Progranulin does not inhibit TNF and lymphotoxin-signalling through TNF receptor 1

Immunology and Cell Biology

Volumn 91, Issue 10, 2013, Pages 661-664

  Etemadi, Nima ^a,b   Webb, Andrew ^a,b   Bankovacki, Aleksandra ^a,b   Silke, John ^a,b   Nachbur, Ueli ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

cell death; inflammation; MAPK; NFkB; progranulin; TNF receptor 1

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; PROGRANULIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NECROPTOSIS; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOTOXIN-ALPHA; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NECROSIS; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888324486     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2013.53     Document Type: Article

References (18)

1. Zhou J, Gao G, Crabb JW, Serrero G. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J Biol Chem 1993; 268: 10863-10869
2. Zhang H, Serrero G. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/ granulin precursor). Proc Natl Acad Sci USA 1998; 95: 14202-14207
3. Toh H, Chitramuthu BP, Bennett HPJ, Bateman A. Structure, function, and mechanism of progranulin; the brain and beyond. J Mol Neurosci 2011; 45: 538-548
4. Cenik B, Sephton CF, Cenik BK, Herz J, Yu G. Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem 2012; 287: 32298-32306
5. Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM et al. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 2002; 111: 867-878
6. Kessenbrock K, Fröhlich L, Sixt M, Lammermann T, Pfister H, Bateman A et al. Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest 2008; 118: 2438-2447
7. Bossu P, Salani F, Alberici A, Archetti S, Bellelli G, Galimberti D et al. Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients. J Neuroinflammation 2011; 8: 65
8. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B et al. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest 2012; 122: 3955-3959
9. Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 2011; 332: 478-484
10. Zhao Y-P, Tian Q-Y, Liu C-j. Progranulin deficiency exaggerates, whereas progranulinderived Atsttrin attenuates, severity of dermatitis in mice. FEBS Lett 2013; 587: 1805-1810
11. Kawase R, Ohama T, Matsuyama A, Matsuwaki T, Okada T, Yamashita T et al. Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. Cardiovasc Res 2013; 100: 125-133
12. Moelants EA, Mortier A, Van Damme J, Proost P. Regulation of TNF-alpha with a focus on rheumatoid arthritis. Immunol Cell Biol 2013; 91: 393-401
13. Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH et al. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNFdependent signaling or bioactivity in immune or neuronal cells. J Neurosci 2013; 33: 9202-9213
14. Etemadi N, Holien JK, Chau D, Dewson G, Murphy JM, Alexander WS et al. Lymphotoxin a induces apoptosis, necroptosis and inflammatory signals with the same potency as TNF. FEBS J (e-pub ahead of print 2 July 2013 doi:10.1111/febs.12419).
15. Chuanju Liu J, Jian, Jyoti Mundra, Sardar Uddin, Elena Gonzalez Gugel, Brendon Richbourgh. Properly folded PGRN Can Bind TNFR. J Neurosci 2013, accessed 7 June 2013; Available from http://www.jneurosci.org/content/33/21/ 9202.full?- sid=23c56273-8c72-4648-9fdd-2aad55f35b11- responses.
16. Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693
17. Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013; 39: 443-453
18. Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann MM et al. Granulin is a soluble cofactor for Toll-like receptor 9 signaling. Immunity 2011; 34: 505-513.