MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4

Expert Opinion on Therapeutic Targets

Volumn 18, Issue 12, 2014, Pages 1355-1365

  Huang, Ying ^a   Qi, Yuan ^a   Du, Jian Qing ^a   Zhang, Dai Fu ^a  

^a Department of Pathology Pudong New Area People s Hospital   (China)

Author keywords

Cardiac fibrosis; Fibroblasts; MicroRNA 34a; Smad4; TGF 1

Indexed keywords

BIOLOGICAL MARKER; MICRORNA 34A; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EXPERIMENTAL MYOCARDIAL INFARCTION; FIBROBLAST CULTURE; FIBROGENESIS; GENE CLUSTER; GENE FUNCTION; GENE INACTIVATION; GENE OVEREXPRESSION; HEART INFARCTION; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN RNA BINDING; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84964247793     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.961424     Document Type: Article

References (44)

1. Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002;14(5):608-16
2. Zamilpa R, Lindsey ML. Extracellular matrix turnover and signaling during cardiac remodeling following MI: causes and consequences. J Mol Cell Cardiol 2010;48(3):558-63
3. Fihn SD, Vaughan-Sarrazin M, Lowy E, et al. Declining mortality following acute myocardial infarction in the Department of Veterans Affairs Health Care System. BMC Cardiovasc Disord 2009;9:44
4. Dai Y, Khaidakov M, Wang X, et al. MicroRNAs involved in the regulation of postischemic cardiac fibrosis. Hypertension 2013;61(4):751-6
5. Latronico MV, Condorelli G. MicroRNAs and cardiac pathology. Nat Rev Cardiol 2009;6(6):419-29
6. Patrick DM, Montgomery RL, Qi X, et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest 2010;120(11):3912-16
7. Lagendijk AK, Goumans MJ, Burkhard SB, et al. MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ Res 2011;109(6):649-57
8. Wang J, Huang W, Xu R, et al. MicroRNA-24 regulates cardiac fibrosis after myocardial infarction. J Cell Mol Med 2012;16(9):2150-60
9. van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008;105(35):13027-32
10. Zhou L, Wang L, Lu L, et al. Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS One 2012;7(3):e33766
11. Pan Z, Sun X, Shan H, et al. MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-beta1 pathway. Circulation 2012;126(7):840-50
12. Katare R, Riu F, Mitchell K, et al. Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res 2011;109(8):894-906
13. Winbanks CE, Wang B, Beyer C, et al. TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. J Biol Chem 2011;286(16):13805-14
14. He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007;447(7148):1130-4
15. Chang TC, Wentzel EA, Kent OA, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007;26(5):745-52
16. Du R, Sun W, Xia L, et al. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 2012;7(2):e30771
17. Xu Y, Liu L, Liu J, et al. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer 2010;128(2):412-17
18. Li WQ, Chen C, Xu MD, et al. The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamineinduced hepatic fibrosis in rats. FEBS J 2011;278(9):1522-32
19. Meng F, Glaser SS, Francis H, et al. Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol 2012;181(3):804-17
20. Boon RA, Iekushi K, Lechner S, et al. MicroRNA-34a regulates cardiac ageing and function. Nature 2013;495(7439):107-10
21. Bernardo BC, Gao XM, Winbanks CE, et al. Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci USA 2012;109(43):17615-20
22. Bernardo BC, Gao XM, Tham YK, et al. Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy. PLoS One 2014;9(2):e90337
23. Dixon IM, Lee SL, Dhalla NS. Nitrendipine binding in congestive heart failure due to myocardial infarction. Circ Res 1990;66(3):782-8
24. Ju H, Zhao S, Tappia PS, et al. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Circulation 1998;97(9):892-9
25. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438(7068):685-9
26. Kurrelmeyer KM, Michael LH, Baumgarten G, et al. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci USA 2000;97(10):5456-61
27. Alhaddad IA, Tkaczevski L, Siddiqui F, et al. Aspirin enhances the benefits of late reperfusion on infarct shape. A possible mechanism of the beneficial effects of aspirin on survival after acute myocardial infarction. Circulation 1995;91(11):2819-23
28. Liang H, Zhang C, Ban T, et al. A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis. Int J Biochem Cell Biol 2012;44(12):2152-60
29. Wang Y, Ren J, Gao Y, et al. MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. PLoS One 2013;8(7):e68744
30. Porter KE, Turner NA. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 2009;123(2):255-78
31. Hao J, Ju H, Zhao S, et al. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol 1999;31(3):667-78
32. Honeyman L, Bazett M, Tomko TG, et al. MicroRNA profiling implicates the insulin-like growth factor pathway in bleomycin-induced pulmonary fibrosis in mice. Fibrogenesis Tissue Repair 2013;6(1):16
33. Xie T, Liang J, Guo R, et al. Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics 2011;43(9):479-87
34. Liu G, Friggeri A, Yang Y, et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010;207(8):1589-97
35. Eghbali M. Cellular origin and distribution of transforming growth factor-beta in the normal rat myocardium. Cell Tissue Res 1989;256(3):553-8
36. Flanders KC, Winokur TS, Holder MG, et al. Hyperthermia induces expression of transforming growth factor-beta s in rat cardiac cells in vitro and in vivo. J Clin Invest 1993;92(1):404-10
37. Lee AA, Dillmann WH, McCulloch AD, et al. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 1995;27(10):2347-57
38. Takahashi N, Calderone A, Izzo NJ Jr, et al. Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes. J Clin Invest 1994;94(4):1470-6
39. Engelmann GL, Grutkoski PS. Coordinate TGF-beta receptor gene expression during rat heart development. Cell Mol Biol Res 1994;40(2):93-104
40. He Y, Huang C, Sun X, et al. MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal 2012;24(10):1923-30
41. Liu X, Hu H, Yin JQ. Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis. Liver Int 2006;26(1):8-22
42. Qin BY, Lam SS, Correia JJ, et al. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev 2002;16(15):1950-63
43. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 2011;51(4):600-6
44. Wang J, Xu N, Feng X, et al. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res 2005;97(8):821-8