The four-dimensional stress test: Psychological, sympathetic-adrenal-medullary, parasympathetic and hypothalamic-pituitary-adrenal responses following inhalation of 35% CO2

Psychoneuroendocrinology

Volumn 31, Issue 6, 2006, Pages 736-747

  Wetherell, Mark A ^a,b   Crown, Anna L ^b   Lightman, Stafford L ^b   Miles, Jeremy N V ^c   Kaye, Joey ^d   Vedhara, Kavita ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

35 CO2 stress test; Carbon dioxide inhalation; HPA and SAM axes; Parasympathetic activation; Stress reactivity

Indexed keywords

AMYLASE; CARBON DIOXIDE; HYDROCORTISONE; NORADRENALIN;

ADRENAL MEDULLA; ADRENERGIC SYSTEM; AMYLASE BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; BRADYCARDIA; CARBON DIOXIDE BREATHING; CHOLINERGIC SYSTEM; CLINICAL PROTOCOL; CONTROLLED STUDY; EXERCISE TEST; FEMALE; HEART RATE; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MENTAL STRESS; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PSYCHOLOGIC TEST; PSYCHOPHYSIOLOGY; PSYCHOSOMATICS; REPEAT PROCEDURE; SALIVA ANALYSIS; SALIVA LEVEL; SYMPATHETIC FUNCTION; VITAL CAPACITY;

ADMINISTRATION, INHALATION; ADRENAL MEDULLA; ADULT; ALPHA-AMYLASE; BIOLOGICAL MARKERS; BLOOD PRESSURE; CARBON DIOXIDE; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; HYPERCAPNIA; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; NOREPINEPHRINE; PARASYMPATHETIC NERVOUS SYSTEM; PITUITARY-ADRENAL SYSTEM; REFERENCE VALUES; SALIVA; STATISTICS, NONPARAMETRIC; STRESS; STRESS, PSYCHOLOGICAL;

EID: 33646524294     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2006.02.005     Document Type: Article

References (55)

