Effect of aqueous extract of bitter leaf (Vernonia Amygdalina Del) on carbon tetrachloride (CCl4) induced liver damage in albino wistar rats

European Journal of Scientific Research

Volumn 26, Issue 1, 2009, Pages 122-130

  Arhoghro, E M ^a   Ekpo, K E ^b   Anosike, E O ^a   Ibeh, G O ^a  

^a UNIVERSITY OF PORT HARCOURT   (Nigeria)

^b NIGER DELTA UNIVERSITY   (Nigeria)

Author keywords

Aqueous extract; Carbon tetrachloride; Vernonia amygdalina

Indexed keywords

EID: 65449178894     PISSN: 1450216X     EISSN: 1450202X     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Abosi AO, Raseroka BH (2003). Invivo antimalarial activity of Vernonia amygdalina. Br. J. Biomedical Sci. 60(2): 89-91.
2. Akah PA, Okafor CI (1992). Blood sugar lowering effect of Vernonia amygdalina (del) in an experimental rabbit model. Phytotherapy Research 6: 171-173.
3. Babalola OO, Anetor JI, Adeniyi FA (2001). Amelioration of carbon tetrachloride induced hepatotoxicity of terpenoid extract from leaves of Vernonia amygdalina. Afr. J. Med. Sci. 30(1-2): 91-93.
4. Bonsi MLK, Osuji PO, Tuah AK, Umunna MN (1995). Vernonia amygdalina as a supplement of teff straw (Eragrostis tef) fed to Ethiopian Menz. Sheep. Agroforestry systems 31(3): 229-244.
5. Butler GW, Bailey RW (1973). Chemistry and Biochemistry of herbage. Vol. 1, Accident Press, London and New York.
6. Huffman MA, Seifu M. (1989). Observations on the illness and composition of a possibly medicinal plant Vernonia amygdalina (Del.) by a wild chimpanzee in the Mohale Mountains National Park, Tanzania. Primates 30(1): 51-63.
7. Iwalokun BA, Efedede BU, Alabi-Sofunde JA, Oduala T, Magbagveola OA, Akinwande AI (2006). Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice. J. Med. Food. 9(4): 524-530.
8. Izevbige EB, Bryant TL, Walker A. (2004). A novel natural hibitor of extracellular signal-regulated kinases and human breast cancer cell growth. Experimental Biol. Med. (May Wood) 229(2): 163-169.
9. Leonard BS, Karen LL, Bruce B, Thomas FK, Jay HH (2002). Complementary and alternative medicine in chronic liver disease. Hepatology 34(3): 595-603.
10. 4-induced hepatotoxicity in the rat by H. rosasinensis anthocyanin extracts administered in ethanol. Toxicol. 131: 93-98.
11. Ojiako OA, Nwanjo HU (2006). Is Vernonia amygdalina hepatotoxic or hepatoprotective? Response from biochemical and toxicity studies in rats. Afr. J. Biotechnol. 5(18): 1648-1651.
12. Philipson JD, Wright CW, Kirby CC, Warhust DC (1993). Phytochemistry of some plants used in traditional medicine for the treatment of protozoal diseases. Abstracts, international symposium of the phytochemical society of Europe, Univ. of Lausanne, Switzerland. P.13.
13. Ramanathan R, Luu KK, Das NP (1989). Anti peroxidative action of flavonoids and related products in ground pork (Abstracts). Proceeding of III Int. Symp. on flavonoids in biology and medicine. Singapore. Pp. 56.
14. Rec. Gscc (1972). Optimised standard colorimetric methods. Journal of clinical chemistry and clinical biochemistry 10:182.
15. Reink LA, Lai EK, McCay PB (1988). Ethanol feeding stimulates trichloromethyl radical formation from carbon tetrachloride in liver. Xenobiotica 18:1311-1318.
16. Reitman S, Frankel AS (1957). A colorimetric method of determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28: 53-63.
17. Robak K, Gryglewski RJ (1988). Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 37: 837-841.
18. Uhegbu FO, Ogbuehi KJ (2004). Effect of aqueous extract (crude) of leaves of Vernonia amygdalina (Del) on blood glucose, serum albumin and cholesterol levels in diabetic albino rats. Global J. of Pure and Applied Sciences 10(1): 189-194.
19. 4-induced liver damage in rats. Physiol. Res. 52: 461-466.
20. 4-induced liver fibrosis in rats. World J. of Gastroenterology 10: 1037-1042.