Per cent emphysema is associated with respiratory and lung cancer mortality in the general population: A cohort study

Thorax

Volumn 71, Issue 7, 2016, Pages 624-632

  Oelsner, Elizabeth C ^a,b   Carr, J Jeffrey ^c   Enright, Paul L ^d   Hoffman, Eric A ^e   Folsom, Aaron R ^f   Kawut, Steven M ^g   Kronmal, Richard A ^h   Lederer, David J ^a   Lima, Joao A C ⁱ   Lovasi, Gina S ^b   Smith, Benjamin M ^a,j   Shea, Steven J ^a,b   Barr, R Graham ^a,b  

^a NewYork Presbyterian Hospital   (United States)

^b Columbia University ^*  (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j MCGILL UNIVERSITY   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BODY MASS; CANCER MORTALITY; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHRONIC RESPIRATORY FAILURE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY CALCIUM SCORE; DISEASE ASSOCIATION; EDUCATIONAL STATUS; ETHNICITY; FEMALE; FOLLOW UP; HUMAN; LOWER RESPIRATORY TRACT; LUNG CANCER; LUNG EMPHYSEMA; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE STUDY; RACE DIFFERENCE; RESPIRATORY AIRFLOW; RISK FACTOR; SMOKING HABIT; SPIROMETRY; ADVERSE EFFECTS; DIAGNOSTIC IMAGING; LUNG FUNCTION TEST; LUNG TUMOR; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; PROGNOSIS; RESPIRATORY TRACT DISEASE; SMOKING; VERY ELDERLY; X-RAY COMPUTED TOMOGRAPHY;

AGED; AGED, 80 AND OVER; CAUSE OF DEATH; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; PULMONARY EMPHYSEMA; RESPIRATORY FUNCTION TESTS; RESPIRATORY TRACT DISEASES; RISK FACTORS; SMOKING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84963940281     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-207822     Document Type: Article

References (47)

1. Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395-409.
2. Zulueta JJ, Wisnivesky JP, Henschke CI, et al. Emphysema scores predict death from COPD and lung cancer. Chest 2012;141:1216-23.
3. Tsushima K, Sone S, Fujimoto K, et al. Identification of occult parenchymal disease such as emphysema or airway disease using screening computed tomography. COPD 2010;7:117-25.
4. Burt JR, Iribarren C, Fair JM, et al. Incidental findings on cardiac multidetector row computed tomography among healthy older adults: prevalence and clinical correlates. Arch Intern Med 2008;168:756-61.
5. Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet 2012;379:1341-51.
6. Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65.
7. Johannessen A, Skorge TD, Bottai M, et al. Mortality by level of emphysema and airway wall thickness. Am J Respir Crit Care Med 2013;187:602-8.
8. Regan EA, Lynch DA, Curran-Everett D, et al. Clinical and radiologic disease in smokers with normal spirometry. JAMA Intern Med 2015;175:1539-49.
9. Marsh SE, Travers J, Weatherall M, et al. Proportional classifications of COPD phenotypes. Thorax 2008;63:761-7.
10. Anderson AE Jr, Hernandez JA, Eckert P, et al. Emphysema in lung macrosections correlated with smoking habits. Science 1964;144:1025-6.
11. Sanchez-Salcedo P, Wilson DO, de-Torres JP, et al. Improving selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med 2015;191:924-31.
12. de-Torres JP, Wilson DO, Sanchez-Salcedo P, et al. Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am J Respir Crit Care Med 2015;191:285-91.
13. McWilliams A, Tammemagi MC, Mayo JR, et al. Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med 2013;369:910-19.
14. Smith BM, Pinto L, Ezer N, et al. Emphysema detected on computed tomography and risk of lung cancer: a systematic review and meta-Analysis. Lung Cancer 2012;77:58-63.
15. Centers for Disease Control. National Health and Nutrition Examination Survey Data, 2009-10. Hyattsville, MD: National Center for Health Statistics, 2001.
16. Jamal A, Homa DM, O Connor E, et al. Current cigarette smoking among adults-United States, 2005-2014. MMWR Morb Mortal Wkly Rep 2015;64:1233-40.
17. Navas-Nacher EL, Kelley MA, Birnbaum-Weitzman O, et al. Association between exposure to household cigarette smoking behavior and cigarette smoking in Hispanic adults: Findings from the Hispanic Community Health Study/Study of Latinos. Prev Med 2015;77:35-40.
18. Oelsner EC, Hoffman EA, Folsom AR, et al. Association between emphysema-like lung on cardiac computed tomography and mortality in persons without airflow obstruction: a cohort study. Ann Intern Med 2014;161:863-73.
19. Bild DE, Bluemke DA, Burke GL, et al. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871-81.
20. World Health Organization. International Classification of Diseases. 10th edn. Geneva: WHO, 2010.
21. Ford ES, Croft JB, Mannino DM, et al. COPD surveillance-United States, 1999-2011. Chest 2013;144:284-305.
22. Carr JJ, Nelson JC, Wong ND, et al. Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology 2005;234:35-43.
23. Hoffman EA, Jiang R, Baumhauer H, et al. Reproducibility and validity of lung density measures from cardiac CT Scans-The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Acad Radiol 2009;16:689-99.
24. Hoffman EA, Ahmed FS, Baumhauer H, et al. Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study. Ann Am Thorac Soc 2014;11:898-907.
25. Lederer DJ, Enright PL, Kawut SM, et al. Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study. Am J Respir Crit Care Med 2009;180:407-14.
26. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-38.
27. Detrano R, Guerci AD, Carr JJ, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 2008;358:1336-45.
28. Martinez FJ, Foster G, Curtis JL, et al. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med 2006;173:1326-34.
29. Müllerova H, Maselli DJ, Locantore N, et al. Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort. Chest 2015;147:999-1007.
30. Dawkins PA, Dowson LJ, Guest PJ, et al. Predictors of mortality in alpha1-Antitrypsin deficiency. Thorax 2003;58:1020-6.
31. Auerbach O, Hammond EC, Garfinkel L, et al. Relation of smoking and age to emphysema. Whole-lung section study. N Engl J Med 1972;286:853-7.
32. Jairam PM, van der Graaf Y, Lammers JW, et al. Incidental findings on chest CT imaging are associated with increased COPD exacerbations and mortality. Thorax 2015;70:725-31.
33. Henschke CI, Yip R, Boffetta P, et al. CT screening for lung cancer: Importance of emphysema for never smokers and smokers. Lung Cancer 2015;88:42-7.
34. Oelsner EC, Lima JA, Kawut SM, et al. Noninvasive tests for the diagnostic evaluation of dyspnea among outpatients: the Multi-Ethnic Study of Atherosclerosis lung study. Am J Med 2015;128:171-80 e175.
35. McAllister DA, Ahmed FS, Austin JH, et al. Emphysema predicts hospitalisation and incident airflow obstruction among older smokers: a prospective cohort study. PLoS ONE 2014;9:e93221.
36. Copley SJ, Wells AU, Müller NL, et al. Thin-section CT in obstructive pulmonary disease: discriminatory value. Radiology 2002;223:812-19.
37. Manichaikul A, Hoffman EA, Smolonska J, et al. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med 2014;189:408-18.
38. Saetta M, Finkelstein R, Cosio MG. Morphological and cellular basis for airflow limitation in smokers. Eur Respir J 1994;7:1505-15.
39. Beasley V, Joshi PV, Singanayagam A, et al. Lung microbiology and exacerbations in COPD. Int J COPD 2012;7:555-69.
40. Barr RG, Bluemke DA, Ahmed FS, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med 2010;362:217-27.
41. Estépar RS, Kinney GL, Black-Shinn JL, et al. Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med 2013;188:231-9.
42. Sun Z, Yang P. Role of imbalance between neutrophil elastase and alpha 1-Antitrypsin in cancer development and progression. Lancet Oncol 2004;5:182-90.
43. Barr RG, Ahmed FS, Carr JJ, et al. Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study. Eur Respir J 2012;39:846-54.
44. Sin DD, Anthonisen NR, Soriano JB, et al. Mortality in COPD: Role of comorbidities. Eur Respir J 2006;28:1245-57.
45. Hankinson JL, Kawut SM, Shahar E, et al. Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the Multi-Ethnic Study of Atherosclerosis (MESA) lung study. Chest 2010;137:138-45.
46. Jensen HH, Godtfredsen NS, Lange P, et al. Potential misclassification of causes of death from COPD. Eur Respir J 2006;28:781-5.
47. Barr RG, Herbstman J, Speizer FE, et al. Validation of self-reported chronic obstructive pulmonary disease in a cohort study of nurses. Am J Epidemiol 2002;155:965-71.