메뉴 건너뛰기




Volumn 6, Issue 4, 2016, Pages

EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21

Author keywords

EZH2; Gene silencing; Histone methylation; Neural development; Neuroblast proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR EZH2;

EID: 84964430206     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.150227     Document Type: Article
Times cited : (29)

References (57)
  • 2
    • 33846983276 scopus 로고    scopus 로고
    • Polycomb/Trithorax response elements and epigenetic memory of cell identity
    • Ringrose L, Paro R. 2007 Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134, 223-232. (doi:10.1242/dev.02723.
    • (2007) Development , vol.134 , pp. 223-232
    • Ringrose, L.1    Paro, R.2
  • 3
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. 2002 Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185-196. (doi:10.1016/S0092-8674(02)00975-3).
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 4
    • 18644383738 scopus 로고    scopus 로고
    • Histone methyltransferase activity of a drosophila polycomb group repressor complex
    • Muller J et al. 2002 Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197-208. (doi:10.1016/S0092-8674(02)00976-5).
    • (2002) Cell , vol.111 , pp. 197-208
    • Muller, J.1
  • 6
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein
    • Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. 2002 Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of Zeste protein. Genes Dev. 16, 2893-2905. (doi:10.1101/gad.1035902).
    • (2002) Genes Dev , vol.16 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 8
    • 55949124844 scopus 로고    scopus 로고
    • EZH1 mediates methylation on histone H3 lysine 27 and complements Ezh2 in maintaining stem cell identity and executing pluripotency
    • Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. 2008 EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32, 491-502. (doi:10.1016/j.molcel.2008.10.016).
    • (2008) Mol. Cell , vol.32 , pp. 491-502
    • Shen, X.1    Liu, Y.2    Hsu, Y.J.3    Fujiwara, Y.4    Kim, J.5    Mao, X.6    Yuan, G.C.7    Orkin, S.H.8
  • 10
    • 0042310137 scopus 로고    scopus 로고
    • Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    • Erhardt S et al. 2003 Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130, 4235-4248. (doi:10.1242/dev.00625).
    • (2003) Development , vol.130 , pp. 4235-4248
    • Erhardt, S.1
  • 11
    • 7544230144 scopus 로고    scopus 로고
    • The polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    • Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V. 2004 The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18, 2627-2638. (doi:10.1101/gad.1241904).
    • (2004) Genes Dev , vol.18 , pp. 2627-2638
    • Caretti, G.1    Di Padova, M.2    Micales, B.3    Lyons, G.E.4    Sartorelli, V.5
  • 12
    • 62149122634 scopus 로고    scopus 로고
    • Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    • Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. 2009 Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136, 1122-1135. (doi:10.1016/j.cell.2008.12.043).
    • (2009) Cell , vol.136 , pp. 1122-1135
    • Ezhkova, E.1    Pasolli, H.A.2    Parker, J.S.3    Stokes, N.4    Su, I.H.5    Hannon, G.6    Tarakhovsky, A.7    Fuchs, E.8
  • 13
    • 80052394243 scopus 로고    scopus 로고
    • Chromatin in the nuclear landscape
    • Beck DB et al. 2010 Chromatin in the nuclear landscape. Cold Spring Harb. Symp. Quant. Biol. 75, 11-22. (doi:10.1101/sqb.2010.75.052).
    • (2010) Cold Spring Harb. Symp. Quant. Biol , vol.75 , pp. 11-22
    • Beck, D.B.1
  • 14
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S et al. 2002 The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629. (doi:10.1038/nature01075).
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1
  • 16
    • 84920192280 scopus 로고    scopus 로고
    • Ezh2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene
    • Ferraro A, Boni T, Pintzas A. 2014 EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene. PLoS ONE 9, e115276. (doi:10.1371/journal.pone.0115276).
    • (2014) PLoS ONE , vol.9 , pp. e115276
    • Ferraro, A.1    Boni, T.2    Pintzas, A.3
  • 17
    • 13344259902 scopus 로고    scopus 로고
    • The transcriptional control of trunk neural crest induction, survival, and delamination
    • Cheung M, Chaboissier MC, Mynett A, Hirst E, Schedl A, Briscoe J. 2005 The transcriptional control of trunk neural crest induction, survival, and delamination. Dev. Cell 8, 179-192. (doi:10.1016/j.devcel.2004.12.010).
