-
1
-
-
0037049977
-
Cardiac excitation-contraction coupling
-
D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205
-
(2002)
Nature
, vol.415
, pp. 198-205
-
-
Bers, D.M.1
-
2
-
-
0034383952
-
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
-
O.F. Bueno, L.J. De Windt, K.M. Tymitz, S.A. Witt, T.R. Kimball, R. Klevitsky, T.E. Hewett, S.P. Jones, D.J. Lefer, C.F. Peng, and et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice EMBO J. 19 2000 6341 6350
-
(2000)
EMBO J.
, vol.19
, pp. 6341-6350
-
-
Bueno, O.F.1
De Windt, L.J.2
Tymitz, K.M.3
Witt, S.A.4
Kimball, T.R.5
Klevitsky, R.6
Hewett, T.E.7
Jones, S.P.8
Lefer, D.J.9
Peng, C.F.10
-
3
-
-
77949358459
-
Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: A predictive cellular model of myofilament dysregulation in disease
-
J. Davis, and J.M. Metzger Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease PLoS ONE 5 2010 e9140
-
(2010)
PLoS ONE
, vol.5
, pp. e9140
-
-
Davis, J.1
Metzger, J.M.2
-
4
-
-
34249673442
-
Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin i induces Ca2+-independent mechanical tone and acute myocyte remodeling
-
J. Davis, H. Wen, T. Edwards, and J.M. Metzger Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling Circ. Res. 100 2007 1494 1502
-
(2007)
Circ. Res.
, vol.100
, pp. 1494-1502
-
-
Davis, J.1
Wen, H.2
Edwards, T.3
Metzger, J.M.4
-
5
-
-
43049093311
-
Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin i mutants
-
J. Davis, H. Wen, T. Edwards, and J.M. Metzger Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants J. Mol. Cell. Cardiol. 44 2008 891 904
-
(2008)
J. Mol. Cell. Cardiol.
, vol.44
, pp. 891-904
-
-
Davis, J.1
Wen, H.2
Edwards, T.3
Metzger, J.M.4
-
6
-
-
84864796741
-
Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy
-
J. Davis, S. Yasuda, N.J. Palpant, J. Martindale, T. Stevenson, K. Converso, and J.M. Metzger Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy J. Mol. Cell. Cardiol. 53 2012 446 457
-
(2012)
J. Mol. Cell. Cardiol.
, vol.53
, pp. 446-457
-
-
Davis, J.1
Yasuda, S.2
Palpant, N.J.3
Martindale, J.4
Stevenson, T.5
Converso, K.6
Metzger, J.M.7
-
7
-
-
0036787237
-
Molecular mechanisms of inherited cardiomyopathies
-
D. Fatkin, and R.M. Graham Molecular mechanisms of inherited cardiomyopathies Physiol. Rev. 82 2002 945 980
-
(2002)
Physiol. Rev.
, vol.82
, pp. 945-980
-
-
Fatkin, D.1
Graham, R.M.2
-
8
-
-
0033653534
-
An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy
-
D. Fatkin, B.K. McConnell, J.O. Mudd, C. Semsarian, I.G. Moskowitz, F.J. Schoen, M. Giewat, C.E. Seidman, and J.G. Seidman An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy J. Clin. Invest. 106 2000 1351 1359
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1351-1359
-
-
Fatkin, D.1
McConnell, B.K.2
Mudd, J.O.3
Semsarian, C.4
Moskowitz, I.G.5
Schoen, F.J.6
Giewat, M.7
Seidman, C.E.8
Seidman, J.G.9
-
9
-
-
84901367922
-
Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts
-
E.R. Feest, F. Steven Korte, A.Y. Tu, J. Dai, M.V. Razumova, C.E. Murry, and M. Regnier Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts J. Mol. Cell. Cardiol. 72 2014 219 227
-
(2014)
