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Volumn 6, Issue 2, 2016, Pages 87-93

Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes

Author keywords

chenodeoxycholic acid; cholic acid; dexamethasone; matrigel; primary hepatocytes

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; COLLAGEN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOSE 6 PHOSPHATASE; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR ALPHA; STEROID 12ALPHA MONOOXYGENASE;

EID: 84964388624     PISSN: 09736883     EISSN: 22133453     Source Type: Journal    
DOI: 10.1016/j.jceh.2016.01.007     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 1242269851 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms
    • 1 Chiang, J.Y., Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 40 (2004), 539–551.
    • (2004) J Hepatol , vol.40 , pp. 539-551
    • Chiang, J.Y.1
  • 2
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • 2 Russell, D.W., The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72 (2003), 137–174.
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 3
    • 0141532288 scopus 로고    scopus 로고
    • Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor
    • 3 Ellis, E., Axelson, M., Abrahamsson, A., et al. Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. Hepatology 38 (2003), 930–938.
    • (2003) Hepatology , vol.38 , pp. 930-938
    • Ellis, E.1    Axelson, M.2    Abrahamsson, A.3
  • 4
    • 78149353724 scopus 로고    scopus 로고
    • Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice
    • 4 Slatis, K., Gafvels, M., Kannisto, K., et al. Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice. J Lipid Res 51 (2010), 3289–3298.
    • (2010) J Lipid Res , vol.51 , pp. 3289-3298
    • Slatis, K.1    Gafvels, M.2    Kannisto, K.3
  • 5
    • 23744432871 scopus 로고    scopus 로고
    • Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
    • 5 Murphy, C., Parini, P., Wang, J., Bjorkhem, I., Eggertsen, G., Gafvels, M., Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice. Biochim Biophys Acta 1735 (2005), 167–175.
    • (2005) Biochim Biophys Acta , vol.1735 , pp. 167-175
    • Murphy, C.1    Parini, P.2    Wang, J.3    Bjorkhem, I.4    Eggertsen, G.5    Gafvels, M.6
  • 6
    • 33644894501 scopus 로고    scopus 로고
    • Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice
    • 6 Wang, J., Gafvels, M., Rudling, M., et al. Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice. Biochem Biophys Res Commun 342 (2006), 1382–1388.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 1382-1388
    • Wang, J.1    Gafvels, M.2    Rudling, M.3
  • 7
    • 0023032022 scopus 로고
    • HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation
    • 7 Everson, G.T., Polokoff, M.A., HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation. J Biol Chem 261 (1986), 2197–2201.
    • (1986) J Biol Chem , vol.261 , pp. 2197-2201
    • Everson, G.T.1    Polokoff, M.A.2
  • 8
    • 0026007201 scopus 로고
    • Bile acid synthesis in cultured human hepatoblastoma cells
    • 8 Axelson, M., Mork, B., Everson, G.T., Bile acid synthesis in cultured human hepatoblastoma cells. J Biol Chem 266 (1991), 17770–17777.
    • (1991) J Biol Chem , vol.266 , pp. 17770-17777
    • Axelson, M.1    Mork, B.2    Everson, G.T.3
  • 9
    • 0028007161 scopus 로고
    • Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells
    • 9 Cooper, A.D., Craig, W.Y., Taniguchi, T., Everson, G.T., Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells. Hepatology 20 (1994), 1522–1531.
    • (1994) Hepatology , vol.20 , pp. 1522-1531
    • Cooper, A.D.1    Craig, W.Y.2    Taniguchi, T.3    Everson, G.T.4
  • 10
    • 0035952324 scopus 로고    scopus 로고
    • Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids
    • 10 Ellis, E., Roeb, E., Marschall, H., Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids. Biochim Biophys Acta 1530 (2001), 155–161.