    • (2005) Dev. Cell , vol.8 , pp. 179-192
    • Cheung, M.1    Chaboissier, M.C.2    Mynett, A.3    Hirst, E.4    Schedl, A.5    Briscoe, J.6
  • 18
    • 69949085080 scopus 로고    scopus 로고
    • Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
    • Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J, Koseki H, Vidal M, Gotoh Y. 2009 Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63, 600-613. (doi:10.1016/j.neuron.2009.08.021).
    • (2009) Neuron , vol.63 , pp. 600-613
    • Hirabayashi, Y.1    Suzki, N.2    Tsuboi, M.3    Endo, T.A.4    Toyoda, T.5    Shinga, J.6    Koseki, H.7    Vidal, M.8    Gotoh, Y.9
  • 19
    • 77957680712 scopus 로고    scopus 로고
    • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
    • Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ. 2010 Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc. Natl Acad. Sci. USA 107, 15957-15962. (doi:10.1073/pnas.1002530107).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15957-15962
    • Pereira, J.D.1    Sansom, S.N.2    Smith, J.3    Dobenecker, M.W.4    Tarakhovsky, A.5    Livesey, F.J.6
  • 20
    • 33947134834 scopus 로고    scopus 로고
    • The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken AP et al. 2007 The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530. (doi:10.1101/gad.415507).
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1
  • 22
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA et al. 2006 Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353. (doi:10.1038/nature04733).
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1
  • 23
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of poly comb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. 2006 Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136. (doi:10.1101/gad.381706).
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 24
    • 68049136139 scopus 로고    scopus 로고
    • Functional versatility of transcription factors in the nervous system: The SRF paradigm
    • Knoll B, Nordheim A. 2009 Functional versatility of transcription factors in the nervous system: The SRF paradigm. Trends Neurosci. 32, 432-442. (doi:10.1016/j.tins.2009.05.004).
    • (2009) Trends Neurosci , vol.32 , pp. 432-442
    • Knoll, B.1    Nordheim, A.2
  • 25
    • 0037182585 scopus 로고    scopus 로고
    • Lim kinase and diaphanous cooperate to regulate serum response factor and actin dynamics
    • Geneste O, Copeland JW, Treisman R. 2002 LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157, 831-838. (doi:10.1083/jcb.200203126).
    • (2002) J. Cell Biol , vol.157 , pp. 831-838
    • Geneste, O.1    Copeland, J.W.2    Treisman, R.3
  • 27
    • 21044451441 scopus 로고    scopus 로고
    • Polycomb group protein Ezh2 controls actin polymerization and cell signaling
    • Su IH et al. 2005 Polycomb group protein Ezh2 controls actin polymerization and cell signaling. Cell 121, 425-436. (doi:10.1016/j.cell.2005.02.029).
    • (2005) Cell , vol.121 , pp. 425-436
    • Su, I.H.1
  • 28
    • 0036488510 scopus 로고    scopus 로고
    • Rho- GTPases and cancer
    • Sahai E, Marshall CJ. 2002 RHO-GTPases and cancer. Nat. Rev. Cancer 2, 133-142. (doi:10.1038/nrc725).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 133-142
    • Sahai, E.1    Marshall, C.J.2
  • 29
    • 2342502660 scopus 로고    scopus 로고
    • RAS and rho GTPases in G1-phase cell-cycle regulation
    • Coleman ML, Marshall CJ, Olson MF. 2004 RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat. Rev. Mol. Cell Biol. 5, 355-366. (doi:10.1038/nrm1365).
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 355-366
    • Coleman, M.L.1    Marshall, C.J.2    Olson, M.F.3
  • 30
    • 0032413732 scopus 로고    scopus 로고
    • A role for rhoB in the delamination of neural crest cells from the dorsal neural tube
    • Liu JP, Jessell TM. 1998 A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. Development 125, 5055-5067.
