-
1
-
-
0029083650
-
Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults
-
Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, et al. (1995) Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 92: 785-789.
-
(1995)
Circulation
, vol.92
, pp. 785-789
-
-
Maron, B.J.1
Gardin, J.M.2
Flack, J.M.3
Gidding, S.S.4
Kurosaki, T.T.5
-
2
-
-
0037056110
-
Contemporary evaluation and management of hypertrophic cardiomyopathy
-
Braunwald E, Seidman CE, Sigwart U (2002) Contemporary evaluation and management of hypertrophic cardiomyopathy. Circulation 106: 1312-1316.
-
(2002)
Circulation
, vol.106
, pp. 1312-1316
-
-
Braunwald, E.1
Seidman, C.E.2
Sigwart, U.3
-
3
-
-
33646693410
-
Contemporary definitions and classification of the cardiomyopathies: An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention
-
Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, et al. (2006) Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113: 1807-1816.
-
(2006)
Circulation
, vol.113
, pp. 1807-1816
-
-
Maron, B.J.1
Towbin, J.A.2
Thiene, G.3
Antzelevitch, C.4
Corrado, D.5
-
4
-
-
13444281662
-
Hypertrophic cardiomyopathy: From "heart tumour" to a complex molecular genetic disorder
-
Doolan A, Nguyen L, Semsarian C (2004) Hypertrophic cardiomyopathy: from "heart tumour" to a complex molecular genetic disorder. Heart Lung Circ 13: 15-25.
-
(2004)
Heart Lung Circ
, vol.13
, pp. 15-25
-
-
Doolan, A.1
Nguyen, L.2
Semsarian, C.3
-
5
-
-
77949393167
-
-
NHLBI Program for Genomic Applications HMS (7 A.D. June) Genomics of Cardiovascular Development, Adaptation, and Remodeling. http://www. cardiogenomics.org.
-
NHLBI Program for Genomic Applications HMS (7 A.D. June) Genomics of Cardiovascular Development, Adaptation, and Remodeling. http://www. cardiogenomics.org.
-
-
-
-
6
-
-
0032410872
-
The molecular biology and pathophysiology of hypertrophic cardiomyopathy due to mutations in the beta myosin heavy chains and the essential and regulatory light chains
-
Epstein ND (1998) The molecular biology and pathophysiology of hypertrophic cardiomyopathy due to mutations in the beta myosin heavy chains and the essential and regulatory light chains. Adv Exp Med Biol 453: 105-114.
-
(1998)
Adv Exp Med Biol
, vol.453
, pp. 105-114
-
-
Epstein, N.D.1
-
7
-
-
0036787237
-
Molecular mechanisms of inherited cardiomyopathies
-
Fatkin D, Graham RM (2002) Molecular mechanisms of inherited cardiomyopathies. Physiol Rev 82: 945-980.
-
(2002)
Physiol Rev
, vol.82
, pp. 945-980
-
-
Fatkin, D.1
Graham, R.M.2
-
8
-
-
13944253657
-
Molecular and phenotypic effects of heterozygous, homozygous, and compound heterozygote myosin heavy-chain mutations
-
Alpert NR, Mohiddin SA, Tripodi D, Jacobson-Hatzell J, Vaughn-Whitley K, et al. (2005) Molecular and phenotypic effects of heterozygous, homozygous, and compound heterozygote myosin heavy-chain mutations. Am J Physiol Heart Circ Physiol 288: H1097-H1102.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Alpert, N.R.1
Mohiddin, S.A.2
Tripodi, D.3
Jacobson-Hatzell, J.4
Vaughn-Whitley, K.5
-
9
-
-
33646757738
-
Compound and double mutations in patients with hypertrophic cardiomyopathy: Implications for genetic testing and counselling
-
Ingles J, Doolan A, Chiu C, Seidman J, Seidman C, et al. (2005) Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. J Med Genet 42: e59.