    • (2001) Biochim Biophys Acta , vol.1530 , pp. 155-161
    • Ellis, E.1    Roeb, E.2    Marschall, H.3
  • 11
    • 0020522398 scopus 로고
    • Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids
    • 11 Davis, R.A., Highsmith, W.E., McNeal, M.M., Schexnayder, J.A., Kuan, J.C., Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. J Biol Chem 258 (1983), 4079–4082.
    • (1983) J Biol Chem , vol.258 , pp. 4079-4082
    • Davis, R.A.1    Highsmith, W.E.2    McNeal, M.M.3    Schexnayder, J.A.4    Kuan, J.C.5
  • 12
    • 0020606419 scopus 로고
    • Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability
    • 12 Davis, R.A., Hyde, P.M., Kuan, J.C., Malone-McNeal, M., Archambault-Schexnayder, J., Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability. J Biol Chem 258 (1983), 3661–3667.
    • (1983) J Biol Chem , vol.258 , pp. 3661-3667
    • Davis, R.A.1    Hyde, P.M.2    Kuan, J.C.3    Malone-McNeal, M.4    Archambault-Schexnayder, J.5
  • 13
    • 0031889214 scopus 로고    scopus 로고
    • Bile acid synthesis in primary cultures of rat and human hepatocytes
    • 13 Ellis, E., Goodwin, B., Abrahamsson, A., et al. Bile acid synthesis in primary cultures of rat and human hepatocytes. Hepatology 27 (1998), 615–620.
    • (1998) Hepatology , vol.27 , pp. 615-620
    • Ellis, E.1    Goodwin, B.2    Abrahamsson, A.3
  • 14
    • 0034040296 scopus 로고    scopus 로고
    • Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid
    • 14 Axelson, M., Ellis, E., Mork, B., et al. Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid. Hepatology 31 (2000), 1305–1312.
    • (2000) Hepatology , vol.31 , pp. 1305-1312
    • Axelson, M.1    Ellis, E.2    Mork, B.3
  • 15
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • 15 Goodwin, B., Jones, S.A., Price, R.R., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6 (2000), 517–526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3
  • 16
    • 0037663483 scopus 로고    scopus 로고
    • Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    • 16 Holt, J.A., Luo, G., Billin, A.N., et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 17 (2003), 1581–1591.
    • (2003) Genes Dev , vol.17 , pp. 1581-1591
    • Holt, J.A.1    Luo, G.2    Billin, A.N.3
  • 17
    • 15244348080 scopus 로고    scopus 로고
    • Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene
    • 17 Jahan, A., Chiang, J.Y., Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene. Am J Physiol Gastrointest Liver Physiol 288 (2005), G685–G695.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , pp. G685-G695
    • Jahan, A.1    Chiang, J.Y.2
  • 18
    • 33745529832 scopus 로고    scopus 로고
    • Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells
    • 18 Li, T., Jahan, A., Chiang, J.Y., Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 43 (2006), 1202–1210.
    • (2006) Hepatology , vol.43 , pp. 1202-1210
    • Li, T.1    Jahan, A.2    Chiang, J.Y.3
  • 19
    • 0037340125 scopus 로고    scopus 로고
    • Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha
    • 19 Goodwin, B., Watson, M.A., Kim, H., Miao, J., Kemper, J.K., Kliewer, S.A., Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Mol Endocrinol 17 (2003), 386–394.
    • (2003) Mol Endocrinol , vol.17 , pp. 386-394
    • Goodwin, B.1    Watson, M.A.2    Kim, H.3    Miao, J.4    Kemper, J.K.5    Kliewer, S.A.6
  • 20
    • 0034803066 scopus 로고    scopus 로고
    • Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
    • 20 Hamilton, G.A., Jolley, S.L., Gilbert, D., Coon, D.J., Barros, S., LeCluyse, E.L., Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res 306 (2001), 85–99.