    • (1998) Development , vol.125 , pp. 5055-5067
    • Liu, J.P.1    Jessell, T.M.2
  • 31
    • 33845653116 scopus 로고    scopus 로고
    • A cell-autonomous requirement for CIP/KIP cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord
    • Gui H, Li S, Matise MP. 2007 A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev. Biol. 301, 14-26. (doi:10.1016/j.ydbio.2006.10.035).
    • (2007) Dev. Biol , vol.301 , pp. 14-26
    • Gui, H.1    Li, S.2    Matise, M.P.3
  • 32
    • 0029892628 scopus 로고    scopus 로고
    • Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin
    • Flinn HM, Ridley AJ. 1996 Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J. Cell Sci. 109, 1133-1141.
    • (1996) J. Cell Sci. , vol.109 , pp. 1133-1141
    • Flinn, H.M.1    Ridley, A.J.2
  • 33
    • 77956213871 scopus 로고    scopus 로고
    • H3K27me3 regulates bmp activity in developing spinal cord
    • Akizu N, Estaras C, Guerrero L, Marti E, Martinez- Balbas MA. 2010 H3K27me3 regulates BMP activity in developing spinal cord. Development 137, 2915-2925. (doi:10.1242/dev.049395).
    • (2010) Development , vol.137 , pp. 2915-2925
    • Akizu, N.1    Estaras, C.2    Guerrero, L.3    Marti, E.4    Martinez-, B.M.A.5
  • 34
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by polycomb in human embryonic stem cells
    • Lee TI et al. 2006 Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125, 301-313. (doi:10.1016/j.cell.2006.02.043).
    • (2006) Cell , vol.125 , pp. 301-313
    • Lee, T.I.1
  • 35
    • 0037032462 scopus 로고    scopus 로고
    • Identification of the nuclear localization signal of p21(CIP1) and consequences of its mutation on cell proliferation
    • Rodriguez-Vilarrupla A, Diaz C, Canela N, Rahn HP, Bachs O, Agell N. 2002 Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation. FEBS Lett. 531, 319-323. (doi:10.1016/S0014-5793(02)03549-4).
    • (2002) FEBS Lett , vol.531 , pp. 319-323
    • Rodriguez-Vilarrupla, A.1    Diaz, C.2    Canela, N.3    Rahn, H.P.4    Bachs, O.5    Agell, N.6
  • 36
    • 33846526204 scopus 로고    scopus 로고
    • The TGF beta intracellular effector smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord
    • Garcia-Campmany L, Marti E. 2007 The TGF beta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development 134, 65-75. (doi:10.1242/dev.02702).
    • (2007) Development , vol.134 , pp. 65-75
    • Garcia-Campmany, L.1    Marti, E.2
  • 37
    • 84856237597 scopus 로고    scopus 로고
    • Polycomb protein Ezh1 promotes RNA polymerase II elongation
    • Mousavi K, Zare H, Wang AH, Sartorelli V. 2012 Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mol. Cell 45, 255-262. (doi:10.1016/j.molcel.2011.11.019).
    • (2012) Mol. Cell , vol.45 , pp. 255-262
    • Mousavi, K.1    Zare, H.2    Wang, A.H.3    Sartorelli, V.4
  • 38
    • 0032554825 scopus 로고    scopus 로고
    • Distinct roles of the co-activators p300 and cbp in retinoic-acidinduced F9-cell differentiation
    • Kawasaki H, Eckner R, Yao TP, Taira K, Chiu R, Livingston DM, Yokoyama KK. 1998 Distinct roles of the co-activators p300 and CBP in retinoic-acidinduced F9-cell differentiation. Nature 393, 284-289. (doi:10.1038/30538).
    • (1998) Nature , vol.393 , pp. 284-289
    • Kawasaki, H.1    Eckner, R.2    Yao, T.P.3    Taira, K.4    Chiu, R.5    Livingston, D.M.6    Yokoyama, K.K.7
  • 39
    • 0035504278 scopus 로고    scopus 로고
    • Functional analysis of the p300 acetyltransferase domain: The PHD finger of p300 but not of CBP is dispensable for enzymatic activity
    • Bordoli L, Husser S, Luthi U, Netsch M, Osmani H, Eckner R. 2001 Functional analysis of the p300 acetyltransferase domain: The PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res. 29, 4462-4471. (doi:10.1093/nar/29.21.4462).
