Effect of combined cognitive-behavioural therapy and endurance training on cortisol and salivary alpha-amylase in panic disorder

Journal of Psychiatric Research

Volumn 58, Issue , 2014, Pages 12-19

  Plag, Jens ^a   Gaudlitz, Katharina ^a   Schumacher, Sarah ^a   Dimeo, Fernando ^a   Bobbert, Thomas ^a   Kirschbaum, Clemens ^b   Ströhle, Andreas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Cognitive behavioural therapy (CBT); Cortisol; HPA system; Panic disorder; Physical activity; Salivary alpha amylase

Indexed keywords

ALPHA AMYLASE SALIVA ISOENZYME; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; HYDROCORTISONE; PROMETHAZINE;

ADULT; AEROBIC EXERCISE; AGED; AGORAPHOBIA; ARTICLE; COGNITIVE THERAPY; CONTROLLED STUDY; COPING BEHAVIOR; DEPRESSION; DOUBLE BLIND PROCEDURE; ENDURANCE TRAINING; FEMALE; FOLLOW UP; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; NEUROENDOCRINE SYSTEM; PANIC; PHYSICAL ACTIVITY; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; SALIVA; STRESS; THERAPY EFFECT; TREATMENT DURATION; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ENDURANCE; KINESIOTHERAPY; METABOLISM; MIDDLE AGED; PANIC DISORDER; PHYSIOTHERAPY; PROCEDURES; QUESTIONNAIRE;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER CURVE; COGNITIVE THERAPY; DOUBLE-BLIND METHOD; EXERCISE THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; PANIC DISORDER; PHYSICAL ENDURANCE; PHYSICAL THERAPY MODALITIES; PSYCHOMETRICS; QUESTIONNAIRES; SALIVARY ALPHA-AMYLASES;

EID: 84912534938     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.07.008     Document Type: Article

References (52)