1. 2 results in activation of the HPA axis in healthy volunteers. Psychoneuroendocrinology 27 (2002) 715-729
2. Bosch J.A., Ring C., de Geus E.J.C., Veerman E.C.I., and Amerongen A.V.N. Stress and secretory immunity. Int. Rev. Neurobiol. 52 (2002) 213-253
3. Bosch J.A., Turkenburg M., Nazmi K., Veerman E.C.I., De Guess E.J.C., and Nieuw Amerongen A.V. Stress as a determinant of saliva-mediated adherence and coadherence of oral and nonoral microorganisms. Psychom. Med. 65 (2003) 604-612
4. Brunner E., Hemingway H., Walker B., Page M., Clarke P., Juneja M., Shipley M., Kumari M., Andrew R., Seckl J., Papadopoulos A., Checkley S., Rumley A., Lowe G., Stansfeld S., and Marmot M. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation 106 (2002) 2659-2665
5. Buske-Kirschbaum A., Geiben A., Hollig H., Morschhauser E., and Hellhammer D. Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis. J. Clin. Endocrinol. Metab. 87 (2002) 4245-4251
6. Chatterton Jr. R.T., Vogelsong K.M., Lu Y.-C., Ellman A.B., and Hudgens G.A. Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin. Physiol. 16 (1996) 433-448
7. Chatterton Jr. R.T., Vogelsong K.M., Lu Y.-C., and Hudgens G.A. Hormonal responses to psychological stress in men preparing for skydiving. J. Clin. Endocrinol. Metab. 82 (1997) 2503-2509
8. Cohen S., Kamarck T., and Mermelstein R. A global measure of perceived stress. J. Health Soc. Behav. 24 (1983) 385-396
9. Dienstbier R.A. Arousal and physiological toughness: implications for mental and physical health. Psychol. Rev. 96 (1989) 84-100
10. Edgar W.M. Saliva and dental health: clinical implications of saliva: report of a consensus meeting. Br. Dent. J. 169 (1990) 96-98
11. Epel E., McEwen B., Seeman T., Matthews K., Castellazzo G., Brownell K., Bell J., and Ickovics J. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychom. Med. 62 (2000) 623-632
12. Epel E., Lapidus R., McEwen B., and Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behaviour. Psychoneuroendocrinology 26 (2001) 37-49
13. Gerin W., and Pickering T.G. Association between delayed recovery of blood pressure after acute mental stress and parental history of hypertension. J. Hypertens. 13 (1995) 603-610
14. Gerra G., Zaimovic A., Mascetti G.G., Gardini S., Zambelli U., Timpano M., Raggi M.A., and Brambilla F. Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 26 (2001) 91-107
15. Gold P.W., Goodwin F., and Chrousos G.P. Clinical and biochemical manifestations of depression: relationship to the neurobiology of stress (Part II). N. Engl. J. Med. 319 (1998) 413-420
16. Gold P.W., and Chrousos G.P. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7 (2002) 254-275
17. Griez E., de Loof C., Pols H., Zandbergen J., and Lousberg H. Specific sensitivity of patients with panic attacks to carbon dioxide inhalation. Psych. Res. 31 (1990) 193-199
18. Hemingway H., Shipley M., Brunner E., Britton A., Malik M., and Marmot M. Does autonomic function link social position to coronary risk? The Whitehall II Study. Circulation 111 (2005) 3071-3077
19. Johnson E.O., Vlachoyiannopoulos P.G., Skopouli F.N., Tzioufas A.G., and Moutsopoulos H.M. Hypofunction of the stress axis in Sjögren's syndrome. J. Rheumatol. 25 (1998) 1508-1514
20. Kaye, J. 2005. Mechanisms and clinical implications of the neuroendocrine response to a novel carbon dioxide stressor in man. PhD Thesis (Unpublished). University of Western Australia.
21. Kaye J., Buchanan F., Kendrick A., Johnson P., Lowry C., Bailey J., Nutt D., and Lightman S. Acute carbon dioxide exposure in healthy adults: evaluation of a novel means of investigating the stress response. J. Neuroendocrinol. 16 (2004) 256-264
22. Kaye J.M., Corrall R.J., and Lightman S.L. A new test for autonomic cardiovascular and neuroendocrine responses in diabetes mellitus: evidence for early vagal dysfunction. Diabetologia 48 (2005) 180-186
23. 2 inhalation in central versus peripheral autonomic failure. Clin. Auton. Res. In press.
24. Kirschbaum C., and Hellhammer D.H. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology 19 (1994) 313-333
25. Kirschbaum C., Pirke K.M., and Hellhammer D. The trier social stress test-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28 (1993) 76-81
26. Kirschbaum C., Prüssner J.C., Federenko I., Gaab J., Lintz D., Schommer N., and Hellhammer D.H. Persistent high cortisol responses to related psychological stress in a subpopulation of healthy men. Psychosom. Med. 57 (1995) 468-474
27. Kugler J., Breitfeld I., Tewes U., and Schedlowski M. Excavation of caries lesions induces transient decrease of total salivary immunoglobulin A concentration. Eur. J. Oral. Sci. 104 (1996) 17-20