    • (2001) Nucleic Acids Res , vol.29 , pp. 4462-4471
    • Bordoli, L.1    Husser, S.2    Luthi, U.3    Netsch, M.4    Osmani, H.5    Eckner, R.6
  • 40
    • 78649827795 scopus 로고    scopus 로고
    • A switch from hBrm to brg1 at IFNgamma -activated sequences mediates the activation of human genes
    • Zhang Y, Cheng MB, Zhang YJ, Zhong X, Dai H, Yan L, Wu NH, Shen YF. 2010 A switch from hBrm to Brg1 at IFNgamma-activated sequences mediates the activation of human genes. Cell Res. 20, 1345-1360. (doi:10.1038/cr.2010.155).
    • (2010) Cell Res. , vol.20 , pp. 1345-1360
    • Zhang, Y.1    Cheng, M.B.2    Zhang, Y.J.3    Zhong, X.4    Dai, H.5    Yan, L.6    Wu, N.H.7    Shen, Y.F.8
  • 41
    • 84870308969 scopus 로고    scopus 로고
    • Ezh2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    • Lee JM et al. 2012 EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol. Cell 48, 572-586. (doi:10.1016/j.molcel.2012.09.004).
    • (2012) Mol. Cell , vol.48 , pp. 572-586
    • Lee, J.M.1
  • 42
    • 0037422576 scopus 로고    scopus 로고
    • Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
    • Kim SH, Mitchell M, Fujii H, Llanos S, Peters G. 2003 Absence of p16INK4a and truncation of ARF tumor suppressors in chickens. Proc. Natl Acad. Sci. USA 100, 211-216. (doi:10.1073/pnas.0135557100).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 211-216
    • Kim, S.H.1    Mitchell, M.2    Fujii, H.3    Llanos, S.4    Peters, G.5
  • 43
    • 34249907279 scopus 로고    scopus 로고
    • Shrna knockdown of Bmi-1 reveals a critical role for p21-rb pathway in NSC self-renewal during development
    • Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S. 2007 shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1, 87-99. (doi:10.1016/j.stem.2007.04.001).
    • (2007) Cell Stem Cell , vol.1 , pp. 87-99
    • Fasano, C.A.1    Dimos, J.T.2    Ivanova, N.B.3    Lowry, N.4    Lemischka, I.R.5    Temple, S.6
  • 44
    • 84876871047 scopus 로고    scopus 로고
    • Occupying chromatin: Poly comb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
    • Simon JA, Kingston RE. 2013 Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol. Cell 49, 808-824. (doi:10.1016/j.molcel.2013.02.013).
    • (2013) Mol. Cell , vol.49 , pp. 808-824
    • Simon, J.A.1    Kingston, R.E.2
  • 45
    • 84879536747 scopus 로고    scopus 로고
    • EZH2-mediated H3K27me3 is involved in epigenetic repression of deleted in liver cancer 1 in human cancers
    • Au SL, Wong CC, Lee JM, Wong CM, Ng IO. 2013 EZH2-mediated H3K27me3 is involved in epigenetic repression of deleted in liver cancer 1 in human cancers. PLoS One 8, e68226. (doi:10.1371/journal. pone.0068226).
    • (2013) PLoS One , vol.8 , pp. e68226
    • Au, S.L.1    Wong, C.C.2    Lee, J.M.3    Wong, C.M.4    Ng, I.O.5
  • 46
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A. 2002 Rho GTPases in cell biology. Nature 420, 629-635. (doi:10.1038/nature01148).
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 47
    • 79956290878 scopus 로고    scopus 로고
    • Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    • Katayama K et al. 2011 Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc. Natl Acad. Sci. USA 108, 7607-7612. (doi:10.1073/pnas.1101347108).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7607-7612
    • Katayama, K.E.A.1
  • 48
    • 48249120719 scopus 로고    scopus 로고
    • Apical accumulation of rho in the neural plate is important for neural plate cell shape change and neural tube formation
    • Kinoshita N, Sasai N, Misaki K, Yonemura S. 2008 Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation. Mol. Biol. Cell 19, 2289-2299. (doi:10.1091/mbc.E07-12-1286.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2289-2299
    • Kinoshita, N.1    Sasai, N.2    Misaki, K.3    Yonemura, S.4
  • 49
    • 84889600900 scopus 로고    scopus 로고
    • Programmed cell senescence during mammalian embryonic development
    • Munoz-Espin D et al. 2013 Programmed cell senescence during mammalian embryonic development. Cell 155, 1104-1118. (doi:10.1016/j.cell.2013.10.019).