-
(2005)
J Med Genet
, vol.42
-
-
Ingles, J.1
Doolan, A.2
Chiu, C.3
Seidman, J.4
Seidman, C.5
-
10
-
-
0037357857
-
Utility of genetic screening in hypertrophic cardiomyopathy: Prevalence and significance of novel and double (homozygous and heterozygous) beta-myosin mutations
-
Mohiddin SA, Begley DA, McLam E, Cardoso JP, Winkler JB, et al. (2003) Utility of genetic screening in hypertrophic cardiomyopathy: prevalence and significance of novel and double (homozygous and heterozygous) beta-myosin mutations. Genet Test 7: 21-27.
-
(2003)
Genet Test
, vol.7
, pp. 21-27
-
-
Mohiddin, S.A.1
Begley, D.A.2
McLam, E.3
Cardoso, J.P.4
Winkler, J.B.5
-
11
-
-
0033005768
-
Double heterozygosity for mutations in the beta-myosin heavy chain and in the cardiac myosin binding protein C genes in a family with hypertrophic cardiomyopathy
-
Richard P, Isnard R, Carrier L, Dubourg O, Donatien Y, et al. (1999) Double heterozygosity for mutations in the beta-myosin heavy chain and in the cardiac myosin binding protein C genes in a family with hypertrophic cardiomyopathy. J Med Genet 36: 542-545.
-
(1999)
J Med Genet
, vol.36
, pp. 542-545
-
-
Richard, P.1
Isnard, R.2
Carrier, L.3
Dubourg, O.4
Donatien, Y.5
-
12
-
-
0033851630
-
Homozygotes for a R869G mutation in the beta -myosin heavy chain gene have a severe form of familial hypertrophic cardiomyopathy
-
Richard P, Charron P, Leclercq C, Ledeuil C, Carrier L, et al. (2000) Homozygotes for a R869G mutation in the beta -myosin heavy chain gene have a severe form of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 32: 1575-1583.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 1575-1583
-
-
Richard, P.1
Charron, P.2
Leclercq, C.3
Ledeuil, C.4
Carrier, L.5
-
13
-
-
0037058868
-
Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy
-
Van Driest SL, Ackerman MJ, Ommen SR, Shakur R, Will ML, et al. (2002) Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy. Circulation 106: 3085-3090.
-
(2002)
Circulation
, vol.106
, pp. 3085-3090
-
-
Van Driest, S.L.1
Ackerman, M.J.2
Ommen, S.R.3
Shakur, R.4
Will, M.L.5
-
14
-
-
7044264544
-
Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy
-
Van Driest SL, Vasile VC, Ommen SR, Will ML, Tajik AJ, et al. (2004) Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. J Am Coll Cardiol 44: 1903-1910.
-
(2004)
J Am Coll Cardiol
, vol.44
, pp. 1903-1910
-
-
Van Driest, S.L.1
Vasile, V.C.2
Ommen, S.R.3
Will, M.L.4
Tajik, A.J.5
-
15
-
-
0041923834
-
Hypertrophic cardiomyopathy: Two homozygous cases with "typical" hypertrophic cardiomyopathy and three new mutations in cases with progression to dilated cardiomyopathy
-
Nanni L, Pieroni M, Chimenti C, Simionati B, Zimbello R, et al. (2003) Hypertrophic cardiomyopathy: two homozygous cases with "typical" hypertrophic cardiomyopathy and three new mutations in cases with progression to dilated cardiomyopathy. Biochem Biophys Res Commun 309: 391-398.
-
(2003)
Biochem Biophys Res Commun
, vol.309
, pp. 391-398
-
-
Nanni, L.1
Pieroni, M.2
Chimenti, C.3
Simionati, B.4
Zimbello, R.5
-
16
-
-
0032580520
-
Mutations in the gene for cardiac myosin-binding protein C and lateonset familial hypertrophic cardiomyopathy
-
Niimura H, Bachinski LL, Sangwatanaroj S, Watkins H, Chudley AE, et al. (1998) Mutations in the gene for cardiac myosin-binding protein C and lateonset familial hypertrophic cardiomyopathy. N Engl J Med 338: 1248-1257.
