Brain targeted intranasal delivery of tramadol: Comparative study of microemulsion and nanoemulsion

Pharmaceutical Development and Technology

Volumn 20, Issue 8, 2015, Pages 992-1001

  Lalani, Jigar ^a   Baradia, Dipesh ^a   Lalani, Riddhi ^a   Misra, Ambikanandan ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Brain targeting; Intranasal; Microemulsion; Nanoemulsion; Pharmacokinetic

Indexed keywords

TRAMADOL;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG SOLUTION; DRUG STABILITY; EMERGENCY PAIN; EMERGENCY TREATMENT; EPISODIC PAIN; EX VIVO STUDY; HALF LIFE TIME; HISTOPATHOLOGY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICROEMULSION; MOUSE; NANOEMULSION; NASAL DRUG DELIVERY SYSTEM; NONHUMAN; NOSE MUCOSA; PAIN; PAIN THRESHOLD; PARTICLE SIZE; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SHEEP; TARGET ORGAN; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL;

EID: 84964330254     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2014.959177     Document Type: Article

References (40)

1. Mustafa G, Baboota S, Ahuja A, Ali J. Formulation development of chitosan coated intranasal ropinirole nanoemulsion for better management option of parkinson: an in vitro ex vivo evaluation. Curr Nanosci 2012; 8: 348-360.
2. Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003; 87: 187-198.
3. Bahadur S, Pathak K. Buffered nanoemulsion for nose to brain delivery of ziprasidone hydrochloride: preformulation and pharmacodynamic evaluation. Curr Drug Deliv 2012; 9: 596-607.
4. Shah BM, Misra M, Shishoo CJ, Padh H. Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug Deliv 2014. PMID: 24467601. [Epub ahead of print].
5. Porecha S, Pundarikakshudu K, Panchal A, Lalwani A. Preparation and evaluation of transnasal microemulsion of carbamazepine. Asian J Pharm Sci 2013; 8: 64-70.
6. Misra A, Kher G. Drug delivery systems from nose to brain. Curr Pharm Biotechnol 2012; 13: 2355-2379.
7. Li L, Nandi I, Kim K. Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam. Int J Pharm 2002; 237: 77-85.
8. Nicolas A, Thierry F Vandamme. Nano-emulsions and microemulsions: clarifications of the critical differences. Pharm Res 2011; 28: 978-985.
9. Solans C, Esquena J, Forgiarini AM, et al. Nanoemulsion: formation, properties and applications. In: Mittal KL, Shah DO, eds Adsorption and aggregation of surfactants in solution, surfactant science series. 1st ed. Marcel Dekker: New York; 2003: 525-554.
10. Bamigbade TA, Langford RM. Tramadol hydrochloride: an overview of current use. Hosp Med 1998; 59: 373-376.
11. Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 2000; 60: 139-176.
12. Tadros T, Izquierdo P, Esquena J, Solans C. Formation and stability of nano-emulsions. Adv Colloid Interf Sci 2004; 108: 303-318.
13. Shailaja M, Diwan PV, Ramakrishna S, et al. Development of olanzapine nanoemulsion for enhanced brain delivery. Int J Pharm Sci Nanotech 2012; 5: 1648-1659.
14. Kaler EW, Prager S. A model of dynamic scattering by microemulsions. J Colloid Interf Sci 1982; 86: 359-369.
15. Roland I, Piel G, Delattre L, Evrard B. Systematic characterization of oil-in-water emulsions for formulation design. Int J Pharm 2003; 263: 85-94.
16. Shakeel F, Baboota S, Ahuja A, et al. Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS Pharm Sci Tech 2007; 8: 191-199.
17. Florence K, Lalan M, Kumar BA, et al. Intranasal clobazam delivery in the treatment of status epilepticus. J Pharm Sci 2011; 100: 692-703.
18. Seju U, Kumar A, Sawant KK. Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies. Acta Biomater 2011; 7: 4169-4176.
19. Malakar J, Sen S, Nayak AK, Sen KK. Development and evaluation of microemulsions for transdermal delivery of insulin. ISRN Pharm 2011; 2011: 1-7.
20. Kantaria S, Rees GD, Lawrence MJ. Gelatin-stabilised microemulsion-based organogels: rheology and application in iontophoretic transdermal drug delivery. J Control Release 1999; 60: 355-365.
21. Nornoo AO, Chow DS. Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics. Int J Pharm 2008; 349: 117-123.
22. Majithiya RJ, Ghosh PK, Umrthia M, Murthy RSR Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan. AAPS Pharm Sci Tech 2006; 7:E80-E86.
23. Jigar L, Yogesh R, Rashi M, et al. Comparative receptor based brain delivery of tramadol-loaded poly(lactic-co-glycolic acid) nanoparticles. J Biomed Nanotechnol 2012; 8: 918-927.
24. Babbar A, Kashyap R, Chauhan UP. A convenient method for the preparation of 99mTc-labelled pentavalent DMSA and its evaluation as a tumour imaging agent. J Nucl Biol Med 1991; 35: 100-104.
25. Jogani VV, Shah PJ, Mishra P, et al. Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting. Alzheimer Dis Assoc Disord 2008; 22: 116-124.
26. Hatakeyama H, Akita H, Maruyama K, et al. Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. Int J Pharm 2004; 281: 25-33.
27. Zhao Y, Yue P, Tao T, Chen QH. Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats. Acta Pharmacol Sin 2007; 28: 273-278.
28. Jung BH, Chung BC, Chung SJ, et al. Prolonged delivery of nicotine in rats via nasal administration of proliposomes. J Control Release 2000; 66: 73-79.
29. Zhang Q, Jiang X, Jiang W, et al. Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm 2004; 275: 85-96.
30. Woolfe HG The evaluation of the analgesic action of pethidine hydrochloride. J Pharmacol Exp Ther 1944; 80: 300-307.
31. Becher P. J. Effect of preparation parameters on the initial size distribution function in oil-in-water emulsions. Colloid Int Sci 1967; 24: 91-96.
32. Salim N, Basri M, Rahman M, et al. Phase behaviour, formation and characterization of palm-based esters nanoemulsion formulation containing ibuprofen. J Nanomedic Nanotechnol 2011; 2: 113.
33. Donsì F, Wang Y, Huang Q. Freeze-thaw stability of lecithin and modified starch-based nanoemulsions. Food Hydrocolloid 2011; 25: 1327-1336.
34. Piao H, Balakrishnan P, Cho HJ, et al. Preparation and evaluation of fexofenadine microemulsions for intranasal delivery. Int J Pharm 2010; 395: 309-316.
35. Cho HJ, Ku WS, Termsarasab U, et al. Development of udenafilloaded microemulsions for intranasal delivery: in vitro and in vivo evaluations. Int J Pharm 2012; 423: 153-160.
36. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-496.
37. Vyas TK, Babbar RK, Sharma AK, Misra A. Intranasal mucoadhesive microemulsions of zolmitriptan: preliminary studies on braintargeting. J Drug Target 2005; 13: 317-324.
38. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 2000; 45: 89-121.
39. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 2000; 11: 1-18.
40. Romeo VD, de Meireles J, Sileno AP, et al. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv Drug Deliv Rev 1998; 29: 89-116.