    • (2013) Cell , vol.155 , pp. 1104-1118
    • Munoz-Espin, D.1
  • 50
    • 84889565689 scopus 로고    scopus 로고
    • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    • Storer M et al. 2013 Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 155, 1119-1130. (doi:10.1016/j.cell.2013.10.041).
    • (2013) Cell , vol.155 , pp. 1119-1130
    • Storer, M.1
  • 51
    • 79954471872 scopus 로고    scopus 로고
    • EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression
    • Fan T, Jiang S, Chung N, Alikhan A, Ni C, Lee CC, Hornyak TJ. 2011 EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. Mol. Cancer Res. 9, 418-429. (doi:10.1158/1541-7786.MCR-10-0511.
    • (2011) Mol. Cancer Res , vol.9 , pp. 418-429
    • Fan, T.1    Jiang, S.2    Chung, N.3    Alikhan, A.4    Ni, C.5    Lee, C.C.6    Hornyak, T.J.7
  • 52
    • 80053018047 scopus 로고    scopus 로고
    • Lysine-specific demethylase 2b (KDM2B)-let-7- enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells
    • Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N. 2011 Lysine-specific demethylase 2B (KDM2B)-let-7- enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J. Biol. Chem. 286, 33061-33069. (doi:10.1074/jbc.M111.257667).
    • (2011) J. Biol. Chem , vol.286 , pp. 33061-33069
    • Tzatsos, A.1    Paskaleva, P.2    Lymperi, S.3    Contino, G.4    Stoykova, S.5    Chen, Z.6    Wong, K.K.7    Bardeesy, N.8
  • 53
    • 0346024130 scopus 로고    scopus 로고
    • Improved silencing vector co-expressing GFP and small hairpin RNA
    • Kojima S, Vignjevic D, Borisy GG. 2004 Improved silencing vector co-expressing GFP and small hairpin RNA. Biotechniques 36, 74-79.
    • (2004) Biotechniques , vol.36 , pp. 74-79
    • Kojima, S.1    Vignjevic, D.2    Borisy, G.G.3
  • 54
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason SG, McMahon AP. 2002 A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129, 2087-2098.
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 55
    • 6944242562 scopus 로고    scopus 로고
    • LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest
    • Perez-Alcala S, Nieto MA, Barbas JA. 2004 LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development 131, 4455-4465. (doi:10.1242/dev.01329).
    • (2004) Development , vol.131 , pp. 4455-4465
    • Perez-Alcala, S.1    Nieto, M.A.2    Barbas, J.A.3
  • 56
    • 0027018236 scopus 로고
    • A series of normal stages in the development of the chick embryo
    • Hamburger V, Hamilton HL. 1992 A series of normal stages in the development of the chick embryo. Dev. Dyn. 195, 231-272. (doi:10.1002/aja.1001950404).
    • (1992) Dev. Dyn. , vol.195 , pp. 231-272
    • Hamburger, V.1    Hamilton, H.L.2
  • 57
    • 84866788126 scopus 로고    scopus 로고
    • Genome-wide analysis reveals that SMAD3 and JMJD3 HDM co activate the neural developmental program
    • Estaras C, Akizu N, Garcia A, Beltran S, de la Cruz X, Martinez-Balbas MA. 2012 Genome-wide analysis reveals that Smad3 and JMJD3 HDM coactivate the neural developmental program. Development 139, 2681-2691. (doi:10.1242/dev. 078345).
    • (2012) Development , vol.139 , pp. 2681-2691
    • Estaras, C.1    Akizu, N.2    Garcia, A.3    Beltran, S.4    De La Cruz, X.5    Martinez-Balbas, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.