Neuroscience meets salivary bioscience: An integrative perspective

Behavioral Neuroscience

Volumn 130, Issue 2, 2016, Pages 156-175

  Segal, Sabrina K ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Biomarkers; Learning; Memory; Psychiatric; Salivary bioscience

Indexed keywords

ALPHA AMYLASE SALIVA ISOENZYME; AMPHETAMINE PLUS DEXAMPHETAMINE; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; BARBITURIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; ESTRADIOL; HYDROCORTISONE; METHYLPHENIDATE; NEUROLEPTIC AGENT; NEUROTROPHIN; NON PRESCRIPTION DRUG; PROGESTERONE; PSYCHEDELIC AGENT; SALIVARY CORTISOL; SEX HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANOREXIA; ANXIETY DISORDER; BORDERLINE STATE; BULIMIA; CIRCADIAN RHYTHM; DRUG USE; EATING DISORDER; HUMAN; LEARNING; MAJOR DEPRESSION; MEMORY; NERVOUS SYSTEM INJURY; NEUROSCIENCE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PAIN; PARTICULATE MATTER; PERSONALITY DISORDER; PLASMA; POSTTRAUMATIC STRESS DISORDER; PSYCHIATRY; REVIEW; SALIVA; SALIVA ANALYSIS; SALIVA COLLECTOR; SALIVATION; SERUM; SOCIAL PHOBIA; ULTRAFILTRATION; ANATOMY AND HISTOLOGY; ANIMAL; CHEMISTRY; CLASSIFICATION; DEGENERATIVE DISEASE; METABOLISM; PHYSIOLOGY; PROCEDURES; SALIVARY GLAND; SECRETION (PROCESS);

ANIMALS; HUMANS; NEURODEGENERATIVE DISEASES; NEUROSCIENCES; SALIVA; SALIVARY ALPHA-AMYLASES; SALIVARY GLANDS;

EID: 84964324863     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/bne0000141     Document Type: Review

References (159)

1. Ali, N., & Pruessner, J. C. (2012). The salivary alpha amylase over cortisol ratio as a marker to assess dysregulations of the stress systems. Physiology & Behavior, 106, 65-72. http://dx.doi.org/10.1016/j.physbeh.2011.10.003
2. Andreano, J. M., Arjomandi, H., & Cahill, L. (2008). Menstrual cycle modulation of the relationship between cortisol and long-term memory. Psychoneuroendocrinology, 33, 874-882. http://dx.doi.org/10.1016/j .psyneuen.2008.03.009
3. Andreano, J. M., & Cahill, L. (2006). Glucocorticoid release and memory consolidation in men and women. Psychological Science, 17, 466-470. http://dx.doi.org/10.1111/j.1467-9280.2006.01729.x
4. Arendorf, T. M., Bredekamp, B., Cloete, C. A., & Sauer, G. (1998). Oral manifestations of HIV infection in 600 South African patients. Journal of Oral Pathology & Medicine, 27, 176-179. http://dx.doi.org/10.1111/j.1600-0714.1998.tb01936.x
5. Bauer, A. M., Quas, J. A., & Boyce, W. T. (2002). Associations between physiological reactivity and children's behavior: Advantages of a multisystem approach. Journal of Developmental and Behavioral Pediatrics, 23, 102-113. http://dx.doi.org/10.1097/00004703-200204000-00007
6. Beltzer, E. K., Fortunato, C. K., Guaderrama, M. M., Peckins, M. K., Garramone, B. M., & Granger, D. A. (2010). Salivary flow and alphaamylase: Collection technique, duration, and oral fluid type. Physiology & Behavior, 101, 289-296. http://dx.doi.org/10.1016/j.physbeh.2010.05.016
7. Bermejo-Pareja, F., Antequera, D., Vargas, T., Molina, J. A., & Carro, E. (2010). Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: A pilot study. BMC Neurology, 10, 108. http://dx.doi.org/10.1186/1471-2377-10-108
8. Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2003). Increase in concentration of waking salivary cortisol in recovered patients with depression. The American Journal of Psychiatry, 160, 1890-1891. http://dx.doi.org/10.1176/appi.ajp.160.10.1890
9. Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2005). Increased salivary cortisol after waking in depression. Psychopharmacology, 182, 54-57. http://dx.doi.org/10.1007/s00213-005-0062-z
10. Bhandari, R., Bakermans-Kranenburg, M. J., van der Veen, R., Parsons, C. E., Young, K. S., Grewen, K. M., . . . van IJzendoorn, M. H. (2014). Salivary oxytocin mediates the association between emotional maltreatment and responses to emotional infant faces. Physiology & Behavior, 131, 123-128. http://dx.doi.org/10.1016/j.physbeh.2014.04.028
11. Bosch, J. A., Brand, H. S., Ligtenberg, T. J., Bermond, B., Hoogstraten, J., & Nieuw Amerongen, A. V. (1996). Psychological stress as a determinant of protein levels and salivary-induced aggregation of Streptococcus gordonii in human whole saliva. Psychosomatic Medicine, 58, 374-382. http://dx.doi.org/10.1097/00006842-199607000-00010
12. Bosch, J. A., de Geus, E. J. C., Veerman, E. C. I., Hoogstraten, J., & Nieuw Amerongen, A. V. (2003). Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity. Psychosomatic Medicine, 65, 245-258. http://dx.doi.org/10.1097/01.PSY.0000058376.50240.2D
13. Bosch, J. A., Ring, C., de Geus, E. J., Veerman, E. C., & Amerongen, A. V. (2002). Stress and secretory immunity. International Review of Neurobiology, 52, 213-253. http://dx.doi.org/10.1016/S0074-7742(02)52011-0
14. Bosch, J. A., & Veerman, E. C. (2008). Neural regulation of the saliva glands during stress and exercise. In L. M. Sreebny & A. Vissink (Eds.), Dry mouth: A clinical guide (pp. 213-226). New York, NY: Blackwell-Munksgaard.