1. Abelson J.L., Liberzon I., Young E.A., Khan S. Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjects. Arch Gen Psychiatry 2005, 62:668-675.
2. Abelson J.L., Kahn S., Liberzon I., Erickson T.M., Young E.A. Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation. Biol Psychiatry 2008, 64:701-707.
3. American College of Sports Medicine Guidelines for exercise testing and prescription 1995, Lea & Feibiger, Philadelphia.
4. Antoni M.H., Cruess S., Cruess D.G., Kumar M., Lutgendorf S., Ironson G., et al. Cognitive-behavioral stress management reduces distress and 24-hour urinary free cortisol output among symptomatic HIV-infected gay men. Ann Behav Med 2000, 22:29-37.
5. Bandelow B., Wedekind D., Pauls J., Broocks A., Hajak G., Rüther E. Salivary cortisol in panic attacks. Am J Psychiatry 2000, 157:454-456.
6. Bobbert T., Brechtel L., Mai K., Otto B., Maser-Gluth C., Pfeiffer A.F., et al. Adaptation of the hypothalamic-pituitary hormones during intensive endurance training. Clin Endocrinol 2005, 63:530-536.
7. Bosch O.G., Seifritz E., Wetter T.C. Stress-related depression: neuroendocrine, genetic, and therapeutical aspects. World J Biol Psychiatry 2012, 13:556-568.
8. Coryell W., Noyes R., Schlechte J. The significance of HPA axis disturbance in panic disorder. Biol Psychiatry 1989, 25:989-1002.
9. Coupland N.J., Wilson S.J., Potokar J.P., Bell C., Nutt D.J. Increased sympathetic response to standing in panic disorder. Psychiatry Res 2003, 118:69-79.
10. Craig C.L., Marshall A.L., Sjostrom M., Bauman A.E., Booth M.L., Ainsworth B.E., et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003, 35:1381-1395.
11. Cruess D.G., Antoni M.H., Kumar M., Ironson G., McCabe P., Fernandez J.B., et al. Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol/DHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive men. Psychoneuroendocrinology 1999, 24:537-549.
12. Cruess D.G., Antoni M.H., McGregor B.A., Kilbourn K.M., Boyers A.E., Alferi S.M., et al. Cognitive-behavioral stress management reduces serum cortisol by enhancing benefit finding among women being treated for early-stage breast cancer. Psychosom Med 2000, 62:304-308.
13. Deuster P.A., Chrousos G.P., Luger A., DeBolt J.E., Bernier L.L., Trostmann U.H., et al. Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities. Metabolism 1989, 38:141-148.
14. Deuster P.A., Petrides J.S., Singh A., Lucci E.B., Chrousos G.P., Gold P.W. High intensity exercise promotes escape of adrenocorticotropin and cortisol from suppression by dexamethasone: sexually dimorphic responses. JClin Endocrinol Metab 1998, 83:3332-3338.
15. Duclos M., Corcuff J.B., Pehourcq F., Tabarin A. Decreased pituitary sensitivity to glucocorticoids in endurance-trained men. Eur J Endocrinol 2001, 144:363-368.
16. Duclos M., Gouarne C., Bonnemaison D. Acute and chronic effects of exercise on tissue sensitivity to glucocorticoids. JAppl Phys 2003, 94:869-875.
17. Erhardt A., Ising M., Unschuld P.G., Kern N., Lucae S., Pütz B., et al. Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology 2006, 31:2515-2522.
18. Eser D., Schüle C., Baghai T., Floesser A., Krebs-Brown A., Enunwa M., et al. Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study. Psychopharmacol Berl 2007, 200(192):479-487.
19. Fournier P.E., Stalder J., Mermillod B., Chantraine A. Effects of a 110 kilometers ultra-marathon race on plasma hormone levels. Int J Sports Med 1997, 18:252-256.
20. Gaab J., Blättler N., Menzi T., Pabst B., Stoyer S., Ehlert U. Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects. Psychoneuroendocrinology 2003, 28:767-779.
21. Gaudlitz K., Plag J., Schumacher S., Bischoff S., Dimeo F., Ströhle A. Aerobic exercise training facilitates the effectiveness of cognitive behavioral therapy in panic disorder. Speech on the Annual Congress of the German Association for Psychiatry, Psychotherapy and Psychosomatics, Berlin, Germany 2013.
22. Gloster A.T., Wittchen H.U., Einsle F., Lang T., Helbig-Lang S., Fydrich T., et al. Psychological treatment for panic disorder with agoraphopbia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT. JConsult Clin Psychol 2011, 79:406-420.
23. Granger D.A., Kivlighan K.T., el-Sheikh M., Gordis E.B., Stroud L.R. Salivary alpha-amylase in biobehavioral research: recent developments and applications. Ann N Y Acad Sci 2007, 1098:122-144.
24. Guy W. ECDEU assessment manual for psychopharmacology -Revised 1976, 218-222. (DHEW Publ No ADM 76-338), Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, NIMH Psychopharmacology Research Branch, Division of Extramural Research Programs, Rockville, MD, U.S.