-
(1998)
N Engl J Med
, vol.338
, pp. 1248-1257
-
-
Niimura, H.1
Bachinski, L.L.2
Sangwatanaroj, S.3
Watkins, H.4
Chudley, A.E.5
-
17
-
-
0037630018
-
Hypertrophic cardiomyopathy: Distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy
-
Richard P, Charron P, Carrier L, Ledeuil C, Cheav T, et al. (2003) Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation 107: 2227-2232.
-
(2003)
Circulation
, vol.107
, pp. 2227-2232
-
-
Richard, P.1
Charron, P.2
Carrier, L.3
Ledeuil, C.4
Cheav, T.5
-
18
-
-
0034680324
-
Homozygous mutation in cardiac troponin T: Implications for hypertrophic cardiomyopathy
-
Ho CY, Lever HM, DeSanctis R, Farver CF, Seidman JG, et al. (2000) Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy. Circulation 102: 1950-1955.
-
(2000)
Circulation
, vol.102
, pp. 1950-1955
-
-
Ho, C.Y.1
Lever, H.M.2
DeSanctis, R.3
Farver, C.F.4
Seidman, J.G.5
-
19
-
-
0033798520
-
Phenotypic variation of familial hypertrophic cardiomyopathy caused by the Phe(110)->Ile mutation in cardiac troponin T
-
Lin T, Ichihara S, Yamada Y, Nagasaka T, Ishihara H, et al. (2000) Phenotypic variation of familial hypertrophic cardiomyopathy caused by the Phe(110)->Ile mutation in cardiac troponin T. Cardiology 93: 155-162.
-
(2000)
Cardiology
, vol.93
, pp. 155-162
-
-
Lin, T.1
Ichihara, S.2
Yamada, Y.3
Nagasaka, T.4
Ishihara, H.5
-
20
-
-
54249115891
-
Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure
-
Tsoutsman T, Bagnall RD, Semsarian C (2008) Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure. Clin Exp Pharmacol Physiol 35: 1349-1357.
-
(2008)
Clin Exp Pharmacol Physiol
, vol.35
, pp. 1349-1357
-
-
Tsoutsman, T.1
Bagnall, R.D.2
Semsarian, C.3
-
21
-
-
41949113790
-
Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutations
-
Frazier A, Judge DP, Schulman SP, Johnson N, Holmes KW, et al. (2008) Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutations. Pediatr Cardiol 29: 846-850.
-
(2008)
Pediatr Cardiol
, vol.29
, pp. 846-850
-
-
Frazier, A.1
Judge, D.P.2
Schulman, S.P.3
Johnson, N.4
Holmes, K.W.5
-
22
-
-
34249673442
-
Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling
-
Davis J, Wen H, Edwards T, Metzger JM (2007) Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling. Circ Res 100: 1494-1502.
-
(2007)
Circ Res
, vol.100
, pp. 1494-1502
-
-
Davis, J.1
Wen, H.2
Edwards, T.3
Metzger, J.M.4
-
23
-
-
0025040392
-
A molecular basis for familial hypertrophic cardiomyopathy: A beta cardiac myosin heavy chain gene missense mutation
-
Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, et al. (1990) A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell 62: 999-1006.
-
(1990)
Cell
, vol.62
, pp. 999-1006
-
-
Geisterfer-Lowrance, A.A.1
Kass, S.2
Tanigawa, G.3
Vosberg, H.P.4
McKenna, W.5
-
24
-
-
0037155775
-
Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice
-
Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, et al. (2002) Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res 90: 594-601.
-
(2002)
Circ Res
, vol.90
, pp. 594-601
-
-
Harris, S.P.1
Bartley, C.R.2
Hacker, T.A.3
McDonald, K.S.4
Douglas, P.S.5
-
25
-
-
0037047648
-
Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade
-
Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM (2002) Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circ Res 91: 255-262.