15. Bosch, J. A., Veerman, E. C., de Geus, E. J., & Proctor, G. B. (2011). _-Amylase as a reliable and convenient measure of sympathetic activity: Don't start salivating just yet! Psychoneuroendocrinology, 36, 449-453. http://dx.doi.org/10.1016/j.psyneuen.2010.12.019
16. Brown, C. C. (1970). The parotid puzzle: A review of the literature on human salivation and its applications to psychophysiology. Psychophysiology, 7, 66-85. http://dx.doi.org/10.1111/j.1469-8986.1970.tb02277.x
17. Bryant, R. A., McGrath, C., & Felmingham, K. L. (2013). The roles of noradrenergic and glucocorticoid activation in the development of intrusive memories. PLoS ONE, 8, e62675. http://dx.doi.org/10.1371/journal.pone.0062675
18. Buchanan, T. W., & Lovallo, W. R. (2001). Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology, 26, 307-317. http://dx.doi.org/10.1016/S0306-4530(00)00058-5
19. Cahill, L., Gorski, L., & Le, K. (2003). Enhanced human memory consolidation with post-learning stress: Interaction with the degree of arousal at encoding. Learning & Memory, 10, 270-274. http://dx.doi.org/10.1101/lm.62403
20. Cahill, L., Pham, C. A., & Setlow, B. (2000). Impaired memory consolidation in rats produced with beta-adrenergic blockade. Neurobiology of Learning and Memory, 74, 259-266. http://dx.doi.org/10.1006/nlme .1999.3950
21. Cahill, L., Prins, B., Weber, M., & McGaugh, J. L. (1994). Beta-adrenergic activation and memory for emotional events. Nature, 371, 702-704. http://dx.doi.org/10.1038/371702a0
22. Carter, C. S., Pournajafi-Nazarloo, H., Kramer, K. M., Ziegler, T. E., White-Traut, R., Bello, D., & Schwertz, D. (2007). Oxytocin: Behavioral associations and potential as a salivary biomarker. Annals of the New York Academy of Sciences, 1098, 312-322. http://dx.doi.org/10.1196/annals.1384.006
23. Chatterton, R. T., Jr., Vogelsong, K. M., Lu, Y. C., Ellman, A. B., & Hudgens, G. A. (1996). Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clinical Physiology (Oxford, England), 16, 433-448. http://dx.doi.org/10.1111/j.1475-097X.1996.tb00731.x
24. Cornelisse, S., van Stegeren, A. H., & Joëls, M. (2011). Implications of psychosocial stress on memory formation in a typical male versus female student sample. Psychoneuroendocrinology, 36, 569-578. http://dx.doi.org/10.1016/j.psyneuen.2010.09.002
25. Coupland, N. J., Wilson, S. J., Potokar, J. P., Bell, C., & Nutt, D. J. (2003). Increased sympathetic response to standing in panic disorder. Psychiatry Research, 118, 69-79. http://dx.doi.org/10.1016/S0165-1781(03)00045-3
26. Dawidson, I., Blom, M., Lundeberg, T., Theodorsson, E., & Angmar-Månsson, B. (1997). Neuropeptides in the saliva of healthy subjects. Life Sciences, 60, 269-278. http://dx.doi.org/10.1016/S0024-3205(96)00627-3
27. Edgar, W. M. (1992). Saliva: Its secretion, composition and functions. British Dental Journal, 172, 305-312. http://dx.doi.org/10.1038/sj.bdj .4807861
28. Ehlert, U., Erni, K., Hebisch, G., & Nater, U. (2006). Salivary alphaamylase levels after yohimbine challenge in healthy men. The Journal of Clinical Endocrinology and Metabolism, 91, 5130-5133. http://dx.doi .org/10.1210/jc.2006-0461
29. Ekstrom, J., Khosravani, N., Castagnola, M., & Messana, I. (2012). Saliva and the control of its secretion. Dysphagia, Part of the Series of Medical Radiology, 10, 19-47.
30. El-Sheikh, M., Erath, S. A., Buckhalt, J. A., Granger, D. A., & Mize, J. (2008). Cortisol and children's adjustment: The moderating role of sympathetic nervous system activity. Journal of Abnormal Child Psychology, 36, 601-611. http://dx.doi.org/10.1007/s10802-007-9204-6
31. Elzinga, B. M., & Roelofs, K. (2005). Cortisol-induced impairments of working memory require acute sympathetic activation. Behavioral Neuroscience, 119, 98-103. http://dx.doi.org/10.1037/0735-7044.119.1.98
32. Emmelin, N. (1987). Nerve interactions in salivary glands. Journal of Dental Research, 66, 509-517. http://dx.doi.org/10.1177/00220345870660022101
33. Ertman, N., Andreano, J. M., & Cahill, L. (2011). Progesterone at encoding predicts subsequent emotional memory. Learning & Memory, 18, 759-763. http://dx.doi.org/10.1101/lm.023267.111
34. Ferree, N. K., Kamat, R., & Cahill, L. (2011). Influences of menstrual cycle position and sex hormone levels on spontaneous intrusive recollections following emotional stimuli. Consciousness and Cognition: An International Journal, 20, 1154-1162. http://dx.doi.org/10.1016/j .concog.2011.02.003
35. Fisher, A. J., Granger, D. A., & Newman, M. G. (2010). Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder. Biological Psychology, 83, 191-200. http://dx.doi.org/10.1016/j.biopsycho.2009.12.007
36. Frankenhaeuser, M., Lundberg, U., & Forsman, L. (1980). Dissociation between sympathetic-adrenal and pituitary-adrenal responses to an achievement situation characterized by high controllability: Comparison between type A and type B males and females. Biological Psychology, 10, 79-91. http://dx.doi.org/10.1016/0301-0511(80)90029-0
37. Gallacher, D. V., & Petersen, O. H. (1983). Stimulus-secretion coupling in mammalian salivary glands. International Review of Physiology, 28, 1-52.
