Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC/MS Q-TOF

Journal of Ethnopharmacology

Volumn 166, Issue , 2015, Pages 109-118

  Rofiee, M S ^a   Yusof, M I M ^a   Abdul Hisam, E E ^a   Bannur, Z ^a   Zakaria, Z A ^a,b   Somchit, M N ^a,b   Teh, L K ^a   Salleh, M Z ^a  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

CCl4; Hepatoprotective; LC MS Q TOF; Metabolomics; Muntingia calabura

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARACHIDONIC ACID; ASPARTATE AMINOTRANSFERASE; BILE ACID; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; DRUG METABOLITE; FLAVONOID; LIVER PROTECTIVE AGENT; METHANOL; MUNTINGIA CALABURA EXTRACT; PHARMACOLOGY; PLANT EXTRACT; PROTECTIVE AGENT; SILYMARIN; STEROID; TANNIN DERIVATIVE; TRITERPENE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BILE ACID SYNTHESIS; BIOSYNTHESIS; BODY WEIGHT; CARBON TETRACHLORIDE INDUCED LIVER INJURY; CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECTS; DRUG MECHANISM; DRUG SCREENING; DRUG THERAPY; DRUG-INDUCED LIVER INJURY; ELAEOCARPACEAE; EXPERIMENTAL LIVER INJURY; FLUID INTAKE; FOOD INTAKE; HISTOPATHOLOGY; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER PROTECTION; LIVER TOXICITY; MALE; MALVACEAE; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; METABOLOMICS PATHWAY ANALYSIS; NONHUMAN; PLANT LEAF; PROCEDURES; PURINE METABOLISM; QUADRUPOLE MASS SPECTROMETRY; RAT; RAT MODEL; SOLVENT EXTRACTION; SPRAGUE DAWLEY RAT; STEATOSIS; TIME OF FLIGHT MASS SPECTROMETRY; TOXICITY TESTING;

ANIMALS; BIOMARKERS; BODY WEIGHT; CARBON TETRACHLORIDE; CHEMISTRY; CHROMATOGRAPHY, LIQUID; DRUG EFFECTS; DRUG THERAPY; DRUG-INDUCED LIVER INJURY; ELAEOCARPACEAE; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; METABOLISM; METABOLOMICS; METHODS; PHARMACOLOGY; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; TILIACEAE;

MUNTINGIA CALABURA; RATTUS;

EID: 84964273438     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.03.016     Document Type: Article

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