-
(2002)
Circ Res
, vol.91
, pp. 255-262
-
-
Michele, D.E.1
Gomez, C.A.2
Hong, K.E.3
Westfall, M.V.4
Metzger, J.M.5
-
26
-
-
21844449187
-
Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect
-
Garcia-Castro M, Reguero JR, Alvarez V, Batalla A, Soto MI, et al. (2005) Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect. Int J Cardiol 102: 501-507.
-
(2005)
Int J Cardiol
, vol.102
, pp. 501-507
-
-
Garcia-Castro, M.1
Reguero, J.R.2
Alvarez, V.3
Batalla, A.4
Soto, M.I.5
-
27
-
-
0032741970
-
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
-
McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, et al. (1999) Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest 104: 1771.
-
(1999)
J Clin Invest
, vol.104
, pp. 1771
-
-
McConnell, B.K.1
Jones, K.A.2
Fatkin, D.3
Arroyo, L.H.4
Lee, R.T.5
-
28
-
-
41949129330
-
Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy
-
Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, et al. (2008) Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation 117: 1820-1831.
-
(2008)
Circulation
, vol.117
, pp. 1820-1831
-
-
Tsoutsman, T.1
Kelly, M.2
Ng, D.C.3
Tan, J.E.4
Tu, E.5
-
29
-
-
55949108787
-
Designing heart performance by gene transfer
-
Davis J, Westfall M, Townsend D, Blankenship M, Herron TJ, et al. (2008) Designing heart performance by gene transfer. Physiol Rev 4: 1567-1651.
-
(2008)
Physiol Rev
, vol.4
, pp. 1567-1651
-
-
Davis, J.1
Westfall, M.2
Townsend, D.3
Blankenship, M.4
Herron, T.J.5
-
30
-
-
43049093311
-
Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants
-
Davis J, Wen H, Edwards T, Metzger JM (2008) Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants. J Mol Cell Cardiol 44: 891-904.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 891-904
-
-
Davis, J.1
Wen, H.2
Edwards, T.3
Metzger, J.M.4
-
31
-
-
0032751723
-
Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopa-thy mutant alpha-tropomyosins in adult cardiac myocytes
-
Michele DE, Albayya FP, Metzger JM (1999) Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopa-thy mutant alpha-tropomyosins in adult cardiac myocytes. Nat Med 5: 1413-1417.
-
(1999)
Nat Med
, vol.5
, pp. 1413-1417
-
-
Michele, D.E.1
Albayya, F.P.2
Metzger, J.M.3
-
32
-
-
0036370089
-
Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins
-
Michele DE, Coutu P, Metzger JM (2002) Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. Physiol Genomics 9: 103-111.
-
(2002)
Physiol Genomics
, vol.9
, pp. 103-111
-
-
Michele, D.E.1
Coutu, P.2
Metzger, J.M.3
-
33
-
-
0030635151
-
Adenovirus-mediated myofilament gene transfer into adult cardiac myocytes
-
Westfall MV, Rust EM, Albayya F, Metzger JM (1997) Adenovirus-mediated myofilament gene transfer into adult cardiac myocytes. Methods Cell Biol 52: 307-322.
-
(1997)
Methods Cell Biol
, vol.52
, pp. 307-322
-
-
Westfall, M.V.1
Rust, E.M.2
Albayya, F.3
Metzger, J.M.4
-
34
-
-
0030992773
-
Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function
-
Westfall MV, Rust EM, Metzger JM (1997) Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function. Proc Natl Acad Sci U S A 94: 5444-5449.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 5444-5449
-
-
Westfall, M.V.1
Rust, E.M.2
Metzger, J.M.3
-
35
-
-
33845639573
-
Genetic engineering and therapy for inherited and acquired cardiomyopathies
-
Day S, Davis J, Westfall M, Metzger J (2006) Genetic engineering and therapy for inherited and acquired cardiomyopathies. Ann N Y Acad Sci 1080: 437-450.
-
(2006)
Ann N Y Acad Sci
, vol.1080
, pp. 437-450
-
-
Day, S.1
Davis, J.2
Westfall, M.3
Metzger, J.4
-
37
-
-
4544291412
-
Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene
-
Gomes AV, Potter JD (2004) Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem 263: 99-114.
