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Volumn 126, Issue 10, 2014, Pages 707-720

Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation

Author keywords

Albuminuria; Angiotensin II; Diabetic nephropathy; Inflammation; NADPH oxidase (Nox); Podocyte

Indexed keywords

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; GENE EXPRESSION REGULATION; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KIDNEY CORTEX; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; OXIDATIVE STRESS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PODOCYTES; RNA, MESSENGER; TETRAZOLES; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME; VALINE; WT1 PROTEINS;

EID: 84893958447     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20130223     Document Type: Article
Times cited : (53)

References (44)
  • 1
    • 0035948631 scopus 로고    scopus 로고
    • Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    • Gerstein, H. C., Mann, J. F., Yi, Q., Zinman, B., Dinneen, S. F., Hoogwerf, B., Halle, J. P., Young, J., Rashkow, A., Joyce, C. et al. (2001) Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 286, 421-426
    • (2001) JAMA , vol.286 , pp. 421-426
    • Gerstein, H.C.1    Mann, J.F.2    Yi, Q.3    Zinman, B.4    Dinneen, S.F.5    Hoogwerf, B.6    Halle, J.P.7    Young, J.8    Rashkow, A.9    Joyce, C.10
  • 3
    • 34250859407 scopus 로고    scopus 로고
    • Proteinuria as a therapeutic target in patients with chronic kidney disease
    • Palmer, B. F. (2007) Proteinuria as a therapeutic target in patients with chronic kidney disease. Am. J. Nephrol. 27, 287-293
    • (2007) Am. J. Nephrol. , vol.27 , pp. 287-293
    • Palmer, B.F.1
  • 4
    • 34249897487 scopus 로고    scopus 로고
    • Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency
    • Hou, F. F., Xie, D., Zhang, X., Chen, P. Y., Zhang, W. R., Liang, M., Guo, Z. J. and Jiang, J. P. (2007) Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency. J. Am. Soc. Nephrol. 18, 1889-1898
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1889-1898
    • Hou, F.F.1    Xie, D.2    Zhang, X.3    Chen, P.Y.4    Zhang, W.R.5    Liang, M.6    Guo, Z.J.7    Jiang, J.P.8
  • 5
    • 41849141537 scopus 로고    scopus 로고
    • Supratherapeutic doses of angiotensin receptor blockers to decrease proteinuria in patients with chronic kidney disease
    • Palmer, B. F. (2008) Supratherapeutic doses of angiotensin receptor blockers to decrease proteinuria in patients with chronic kidney disease. Am. J. Nephrol. 28, 381-390
    • (2008) Am. J. Nephrol. , vol.28 , pp. 381-390
    • Palmer, B.F.1
  • 11
    • 0019305983 scopus 로고
    • Enzyme-linked immunoassay (ELISA) for connective tissue components
    • Rennard, S. I., Berg, R., Martin, G. R., Foidart, J. M. and Robey, P. G. (1980) Enzyme-linked immunoassay (ELISA) for connective tissue components. Anal. Biochem. 104, 205-214
    • (1980) Anal. Biochem. , vol.104 , pp. 205-214
    • Rennard, S.I.1    Berg, R.2    Martin, G.R.3    Foidart, J.M.4    Robey, P.G.5
  • 12
    • 15844402989 scopus 로고    scopus 로고
    • Combining TGF-β inhibition and Angiotensin II blockade results in enhanced anti-fibrotic effect
    • Yu, L., Border, W. A., Anderson, I., McCourt, M., Huang, Y. and Noble, N. A. (2004) Combining TGF-β inhibition and Angiotensin II blockade results in enhanced anti-fibrotic effect. Kidney Int. 66, 1774-1784
    • (2004) Kidney Int , vol.66 , pp. 1774-1784
    • Yu, L.1    Border, W.A.2    Anderson, I.3    McCourt, M.4    Huang, Y.5    Noble, N.A.6
  • 13
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte's response to injury: role in proteinuria and glomerulosclerosis
    • Shankland, S. J. (2006) The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 69, 2131-2147
    • (2006) Kidney Int , vol.69 , pp. 2131-2147