28. Kunz-Ebrecht S.R., Mohamed-Ali V., Feldman P., Kirschbaum C., and Steptoe A. Cortisol responses to mild psychological stress are inversely related with proinflammatory cytokines. Brain Behav. Immun. 17 (2003) 373-383
29. La Rovere M., Bigger Jr. J., Marcus F., Mortara A., and Schwartz P. ATRAMI investigators Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351 (1998) 478-484
30. Lange M., Svendsen O.L., Skakkebaek N.E., Muller J., Juul A., Schmiegelow M., and Feldt-Rasmussen U. An audit of the insulin-tolerance test in 255 patients with pituitary disease. Eur. J. Endocrinol. 147 (2002) 41-47
31. Lupien S., Roch Lecours A., Lussier I., Schwartz G., Nair N., and Meaney M. Basal cortisol levels and cognitive deficits in human aging. J. Neurosci. 14 (1994) 2893-2903
32. Lupien S., Roch Lecours A., Schwartz G., Sharma A., Hauger R., Meaney M., and Nair N. Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups. Neurobiol. Aging 17 (1996) 95-105
33. Lupien S., de Leon M., de Santi S., Convit A., Tarshish C., Nair N., Thakur M., McEwen B., Hauger R., and Meaney M. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. 1 (1998) 69-73
34. Masi A.T., and Chrousos G.P. Hypothalamic-pituitary-adrenal-glucocorticoid axis function in rheumatoid arthritis. J. Rheumatol. 23 (1996) 577-581
35. McEwen B. Protective and damaging effects of stress mediators. N. Engl. J. Med. 338 (1998) 171-179
36. Nater U.M., Rohleder N., Gaab J., Berger S., Jud A., Kirschbaum C., and Ehlert U. Human salivary alpha-amylase reactivity in a psychosocial stress paradigm. Int. J. Psychophysiol. 55 (2005) 333-342
37. Papp L.A., Martinez J.M., Klein D.F., Coplan J.D., Norman R.G., Cole R., de Jesus M.J., Ross D., Goetz R., and Gorman J.M. Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects. Am. J. Psychiatry. 154 (1997) 1557-1565
38. 2 challenge in panic and mood disorders. J. Affect. Disord. 33 (1995) 189-194
39. Pfeifer M., Kanc K., Verhovec R., and Kocojancic A. Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men. Clin. Endocrinol. 54 (2001) 17-22
40. Porges S.W. The polyvagal theory: phylogenetic substrates of a social nervous system. Int. J. Psychophysiol. 42 (2001) 123-146
41. Ramsay D., and Lewis M. Reactivity and regulation in cortisol and behavioural responses to stress. Child Dev. 74 (2003) 456-464
42. Rohleder N., Nater U.M., Wolf J.M., Ehlert U., and Kirschbaum C. Psychosocial stress-induced activation of salivary alpha amylase. Ann. NY Acad. Sci. 1032 (2004) 258-263
43. Rosmond R., Dallman M., and Björntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and haemodynamic abnormalities. J. Clin. Endocrinol. Metab. 83 (1998) 1853-1859
44. Sapolsky R.M. Why stress is bad for your brain. Science 273 (1996) 749-750
45. Sawada Y., Nagano Y., and Tanaka G. Mirror tracing and the provocation of vascular-dominant reaction pattern through heightened attention. J. Psychophysiol. 16 (2002) 201-210
46. Seeman T., McEwen B., Singer B., Albert M., and Rowe J. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J. Clin. Endocrinol. Metab. 82 (1997) 2458-2465
47. Singh A., Petrides J.S., Gold P.W., Chrousos G.P., and Deuster P.A. Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress. J. Clin. Endocrinol. Metab. 84 (1999) 1944-1948
48. Smyth J., Ockenfels M.C., Porter L., Kirschbaum C., Hellhammer D.H., and Stone A.A. Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology 23 (1998) 353-370
49. Takai N., Yamaguchi M., Aragaki T., Eto K., Uchihashi K., and Nishikawa Y. Effects of psychological stress on the salivary cortisol and amylase levels in healthy adults. Arch. Oral Biol. 49 (2004) 963-968
50. Tsuji H., Larson M., Venditti Jr. F., Manders E., Evans J., Feldman C., and Levy D. Impact of reduced heart rate variability on risk for cardiac events. Circulation 94 (1996) 2850-2855
51. 2 challenge in healthy first-degree relatives of patients with panic disorder. Biol. Psychiatry 47 (2000) 830-835
52. 2 challenge results in HPA activation in healthy volunteers. J. Psychopharmacol. 19 (2005) 243-247
53. Verberg K., Griez E., and Meijer J. Discrimination between panic disorder and generalised anxiety disorder by 35% carbon dioxide challenge. Am. J. Psychiatry 152 (1995) 1081-1083
54. Widmer I.E., Puder J.J., König C., Pargger H., Zerkowski H.R., Girad J., and Müller B. Cortisol responses in relation to the severity of stress and illness. J. Clin. Endocrinol. Metab. 90 8 (2005) 4579-4586
55. Wong M.L., Kling M.A., Munson P.J., Listwak S., Licinio J., Prolo P., Karp B., McCutcheon I.E., Geracioti Jr. T.D., DeBellis M.D., Rice K.C., Goldstein D.S., Veldhuis J.D., Chrousos G.P., Oldfield E.H., McCann S.M., and Gold P.W. Pronounced and sustained hypernoradrenergic function in major depression with melancholic features: relation to hypercorticolism and corticotropin-releasing hormone. Proc. Natl Acad. Sci. USA 97 (2000) 325-330