Increased testosterone levels and cortisol awakening responses in patients with borderline personality disorder: Gender and trait aggressiveness matter

Psychoneuroendocrinology

Volumn 55, Issue , 2015, Pages 116-127

  Rausch, Juliane ^a   Gäbel, Andrea ^a   Nagy, Krisztina ^a   Kleindienst, Nikolaus ^a   Herpertz, Sabine C ^a   Bertsch, Katja ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Androgen metabolism; Endocrinology; Hypothalamus pituitary adrenal axis; Hypothalamus pituitary gonadal axis; Reproductive system; Stress

Indexed keywords

HYDROCORTISONE; ORAL CONTRACEPTIVE AGENT; TESTOSTERONE;

ADULT; AGGRESSIVENESS; ANGER; AREA UNDER THE CURVE; AROUSAL; ARTICLE; BODY MASS; BORDERLINE STATE; COMORBIDITY; CONTROLLED STUDY; CORTISOL AWAKENING RESPONSE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INTELLIGENCE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENSTRUAL CYCLE; MENTAL FUNCTION; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOMETRY; SALIVA LEVEL; SEX DIFFERENCE; SYMPTOMATOLOGY; ADOLESCENT; AGGRESSION; CASE CONTROL STUDY; CHEMISTRY; CIRCADIAN RHYTHM; DEPRESSION; GONAD; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MIDDLE AGED; PERSONALITY; PHYSIOLOGY; PSYCHOLOGY; SALIVA; YOUNG ADULT;

ADOLESCENT; ADULT; AGGRESSION; ANGER; BORDERLINE PERSONALITY DISORDER; CASE-CONTROL STUDIES; CIRCADIAN RHYTHM; DEPRESSIVE DISORDER; FEMALE; GONADS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PERSONALITY; PITUITARY-ADRENAL SYSTEM; SALIVA; SEX FACTORS; STRESS DISORDERS, POST-TRAUMATIC; TESTOSTERONE; YOUNG ADULT;

EID: 84925821207     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.02.002     Document Type: Article

