Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes

Chemico-Biological Interactions

Volumn 125, Issue 3, 2000, Pages 233-243

  Zangar, Richard C ^a   Benson, Janet M ^b   Burnett, Vicki L ^a   Springer, David L ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Carbon tetrachloride; CYP2E1; Human; Liver; Trichloromethyl radical

Indexed keywords

ALPHA NAPHTHOFLAVONE; CARBON TETRACHLORIDE; CLOTRIMAZOLE; CYTOCHROME P450 2B6; CYTOCHROME P450 3A; DIMETHYLNITROSAMINE DEMETHYLASE; ENZYME ANTIBODY; ISOENZYME; SULFAPHENAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME METABOLISM; NORMAL HUMAN;

ACETONITRILES; ANIMALS; ANTIBODIES; ARYL HYDROCARBON HYDROXYLASES; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RODENTIA;

EID: 0034654333     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00149-6     Document Type: Article

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