Characterization of the activity of 2′-C-methylcytidine against dengue virus replication

Antiviral Research

Volumn 116, Issue , 2015, Pages 1-9

  Lee, Jin Ching ^a   Tseng, Chin Kai ^b   Wu, Yu Hsuan ^a   Kaushik Basu, Neerja ^c   Lin, Chun Kuang ^d   Chen, Wei Chun ^e   Wu, Huey Nan ^f  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^f INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

2 C methylcytidine; Dengue virus; RNA polymerase

Indexed keywords

2' DEOXY 2' FLUORO 2' METHYLCYTIDINE; 2' METHYLCYTIDINE; 2'-C-METHYLCYTIDINE; ANTIVIRUS AGENT; CYTIDINE; CYTIDINE TRIPHOSPHATE; NONSTRUCTURAL PROTEIN 5; PHARMACOLOGY; RIBAVIRIN; RNA POLYMERASE; SOFOSBUVIR; VIRUS RNA;

ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BIOASSAY; BIOLUMINESCENCE; CHLOROCEBUS AETHIOPS; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; ENZYME ACTIVITY; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPLICON; RNA REPLICATION; VERO CELL LINE; VIROLOGY; VIRUS REPLICATION; WESTERN BLOTTING; XENOGRAFT;

ANALOGS AND DERIVATIVES; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL ASSAY; CERCOPITHECUS AETHIOPS; CYTIDINE; DENGUE; DENGUE VIRUS; DISEASE MODELS, ANIMAL; DRUG EFFECTS; DRUG THERAPY; GENETICS; GROWTH AND DEVELOPMENT; MICE; PHARMACOLOGY; REPLICON; RNA, VIRAL; TRANSPLANTATION, HETEROLOGOUS; VERO CELLS; VIROLOGY; VIRUS REPLICATION;

DENGUE VIRUS; MUS;

EID: 84964221845     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.01.002     Document Type: Article

References (29)