J. Mol. Cell. Cardiol.
, vol.72
, pp. 219-227
-
-
Feest, E.R.1
Steven Korte, F.2
Tu, A.Y.3
Dai, J.4
Razumova, M.V.5
Murry, C.E.6
Regnier, M.7
-
10
-
-
0030067394
-
A mouse model of familial hypertrophic cardiomyopathy
-
A.A. Geisterfer-Lowrance, M. Christe, D.A. Conner, J.S. Ingwall, F.J. Schoen, C.E. Seidman, and J.G. Seidman A mouse model of familial hypertrophic cardiomyopathy Science 272 1996 731 734
-
(1996)
Science
, vol.272
, pp. 731-734
-
-
Geisterfer-Lowrance, A.A.1
Christe, M.2
Conner, D.A.3
Ingwall, J.S.4
Schoen, F.J.5
Seidman, C.E.6
Seidman, J.G.7
-
11
-
-
0034059761
-
Regulation of contraction in striated muscle
-
A.M. Gordon, E. Homsher, and M. Regnier Regulation of contraction in striated muscle Physiol. Rev. 80 2000 853 924
-
(2000)
Physiol. Rev.
, vol.80
, pp. 853-924
-
-
Gordon, A.M.1
Homsher, E.2
Regnier, M.3
-
12
-
-
84904066433
-
Advances in medical treatment of hypertrophic cardiomyopathy
-
M. Hamada, S. Ikeda, and Y. Shigematsu Advances in medical treatment of hypertrophic cardiomyopathy J. Cardiol. 64 2014 1 10
-
(2014)
J. Cardiol.
, vol.64
, pp. 1-10
-
-
Hamada, M.1
Ikeda, S.2
Shigematsu, Y.3
-
13
-
-
84940491378
-
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
-
J.T. Hinson, A. Chopra, N. Nafissi, W.J. Polacheck, C.C. Benson, S. Swist, J. Gorham, L. Yang, S. Schafer, C.C. Sheng, and et al. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy Science 349 2015 982 986
-
(2015)
Science
, vol.349
, pp. 982-986
-
-
Hinson, J.T.1
Chopra, A.2
Nafissi, N.3
Polacheck, W.J.4
Benson, C.C.5
Swist, S.6
Gorham, J.7
Yang, L.8
Schafer, S.9
Sheng, C.C.10
-
14
-
-
84889006323
-
Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?
-
S.R. Houser, and J.D. Molkentin Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes? Sci. Signal. 1 2008 pe31
-
(2008)
Sci. Signal.
, vol.1
, pp. pe31
-
-
Houser, S.R.1
Molkentin, J.D.2
-
15
-
-
33847013578
-
Muscle structure and theories of contraction
-
A.F. Huxley Muscle structure and theories of contraction Prog. Biophys. Biophys. Chem. 7 1957 255 318
-
(1957)
Prog. Biophys. Biophys. Chem.
, vol.7
, pp. 255-318
-
-
Huxley, A.F.1
-
16
-
-
84904264796
-
Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies
-
A. Kalyva, F.I. Parthenakis, M.E. Marketou, J.E. Kontaraki, and P.E. Vardas Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies J. Muscle Res. Cell Motil. 35 2014 161 178
-
(2014)
J. Muscle Res. Cell Motil.
, vol.35
, pp. 161-178
-
-
Kalyva, A.1
Parthenakis, F.I.2
Marketou, M.E.3
Kontaraki, J.E.4
Vardas, P.E.5
-
17
-
-
78650710691
-
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation
-
I. Kehat, and J.D. Molkentin Molecular pathways underlying cardiac remodeling during pathophysiological stimulation Circulation 122 2010 2727 2735
-
(2010)
Circulation
, vol.122
, pp. 2727-2735
-
-
Kehat, I.1
Molkentin, J.D.2
-
18
-
-
79251617662
-
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth
-
I. Kehat, J. Davis, M. Tiburcy, F. Accornero, M.K. Saba-El-Leil, M. Maillet, A.J. York, J.N. Lorenz, W.H. Zimmermann, S. Meloche, and J.D. Molkentin Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth Circ. Res. 108 2011 176 183
-
(2011)
Circ. Res.