38. Gaul-Alácová, P., Boucek, J., Stejskal, P., Kryl, M., Pastucha, P., & Pavlík, F. (2005). Assessment of the influence of exercise on heart rate variability in anxiety patients. Neuroendocrinology Letters, 26, 713-718.
39. Granger, D. A., Hibel, L. C., Fortunato, C. K., & Kapelewski, C. H. (2009). Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science. Psychoneuroendocrinology, 34, 1437-1448. http://dx.doi.org/10.1016/j.psyneuen.2009.06.017
40. Granger, D. A., Johnson, S. B., Szanton, S. L., Out, D., & Schumann, L. L. (2012). Incorporating salivary biomarkers into nursing research: An overview and review of best practices. Biological Research for Nursing, 14, 347-356. http://dx.doi.org/10.1177/1099800412443892
41. Gröschl, M., & Rauh, M. (2006). Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids, 71, 1097-1100. http://dx.doi.org/10.1016/j.steroids.2006.09.007
42. Hardeveld, F., Spijker, J., Vreeburg, S. A., Graaf, R. D., Hendriks, S. M., Licht, C. M. M., . . . Beekman, A. T. F. (2014). Increased cortisol awakening response was associated with time to recurrence of major depressive disorder. Psychoneuroendocrinology, 50, 62-71. http://dx .doi.org/10.1016/j.psyneuen.2014.07.027
43. Harmon, A. G., Towe-Goodman, N. R., Fortunato, C. K., & Granger, D. A. (2008). Differences in saliva collection location and disparities in baseline and diurnal rhythms of alpha-amylase: A preliminary note of caution. Hormones and Behavior, 54, 592-596. http://dx.doi.org/10.1016/j .yhbeh.2008.05.019
44. Hibel, L. C., Granger, D. A., Cicchetti, D., & Rogosch, F. (2007). Salivary biomarker levels and diurnal variation: Associations with medications prescribed to control children's problem behavior. Child Development, 78, 927-937. http://dx.doi.org/10.1111/j.1467-8624.2007.01041.x
45. Hidalgo, V., Villada, C., Almela, M., Espín, L., Gómez-Amor, J., & Salvador, A. (2012). Enhancing effects of acute psychosocial stress on priming of non-declarative memory in healthy young adults. Stress: The International Journal on the Biology of Stress, 15, 329-338.
46. Holsboer, F. (2001). Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy. Journal of Affective Disorders, 62, 77-91. http://dx.doi.org/10.1016/S0165-0327(00)00352-9
47. Horvat-Gordon, M., Granger, D. A., Schwartz, E. B., Nelson, V. J., & Kivlighan, K. T. (2005). Oxytocin is not a valid biomarker when measured in saliva by immunoassay. Physiology & Behavior, 84, 445-448. http://dx.doi.org/10.1016/j.physbeh.2005.01.007
48. Hui, G. K., Figueroa, I. R., Poytress, B. S., Roozendaal, B., McGaugh, J. L., & Weinberger, N. M. (2004). Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats. Neurobiology of Learning and Memory, 81, 67-74. http://dx.doi.org/10.1016/j.nlm.2003.09.002
49. Iizuka, N., Awano, S., & Ansai, T. (2012). Salivary alpha-amylase activity and stress in Japan air self-defense force cargo pilots involved in Iraq reconstruction. American Journal of Human Biology, 24, 468-472. http://dx.doi.org/10.1002/ajhb.22247
50. Ito, T., Inoue, Y., Sugihara, T., Yamada, H., Katayama, S., & Kawahara, R. (1999). Autonomic function in the early stage of panic disorder: Power spectral analysis of heart rate variability. Psychiatry and Clinical Neurosciences, 53, 667-672. http://dx.doi.org/10.1046/j.1440-1819.1999.00623.x
51. Jang, M. U., Park, J. W., Kho, H. S., Chung, S. C., & Chung, J. W. (2011). Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients. Oral Diseases, 17, 187-193. http://dx.doi.org/10.1111/j.1601-0825.2010.01717.x
52. Johnston, M., Zakharov, A., Papaiconomou, C., Salmasi, G., & Armstrong, D. (2004). Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Research, 1, 2.
53. Jusko, W. J., & Milsap, R. L. (1993). Pharmacokinetic principles of drug distribution in saliva. Annals of the New York Academy of Sciences, 694, 36-47. http://dx.doi.org/10.1111/j.1749-6632.1993.tb18340.x
54. Kang, W. Y., Yang, Q., Jiang, X. F., Chen, W., Zhang, L. Y., Wang, X. Y., . . . Chen, S. D. (2014). Salivary DJ-1 could be an indicator of Parkinson's disease progression. Frontiers of Aging in Neuroscience, 6, 102.