25. Kathol R.G., Anton R., Noyes R., Gehris T. Direct comparison of urinary free cortisol excretion in patients with depression and panic disorder. Biol Psychiatry 1989, 25:873-878.
26. Kawano A., Tanaka Y., Ishitobi Y., Maruyama Y., Ando T., Inoue A., et al. Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients. Psychiatry Res 2012, 209:85-89.
27. Kirschbaum C., Hellhammer D.H. Salivary cortisol in psychobiological research: an overview. Neuropsychobiology 1989, 22:150-169.
28. Kirschbaum C., Hellhammer D.H. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology 1994, 19:313-333.
29. Kjaer M. Regulation of hormonal and metabolic responses during exercise in humans. Exerc Sport Sci Rev 1992, 20:161-184.
30. Knubben K., Reischies F.M., Adli M., Schlattmann P., Bauer M., Dimeo F. Aransomised, controlled study on the effects of a short-term endurance training programme in patients with major depression. Br J Sports Med 2007, 41:29-33.
31. Kop W.J., Stein P.K., Tracy R.P., Barzilay J.I., Schulz R., Gottdiener J.S. Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med 2010, 72:626-635.
32. Lang T., Helbig-Lang S., Westphal D., Gloster A.T., Wittchen H.U. Expositionsbasierte Therapie der Panikstörung mit Agoraphobie 2012, Hogrefe, Göttingen.
33. Lucía A., Díaz B., Hoyos J., Fernández C., Villa G., Bandrés F., et al. Hormone levels of world class cyclists during the Tour of Spain stage race. Br J Sports Med 2001, 35:424-430.
34. Luger A., Deuster P.A., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training. NEngl J Med 1987, 316:1309-1315.
35. Mäestu J., Jürimäe J., Jürimäe T. Hormonal reactions during heavy training stress and following tapering in highly trained male rowers. Horm Metab Res 2003, 35:109-113.
36. Markgraf J., Schneider S. Panik: Angstanfälle und ihre Behandlung 1990, Springer, Berlin.
37. Nater U.M., Rohleder N. Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology 2009, 34:486-496.
38. Petrowski K., Herold U., Joraschky P., Wittchen H.U., Kirschbaum C. Astriking pattern of cortisol non-responsiveness to psychosocial stress in patients with panic disorder with concurrent normal cortisol awakening responses. Psychoneuroendocrinology 2010, 35:414-421.
39. Petrowski K., Wintermann G.B., Schaarschmidt M., Bornstein S.R., Kirschbaum C. Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int J Psychophysiol 2013, 88:35-39.
40. Plag J., Schumacher S., Schmid U., Ströhle A. Baseline and acute changes in the HPA system in patients with anxiety disorders: the current state of research. Neuropsychiatry (London) 2013, 3:45-62.
41. Pruessner J.C., Kirschbaum C., Meinlschmid G., Hellhammer D.H. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28:916-931.
42. Rohleder N., Nater U.M. Determinants of salivary alpha-amylase in humans and methodological considerations. Psychoneuroendocrinology 2009, 34:469-485.
43. Rohleder N., Nater U.M., Wolf J.M., Ehlert U., Kirschbaum C. Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity?. Ann N Y Acad Sci 2004, 1032:258-263.
44. Schumacher S., Kirschbaum C., Fydrich T., Ströhle A. Is salivary alpha-amylase an indicator of autonomic nervous system dysregulations in mental disorders? - a review of preliminary findings and the interactions with cortisol. Psychoneuroendocrinology 2013, 38:729-743.
45. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. JClin Psychiatry 1998, 59:22-33.
46. Southwick S.M., Bremner J.D., Rasmusson A., Morgan C.A., Arnsten A., Charney D.S. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 1999, 46:1192-1204.
47. Tanaka Y., Ishitobi Y., Maruyama Y., Kawano A., Ando T., Imanaga J., et al. Salivary α-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients. Neurosci Res 2012, 73:80-84.
48. Traustadóttir T., Bosch P.R., Matt K.S. The HPA axis response to stress in women: effects of aging and fitness. Psychoneuroendocrinology 2005, 30:392-402.
49. Uusitalo A.L., Huttunen P., Hanin Y., Uusitalo A.J., Rusko H.K. Hormonal responses to endurance training and overtraining in female athletes. Clin J Sport Med 1998, 8:178-186.
50. van Veen J.F., van Vliet I.M., de Rijk R.H., van Pelt J., Mertens B., Fekkes D., et al. Tryptophan depletion affects the autonomic stress response in generalized social anxiety disorder. Psychoneuroendocrinology 2009, 34:1590-1594.
51. Villanueva A.L., Schlosser C., Hopper B., Liu J.H., Hoffman D.I., Rebar R.W. Increased cortisol production in women runners. JClin Endocrinol Metab 1986, 63:133-136.
52. Wedekind D., Sprute A., Broocks A., Hüther G., Engel K., Falkai P. Nocturnal urinary cortisol excretion over a randomized controlled trial with paroxetine vs. placebo combined with relaxation training or aerobic exercise in panic disorder. Curr Pharm Des 2008, 14:3518-3524.