, vol.108
, pp. 176-183
-
-
Kehat, I.1
Davis, J.2
Tiburcy, M.3
Accornero, F.4
Saba-El-Leil, M.K.5
Maillet, M.6
York, A.J.7
Lorenz, J.N.8
Zimmermann, W.H.9
Meloche, S.10
Molkentin, J.D.11
-
19
-
-
78650848080
-
Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle
-
K.L. Kreutziger, N. Piroddi, J.T. McMichael, C. Tesi, C. Poggesi, and M. Regnier Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle J. Mol. Cell. Cardiol. 50 2011 165 174
-
(2011)
J. Mol. Cell. Cardiol.
, vol.50
, pp. 165-174
-
-
Kreutziger, K.L.1
Piroddi, N.2
McMichael, J.T.3
Tesi, C.4
Poggesi, C.5
Regnier, M.6
-
20
-
-
84872026086
-
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells
-
F. Lan, A.S. Lee, P. Liang, V. Sanchez-Freire, P.K. Nguyen, L. Wang, L. Han, M. Yen, Y. Wang, N. Sun, and et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells Cell Stem Cell 12 2013 101 113
-
(2013)
Cell Stem Cell
, vol.12
, pp. 101-113
-
-
Lan, F.1
Lee, A.S.2
Liang, P.3
Sanchez-Freire, V.4
Nguyen, P.K.5
Wang, L.6
Han, L.7
Yen, M.8
Wang, Y.9
Sun, N.10
-
21
-
-
84874476580
-
Titin is a major human disease gene
-
M.M. LeWinter, and H.L. Granzier Titin is a major human disease gene Circulation 127 2013 938 944
-
(2013)
Circulation
, vol.127
, pp. 938-944
-
-
LeWinter, M.M.1
Granzier, H.L.2
-
22
-
-
63349095616
-
The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy
-
S.W. Luckey, L.A. Walker, T. Smyth, J. Mansoori, A. Messmer-Kratzsch, A. Rosenzweig, E.N. Olson, and L.A. Leinwand The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy J. Mol. Cell. Cardiol. 46 2009 739 747
-
(2009)
J. Mol. Cell. Cardiol.
, vol.46
, pp. 739-747
-
-
Luckey, S.W.1
Walker, L.A.2
Smyth, T.3
Mansoori, J.4
Messmer-Kratzsch, A.5
Rosenzweig, A.6
Olson, E.N.7
Leinwand, L.A.8
-
23
-
-
84862825070
-
2+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility
-
2+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility Circ. Res. 110 2012 669 674
-
(2012)
Circ. Res.
, vol.110
, pp. 669-674
-
-
Makarewich, C.A.1
Correll, R.N.2
Gao, H.3
Zhang, H.4
Yang, B.5
Berretta, R.M.6
Rizzo, V.7
Molkentin, J.D.8
Houser, S.R.9
-
25
-
-
1042302791
-
Covalent and noncovalent modification of thin filament action: The essential role of troponin in cardiac muscle regulation
-
J.M. Metzger, and M.V. Westfall Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation Circ. Res. 94 2004 146 158
-
(2004)
Circ. Res.
, vol.94
, pp. 146-158
-
-
Metzger, J.M.1
Westfall, M.V.2
-
26
-
-
0037047648
-
Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade
-
D.E. Michele, C.A. Gomez, K.E. Hong, M.V. Westfall, and J.M. Metzger Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade Circ. Res. 91 2002 255 262
-
(2002)
Circ. Res.
, vol.91
, pp. 255-262
-
-
Michele, D.E.1
Gomez, C.A.2
Hong, K.E.3
Westfall, M.V.4
Metzger, J.M.5
-
27
-
-
0037238265
-
Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin i mutations
-
J. Mogensen, T. Kubo, M. Duque, W. Uribe, A. Shaw, R. Murphy, J.R. Gimeno, P. Elliott, and W.J. McKenna Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations J. Clin. Invest. 111 2003 209 216
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 209-216
-
-
Mogensen, J.1
Kubo, T.2
Duque, M.3
Uribe, W.4
Shaw, A.5
Murphy, R.6
Gimeno, J.R.7
Elliott, P.8
McKenna, W.J.9
-
28
-
-
48849083417
-
Simulation of steady state and transient cardiac muscle response experiments with a Huxley-based contraction model
-
J.A. Negroni, and E.C. Lascano Simulation of steady state and transient cardiac muscle response experiments with a Huxley-based contraction model J. Mol. Cell. Cardiol. 45 2008 300 312
-
(2008)
J. Mol. Cell. Cardiol.
, vol.45
, pp. 300-312
-
-
Negroni, J.A.1
Lascano, E.C.2
-
29
-
-
77956953740
-
Hypertrophic cardiomyopathy in childhood and adolescence - Strategies to prevent sudden death
-
I. Ostman-Smith Hypertrophic cardiomyopathy in childhood and adolescence - strategies to prevent sudden death Fundam. Clin. Pharmacol. 24 2010 637 652
-
(2010)
Fundam. Clin. Pharmacol.