-
(2004)
Mol Cell Biochem
, vol.263
, pp. 99-114
-
-
Gomes, A.V.1
Potter, J.D.2
-
38
-
-
0037969617
-
Sarcomere thin filament regulatory isoforms. Evidence of a dominant effect of slow skeletal troponin I on cardiac contraction
-
Metzger JM, Michele DE, Rust EM, Borton AR, Westfall MV (2003) Sarcomere thin filament regulatory isoforms. Evidence of a dominant effect of slow skeletal troponin I on cardiac contraction. J Biol Chem 278: 13118-13123.
-
(2003)
J Biol Chem
, vol.278
, pp. 13118-13123
-
-
Metzger, J.M.1
Michele, D.E.2
Rust, E.M.3
Borton, A.R.4
Westfall, M.V.5
-
39
-
-
0034059761
-
Regulation of contraction in striated muscle
-
Gordon AM, Homsher E, Regnier M (2000) Regulation of contraction in striated muscle. Physiol Rev 80: 853-924.
-
(2000)
Physiol Rev
, vol.80
, pp. 853-924
-
-
Gordon, A.M.1
Homsher, E.2
Regnier, M.3
-
40
-
-
0026611165
-
Ca2+ regulation of mechanical properties of striated muscle. Mechanistic studies using extraction and replacement of regulatory proteins
-
Moss RL (1992) Ca2+ regulation of mechanical properties of striated muscle. Mechanistic studies using extraction and replacement of regulatory proteins. Circ Res 70: 865-884.
-
(1992)
Circ Res
, vol.70
, pp. 865-884
-
-
Moss, R.L.1
-
41
-
-
0030004861
-
Thin filament-mediated regulation of cardiac contraction
-
Tobacman LS (1996) Thin filament-mediated regulation of cardiac contraction. Annu Rev Physiol 58: 447-481.
-
(1996)
Annu Rev Physiol
, vol.58
, pp. 447-481
-
-
Tobacman, L.S.1
-
42
-
-
0024399874
-
Reciprocal coupling between troponin C and myosin crossbridge attachment
-
Zot AS, Potter JD (1989) Reciprocal coupling between troponin C and myosin crossbridge attachment. Biochemistry 28: 6751-6756.
-
(1989)
Biochemistry
, vol.28
, pp. 6751-6756
-
-
Zot, A.S.1
Potter, J.D.2
-
43
-
-
0028944618
-
Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers
-
Metzger JM (1995) Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers. Biophys J 68: 1430-1442.
-
(1995)
Biophys J
, vol.68
, pp. 1430-1442
-
-
Metzger, J.M.1
-
44
-
-
0026774946
-
Influence of a strong-binding myosin analogue on calcium-sensitive mechanical properties of skinned skeletal muscle fibers
-
Swartz DR, Moss RL (1992) Influence of a strong-binding myosin analogue on calcium-sensitive mechanical properties of skinned skeletal muscle fibers. J Biol Chem 267: 20497-20506.
-
(1992)
J Biol Chem
, vol.267
, pp. 20497-20506
-
-
Swartz, D.R.1
Moss, R.L.2
-
45
-
-
0037144655
-
Myofilament calcium sensitivity and cardiac disease: Insights from troponin I isoforms and mutants
-
Westfall MV, Borton AR, Albayya FP, Metzger JM (2002) Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants. Circ Res 91: 525-531.
-
(2002)
Circ Res
, vol.91
, pp. 525-531
-
-
Westfall, M.V.1
Borton, A.R.2
Albayya, F.P.3
Metzger, J.M.4
-
46
-
-
12344276300
-
Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies
-
Coutu P, Metzger JM (2005) Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies. Am J Physiol Heart Circ Physiol 288: H601-H612.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Coutu, P.1
Metzger, J.M.2
-
47
-
-
0033612534
-
Thin filament protein dynamics in fully differentiated adult cardiac myocytes: Toward a model of sarcomere maintenance
-
Michele DE, Albayya FP, Metzger JM (1999) Thin filament protein dynamics in fully differentiated adult cardiac myocytes: toward a model of sarcomere maintenance. J Cell Biol 145: 1483-1495.