    • Shankland, S.J.1
  • 14
    • 38949151661 scopus 로고    scopus 로고
    • Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    • Ziyadeh, F. N. and Wolf, G. (2008) Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr. Diabetes Rev. 4, 39-45
    • (2008) Curr. Diabetes Rev. , vol.4 , pp. 39-45
    • Ziyadeh, F.N.1    Wolf, G.2
  • 15
    • 21344446946 scopus 로고    scopus 로고
    • Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    • Yu, D., Petermann, A., Kunter, U., Rong, S., Shankland, S. J. and Floege, J. (2005) Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J. Am. Soc. Nephrol. 16, 1733-1741
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 1733-1741
    • Yu, D.1    Petermann, A.2    Kunter, U.3    Rong, S.4    Shankland, S.J.5    Floege, J.6
  • 16
    • 0141790220 scopus 로고    scopus 로고
    • Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker
    • Sanden, S. K., Wiggins, J. E., Goyal, M., Riggs, L. K. and Wiggins, R. C. (2003) Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker. J. Am. Soc. Nephrol. 14, 2484-2493
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2484-2493
    • Sanden, S.K.1    Wiggins, J.E.2    Goyal, M.3    Riggs, L.K.4    Wiggins, R.C.5
  • 17
    • 0037087593 scopus 로고    scopus 로고
    • WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    • Guo, J. K., Menke, A. L., Gubler, M. C., Clarke, A. R., Harrison, D., Hammes, A., Hastie, N. D. and Schedl, A. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum. Mol. Genet. 11, 651-659
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 651-659
    • Guo, J.K.1    Menke, A.L.2    Gubler, M.C.3    Clarke, A.R.4    Harrison, D.5    Hammes, A.6    Hastie, N.D.7    Schedl, A.8
  • 18
    • 84872041647 scopus 로고    scopus 로고
    • Inflammation and the pathogenesis of diabetic nephropathy
    • Wada, J. and Makino, H. (2013) Inflammation and the pathogenesis of diabetic nephropathy. Clin. Sci. 124, 139-152
    • (2013) Clin. Sci. , vol.124 , pp. 139-152
    • Wada, J.1    Makino, H.2
  • 19
    • 34547788748 scopus 로고    scopus 로고
    • Suppressing renal NADPH oxidase to treat diabetic nephropathy
    • Tojo, A., Asaba, K. and Onozato, M. L. (2007) Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin. Ther. Targets 11, 1011-1018
    • (2007) Expert Opin. Ther. Targets , vol.11 , pp. 1011-1018
    • Tojo, A.1    Asaba, K.2    Onozato, M.L.3
  • 20
    • 51849122365 scopus 로고    scopus 로고
    • Normalizing NADPH oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats
    • Xu, M., Dai, D. Z. and Dai, Y. (2009) Normalizing NADPH oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats. Am. J. Nephrol. 29, 252-256
    • (2009) Am. J. Nephrol. , vol.29 , pp. 252-256
    • Xu, M.1    Dai, D.Z.2    Dai, Y.3
  • 24
    • 83555173571 scopus 로고    scopus 로고
    • Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1
    • Ren, Z., Liang, W., Chen, C., Yang, H., Singhal, P. C. and Ding, G. (2012) Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1. Cell. Signal. 24, 443-450
    • (2012) Cell. Signal. , vol.24 , pp. 443-450
    • Ren, Z.1    Liang, W.2    Chen, C.3    Yang, H.4    Singhal, P.C.5    Ding, G.6
  • 27
    • 33751418490 scopus 로고    scopus 로고
    • Urinary tumour necrosis factor-α excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients
    • Navarro, J. F., Mora, C., Muros, M. and Garcia, J. (2006) Urinary tumour necrosis factor-α excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients. Nephrol. Dial. Transplant. 21, 3428-3434
    • (2006) Nephrol. Dial. Transplant. , vol.21 , pp. 3428-3434
    • Navarro, J.F.1    Mora, C.2    Muros, M.3    Garcia, J.4
  • 29
    • 34249802935 scopus 로고    scopus 로고
    • Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells
    • Chipitsyna, G., Gong, Q., Gray, C. F., Haroon, Y., Kamer, E. and Arafat, H. A. (2007) Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells. Endocrinology 148, 2198-2208
    • (2007) Endocrinology , vol.148 , pp. 2198-2208
    • Chipitsyna, G.1    Gong, Q.2    Gray, C.F.3    Haroon, Y.4    Kamer, E.5    Arafat, H.A.6
  • 31
    • 0141564521 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-κB, in mononuclear cells of normal subjects: evidence of an antiinflammatory action
    • Dandona, P., Kumar, V., Aljada, A., Ghanim, H., Syed, T., Hofmayer, D., Mohanty, P., Tripathy, D. and Garg, R. (2003) Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-κB, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J. Clin. Endocrinol. Metab. 88, 4496-4501
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4496-4501
    • Dandona, P.1    Kumar, V.2    Aljada, A.3    Ghanim, H.4    Syed, T.5    Hofmayer, D.6    Mohanty, P.7    Tripathy, D.8    Garg, R.9
  • 33
    • 48249085391 scopus 로고    scopus 로고
    • Oxidative stress as a major culprit in kidney disease in diabetes
    • Forbes, J. M., Coughlan, M. T. and Cooper, M. E. (2008) Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 57, 1446-1454
    • (2008) Diabetes , vol.57 , pp. 1446-1454
    • Forbes, J.M.1    Coughlan, M.T.2    Cooper, M.E.3
  • 34
    • 0036062227 scopus 로고    scopus 로고
    • Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes
    • Kim, Y. K., Lee, M. S., Son, S. M., Kim, I. J., Lee, W. S., Rhim, B. Y., Hong, K. W. and Kim, C. D. (2002) Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 51, 522-527
    • (2002) Diabetes , vol.51 , pp. 522-527
    • Kim, Y.K.1    Lee, M.S.2    Son, S.M.3    Kim, I.J.4    Lee, W.S.5    Rhim, B.Y.6    Hong, K.W.7    Kim, C.D.8
  • 36
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • Bedard, K. and Krause, K. H. (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245-313
    • (2007) Physiol. Rev. , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 38
    • 79959704368 scopus 로고    scopus 로고
    • Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction
    • Murdoch, C. E., Alom-Ruiz, S. P., Wang, M., Zhang, M., Walker, S., Yu, B., Brewer, A. and Shah, A. M. (2011) Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res. Cardiol. 106, 527-538
    • (2011) Basic Res. Cardiol. , vol.106 , pp. 527-538
    • Murdoch, C.E.1    Alom-Ruiz, S.P.2    Wang, M.3    Zhang, M.4    Walker, S.5    Yu, B.6    Brewer, A.7    Shah, A.M.8
  • 41
    • 45549094095 scopus 로고    scopus 로고
    • Comparison of dual RAAS blockade and higher-dose RAAS inhibition on nephropathy progression
    • Bakris, G. L. and Weir, M. R. (2008) Comparison of dual RAAS blockade and higher-dose RAAS inhibition on nephropathy progression. Postgrad. Med. 120, 33-42
    • (2008) Postgrad. Med. , vol.120 , pp. 33-42
    • Bakris, G.L.1    Weir, M.R.2
  • 42
    • 34147192256 scopus 로고    scopus 로고
    • Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan
    • Wang, P., Tang, F., Li, R., Zhang, H., Chen, S., Liu, P. and Huang, H. (2007) Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan. Pharmacol. Res. 55, 408-417
    • (2007) Pharmacol. Res. , vol.55 , pp. 408-417
    • Wang, P.1    Tang, F.2    Li, R.3    Zhang, H.4    Chen, S.5    Liu, P.6    Huang, H.7
  • 44
    • 38949093861 scopus 로고    scopus 로고
    • Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-κB activation via NADPH oxidase
    • Wei, Y., Sowers, J. R., Clark, S. E., Li, W., Ferrario, C. M. and Stump, C. S. (2008) Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-κB activation via NADPH oxidase. Am. J. Physiol. Endocrinol. Metab. 294, E345-E351
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Wei, Y.1    Sowers, J.R.2    Clark, S.E.3    Li, W.4    Ferrario, C.M.5    Stump, C.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.