, vol.24
, pp. 637-652
-
-
Ostman-Smith, I.1
-
30
-
-
77956236251
-
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C
-
M.S. Parvatiyar, J.R. Pinto, J. Liang, and J.D. Potter Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C J. Biol. Chem. 285 2010 27785 27797
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27785-27797
-
-
Parvatiyar, M.S.1
Pinto, J.R.2
Liang, J.3
Potter, J.D.4
-
31
-
-
84959386936
-
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
-
V. Shettigar, B. Zhang, S.C. Little, H.E. Salhi, B.J. Hansen, N. Li, J. Zhang, S.R. Roof, H.T. Ho, L. Brunello, and et al. Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease Nat. Commun. 7 2016 10794
-
(2016)
Nat. Commun.
, vol.7
, pp. 10794
-
-
Shettigar, V.1
Zhang, B.2
Little, S.C.3
Salhi, H.E.4
Hansen, B.J.5
Li, N.6
Zhang, J.7
Roof, S.R.8
Ho, H.T.9
Brunello, L.10
-
32
-
-
84867151300
-
Pharmacological treatment options for hypertrophic cardiomyopathy: High time for evidence
-
R. Spoladore, M.S. Maron, R. D'Amato, P.G. Camici, and I. Olivotto Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence Eur. Heart J. 33 2012 1724 1733
-
(2012)
Eur. Heart J.
, vol.33
, pp. 1724-1733
-
-
Spoladore, R.1
Maron, M.S.2
D'Amato, R.3
Camici, P.G.4
Olivotto, I.5
-
33
-
-
84860156650
-
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
-
N. Sun, M. Yazawa, J. Liu, L. Han, V. Sanchez-Freire, O.J. Abilez, E.G. Navarrete, S. Hu, L. Wang, A. Lee, and et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy Sci. Transl. Med. 4 2012 130ra47
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 130ra47
-
-
Sun, N.1
Yazawa, M.2
Liu, J.3
Han, L.4
Sanchez-Freire, V.5
Abilez, O.J.6
Navarrete, E.G.7
Hu, S.8
Wang, L.9
Lee, A.10
-
34
-
-
84926655338
-
Targets for therapy in sarcomeric cardiomyopathies
-
J.C. Tardiff, L. Carrier, D.M. Bers, C. Poggesi, C. Ferrantini, R. Coppini, L.S. Maier, H. Ashrafian, S. Huke, and J. van der Velden Targets for therapy in sarcomeric cardiomyopathies Cardiovasc. Res. 105 2015 457 470
-
(2015)
Cardiovasc. Res.
, vol.105
, pp. 457-470
-
-
Tardiff, J.C.1
Carrier, L.2
Bers, D.M.3
Poggesi, C.4
Ferrantini, C.5
Coppini, R.6
Maier, L.S.7
Ashrafian, H.8
Huke, S.9
Van Der Velden, J.10
-
35
-
-
4143085980
-
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C
-
S.B. Tikunova, and J.P. Davis Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C J. Biol. Chem. 279 2004 35341 35352
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35341-35352
-
-
Tikunova, S.B.1
Davis, J.P.2
-
36
-
-
84861857352
-
Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation
-
D. Wang, I.M. Robertson, M.X. Li, M.E. McCully, M.L. Crane, Z. Luo, A.Y. Tu, V. Daggett, B.D. Sykes, and M. Regnier Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation Biochemistry 51 2012 4473 4487
-
(2012)
Biochemistry
, vol.51
, pp. 4473-4487
-
-
Wang, D.1
Robertson, I.M.2
Li, M.X.3
McCully, M.E.4
Crane, M.L.5
Luo, Z.6
Tu, A.Y.7
Daggett, V.8
Sykes, B.D.9
Regnier, M.10
|