BP, Akarte AS. Effective blockade of RAAS by combination of aliskiren and olmesartan improves glucose homeosta-sis, glomerular fltration rate along with renal variables in streptozotocin induced diabetic rats. Eur J Pharm Sci 2012; 46: 32-42.
    • (2012) Eur J Pharm Sci , vol.46 , pp. 32-42
    • Gandhi, S.1    Srinivasan, B.P.2    Akarte, A.S.3
  • 36
    • 78349289577 scopus 로고    scopus 로고
    • A reduction of unilateral ureteral obstruction-induced renal fbrosis by a therapy combining valsartan with aliskiren
    • [36] Wu WP, Chang CH, Chiu YT, Ku CL, Wen MC, Shu KH and Wu MJ. A reduction of unilateral ureteral obstruction-induced renal fbrosis by a therapy combining valsartan with aliskiren. Am J Physiol Renal Physiol 2010; 299: F929-941.
    • (2010) Am J Physiol Renal Physiol , vol.299 , pp. F929-F941
    • Wu, W.P.1    Chang, C.H.2    Chiu, Y.T.3    Ku, C.L.4    Wen, M.C.5    Shu, K.H.6    Wu, M.J.7
  • 38
    • 84863180525 scopus 로고    scopus 로고
    • Comparative effects of different modes of renin angiotensin system inhibition on hypercholes-terolaemia-induced atherosclerosis
    • [38] Lu H, Balakrishnan A, Howatt DA, Wu C, Charni-go R, Liau G, Cassis LA and Daugherty A. Comparative effects of different modes of renin angiotensin system inhibition on hypercholes-terolaemia-induced atherosclerosis. Br J Pharmacol 2012; 165: 2000-2008.
    • (2012) Br J Pharmacol , vol.165 , pp. 2000-2008
    • Lu, H.1    Balakrishnan, A.2    Howatt, D.A.3    Wu, C.4    Charni-Go, R.5    Liau, G.6    Cassis, L.A.7    Daugherty, A.8
  • 39
    • 34249080813 scopus 로고    scopus 로고
    • Functional re-nin receptors in renal mesangial cells
    • [39] Huang Y, Border WA, Noble NA. Functional re-nin receptors in renal mesangial cells. Curr Hy-pertens Rep 2007; 9: 133-139.
    • (2007) Curr Hy-Pertens Rep , vol.9 , pp. 133-139
    • Huang, Y.1    Border, W.A.2    Noble, N.A.3
  • 40
    • 42649109044 scopus 로고    scopus 로고
    • Prorenin and (pro)renin receptor: A review of available data from in vitro studies and experimental models in rodents
    • [40] Nguyen G, Danser AH. Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. Exp Physiol 2008; 93: 557-563.
    • (2008) Exp Physiol , vol.93 , pp. 557-563
    • Nguyen, G.1    Danser, A.H.2
  • 41
    • 84861548178 scopus 로고    scopus 로고
    • (Pro)renin and its
    • [41] Batenburg WW, Danser AH. (Pro)renin and its receptors: pathophysiological implications. Clin Sci (Lond) 2012; 123: 121-133.
    • (2012) Clin Sci (Lond) , vol.123 , pp. 121-133
    • Batenburg, W.W.1    Danser, A.H.2
  • 42
    • 84858997658 scopus 로고    scopus 로고
    • The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: Systematic review and meta-analysis
    • [42] Harel Z, Gilbert C, Wald R, Bell C, Perl J, Juur-link D, Beyene J and Shah PS. The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis. BMJ 2012; 344: e42.
    • (2012) BMJ , vol.42 , pp. 344
    • Harel, Z.1    Gilbert, C.2    Wald, R.3    Bell, C.4    Perl, J.5    Juur-Link, D.6    Beyene, J.7    Shah, P.S.8


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