55. Kaufman, E., & Lamster, I. B. (2002). The diagnostic applications of saliva: A review. Critical Reviews in Oral Biology and Medicine, 13, 197-212. http://dx.doi.org/10.1177/154411130201300209
56. Kirschbaum, C., & Hellhammer, D. H. (1994). Salivary cortisol in psychoneuroendocrine research: Recent developments and applications. Psychoneuroendocrinology, 19, 313-333. http://dx.doi.org/10.1016/0306-4530(94)90013-2
57. Kirschbaum, C., Pirke, K. M., & Hellhammer, D. H. (1993). The "Trier Social Stress Test": A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28, 76-81. http://dx.doi.org/10.1159/000119004
58. Kivlighan, K. T., & Granger, D. A. (2006). Salivary alpha-amylase response to competition: Relation to gender, previous experience, and attitudes. Psychoneuroendocrinology, 31, 703-714. http://dx.doi.org/10.1016/j.psyneuen.2006.01.007
59. Kivlighan, K. T., Granger, D. A., Schwartz, E. B., Nelson, V., Curran, M., & Shirtcliff, E. A. (2004). Quantifying blood leakage into the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva. Hormones and Behavior, 46, 39-46. http://dx.doi.org/10.1016/j.yhbeh.2004.01.006
60. Kop, W. J., Stein, P. K., Tracy, R. P., Barzilay, J. I., Schulz, R., & Gottdiener, J. S. (2010). Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosomatic Medicine, 72, 626-635. http://dx.doi.org/10.1097/PSY.0b013e3181eadd2b
61. Kudielka, B. M., Gierens, A., Hellhammer, D. H., Wüst, S., & Schlotz, W. (2012). Salivary cortisol in ambulatory assessment: Some dos, some don'ts, and some open questions. Psychosomatic Medicine, 74, 418-431. http://dx.doi.org/10.1097/PSY.0b013e31825434c7
62. Kuffel, A., Eikelmann, S., Terfehr, K., Mau, G., Kuehl, L. K., Otte, C., . . . Wingenfeld, K. (2014). Noradrenergic blockade and memory in patients with major depression and healthy participants. Psychoneuroendocrinology, 40, 86-90. http://dx.doi.org/10.1016/j.psyneuen.2013.11.001
63. Kugler, J., Hess, M., & Haake, D. (1992). Secretion of salivary immunoglobulin A in relation to age, saliva flow, mood states, secretion of albumin, cortisol, and catecholamines in saliva. Journal of Clinical Immunology, 12, 45-49. http://dx.doi.org/10.1007/BF00918272
64. Kuhlmann, S., & Wolf, O. T. (2005). Cortisol and memory retrieval in women: Influence of menstrual cycle and oral contraceptives. Psychopharmacology, 183, 65-71. http://dx.doi.org/10.1007/s00213-005-0143-z
65. Lehman, E. J., Kulnane, L. S., Gao, Y., Petriello, M. C., Pimpis, K. M., Younkin, L., . . . Lamb, B. T. (2003). Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Human Molecular Genetics, 12, 2949-2956.
66. Lewis, J. G. (2006). Steroid analysis in saliva: An overview. The Clinical Biochemist Reviews/Australian Association of Clinical Biochemists, 27, 139-146.
67. Lord, C., Hall, G., Soares, C. N., & Steiner, M. (2011). Physiological stress response in postpartum women with obsessive-compulsive disorder: A pilot study. Psychoneuroendocrinology, 36, 133-138. http://dx.doi.org/10.1016/j.psyneuen.2010.04.014
68. Luethi, M., Meier, B., & Sandi, C. (2009). Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men. Frontiers in Behavioral Neuroscience, 2, 5. http://dx.doi.org/10.3389/neuro.08.005.2008
69. Lundberg, U., & Frankenhaeuser, M. (1980). Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort. Journal of Psychosomatic Research, 24, 125-130. http://dx.doi.org/10.1016/0022-3999(80)90033-1
70. Makinen, K. K. (1989). Salivary enzymes. In J. O. Tenovuo (Ed.), Human saliva: Clinical chemistry and microbiology (Vol. 2, pp. 93-119). Boca Raton, FL: CRC Press.
71. Malamud, D., & Tabak, L. (1993). Saliva as a diagnostic fluid. Annals of the New York Academy of Sciences, 694, 216-233.
72. Mandel, A. L., Ozdener, H., & Utermohlen, V. (2011). Brain-derived neurotrophic factor in human saliva: ELISA optimization and biological correlates. Journal of Immunoassay & Immunochemistry, 32, 18-30. http://dx.doi.org/10.1080/15321819.2011.538625
73. Mannie, Z. N., Harmer, C. J., & Cowen, P. J. (2007). Increased waking salivary cortisol levels in young people at familial risk of depression. The American Journal of Psychiatry, 164, 617-621. http://dx.doi.org/10.1176/ajp.2007.164.4.617
74. Matin, M. J., Peterson, J., Taylor, M. K., Laurent, H. K., Lucas, T., Granger, S. J., . . . Granger, S. W. (2016). Measuring nerve growth factor in saliva by immunoassay: A cautionary note. Psychoneuroendocrinology, 63, 235-237.
75. Matsuo, R. (1999). Central connections for salivary innervations and efferent impulse formation. In J. R. Garrett, J. Ekstrom, & L. C. Anderson (Eds.), Neural mechanisms of salivary gland secretion (pp. 26-43). Basel, Switzerland: Karger. http://dx.doi.org/10.1159/000061119
76. McEwen, B. S. (1998). Stress, adaptation, and disease. Allostatis and allostatic load. Annals of the New York Academy of Sciences, 840, 33-44.
77. McEwen, B. S. (2008). Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. European Journal of Pharmacology, 583, 174-185. http://dx.doi.org/10.1016/j.ejphar.2007.11.071
78. McEwen, B. S., & Gianaros, P. J. (2010). Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Annals of the New York Academy of Sciences, 1186, 190-222. http://dx .doi.org/10.1111/j.1749-6632.2009.05331.x
79. McEwen, B. S., & Seeman, T. (1999). Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Annals of the New York Academy of Sciences, 896, 30-47.