    • (2001) Cell Tissue Res , vol.306 , pp. 85-99
    • Hamilton, G.A.1    Jolley, S.L.2    Gilbert, D.3    Coon, D.J.4    Barros, S.5    LeCluyse, E.L.6
  • 21
    • 0031925698 scopus 로고    scopus 로고
    • Refinement of an in vitro cell model for cytochrome P450 induction
    • 21 Silva, J.M., Morin, P.E., Day, S.H., et al. Refinement of an in vitro cell model for cytochrome P450 induction. Drug Metab Dispos 26 (1998), 490–496.
    • (1998) Drug Metab Dispos , vol.26 , pp. 490-496
    • Silva, J.M.1    Morin, P.E.2    Day, S.H.3
  • 22
    • 84871049588 scopus 로고    scopus 로고
    • Comparison of culture media for bile acid transport studies in primary human hepatocytes
    • 22 Mork, L.M., Isaksson, B., Boran, N., et al. Comparison of culture media for bile acid transport studies in primary human hepatocytes. J Clin Exp Hepatol 2 (2012), 315–322.
    • (2012) J Clin Exp Hepatol , vol.2 , pp. 315-322
    • Mork, L.M.1    Isaksson, B.2    Boran, N.3
  • 24
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • 24 Pascussi, J.M., Drocourt, L., Fabre, J.M., Maurel, P., Vilarem, M.J., Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 58 (2000), 361–372.
    • (2000) Mol Pharmacol , vol.58 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 25
    • 0021022297 scopus 로고
    • Antiglucocorticoid properties of RU 38486 in a differentiated hepatoma cell line
    • 25 Chobert, M.N., Barouki, R., Finidori, J., et al. Antiglucocorticoid properties of RU 38486 in a differentiated hepatoma cell line. Biochem Pharmacol 32 (1983), 3481–3483.
    • (1983) Biochem Pharmacol , vol.32 , pp. 3481-3483
    • Chobert, M.N.1    Barouki, R.2    Finidori, J.3
  • 26
    • 0017205452 scopus 로고
    • Conditions affecting primary cell cultures of functional adult rat hepatocytes. II. Dexamethasone enhanced longevity and maintenance of morphology
    • 26 Laishes, B.A., Williams, G.M., Conditions affecting primary cell cultures of functional adult rat hepatocytes. II. Dexamethasone enhanced longevity and maintenance of morphology. In Vitro 12 (1976), 821–832.
    • (1976) In Vitro , vol.12 , pp. 821-832
    • Laishes, B.A.1    Williams, G.M.2
  • 27
    • 0028855670 scopus 로고
    • Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes
    • 27 Sidhu, J.S., Omiecinski, C.J., Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics 5 (1995), 24–36.
    • (1995) Pharmacogenetics , vol.5 , pp. 24-36
    • Sidhu, J.S.1    Omiecinski, C.J.2
  • 28
    • 82755163945 scopus 로고    scopus 로고
    • Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs
    • 28 Kook, P.H., Schellenberg, S., Rentsch, K.M., Reusch, C.E., Glaus, T.M., Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs. Am J Vet Res 72 (2011), 1607–1612.
    • (2011) Am J Vet Res , vol.72 , pp. 1607-1612
    • Kook, P.H.1    Schellenberg, S.2    Rentsch, K.M.3    Reusch, C.E.4    Glaus, T.M.5
  • 29
    • 0025514092 scopus 로고
    • Characteristics of biliary lipid metabolism after liver transplantation
    • 29 Ericzon, B.G., Eusufzai, S., Kubota, K., Einarsson, K., Angelin, B., Characteristics of biliary lipid metabolism after liver transplantation. Hepatology 12 (1990), 1222–1228.
    • (1990) Hepatology , vol.12 , pp. 1222-1228
    • Ericzon, B.G.1    Eusufzai, S.2    Kubota, K.3    Einarsson, K.4    Angelin, B.5
  • 30
    • 0024422086 scopus 로고
    • Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase
    • 30 Princen, H.M., Meijer, P., Hofstee, B., Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase. Biochem J 262 (1989), 341–348.
