Association between emphysema-like lung on cardiac computed tomography and mortality in persons without airflow obstruction

Annals of Internal Medicine

Volumn 161, Issue 12, 2014, Pages 863-873

  Oelsner, Elizabeth C ^a   Hoffman, Eric A ^b   Folsom, Aaron R ^c   Carr, Jeffrey ^d   Enright, Paul L ^e   Kawut, Steven M ^f   Kronmal, Richard ^g   Lederer, David ^h   Lima, Joao A C ⁱ   Lovasi, Gina S ^h   Shea, Steven ^a   Barr, Graham ^a  

^a NewYork Presbyterian Hospital   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

^h Och Spine at New York Presbyterian Hospitals   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG EMPHYSEMA; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; SMOKING; SPIROMETRY; UNITED STATES; ADVERSE EFFECTS; COMPLICATION; DEVICES; HEART; LUNG; LUNG VENTILATION; LUNG VOLUME; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; RADIOGRAPHY; RISK FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; HEART; HUMANS; LUNG; LUNG VOLUME MEASUREMENTS; MALE; MIDDLE AGED; MORTALITY; PROSPECTIVE STUDIES; PULMONARY EMPHYSEMA; PULMONARY VENTILATION; RISK FACTORS; SMOKING; SPIROMETRY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84919651166     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M13-2570     Document Type: Article

References (64)