-
(1999)
J Cell Biol
, vol.145
, pp. 1483-1495
-
-
Michele, D.E.1
Albayya, F.P.2
Metzger, J.M.3
-
48
-
-
2442710177
-
Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations
-
Coutu P, Bennett CN, Favre EG, Day SM, Metzger JM (2004) Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations. Circ Res 94: 1235-1241.
-
(2004)
Circ Res
, vol.94
, pp. 1235-1241
-
-
Coutu, P.1
Bennett, C.N.2
Favre, E.G.3
Day, S.M.4
Metzger, J.M.5
-
49
-
-
0031907568
-
Stability of the contractile assembly and Ca2+-activated tension in adenovirus infected adult cardiac myocytes
-
Rust EM, Westfall MV, Metzger JM (1998) Stability of the contractile assembly and Ca2+-activated tension in adenovirus infected adult cardiac myocytes. Mol Cell Biochem 181: 143-155.
-
(1998)
Mol Cell Biochem
, vol.181
, pp. 143-155
-
-
Rust, E.M.1
Westfall, M.V.2
Metzger, J.M.3
-
50
-
-
34247585621
-
Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes
-
Herron TJ, Vandenboom R, Fomicheva E, Mundada L, Edwards T, et al. (2007) Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circ Res 100: 1182-1190.
-
(2007)
Circ Res
, vol.100
, pp. 1182-1190
-
-
Herron, T.J.1
Vandenboom, R.2
Fomicheva, E.3
Mundada, L.4
Edwards, T.5
-
51
-
-
32244445605
-
Histidine button engineered into cardiac troponin I protects the ischemic and failing heart
-
Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, et al. (2006) Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med 12: 181-189.
-
(2006)
Nat Med
, vol.12
, pp. 181-189
-
-
Day, S.M.1
Westfall, M.V.2
Fomicheva, E.V.3
Hoyer, K.4
Yasuda, S.5
-
52
-
-
43649089498
-
A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility
-
Lim CC, Yang H, Yang M, Wang CK, Shi J, et al. (2008) A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J 94: 3577-3589.
-
(2008)
Biophys J
, vol.94
, pp. 3577-3589
-
-
Lim, C.C.1
Yang, H.2
Yang, M.3
Wang, C.K.4
Shi, J.5
-
54
-
-
34249676905
-
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation
-
Biesiadecki BJ, Kobayashi T, Walker JS, John SR, de Tombe PP (2007) The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res 100: 1486-1493.
-
(2007)
Circ Res
, vol.100
, pp. 1486-1493
-
-
Biesiadecki, B.J.1
Kobayashi, T.2
Walker, J.S.3
John, S.R.4
de Tombe, P.P.5
-
55
-
-
33847116576
-
Functional effects of the DCM mutant Gly159Asp Troponin C in skinned muscle fibres
-
Preston LC, Lipscomb S, Robinson P, Mogensen J, McKenna WJ, et al. (2007) Functional effects of the DCM mutant Gly159Asp Troponin C in skinned muscle fibres. Pflugers Arch 453: 771-776.
-
(2007)
Pflugers Arch
, vol.453
, pp. 771-776
-
-
Preston, L.C.1
Lipscomb, S.2
Robinson, P.3
Mogensen, J.4
McKenna, W.J.5
-
56
-
-
0036100436
-
Modifier genes for hypertrophic cardiomyopathy
-
Marian AJ (2002) Modifier genes for hypertrophic cardiomyopathy. Curr Opin Cardiol 17: 242-252.