80. McGaugh, J. L., Cahill, L., & Roozendaal, B. (1996). Involvement of the amygdala in memory storage: Interaction with other brain systems. Proceedings of the National Academy of Sciences of the United States of America, 93, 13508-13514. http://dx.doi.org/10.1073/pnas.93.24.13508
81. McGaugh, J. L., Liang, K. C., Bennet, C., & Sternberg, D. (1984). Involvement of the amygdala in memory storage: Interaction of peripheral and central systems. In G. Lynch, J. L. McGaugh, & N. M. Weinberger (Eds.), Neurobiology of learning and memory. New York, NY: Guilford Press.
82. McIntyre, C. K., Hatfield, T., & McGaugh, J. L. (2002). Amygdala norepinephrine levels after training predict inhibitory avoidance retention performance in rats. European Journal of Neuroscience, 16, 1223-1226. http://dx.doi.org/10.1046/j.1460-9568.2002.02188.x
83. Meuret, A. E., Trueba, A. F., Abelson, J. L., Liberzon, I., Auchus, R., Bhaskara, L., . . . Rosenfield, D. (2015). High cortisol awakening response and cortisol levels moderate exposure-based psychotherapy success. Psychoneuroendocrinology, 51, 331-340. http://dx.doi.org/10.1016/j.psyneuen.2014.10.008
84. Mollanji, R., Bozanovic-Sosic, R., Zakharov, A., Makarian, L., & Johnston, M. G. (2002). Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure. American Journal of Physiology, Regulatory, Integrative Comparative Physiology, 282, R1593-R1599.
85. Monteleone, P., Scognamiglio, P., Canestrelli, B., Serino, I., Monteleone, A. M., & Maj, M. (2011a). Asymmetry of salivary cortisol and _-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. Psychological Medicine, 41, 1963-1969. http://dx .doi.org/10.1017/S0033291711000092
86. Monteleone, P., Scognamiglio, P., Monteleone, A. M., Mastromo, D., Steardo, L., Jr., Serino, I., & Maj, M. (2011b). Abnormal diurnal patterns of salivary _-amylase and cortisol secretion in acute patients with anorexia nervosa. The World Journal of Biological Psychiatry, 12, 455-461. http://dx.doi.org/10.3109/15622975.2011.590226
87. Nam, J. W., Chung, J. W., Kho, H. S., Chung, S. C., & Kim, Y. K. (2007). Nerve growth factor concentration in human saliva. Oral Diseases, 13, 187-192. http://dx.doi.org/10.1111/j.1601-0825.2006.01265.x
88. Nater, U. M., Bohus, M., Abbruzzese, E., Ditzen, B., Gaab, J., Kleindienst, N., . . . Ehlert, U. (2010). Increased psychological and attenuated cortisol and alpha-amylase responses to acute psychosocial stress in female patients with borderline personality disorder. Psychoneuroendocrinology, 35, 1565-1572. http://dx.doi.org/10.1016/j.psyneuen.2010.06.002
89. Nater, U. M. L. A. Marca, R., Florin, L., Moses, A., Langhans, W., Koller, M. M., & Ehlert, U. (2006). Stress-induced changes in human salivary alpha-amylase activity: Associations with adrenergic activity. Psychoneuroendocrinology, 31, 49-58. http://dx.doi.org/10.1016/j.psyneuen .2005.05.010
90. Nater, U. M., & Rohleder, N. (2009). Salivary alpha-amylase as a noninvasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology, 34, 486-496. http://dx.doi.org/10.1016/j.psyneuen.2009.01.014
91. Nater, U. M., Rohleder, N., Gaab, J., Berger, S., Jud, A., Kirschbaum, C., & Ehlert, U. (2005). Human salivary alpha-amylase reactivity in a psychosocial stress paradigm. International Journal of Psychophysiology, 55, 333-342. http://dx.doi.org/10.1016/j.ijpsycho.2004.09.009
92. Nater, U. M., Rohleder, N., Schlotz, W., Ehlert, U., & Kirschbaum, C. (2007). Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology, 32, 392-401. http://dx.doi.org/10.1016/j .psyneuen.2007.02.007
93. Nederfors, T., & Dahlöf, C. (1992). Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human whole saliva flow rate and composition. Archives of Oral Biology, 37, 579-584. http://dx.doi .org/10.1016/0003-9969(92)90141-T
94. Nederfors, T., Dahlöf, C., & Twetman, S. (1994). Effects of the betaadrenoceptor antagonists atenolol and propranolol on human unstimulated whole saliva flow rate and protein composition. Scandinavian Journal of Dental Research, 102, 235-237.