1. Miniño AM, Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2008. Natl Vital Stat Rep. 2011;59:1-126. [PMID: 22808755]
2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095-128. [PMID: 23245604] doi:10.1016/S0140-6736(12)61728-0
3. Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187:347-65. [PMID: 22878278] doi:10.1164/rccm.201204-0596PP
4. Karner C, Chong J, Poole P. Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;7:CD009285. [PMID: 22786525] doi:10.1002/14651858.CD009285.pub2
5. Chong J, Karner C, Poole P. Tiotropium versus long-acting beta-agonists for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012; 9:CD009157. [PMID: 22972134] doi:10.1002/14651858.CD009157.pub2
6. Yang IA, Clarke MS, Sim EH, Fong KM. Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;7:CD002991. [PMID: 22786484] doi:10.1002/14651858.CD002991.pub3
7. Karner C, Cates CJ. Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;4:CD008989. [PMID: 22513969] doi:10.1002/14651858.CD008989.pub2
8. Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012;379:1341-51. [PMID: 22314182] doi:10.1016/S0140-6736(11)60968-9
9. Yokohori N, Aoshiba K, Nagai A; Respiratory Failure Research Group in Japan. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest. 2004;125:626-32. [PMID: 14769747]
10. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al; National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395-409. [PMID: 21714641] doi:10.1056/NEJMoa1102873
11. U.S. Preventive Services Task Force. Screening for chronic obstructive pulmonary disease using spirometry: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;148:529-34. [PMID: 18316747] doi: 10.7326/0003-4819-148-7-200804010-00212
12. Humphrey LL, Deffebach M, Pappas M, Baumann C, Artis K, Mitchell JP, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the US Preventive Services Task Force recommendation. Ann Intern Med. 2013;159:411-20. [PMID: 23897166] doi:10.7326/0003-4819-159-6-201309170-00690
13. Anderson AE Jr, Hernandez JA, Eckert P, Foraker AG. Emphysema in lung macrosections correlated with smoking habits. Science. 1964;144:1025-6. [PMID: 14137940]
14. Zulueta JJ, Wisnivesky JP, Henschke CI, Yip R, Farooqi AO, McCauley DI, et al. Emphysema scores predict death from COPD and lung cancer. Chest. 2012;141:1216-23. [PMID: 22016483] doi:10.1378/chest.11-0101
15. Burt JR, Iribarren C, Fair JM, Norton LC, Mahbouba M, Rubin GD, et al; Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology (ADVANCE) Study. Incidental findings on cardiac multidetector row computed tomography among healthy older adults: prevalence and clinical correlates. Arch Intern Med. 2008;168:756-61. [PMID: 18413559] doi:10.1001/archinte.168.7.756
16. Johannessen A, Skorge TD, Bottai M, Grydeland TB, Nilsen RM, Coxson H, et al. Mortality by level of emphysema and airway wall thickness. Am J Respir Crit Care Med. 2013;187:602-8. [PMID: 23328525] doi:10.1164/rccm.201209-1722OC
17. Smith BM, Austin JH, Newell JD Jr, D'Souza BM, Rozenshtein A, Hoffman EA, et al. Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 2014;127:94.e7-23. [PMID: 24384106] doi: 10.1016/j.amjmed.2013.09.020
18. Tsushima K, Sone S, Fujimoto K, Kubo K, Morita S, Takegami M, et al. Identification of occult parechymal disease such as emphysema or airway disease using screening computed tomography. COPD. 2010;7:117-25. [PMID: 20397812] doi:10.3109/15412551003631717
19. Marsh SE, Travers J, Weatherall M, Williams MV, Aldington S, Shirtcliffe PM, et al. Proportional classifications of COPD phenotypes. Thorax. 2008;63:761-7. [PMID: 18728201] doi:10.1136/thx.2007.089193
20. Mannino DM, Diaz-Guzman E, Buist S. Pre- and post-bronchodilator lung function as predictors of mortality in the Lung Health Study. Respir Res. 2011;12:136. [PMID: 21991942] doi:10.1186/1465-9921-12-136
21. Mannino DM, Diaz-Guzman E. Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality. Chest. 2012;141:73-80. [PMID: 21659434] doi:10.1378/chest.11-0797
22. Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC. Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax. 2003;58:388-93. [PMID: 12728157]
23. Haruna A, Muro S, Nakano Y, Ohara T, Hoshino Y, Ogawa E, et al. CT scan findings of emphysema predict mortality in COPD. Chest. 2010;138:635-40. [PMID: 20382712] doi:10.1378/chest.09-2836
24. Martinez FJ, Foster G, Curtis JL, Criner G, Weinmann G, Fishman A, et al; NETT Research Group. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med. 2006;173:1326-34. [PMID: 16543549]
25. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871-81. [PMID: 12397006]
26. Carr JJ, Nelson JC, Wong ND, McNitt-Gray M, Arad Y, Jacobs DR Jr, et al. Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology. 2005;234:35-43. [PMID: 15618373]
27. Hoffman EA, Jiang R, Baumhauer H, Brooks MA, Carr JJ, Detrano R, et al. Reproducibility and validity of lung density measures from cardiac CT scans - The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Acad Radiol. 2009;16:689-99. [PMID: 19427979] doi:10.1016/j.acra.2008.12.024
28. Guo J, Reinhardt JM, Kitaoka H, Zhang L, Sonka M, McLennan G, et al. Integrated system for CT-based assessment of parenchymal lung disease. Proceedings of the IEEE International Symposium on Biomedical Imaging, Washington, DC, 7-10 July 2002. New York: Inst Electrical and Electronics Engineers; 2002:871-4.
29. Hoffman EA, Reinhardt JM, Sonka M, Simon BA, Guo J, Saba O, et al. Characterization of the interstitial lung diseases via density-based and texture-based analysis of computed tomography images of lung structure and function. Acad Radiol. 2003;10:1104-18. [PMID: 14587629]
30. Gevenois PA, de Maertelaer V, De Vuyst P, Zanen J, Yernault JC. Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med. 1995;152:653-7. [PMID: 7633722]
31. Lederer DJ, Enright PL, Kawut SM, Hoffman EA, Hunninghake G, van Beek EJ, et al. Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-Lung study. Am J Respir Crit Care Med. 2009;180:407-14. [PMID: 19542480] doi:10.1164/rccm.200812-1966OC
32. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005; 26:319-38. [PMID: 16055882]
33. Hankinson JL, Kawut SM, Shahar E, Smith LJ, Stukovsky KH, Barr RG. Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung study. Chest. 2010;137:138-45. [PMID: 19741060] doi: 10.1378/chest.09-0919
34. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179-87. [PMID: 9872837]
35. DeGoma EM, French B, Dunbar RL, Allison MA, Mohler ER 3rd, Budoff MJ. Intraindividual variability of C-reactive protein: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2012;224:274-9. [PMID: 22846611] doi: 10.1016/j.atherosclerosis.2012.07.017
36. Smith NL, Psaty BM, Heckbert SR, Tracy RP, Cornell ES. The reliability of medication inventory methods compared to serum levels of cardiovascular drugs in the elderly. J Clin Epidemiol. 1999;52:143-6. [PMID: 10201655]
37. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-32. [PMID: 2407762]
38. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336-45. [PMID: 18367736] doi:10.1056/NEJMoa072100
39. The R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2012.
40. Auerbach O, Hammond EC, Garfinkel L, Benante C. Relation of smoking and age to emphysema. Whole-lung section study. N Engl J Med. 1972;286: 853-7. [PMID: 5061068]
41. Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, et al American College of Cardiology Foundation. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:e50-103. [PMID: 21144964] doi:10.1016/j.jacc.2010.09.001
42. Dawkins PA, Dowson LJ, Guest PJ, Stockley RA. Predictors of mortality in alpha1-antitrypsin deficiency. Thorax. 2003;58:1020-6. [PMID: 14645964]
43. Sverzellati N, Cademartiri F, Bravi F, Martini C, Gira FA, Maffei E, et al. Relationship and prognostic value of modified coronary artery calcium score, FEV1, and emphysema in lung cancer screening population: the MILD trial. Radiology. 2012;262:460-7. [PMID: 22114241] doi:10.1148/radiol.11110364
44. Mascalchi M, Diciotti S, Sverzellati N, Camiciottoli G, Ciccotosto C, Falaschi F, et al. Low agreement of visual rating for detailed quantification of pulmonary emphysema in whole-lung CT. Acta Radiol. 2012;53:53-60. [PMID: 22114019] doi:10.1258/ar.2011.110419
45. Copley SJ, Wells AU, Müller NL, Rubens MB, Hollings NP, Cleverley JR, et al. Thin-section CT in obstructive pulmonary disease: discriminatory value. Radiology. 2002;223:812-9. [PMID: 12034954]
46. Estépar RS, Kinney GL, Black-Shinn JL, Bowler RP, Kindlmann GL, Ross JC, et al; COPDGene Study. Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med. 2013;188:231-9. [PMID: 23656466] doi:10.1164/rccm.201301-0162OC
47. Hamid Q, Shannon J, Martin J. Physiologic Basis of Respiratory Disease. Hamilton, Ontario, Canada: BC Decker; 2005.
48. Saetta M, Finkelstein R, Cosio MG. Morphological and cellular basis for airflow limitation in smokers. Eur Respir J. 1994;7:1505-15. [PMID: 7957838]
49. Martin C, Frija J, Burgel PR. Dysfunctional lung anatomy and small airways degeneration in COPD. Int J Chron Obstruct Pulmon Dis. 2013;8:7-13. [PMID: 23319856] doi:10.2147/COPD.S28290
50. McAllister DA, Ahmed FS, Austin JH, Henschke CI, Keller BM, Lemeshow A, et al. Emphysema predicts hospitalisation and incident airflow obstruction among older smokers: a prospective cohort study. PLoS One. 2014;9:e93221. [PMID: 24699215] doi:10.1371/journal.pone.0093221
51. Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia P. Lung microbiology and exacerbations in COPD. Int J Chron Obstruct Pulmon Dis. 2012;7:555-69. [PMID: 22969296] doi:10.2147/COPD.S28286
52. Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010;362:217-27. [PMID: 20089972] doi:10.1056/NEJMoa0808836
53. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 2009;360:2445-54. [PMID: 19494220] doi: 10.1056/NEJMra0804752
54. D'Anna SE, Asnaghi R, Caramori G, Appendini L, Rizzo M, Cavallaro C, et al. High-resolution computed tomography quantitation of emphysema is correlated with selected lung function values in stable COPD. Respiration. 2012;83:383-90. [PMID: 21832824] doi:10.1159/000329871
55. Powell R, Davidson D, Divers J, Manichaikul A, Carr JJ, Detrano R, et al. Genetic ancestry and the relationship of cigarette smoking to lung function and percent emphysema in four race/ethnic groups: a cross-sectional study. Thorax. 2013;68:634-42. [PMID: 23585509] doi:10.1136/thoraxjnl-2012-202116
56. Dransfield MT, Washko GR, Foreman MG, Estepar RS, Reilly J, Bailey WC. Gender differences in the severity of CT emphysema in COPD. Chest. 2007;132:464-70. [PMID: 17573503]
57. Camp PG, Coxson HO, Levy RD, Pillai SG, Anderson W, Vestbo J, et al. Sex differences in emphysema and airway disease in smokers. Chest. 2009;136:1480-8. [PMID: 19617404] doi:10.1378/chest.09-0676
58. Ashraf H, Lo P, Shaker SB, de Bruijne M, Dirksen A, Tonnesen P, et al. Short-term effect of changes in smoking behaviour on emphysema quantification by CT. Thorax. 2011;66:55-60. [PMID: 20978026] doi:10.1136/thx.2009.132688
59. Tilert T, Dillon C, Paulose-Ram R, Hnizdo E, Doney B. Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and postbronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Respir Res. 2013;14:103. [PMID: 24107140] doi: 10.1186/1465-9921-14-103
60. Dirksen A, MacNee W. The search for distinct and clinically useful phenotypes in chronic obstructive pulmonary disease [Editorial]. Am J Respir Crit Care Med. 2013;188:1045-6. [PMID: 24180437] doi:10.1164/rccm.201309-1649ED
61. Castaldi PJ, San José Estépar R, Mendoza CS, Hersh CP, Laird N, Crapo JD, et al. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med. 2013;188:1083-90. [PMID: 23980521] doi:10.1164/rccm.201305-0873OC
62. Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, et al. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014;189:408-18. [PMID: 24383474] doi:10.1164/rccm.201306-1061OC
63. Newell JD Jr, Sieren J, Hoffman EA. Development of quantitative computed tomography lung protocols. J Thorac Imaging. 2013;28:266-71. [PMID: 23934142] doi:10.1097/RTI.0b013e31829f6796
64. Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350: 1005-12. [PMID: 14999112]