-
(2002)
Curr Opin Cardiol
, vol.17
, pp. 242-252
-
-
Marian, A.J.1
-
57
-
-
0035201270
-
A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy
-
Semsarian C, Healey MJ, Fatkin D, Giewat M, Duffy C, et al. (2001) A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 33: 2055-2060.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 2055-2060
-
-
Semsarian, C.1
Healey, M.J.2
Fatkin, D.3
Giewat, M.4
Duffy, C.5
-
58
-
-
0035830841
-
Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation
-
Miller T, Szczesna D, Housmans PR, Zhao J, de Freitas F, et al. (2001) Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem 276: 3743-3755.
-
(2001)
J Biol Chem
, vol.276
, pp. 3743-3755
-
-
Miller, T.1
Szczesna, D.2
Housmans, P.R.3
Zhao, J.4
de Freitas, F.5
-
59
-
-
33646203967
-
Dynamics of the C-terminal region of TnI in the troponin complex in solution
-
Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD (2006) Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J 90: 2436-2444.
-
(2006)
Biophys J
, vol.90
, pp. 2436-2444
-
-
Blumenschein, T.M.1
Stone, D.B.2
Fletterick, R.J.3
Mendelson, R.A.4
Sykes, B.D.5
-
60
-
-
27744497723
-
The role of electrostatics in the interaction of the inhibitory region of troponin I with troponin C
-
Lindhout DA, Boyko RF, Corson DC, Li MX, Sykes BD (2005) The role of electrostatics in the interaction of the inhibitory region of troponin I with troponin C. Biochemistry 44: 14750-14759.
-
(2005)
Biochemistry
, vol.44
, pp. 14750-14759
-
-
Lindhout, D.A.1
Boyko, R.F.2
Corson, D.C.3
Li, M.X.4
Sykes, B.D.5
-
61
-
-
7044286437
-
Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin
-
Hilario E, da Silva SL, Ramos CH, Bertolini MC (2004) Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin. Eur J Biochem 271: 4132-4140.
-
(2004)
Eur J Biochem
, vol.271
, pp. 4132-4140
-
-
Hilario, E.1
da Silva, S.L.2
Ramos, C.H.3
Bertolini, M.C.4
-
62
-
-
0022491789
-
Effects of partial extraction of troponin complex upon the tension-pCa relation in rabbit skeletal muscle. Further evidence that tension development involves cooperative effects within the thin filament
-
Moss RL, Allen JD, Greaser ML (1986) Effects of partial extraction of troponin complex upon the tension-pCa relation in rabbit skeletal muscle. Further evidence that tension development involves cooperative effects within the thin filament. J Gen Physiol 87: 761-774.
-
(1986)
J Gen Physiol
, vol.87
, pp. 761-774
-
-
Moss, R.L.1
Allen, J.D.2
Greaser, M.L.3
-
63
-
-
0023187156
-
Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle
-
Brandt PW, Diamond MS, Rutchik JS, Schachat FH (1987) Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle. J Mol Biol 195: 885-896.
-
(1987)
J Mol Biol
, vol.195
, pp. 885-896
-
-
Brandt, P.W.1
Diamond, M.S.2
Rutchik, J.S.3
Schachat, F.H.4
-
64
-
-
0025308077
-
Co-operative activation of skeletal muscle thin filaments by rigor crossbridges. The effect of troponin C extraction
-
Brandt PW, Roemer D, Schachat FH (1990) Co-operative activation of skeletal muscle thin filaments by rigor crossbridges. The effect of troponin C extraction. J Mol Biol 212: 473-480.
-
(1990)
J Mol Biol
, vol.212
, pp. 473-480
-
-
Brandt, P.W.1
Roemer, D.2
Schachat, F.H.3
-
65
-
-
0026020902
-
Cooperative interactions between troponin molecules bound to the cardiac thin filament
-
Mehegan JP, Tobacman LS (1991) Cooperative interactions between troponin molecules bound to the cardiac thin filament. J Biol Chem 266: 966-972.
-
(1991)
J Biol Chem
, vol.266
, pp. 966-972
-
-
Mehegan, J.P.1
Tobacman, L.S.2
-
66
-
-
0019431847
-
Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I
-
Martin AF (1981) Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I. J Biol Chem 256: 964-968.