1. T. Asselah Sofosbuvir-based interferon-free therapy for patients with HCV infection J. Hepatol. 59 2013 1342 1345
2. Y.L. Chen, Z. Yin, J. Duraiswamy, W. Schul, C.C. Lim, B. Liu, H.Y. Xu, M. Qing, A. Yip, G. Wang, W.L. Chan, H.P. Tan, M. Lo, S. Liung, R.R. Kondreddi, R. Rao, H. Gu, H. He, T.H. Keller, and P.Y. Shi Inhibition of dengue virus RNA synthesis by an adenosine nucleoside Antimicrob. Agents Chemother. 54 2010 2932 2939
3. Y.L. Chen, N. Abdul Ghafar, R. Karuna, Y. Fu, S.P. Lim, W. Schul, F. Gu, M. Herve, F. Yokohama, G. Wang, D. Cerny, K. Fink, F. Blasco, and P.Y. Shi Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir J. Virol. 88 2014 1740 1747
4. J.L. Clark, L. Hollecker, J.C. Mason, L.J. Stuyver, P.M. Tharnish, S. Lostia, T.R. McBrayer, R.F. Schinazi, K.A. Watanabe, M.J. Otto, P.A. Furman, W.J. Stec, S.E. Patterson, and K.W. Pankiewicz Design, synthesis, and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methylcytidine, a potent inhibitor of hepatitis C virus replication J. Med. Chem. 48 2005 5504 5508
5. N.L. Golitsina, F.T. Danehy Jr., R. Fellows, E. Cretton-Scott, and D.N. Standring Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2′-C-methyl-cytidine to its 5′-monophosphate metabolite Antiviral Res. 85 2010 470 481
6. N. Goris, A. De Palma, J.F. Toussaint, I. Musch, J. Neyts, and K. De Clercq 2′-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus Antiviral Res. 73 2007 161 168
7. M.G. Guzman, S.B. Halstead, H. Artsob, P. Buchy, J. Farrar, D.J. Gubler, E. Hunsperger, A. Kroeger, H.S. Margolis, E. Martinez, M.B. Nathan, J.L. Pelegrino, C. Simmons, S. Yoksan, and R.W. Peeling Dengue: a continuing global threat Nat. Rev. Microbiol. 8 2010 S7 S16
8. T. Heller, S. Saito, J. Auerbach, T. Williams, T.R. Moreen, A. Jazwinski, B. Cruz, N. Jeurkar, R. Sapp, G. Luo, and T.J. Liang An in vitro model of hepatitis C virion production Proc. Natl. Acad. Sci. USA 102 2005 2579 2583
9. Y.C. Hsu, N.C. Chen, P.C. Chen, C.C. Wang, W.C. Cheng, and H.N. Wu Identification of a small-molecule inhibitor of dengue virus using a replicon system Arch. Virol. 157 2012 681 688
10. J.G. Julander, A.K. Jha, J.A. Choi, K.H. Jung, D.F. Smee, J.D. Morrey, and C.K. Chu Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model Antiviral Res. 86 2010 261 267
11. J.J. Kiser, and C. Flexner Direct-acting antiviral agents for hepatitis C virus infection Annu. Rev. Pharmacol. Toxicol. 53 2013 427 449
12. K. Klumpp, G. Kalayanov, H. Ma, S. Le Pogam, V. Leveque, W.R. Jiang, N. Inocencio, A. De Witte, S. Rajyaguru, E. Tai, S. Chanda, M.R. Irwin, C. Sund, A. Winqist, T. Maltseva, S. Eriksson, E. Usova, M. Smith, A. Alker, I. Najera, N. Cammack, J.A. Martin, N.G. Johansson, and D.B. Smith 2′-Deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-alpha-hydroxyl groups J. Biol. Chem. 283 2008 2167 2175
13. Y.R. Lee, K.J. Huang, H.Y. Lei, S.H. Chen, Y.S. Lin, T.M. Yeh, and H.S. Liu Suckling mice were used to detect infectious dengue-2 viruses by intracerebral injection of the full-length RNA transcript Intervirology 48 2005 161 166
14. J.C. Lee, C.K. Tseng, K.J. Chen, K.J. Huang, C.K. Lin, and Y.T. Lin A cell-based reporter assay for inhibitor screening of hepatitis C virus RNA-dependent RNA polymerase Anal. Biochem. 403 2010 52 62
15. J.C. Lee, W.C. Chen, S.F. Wu, C.K. Tseng, C.Y. Chiou, F.R. Chang, S.H. Hsu, and Y.C. Wu Anti-hepatitis C virus activity of Acacia confusa extract via suppressing cyclooxygenase-2 Antiviral Res. 89 2011 35 42
16. Y.R. Lee, H.Y. Hu, S.H. Kuo, H.Y. Lei, Y.S. Lin, T.M. Yeh, C.C. Liu, and H.S. Liu Dengue virus infection induces autophagy: an in vivo study J. Biomed. Sci. 20 2013 65
17. J.C. Lee, C.K. Tseng, K.C. Young, H.Y. Sun, S.W. Wang, W.C. Chen, C.K. Lin, and Y.H. Wu Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells Br. J. Pharmacol. 171 2014 237 252
18. D.J. Lefebvre, A.R. De Vleeschauwer, N. Goris, D. Kollanur, A. Billiet, L. Murao, J. Neyts, and K. De Clercq Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2′-C-methylcytidine in severe combined immunodeficient mice Transboundary Emerg. Dis. 2013
19. H. Malet, N. Masse, B. Selisko, J.L. Romette, K. Alvarez, J.C. Guillemot, H. Tolou, T.L. Yap, S. Vasudevan, J. Lescar, and B. Canard The flavivirus polymerase as a target for drug discovery Antiviral Res. 80 2008 23 35
20. H. Malet, N. Masse, B. Selisko, J.L. Romette, K. Alvarez, J.C. Guillemot, H. Tolou, T.L. Yap, S. Vasudevan, J. Lescar, and B. Canard The flavivirus polymerase as a target for drug discovery Antiviral Res. 80 2008 23 35
21. N.M. Nguyen, C.N. Tran, L.K. Phung, K.T. Duong, A. Huynh Hle, J. Farrar, Q.T. Nguyen, H.T. Tran, C.V. Nguyen, L. Merson, L.T. Hoang, M.L. Hibberd, P.P. Aw, A. Wilm, N. Nagarajan, D.T. Nguyen, M.P. Pham, T.T. Nguyen, H. Javanbakht, K. Klumpp, J. Hammond, R. Petric, M. Wolbers, C.T. Nguyen, and C.P. Simmons A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients J. Infect. Dis. 207 2013 1442 1450
22. S.M. Rawlinson, M.J. Pryor, P.J. Wright, and D.A. Jans Dengue virus RNA polymerase NS5: a potential therapeutic target? Curr. Drug Targets 7 2006 1623 1638
23. J. Rocha-Pereira, D. Jochmans, Y. Debing, E. Verbeken, M.S. Nascimento, and J. Neyts The viral polymerase inhibitor 2′-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model J. Virol. 87 2013 11798 11805
24. R. Schinazi, P. Halfon, P. Marcellin, and T. Asselah HCV direct-acting antiviral agents: the best interferon-free combinations Liver Int. 34 Suppl. 1 2014 69 78
25. M.J. Sofia, D. Bao, W. Chang, J. Du, D. Nagarathnam, S. Rachakonda, P.G. Reddy, B.S. Ross, P. Wang, H.R. Zhang, S. Bansal, C. Espiritu, M. Keilman, A.M. Lam, H.M. Steuer, C. Niu, M.J. Otto, and P.A. Furman Discovery of a beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus J. Med. Chem. 53 2010 7202 7218
26. C.K. Tseng, K.J. Chen, C.K. Lin, S.H. Hsu, and J.C. Lee An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase Anal. Biochem. 418 2011 50 57
27. Y.C. Tung, K.H. Lin, H.C. Chiang, L.Y. Ke, Y.H. Chen, G.M. Ke, T.C. Chen, L.C. Chou, and P.L. Lu Molecular epidemiology of dengue virus serotype 2 in the Taiwan 2002 outbreak with envelope gene and nonstructural protein 1 gene analysis Kaohsiung J. Med. Sci. 24 2008 398 407
28. P. Wang, B.K. Chun, S. Rachakonda, J. Du, N. Khan, J. Shi, W. Stec, D. Cleary, B.S. Ross, and M.J. Sofia An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase J. Org. Chem. 74 2009 6819 6824
29. Z. Yin, Y.L. Chen, W. Schul, Q.Y. Wang, F. Gu, J. Duraiswamy, R.R. Kondreddi, P. Niyomrattanakit, S.B. Lakshminarayana, A. Goh, H.Y. Xu, W. Liu, B. Liu, J.Y. Lim, C.Y. Ng, M. Qing, C.C. Lim, A. Yip, G. Wang, W.L. Chan, H.P. Tan, K. Lin, B. Zhang, G. Zou, K.A. Bernard, C. Garrett, K. Beltz, M. Dong, M. Weaver, H. He, A. Pichota, V. Dartois, T.H. Keller, and P.Y. Shi An adenosine nucleoside inhibitor of dengue virus Proc. Natl. Acad. Sci. USA 106 2009 20435 20439