References (73)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Publishing (APP), Arlington, VA. 5th ed.
2. Arai Y., Sekine Y., Murakami S. Estrogen and apoptosis in the developing sexually dimorphic preoptic area in female rats. Neurosci. Res. 1996, 25:403-407.
3. Archer J., Graham-Kevan N., Davies M. Testosterone and aggression: a reanalysis of Book, Starzyk, and Quinsey's (2001) study. Aggress. Violent Behav. 2005, 10:241-261.
4. Beck A.T., Steer R.A. Beck-Depressions-Inventar: BDI, 2., überarb. Aufl. 1995, Huber/Bern, Göttingen.
5. Bernstein D.P., Fink L. Childhood Traume Questionnaire. A Retrospective Self-report: Maunal 1998, The Psychological Corporation, Orlando.
6. Bertsch K., Gamer M., Schmidt B., Schmidinger I., Walther S., Kastel T., Schnell K., Buchel C., Domes G., Herpertz S.C. Oxytocin and reduction of social threat hypersensitivity in women with borderline personality disorder. Am. J. Psych. 2013, 170:1169-1177.
7. Bertsch K., Schmidinger I., Neumann I., Herpertz S.C. Reduced plasma oxytocin levels in female patients with borderline personality disorder. Horm. Behav. 2013, 63:424-429.
8. Böhnke R., Bertsch K., Kruk M., Naumann E. The relationship between basal and acute HPA axis activity and aggressive behavior in adults. J. Neural Transm. 2010, 117:629-637.
9. Böhnke R., Bertsch K., Kruk M.R., Richter S., Naumann E. Exogenous cortisol enhances aggressive behavior in females, but not in males. Psychoneuroendocrinology 2010, 35:1034-1044.
10. Bohus M., Kleindienst N., Limberger M.F., Stieglitz R.D., Domsalla M., Chapman A.L., Steil R., Philipsen A., Wolf M. The short version of the Borderline Symptom List (BSL-23): development and initial data on psychometric properties. Psychopathology 2009, 42:32-39.
11. Buss A.H., Perry M. The aggression questionnaire. J. Pers. Soc. Psychol. 1992, 63:452-459.
12. Carre J.M., McCormick C.M. Aggressive behavior and change in salivary testosterone concentrations predict willingness to engage in a competitive task. Horm. Behav. 2008, 54(3):403-409.
13. Carre J.M., Mehta P.H. Importance of considering testosterone-cortisol interactions in predicting human aggression and dominance. Aggress. Behav. 2011, 37:489-491.
14. Carvalho Fernando S., Beblo T., Schlosser N., Terfehr K., Otte C., Lowe B., Wolf O.T., Spitzer C., Driessen M., Wingenfeld K. Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology 2012, 37:1659-1668.
15. Chichinadze K., Lazarashvili A., Chichinadze N., Gachechiladze L. Testosterone dynamics during encounter: role of emotional factors. J. Comp. Physiol. A: Neuroethol. Sens. Neural Behav. Physiol. 2012, 198:485-494.
16. Clow A., Thorn L., Evans P., Hucklebridge F. The awakening cortisol response: methodological issues and significance. Stress 2004, 7:29-37.
17. Coccaro E.F., Beresford B., Minar P., Kaskow J., Geracioti T. CSF testosterone: relationship to aggression, impulsivity, and venutresomeness in adult males with personality disorder. J. Psychiatr. Res. 2007, 41:488-492.
18. Dabbs J.M., Jurkovic G.J., Frady R.L. Salivary testosterone and cortisol among late adolescent male offenders. J. Abnorm. Child Psychol. 1991, 19:469-478.
19. Domes G., Czieschnek D., Weidler F., Berger C., Fast K., Herpertz S.C. Recognition of facial affect in Borderline Personality Disorder. J. Pers. Disord. 2008, 22:135-147.
20. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV (SCID-I) 1995, Biometrics Research Department, New York State Psychiatric Institute, New York.
21. Franks S., Gilling-Smith C., Gharani N., McCarthy M. Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production. Hum. Fertil. (Camb.) 2000, 3:77-79.
22. Garner B., Chanen A.M., Phillips L., Velakoulis D., Wood S.J., Jackson H.J., Pantelis C., McGorry P.D. Pituitary volume in teenagers with first-presentation borderline personality disorder. Psychiatry Res. 2007, 156:257-261.
23. Gerra G., Zaimovic A., Raggi M.A., Moi G., Branchi B., Moroni M., et al. Experimentally induced aggressiveness in heroin-dependent patients treated with buprenophine: comparison of patients receiving metahdone and healthy subjects. Psychiatry Res. 2007, 149:201-213.
24. Haller J. The neurobiology of abnormal manifestations of aggression - a review of hypothalamic mechanisms in cats, rodents, and humans. Brain Res. Bull. 2013, 93:97-109.
25. Haller J. The gucocorticoid/aggression relationship in animals and humans: an analysis sensitive to behavioral characteristics, glucocorticoid secretion patterns, and neural mechanisms. Curr. Top. Behav. Neurosci. 2014, 17:73-109.