95. Nelson, D. L., & Cox, M. M. (2005). Principals of biochemistry (4th ed.). New York, NY: WH Freeman.
96. Nielsen, S. E., Segal, S. K., Worden, I. V., Yim, I. S., & Cahill, L. (2013). Hormonal contraception use alters stress responses and emotional memory. Biological Psychology, 92, 257-266. http://dx.doi.org/10.1016/j .biopsycho.2012.10.007
97. Nicholson, E. L., Bryant, R. A., & Felmingham, K. L. (2014). Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder. Neurobiology of Learning and Memory, 112, 204-211. http://dx.doi.org/10.1016/j.nlm.2013.11.018
98. Noto, Y., Sato, T., Kudo, M., Kurata, K., & Hirota, K. (2005). The relationship between salivary biomarkers and state-trait anxiety inventory score under mental arithmetic stress: A pilot study. Anesthesia and Analgesia, 101, 1873-1876. http://dx.doi.org/10.1213/01.ANE.0000184196.60838.8D
99. Oei, N. Y., Everaerd, W. T., Elzinga, B. M., van Well, S., & Bermond, B. (2006). Psychosocial stress impairs working memory at high loads: An association with cortisol levels and memory retrieval. Stress: The International Journal on the Biology of Stress, 9, 133-141. http://dx.doi.org/10.1080/10253890600965773
100. Okuda, S., Roozendaal, B., & McGaugh, J. L. (2004). Glucocorticoid effects on object recognition memory require training-associated emotional arousal. Proceedings of the National Academy of Sciences of the United States of America, 101, 853-858. http://dx.doi.org/10.1073/pnas .0307803100
101. Payne, J. D., Jackson, E. D., Hoscheidt, S., Ryan, L., Jacobs, W. J., & Nadel, L. (2007). Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories. Learning & Memory, 14, 861-868. http://dx.doi.org/10.1101/lm.743507
102. Petrowski, K., Herold, U., Joraschky, P., Wittchen, H. U., & Kirschbaum, C. (2010). A striking pattern of cortisol non-responsiveness to psychosocial stress in patients with panic disorder with concurrent normal cortisol awakening responses. Psychoneuroendocrinology, 35, 414-421. http://dx.doi.org/10.1016/j.psyneuen.2009.08.003
103. Petrowski, K., Wintermann, G. B., Schaarschmidt, M., Bornstein, S. R., & Kirschbaum, C. (2013). Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. International Journal of Psychophysiology, 88, 35-39. http://dx.doi.org/10.1016/j .ijpsycho.2013.01.002
104. Plag, J., Gaudlitz, K., Schumacher, S., Dimeo, F., Bobbert, T., Kirschbaum, C., & Ströhle, A. (2014). Effect of combined cognitivebehavioural therapy and endurance training on cortisol and salivary alpha-amylase in panic disorder. Journal of Psychiatric Research, 58, 12-19. http://dx.doi.org/10.1016/j.jpsychires.2014.07.008
105. Proctor, G. B., & Carpenter, G. H. (2007). Regulation of salivary gland function by autonomic nerves. Autonomic Neuroscience, 133, 3-18. http://dx.doi.org/10.1016/j.autneu.2006.10.006
106. Rausch, J., Gäbel, A., Nagy, K., Kleindienst, N., Herpertz, S. C., & Bertsch, K. (2015). Increased testosterone levels and cortisol awakening responses in patients with borderline personality disorder: Gender and trait aggressiveness matter. Psychoneuroendocrinology, 55, 116-127.
107. Rees, T. D. (1992). Oral effects of drug abuse. Critical Reviews in Oral Biology and Medicine, 3, 163-184.
108. Reibel, J. (2003). Tobacco and oral diseases. Update on the evidence, with recommendations. Medical Principles and Practice, 12(Suppl. 1), 22-32. http://dx.doi.org/10.1159/000069845
109. Riis, J. L., Granger, D. A., DiPietro, J. A., Bandeen-Roche, K., & Johnson, S. B. (2015). Salivary cytokines as a minimally-invasive measure of immune functioning in young children: Correlates of individual differences and sensitivity to laboratory stress. Developmental Psychobiology, 57, 153-167.
110. Rohleder, N., & Nater, U. M. (2009). Determinants of salivary alphaamylase in humans and methodological considerations. Psychoneuroendocrinology, 34, 469-485. http://dx.doi.org/10.1016/j.psyneuen.2008.12.004
111. Rohleder, N., Nater, U. M., Wolf, J. M., Ehlert, U., & Kirschbaum, C. (2004). Psychosocial stress-induced activation of salivary alphaamylase: An indicator of sympathetic activity? Annals of the New York Academy of Sciences, 1032, 258-263. http://dx.doi.org/10.1196/annals .1314.033
112. Roozendaal, B. (2000). 1999 Curt P. Richter award: Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology, 25, 213-238. http://dx.doi.org/10.1016/S0306-4530(99)00058-X
113. Roozendaal, B. (2002). Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiology of Learning and Memory, 78, 578-595. http://dx.doi.org/10.1006/nlme .2002.4080
114. Roozendaal, B. (2003). Systems mediating acute glucocorticoid effects on memory consolidation and retrieval. Programs in Neuropsychopharmacological Biological Psychiatry, 27, 1213-1223. http://dx.doi.org/10.1016/j.pnpbp.2003.09.015
115. Roozendaal, B., Hahn, E. L., Nathan, S. V., deq Uervain, D. J., & McGaugh, J. L. (2004). Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. The Journal of Neuroscience, 24, 8161-8169. http://dx.doi.org/10.1523/JNEUROSCI.2574-04.2004
116. Roozendaal, B., Okuda, S., deq Uervain, D. J., & McGaugh, J. L. (2006). Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. Neuroscience, 138, 901-910. http://dx.doi.org/10.1016/j.neuroscience.2005.07.049
117. Roozendaal, B., Okuda, S., Van der Zee, E. A., & McGaugh, J. L. (2006). Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala. Proceedings of the National Academy of Sciences of the United States of America, 103, 6741-6746. http://dx.doi.org/10.1073/pnas.0601874103
118. Ruhl, S., Hamberger, S., Betz, R., Sukkar, T., Schmalz, G., Seymour, R. A., . . . Thomason, J. M. (2004). Salivary proteins and cytokines in drug-induced gingival overgrowth. Journal of Dental Research, 83, 322-326. http://dx.doi.org/10.1177/154405910408300410
119. Santavirta, N., Konttinen, Y. T., Törnwall, J., Segerberg, M., Santavirta, S., Matucci-Cerinic, M., & Björvell, H. (1997). Neuropeptides of the autonomic nervous system in Sjögren's syndrome. Annals of Rheumatoid Disease, 56, 737-740. http://dx.doi.org/10.1136/ard.56.12.737
120. Schoofs, D., Preuss, D., & Wolf, O. T. (2008). Psychosocial stress induces working memory impairments in an n-back paradigm. Psychoneuroendocrinology, 33, 643-653. http://dx.doi.org/10.1016/j.psyneuen.2008.02.004
121. Schumacher, S., Gaudlitz, K., Plag, J., Miller, R., Kirschbaum, C., Fehm, L., . . . Ströhle, A. (2014). Who is stressed? A pilot study of salivary cortisol and alpha-amylase concentrations in agoraphobic patients and their novice therapists undergoing in vivo exposure. Psychoneuroendocrinology, 49, 280-289. http://dx.doi.org/10.1016/j.psyneuen.2014.07.016
122. Schumacher, S., Kirschbaum, C., Fydrich, T., & Ströhle, A. (2013). Is salivary alpha-amylase an indicator of autonomic nervous system dysregulations in mental disorders? A review of preliminary findings and the interactions with cortisol. Psychoneuroendocrinology, 38, 729-743. http://dx.doi.org/10.1016/j.psyneuen.2013.02.003
123. Schwartz, E. B., Eppihimer, L., & Granger, D. A. (2005). Effects of sample storage temperature on the measurement of salivary analytes: Degradation of testosterone, estradiol, and progesterone. Presented at the annual meeting of the American Association for Clinical Chemistry, Chicago, IL.
124. Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998). Assessing salivary cortisol in studies of child development. Child Development, 69, 1503-1513. http://dx.doi.org/10.1111/j.1467-8624.1998.tb06173.x
125. Segal, S. K., & Cahill, L. (2009). Endogenous noradrenergic activation and memory for emotional material in men and women. Psychoneuroendocrinology, 34, 1263-1271. http://dx.doi.org/10.1016/j.psyneuen.2009.04.020
126. Segal, S. K., Cotman, C. W., & Cahill, L. F. (2012). Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. Journal of Alzheimer's Disease, 32, 1011-1018.
127. Segal, S. K., Simon, R., McFarlin, S., Alkire, M., Desai, A., & Cahill, L. F. (2014). Glucocorticoids interact with noradrenergic activation at encoding to enhance long-term memory for emotional material in women. Neuroscience, 277, 267-272. http://dx.doi.org/10.1016/j.neuroscience .2014.06.059
128. Segal, S. K., Stark, S. M., Kattan, D., Stark, C. E., & Yassa, M. A. (2012). Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiology of Learning and Memory, 97, 465-469. http://dx.doi.org/10.1016/j.nlm.2012.03.010
129. Shi, M., Sui, Y. T., Peskind, E. R., Li, G., Hwang, H., Devic, I., . . . Zhang, J. (2011). Salivary tau species are potential biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease, 27, 299-305.
130. Shirtcliff, E. A., Granger, D. A., Schwartz, E., & Curran, M. J. (2001). Use of salivary biomarkers in biobehavioral research: Cotton-based sample collection methods can interfere with salivary immunoassay results. Psychoneuroendocrinology, 26, 165-173. http://dx.doi.org/10.1016/S0306-4530(00)00042-1
131. Simeon, D., Knutelska, M., Smith, L., Baker, B. R., & Hollander, E. (2007). A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociation. Psychiatry Research, 149, 177-184. http://dx.doi.org/10.1016/j.psychres.2005.11.014
132. Skoluda, N., Strahler, J., Schlotz, W., Niederberger, L., Marques, S., Fischer, S., . . . Nater, U. M. (2015). Intra-individual psychological and physiological responses to acute laboratory stressors of different intensity. Psychoneuroendocrinology, 51, 227-236. http://dx.doi.org/10.1016/j.psyneuen.2014.10.002
133. Smeets, T., Otgaar, H., Candel, I., & Wolf, O. T. (2008). True or false? Memory is differentially affected by stress-induced cortisol elevations and sympathetic activity at consolidation and retrieval. Psychoneuroendocrinology, 33, 1378-1386. http://dx.doi.org/10.1016/j.psyneuen.2008.07.009
134. Smith, P. M. (1996). Mechanisms of secretion by salivary glands. In W. M. Edgar & D. M. O'Mullane (Eds.), Saliva and oral health (pp. 9-25). London, England: British Dental Association.
135. Soria, C. A., Remedi, C., Núñez, D. A., D'Alessio, L., & Roldán, E. J. A. (2015). Impact of alprazolam in allostatic load and neurocognition of patients with anxiety disorders and chronic stress (GEMA): Observational study protocol. British Medical Journal Open, 5, e007231. http://dx.doi.org/10.1136/bmjopen-2014-007231
136. Southwick, S. M., Bremner, J. D., Rasmusson, A., Morgan, C. A., III, Arnsten, A., & Charney, D. S. (1999). Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biological Psychiatry, 46, 1192-1204. http://dx.doi.org/10.1016/S0006-3223(99)00219-X
137. Speirs, R. L., Herring, J., Cooper, W. D., Hardy, C. C., & Hind, C. R. (1974). The influence of sympathetic activity and isoprenaline on the secretion of amylase from the human parotid gland. Archives of Oral Biology, 19, 747-752. http://dx.doi.org/10.1016/0003-9969(74)90161-7
138. Sreebny, L. M., & Schwartz, S. S. (1997). A reference guide to drugs and dry mouth-2nd ed. Gerodontology, 14, 33-47.
139. Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher & J. T. Reason (Eds.), Handbook of Life Stress, Cognition, and Health (pp. 629-649). Chicester, NY: Wiley.
