MicroRNA-224 Targets SMAD Family Member 4 to Promote Cell Proliferation and Negatively Influence Patient Survival

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wang, Yu ^a,e   Ren, Jianwei ^a,f   Gao, Yun ^a   Ma, Joel Z I ^b   Toh, Han Chong ^a   Chow, Pierce ^c,d   Chung, Alexander Y F ^d   Ooi, London L P J ^a,d   Lee, Caroline G L ^a,b,c  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

^e GENOME INSTITUTE OF SINGAPORE   (Singapore)

^f Chinese University of Hong Kong   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 224; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL PROLIFERATION; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TARGETING; TUMOR GROWTH; UPREGULATION;

EID: 84880826932     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068744     Document Type: Article

References (27)

1. Wang Y, Lee CG, (2009) MicroRNA and cancer- focus on apoptosis. J Cell Mol Med 13: 12-23.
2. Selcuklu SD, Donoghue MT, Spillane C, (2009) miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans 37: 918-925.
3. Wang Y, Lu Y, Toh ST, Sung WK, Tan P, et al. (2010) Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol 53: 57-66.
4. Wang Y, Lee CG, (2011) Role of miR-224 in hepatocellular carcinoma: a tool for possible therapeutic intervention? Epigenomics 3: 235-243.
5. Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, et al. (2009) Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer. BMC Cancer 9: 374.
6. Wang YX, Zhang XY, Zhang BF, Yang CQ, Chen XM, et al. (2010) Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis. J Dig Dis 11: 50-54.
7. Brunet Vega A, Pericay C, Moya I, Ferrer A, Dotor E, et al. (2013) microRNA expression profile in stage III colorectal cancer: Circulating miR-18a and miR-29a as promising biomarkers. Oncol Rep 30: 320-326.
8. Shen SN, Wang LF, Jia YF, Hao YQ, Zhang L, et al. (2013) Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer. Diagn Pathol 8: 69.
9. Lu S, Wang S, Geng S, Ma S, Liang Z, et al. (2012) Upregulation of microRNA-224 confers a poor prognosis in glioma patients. Clin Transl Oncol.
10. Huang L, Dai T, Lin X, Zhao X, Chen X, et al. (2012) MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. Biochem Biophys Res Commun 425: 127-133.
11. Wang Y, Lee AT, Ma JZ, Wang J, Ren J, et al. (2008) Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J Biol Chem 283: 13205-13215.
12. Li Q, Wang G, Shan JL, Yang ZX, Wang HZ, et al. (2010) MicroRNA-224 is upregulated in HepG2 cells and involved in cellular migration and invasion. J Gastroenterol Hepatol 25: 164-171.
13. Yao G, Yin M, Lian J, Tian H, Liu L, et al. (2010) MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol 24: 540-551.
14. Li X, Shen Y, Ichikawa H, Antes T, Goldberg GS, (2009) Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene 28: 4272-4283.
15. Boguslawska J, Wojcicka A, Piekielko-Witkowska A, Master A, Nauman A, (2011) MiR-224 targets the 3′UTR of type 1 5′-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer. PLoS ONE 6: e24541.
16. Xiao F, Zuo Z, Cai G, Kang S, Gao X, et al. (2009) miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res 37: D105-110.
17. Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
18. Huang da W, Sherman BT, Lempicki RA, (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13.
19. Alibes A, Yankilevich P, Canada A, Diaz-Uriarte R, (2007) IDconverter and IDClight: conversion and annotation of gene and protein IDs. BMC Bioinformatics 8: 9.
20. Ren J, Wang Y, Gao Y, Mehta S, Lee CG (2011) FAT10 mediates the effect of TNF-a in inducing chromosomal instability. J Cell Sci.
21. Giannelli G, Mazzocca A, Fransvea E, Lahn M, Antonaci S, (2011) Inhibiting TGF-beta signaling in hepatocellular carcinoma. Biochim Biophys Acta 1815: 214-223.
22. Wang Y, Toh HC, Chow P, Chung AY, Meyers DJ, et al. (2012) MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J 26: 3032-3041.
23. Scisciani C, Vossio S, Guerrieri F, Schinzari V, De Iaco R, et al. (2012) Transcriptional regulation of miR-224 upregulated in human HCCs by NFkappaB inflammatory pathways. J Hepatol 56: 855-861.
24. Meindl-Beinker NM, Matsuzaki K, Dooley S, (2012) TGF-beta signaling in onset and progression of hepatocellular carcinoma. Dig Dis 30: 514-523.
25. Miyaki M, Kuroki T, (2003) Role of Smad4 (DPC4) inactivation in human cancer. Biochem Biophys Res Commun 306: 799-804.
26. Yang G, Yang X, (2010) Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci 6: 1-8.
27. Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, et al. (2005) Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res 65: 4228-4237.