    • (1989) Biochem J , vol.262 , pp. 341-348
    • Princen, H.M.1    Meijer, P.2    Hofstee, B.3
  • 31
    • 0028868818 scopus 로고
    • Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7)
    • 31 Crestani, M., Stroup, D., Chiang, J.Y., Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7). J Lipid Res 36 (1995), 2419–2432.
    • (1995) J Lipid Res , vol.36 , pp. 2419-2432
    • Crestani, M.1    Stroup, D.2    Chiang, J.Y.3
  • 32
    • 33846968795 scopus 로고    scopus 로고
    • ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines
    • 32 Sporstol, M., Mousavi, S.A., Eskild, W., Roos, N., Berg, T., ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol, 8, 2007, 5.
    • (2007) BMC Mol Biol , vol.8 , pp. 5
    • Sporstol, M.1    Mousavi, S.A.2    Eskild, W.3    Roos, N.4    Berg, T.5
  • 33
    • 56049086106 scopus 로고    scopus 로고
    • Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme
    • 33 Tang, W., Norlin, M., Wikvall, K., Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. Biochim Biophys Acta 1781 (2008), 718–723.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 718-723
    • Tang, W.1    Norlin, M.2    Wikvall, K.3
  • 34
    • 0028965012 scopus 로고
    • Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription
    • 34 Twisk, J., Hoekman, M.F., Lehmann, E.M., Meijer, P., Mager, W.H., Princen, H.M., Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription. Hepatology 21 (1995), 501–510.
    • (1995) Hepatology , vol.21 , pp. 501-510
    • Twisk, J.1    Hoekman, M.F.2    Lehmann, E.M.3    Meijer, P.4    Mager, W.H.5    Princen, H.M.6
  • 35
    • 34748836338 scopus 로고    scopus 로고
    • Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phe nylacetic acid hydrochloride (GW3965)
    • 35 Kotokorpi, P., Ellis, E., Parini, P., et al. Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phe nylacetic acid hydrochloride (GW3965). Mol Pharmacol 72 (2007), 947–955.
    • (2007) Mol Pharmacol , vol.72 , pp. 947-955
    • Kotokorpi, P.1    Ellis, E.2    Parini, P.3
  • 36
    • 35548949049 scopus 로고    scopus 로고
    • Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism
    • 36 Kang, H.S., Angers, M., Beak, J.Y., et al. Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics 31 (2007), 281–294.
    • (2007) Physiol Genomics , vol.31 , pp. 281-294
    • Kang, H.S.1    Angers, M.2    Beak, J.Y.3
  • 37
    • 0035238364 scopus 로고    scopus 로고
    • The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
    • 37 Jetten, A.M., Kurebayashi, S., Ueda, E., The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol 69 (2001), 205–247.
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 205-247
    • Jetten, A.M.1    Kurebayashi, S.2    Ueda, E.3
  • 38
    • 84891439386 scopus 로고    scopus 로고
    • Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis
    • 38 Pathak, P., Li, T., Chiang, J.Y., Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis. J Biol Chem 288 (2013), 37154–37165.
    • (2013) J Biol Chem , vol.288 , pp. 37154-37165
    • Pathak, P.1    Li, T.2    Chiang, J.Y.3
  • 39
    • 77952358850 scopus 로고    scopus 로고
    • Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics
    • 39 Solt, L.A., Griffin, P.R., Burris, T.P., Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr Opin Lipidol 21 (2010), 204–211.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 204-211
    • Solt, L.A.1    Griffin, P.R.2    Burris, T.P.3
  • 40
    • 57149089662 scopus 로고    scopus 로고
    • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    • 40 Chopra, A.R., Louet, J.F., Saha, P., et al. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science 322 (2008), 1395–1399.
    • (2008) Science , vol.322 , pp. 1395-1399
    • Chopra, A.R.1    Louet, J.F.2    Saha, P.3


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