26. Hazlett E.A., New A.S., Newmark R., Haznedar M.M., Lo J.N., Speiser L.J., Chen A.D., Mitropoulou V., Minzenberg M., Siever L.J., Buchsbaum M.S. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol. Psychiatry 2005, 58:614-623.
27. Hazlett E.A., Zhang J., New A.S., Zelmanova Y., Goldstein K.E., Haznedar M.M., Meyerson D., Goodman M., Siever L.J., Chu K.-W. Potentiated amygdala response to repeated emotional pictures in borderline personality disorder. Biol. Psychiatry 2012, 72:448-456.
28. Heim C., Young L.J., Newport D.J., Mletzko T., Miller A.H., Nemeroff C.B. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol. Psychiatry 2009, 14:954-958.
29. Hellhammer J., Fries E., Schweisthal O.W., Schlotz W., Stone A.A., Hagemann D. Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components. Psychoneuroendocrinology 2007, 32:80-86.
30. Herman J.L., Perry J.C., van der Kolk B.A. Childhood trauma in borderline personality disorder. Am. J. Psych. 1989, 146:490-495.
31. Herpertz S.C., Dietrich T.M., Wenning B., Krings T., Erberich S.G., Willmes K., Thron A., Sass H. Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biol. Psychiatry 2001, 50:292-298.
32. Huynh H., Feldt L.S. Estimation of the box correction for degrees of freedom from sample data in randomized block and split-plot designs. J. Educ. Stat. 1976, 1:69-82.
33. Jovev M., Jackson H.J. The relationship of borderline personality disorder, life events and functioning in an Australian psychiatric sample. J. Pers. Disord. 2006, 20:205-217.
34. Kahl K.G., Bester M., Greggersen W., Rudolf S., Dibbelt L., Stoeckelhuber B.M., Gehl H.B., Sipos V., Hohagen F., Schweiger U. Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. Psychosom. Med. 2005, 67:407-412.
35. Kawata M. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci. Res. 1995, 24:1-46.
36. Kleindienst N., Bohus M., Ludascher P., Limberger M.F., Kuenkele K., Ebner-Priemer U.W., Chapman A.L., Reicherzer M., Stieglitz R.D., Schmahl C. Motives for nonsuicidal self-injury among women with borderline personality disorder. J. Nerv. Ment. Dis. 2008, 196:230-236.
37. Kudielka B.M., Gierens A., Hellhammer D.H., Wüst S., Schlotz W. Salivary cortisol in ambulatory assessment-some dos, some don'ts, and some open questions. Psychosom. Med. 2012, 74:418-431.
38. Kuhlmann A., Bertsch K., Schmidinger I., Thomann P.A., Herpertz S.C. Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder. J. Psychiatry Neurosci. 2013, 38:129-137.
39. Kuo J.R., Linehan M.M. Disentangling emotion processes in borderline personality disorder: physiological and self-reported assessment of biological vulnerability, baseline intensity, and reactivity to emotionally evocative stimuli. J. Abnorm. Psychol. 2009, 118:531-544.
40. Lieb K., Rexhausen J.E., Kahl K.G., Schweiger U., Philipsen A., Hellhammer D.H., Bohus M. Increased diurnal salivary cortisol in women with borderline personality disorder. J. Psychiatr. Res. 2004, 38:559-565.
41. Loranger A.W., Sartorius N., Andreoli A., Berger P., Buchheim P., Channabasavanna S.M., Coid B., Dahl A., Diekstra R.F., Ferguson B., et al. The International Personality Disorder Examination. The World Health Organization/Alcohol, Drug Abuse, and Mental Health Administration international pilot study of personality disorders. Arch. Gen. Psychiatry 1994, 51:215-224.
42. MacLusky N.J., Clark A.S., Naftolin F., Goldman-Rakic P.S. Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex. Steroids 1987, 50:459-474.
43. Mancke F., Herpertz S.C., Bertsch K. Aggression in borderline personality disorder - a multidimensional model. Pers. Disord.: Theory Res. Treat. 2015, (in press). 10.1037/per0000098.
44. Matsuzaka H., Maeshima H., Kida S., Kurita H., Shimano T., Nakano Y., Baba H., Suzuki T., Arai H. Gender differences in serum testosterone and cortisol in patients with major depressive disorder compared with controls. Int. J. Psychiatry Med. 2013, 46:203-321.
45. Mazur A., Booth A. Testosterone and dominance in men. Behav. Brain Sci. 1998, 21:353-363. discussion 363-397.
46. Mehta P.H., Jones A.C., Josephs R.A. The social endocrinology of dominance: basal testosterone predicts cortisol changes and behavior following victory and defeat. J. Pers. Soc. Psychol. 2008, 94(6):1078-1093.
47. Mehta P.H., Josephs R.A. Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis. Horm. Behav. 2010, 58:898-906.
48. Minzenberg M.J., Fan J., New A.S., Tang C.Y., Siever L.J. Frontolimbic structural changes in borderline personality disorder. J. Psychiatr. Res. 2008, 42:727-733.
49. Morris M.C., Compas B.E., Garber J. Relations among posttraumatic stress disorder, comorbid depression, and HPA function: a systematic review and meta-analysis. Clin. Psychol. Rev. 2012, 32:301-315.