-
(1981)
J Biol Chem
, vol.256
, pp. 964-968
-
-
Martin, A.F.1
-
67
-
-
0029031198
-
The troponin complex and regulation of muscle contraction
-
Farah CS, Reinach FC (1995) The troponin complex and regulation of muscle contraction. FASEB J 9: 755-767.
-
(1995)
FASEB J
, vol.9
, pp. 755-767
-
-
Farah, C.S.1
Reinach, F.C.2
-
68
-
-
0029920689
-
Altered interactions among thin filament proteins modulate cardiac function
-
Solaro RJ, Van Eyk J (1996) Altered interactions among thin filament proteins modulate cardiac function. J Mol Cell Cardiol 28: 217-230.
-
(1996)
J Mol Cell Cardiol
, vol.28
, pp. 217-230
-
-
Solaro, R.J.1
Van Eyk, J.2
-
69
-
-
0034599031
-
Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes
-
Westfall MV, Albayya FP, Turner II, Metzger JM (2000) Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes. Circ Res 86: 470-477.
-
(2000)
Circ Res
, vol.86
, pp. 470-477
-
-
Westfall, M.V.1
Albayya, F.P.2
Turner II, M.J.M.3
-
70
-
-
30944444021
-
Sarcomeric proteins and familial hypertrophic cardiomyopathy: Linking mutations in structural proteins to complex cardiovascular phenotypes
-
Tardiff JC (2005) Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Fail Rev 10: 237-248.
-
(2005)
Heart Fail Rev
, vol.10
, pp. 237-248
-
-
Tardiff, J.C.1
-
71
-
-
20244368785
-
An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes
-
Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, et al. (1999) An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol 276: H1780-H1787.
-
(1999)
Am J Physiol
, vol.276
-
-
Kim, S.J.1
Iizuka, K.2
Kelly, R.A.3
Geng, Y.J.4
Bishop, S.P.5
-
72
-
-
3042621438
-
Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium
-
Palmer BM, Fishbaugher DE, Schmitt JP, Wang Y, Alpert NR, et al. (2004) Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium. Am J Physiol Heart Circ Physiol 287: H91-H99.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.287
-
-
Palmer, B.M.1
Fishbaugher, D.E.2
Schmitt, J.P.3
Wang, Y.4
Alpert, N.R.5
-
73
-
-
0036117921
-
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model
-
Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, et al. (2002) The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest 109: 1013-1020.
-
(2002)
J Clin Invest
, vol.109
, pp. 1013-1020
-
-
Semsarian, C.1
Ahmad, I.2
Giewat, M.3
Georgakopoulos, D.4
Schmitt, J.P.5
-
74
-
-
0016767561
-
Correlation between the inhibition of the acto-heavy meromyosin ATPase and the binding of tropomyosin to Factin: Effects of Mg2+, KCl, troponin I, and troponin C
-
Eaton BL, Kominz DR, Eisenberg E (1975) Correlation between the inhibition of the acto-heavy meromyosin ATPase and the binding of tropomyosin to Factin: effects of Mg2+, KCl, troponin I, and troponin C. Biochemistry 14: 2718-2725.
-
(1975)
Biochemistry
, vol.14
, pp. 2718-2725
-
-
Eaton, B.L.1
Kominz, D.R.2
Eisenberg, E.3
-
75
-
-
34547605959
-
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity
-
Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, et al. (2007) Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res 101: 205-214.
-
(2007)
Circ Res
, vol.101
, pp. 205-214
-
-
Rajan, S.1
Ahmed, R.P.2
Jagatheesan, G.3
Petrashevskaya, N.4
Boivin, G.P.5
-
76
-
-
33748537975
-
Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy
-
Tsoutsman T, Chung J, Doolan A, Nguyen L, Williams IA, et al. (2006) Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 41: 623-632.
-
(2006)
J Mol Cell Cardiol
, vol.41
, pp. 623-632
-
-
Tsoutsman, T.1
Chung, J.2
Doolan, A.3
Nguyen, L.4
Williams, I.A.5
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