140. Strahler, J., Berndt, C., Kirschbaum, C., & Rohleder, N. (2010). Aging diurnal rhythms and chronic stress: Distinct alteration of diurnal rhythmicity of salivary alpha-amylase and cortisol. Biological Psychology, 84, 248-256. http://dx.doi.org/10.1016/j.biopsycho.2010.01.019
141. Takai, N., Yamaguchi, M., Aragaki, T., Eto, K., Uchihashi, K., & Nishikawa, Y. (2004). Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults. Archives of Oral Biology, 49, 963-968. http://dx.doi.org/10.1016/j.archoralbio.2004.06.007
142. Tanaka, Y., Ishitobi, Y., Maruyama, Y., Kawano, A., Ando, T., Imanaga, J., . . . Akiyoshi, J. (2012). Salivary _-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients. Neuroscience Research, 73, 80-84. http://dx.doi.org/10.1016/j.neures .2012.01.006
143. Thoma, M. V., Kirschbaum, C., Wolf, J. M., & Rohleder, N. (2012). Acute stress responses in salivary alpha-amylase predict increases of plasma norepinephrine. Biological Psychology, 91, 342-348. http://dx.doi.org/10.1016/j.biopsycho.2012.07.008
144. van Stegeren, A., Rohleder, N., Everaerd, W., & Wolf, O. T. (2006). Salivary alpha amylase as marker for adrenergic activity during stress: Effect of betablockade. Psychoneuroendocrinology, 31, 137-141. http://dx.doi.org/10.1016/j.psyneuen.2005.05.012
145. van Stegeren, A. H., Wolf, O. T., & Kindt, M. (2008). Salivary alpha amylase and cortisol responses to different stress tasks: Impact of sex. International Journal of Psychophysiology, 69, 33-40. http://dx.doi.org/10.1016/j.ijpsycho.2008.02.008
146. van Veen, J. F., van Vliet, I. M., Derijk, R. H., van Pelt, J., Mertens, B., & Zitman, F. G. (2008). Elevated alpha-amylase but not cortisol in generalized social anxiety disorder. Psychoneuroendocrinology, 33, 1313-1321. http://dx.doi.org/10.1016/j.psyneuen.2008.07.004
147. Veerman, E. C. I., van den Keybus, P. A., Vissink, A., & Nieuw Amerongen, A. V. (1996). Human glandular salivas: Their separate collection and analysis. European Journal of Oral Sciences, 104, 346-352. http://dx.doi.org/10.1111/j.1600-0722.1996.tb00090.x
148. Visser, R. M., Kunze, A. E., Westhoff, B., Scholte, H. S., & Kindt, M. (2015). Representational similarity analysis offers a preview of the noradrenergic modulation of long-term fear memory at the time of encoding. Psychoneuroendocrinology, 55, 8-20.
149. Voss, A., Schulz, S., Koschke, M., & Bar, K. J. (2008). Linear and nonlinear analysis of autonomic regulation in depressed patients. In Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Conference 2008, IEEE Engineering in Medicine and Biology Society (pp. 2653-2656). Vancouver, BC, Canada: IEEE.
150. Wang, T., Chen, W. Y., Chen, J., Yu, Q. X., & Wang, J. J. (1993). Effects of stimulating lateral hypothalamic area and ventromedial nucleus of hypothalamus on cerebellar cortical neuronal activity in the cat. Sheng Li Xue Bao, 45, 338-347.
151. Weerda, R., Muehlhan, M., Wolf, O. T., & Thiel, C. M. (2010). Effects of acute psychosocial stress on working memory related brain activity in men. Human Brain Mapping, 31, 1418-1429. http://dx.doi.org/10.1002/hbm.20945
152. Weinberg, L., Hasni, A., Shinohara, M., & Duarte, A. (2014). A single bout of resistance exercise can enhance episodic memory performance. Acta Psychologica, 153, 13-19. http://dx.doi.org/10.1016/j.actpsy.2014.06.011
153. Wetherell, M. A., Crown, A. L., Lightman, S. L., Miles, J. N., Kaye, J., & Vedhara, K. (2006). The four-dimensional stress test: Psychological, sympathetic-adrenal-medullary, parasympathetic and hypothalamicpituitary-adrenal responses following inhalation of 35% CO2. Psychoneuroendocrinology, 31, 736-747. http://dx.doi.org/10.1016/j.psyneuen .2006.02.005
154. Weymar, M., Löw, A., Modess, C., Engel, G., Gründling, M., Petersmann, A., . . . Hamm, A. O. (2010). Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleas-ant pictures: A high density ERP study. NeuroImage, 49, 2800-2806. http://dx.doi.org/10.1016/j.neuroimage.2009.10.025
155. Whembolua, G. L., Granger, D. A., Singer, S., Kivlighan, K. T., & Marguin, J. A. (2006). Bacteria in the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva. Hormones and Behavior, 49, 478-483. http://dx.doi.org/10.1016/j.yhbeh.2005.10.005
156. Wingenfeld, K., Kuffel, A., Uhlmann, C., Terfehr, K., Schreiner, J., Kuehl, L. K., . . . Spitzer, C. (2013). Effects of noradrenergic stimulation on memory in patients with major depressive disorder. Stress: The International Journal of the Biology of Stress, 16, 191-201. http://dx.doi.org/10.3109/10253890.2012.708951
157. Yassa, M. A., & Stark, C. E. L. (2011). Pattern separation in the hippocampus. Trends in Neurosciences, 34, 515-525.
158. Yoshimura, K., Fujita-Yoshigaki, J., Murakami, M., & Segawa, A. (2002). Cyclic AMP has distinct effects from Ca(2_) in evoking priming and fusion/exocytosis in parotid amylase secretion. European Journal of Phycology, 444, 586-596. http://dx.doi.org/10.1007/s00424-002-0844-7
159. Zakowski, J. J., & Bruns, D. E. (1985). Biochemistry of human alpha amylase isoenzymes. Critical Reviews in Clinical Laboratory Sciences, 21, 283-322. http://dx.doi.org/10.3109/10408368509165786