50. New A.S., aan het Rot M., Ripoll L.H., Perez-Rodriguez M.M., Lazarus S., Zipursky E., Weinstein S.R., Koenigsberg H.W., Hazlett E.A., Goodman M., Siever L.J. Empathy and alexithymia in borderline personality disorder: clinical and laboratory measures. J. Pers. Disord. 2012, 26:660-675.
51. Nunes P.M., Wenzel A., Borges K.T., Porto C.R., Caminha R.M., de Oliveira I.R. Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis. J. Pers. Disord. 2009, 23:333-345.
52. Ogata S.N., Silk K.R., Goodrich S., Lohr N.E., Westen D., Hill E.M. Childhood sexual and physical abuse in adult patients with borderline personality disorder. Am. J. Psych. 1990, 147:1008-1013.
53. Popma A., Vermeiren R., Geluk C.A., Rinne T., van den Brink W., Knol D.L., Jansen L.M., van Engeland H., Doreleijers T.A. Cortisol moderates the relationship between testosterone and aggression in delinquent male adolescents. Biol. Psychiatry 2007, 61:405-411.
54. Pruessner J.C., Kirschbaum C., Meinlschmid G., Hellhammer D.H. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28:916-931.
55. Raven J.C., Horn R. Standard progressive matrices: SPM (SPM-C/SPM-P/SPM Plus)Raven's progressive matrices und vocabulary scales [2. Aufl.] 2009, Pearson, Frankfurt, p. Test.
56. Roepke S., Ziegenhorn A., Kronsbein J., Merkl A., Bahri S., Lange J., Lubbert H., Schweiger U., Heuser I., Lammers C.H. Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder. J. Psychiatr. Res. 2010, 44:847-852.
57. Russo M., Proujansky R., Gilbert A., Braga R.J., Burdick K.E. Initial evidence for sex-specific effects of early emotional abuse on affective processing in bipolar disorder. Eur. Psychiatry 2014, 29:52-57.
58. Ruttle P.L., Klein M.H., Slattery M.J., Kalin N.H., Armstrong J.M., Essex M.J. Adolescent adrenocortical activity and adiposity: differences by sex and exposure to early maternal depression. Psychoneuroendocrinology 2014, 47:68-77.
59. Schmahl C., Herpertz S.C., Bertsch K., Ende G., Flor H., Kirsch P., Meyer-Lindenberg A., Rietschel M., Schneider M., Spanagel R., Treede R.-D., Bohus M. Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit. Borderline Pers. Disord. Emot. Dysregul. 2014, 1(12). 10.1186/2051-6673-1-12.
60. Schmidt-Reinwald A., Pruessner J.C., Hellhammer D.H., Federenko I., Rohleder N., Schurmeyer T.H., Kirschbaum C. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci. 1999, 64:1653-1660.
61. Schultheiss O.C., Stanton S.J. Assessment of salivary hormones. Methods in the Neurobiology of Social and Personality Psychology 2009, 17-44. Guilford, New York, NY. E. Harmon-Jones, J.S. Beer (Eds.).
62. Schulze L., Domes G., Krüger A., Berger C., Fleischer M., Prehn K., Schmahl C., Grossmann A., Hauenstein K., Herpertz S.C. Neuronal correlates of cognitive reappraisal in borderline patients with affective instability. Biol. Psychiatry 2011, 69:564-573.
63. Schwenkmezger P., Hodapp V., Spielberger C.D. Das State-Trait-Ärgerausdrucks-Inventar STAXI: Handbuch, 1. Aufl. 1992, Huber/Bern, Göttingen/Toronto.
64. Sjörs A., Ljung T., Jonsdottir I.H. Diurnal salivary cortisol in relation to perceived stress at home and at work in healthy men and women. Biol. Psychol. 2014, 99:193-197.
65. Toufexis D., Rivarola M.A., Lara H., Viau V. Stress and the reproductive axis. J. Neuroendocrinol. 2014, 26:573-586.
66. van Goozen S.H.M., Fairchild G., Snoek H., Harold G.T. The evidence for a neurobiological model of childhood antisocial behavior. Psychol. Bull. 2007, 133:149-182.
67. Van Honk J., Harmon-Jones E., Morgan B.E., Schutter D.J. Socially explosive minds: the triple imbalance hypothesis of reactive aggression. J. Pers. 2010, 78:67-94.
68. Volman I., Toni I., Verhagen L., Roelofs K. Endogenous testosterone modulates prefrontal-amygdala connectivity during social emotional behavior. Cereb. Cortex 2011, 21:2282-2290.
69. Wingenfeld K., Hill A., Adam B., Driessen M. Dexamethasone suppression test in borderline personality disorder: impact of PTSD symptoms. Psychiatry Clin. Neurosci. 2007, 61:681-683.
70. Wingenfeld K., Spitzer C., Rullkotter N., Lowe B. Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies. Psychoneuroendocrinology 2010, 35:154-170.
71. Wust S., Wolf J., Hellhammer D.H., Federenko I., Schommer N., Kirschbaum C. The cortisol awakening response - normal values and confounds. Noise Health 2000, 2:79-88.
72. Young E.A., Haskett R.F., Murphy-Weinberg V., Watson S.J., Akil H. Loss of glucocorticoid fast feedback in depression. Arch. Gen. Psychiatry 1991, 48:693-699.
73. Zimmerman D.J., Choi-Kain L.W. The hypothalamic-pituitary-adrenal axis in borderline personality disorder: a review. Harv. Rev. Psychiatry 2009, 17(3):167-183.