Anti-cancer effect of luminacin, a marine microbial extract, in head and neck squamous cell carcinoma progression via autophagic cell death

Cancer Research and Treatment

Volumn 48, Issue 2, 2016, Pages 738-752

  Shin, Yoo Seob ^a   Cha, Hyun Young ^a   Lee, Bok Soon ^a   Kang, Sung Un ^a   Hwang, Hye Sook ^a   Kwon, Hak Cheol ^b   Kim, Chul Ho ^a   Choi, Eun Chang ^c  

^a Ajou University School of Medicine   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Autophagy; Cytotoxicity; Head and neck neoplasms; Luminacin; Streptomyces

Indexed keywords

ANTINEOPLASTIC AGENT; LUMINACIN; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; UNCLASSIFIED DRUG; BENZALDEHYDE DERIVATIVE; CELL EXTRACT; LUMINACIN D; SPIRO COMPOUND;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS ASSAY; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CANCER GROWTH; CELL DEATH; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXIC CONCENTRATION; CYTOTOXICITY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; NONHUMAN; SIGNAL TRANSDUCTION; STREPTOMYCES; TOXICITY TESTING; TUMOR INVASION; WOUND HEALING; ZEBRA FISH; ANIMAL; CELL MOTION; CYTOLOGY; DISEASE EXACERBATION; DRUG EFFECTS; EMBRYOLOGY; HEAD AND NECK TUMOR; PATHOLOGY; PREVENTION AND CONTROL; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; BENZALDEHYDES; CARCINOMA, SQUAMOUS CELL; CELL EXTRACTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DISEASE PROGRESSION; HEAD AND NECK NEOPLASMS; HUMANS; KERATINOCYTES; NEOPLASM INVASIVENESS; SPIRO COMPOUNDS; ZEBRAFISH;

EID: 84963831435     PISSN: 15982998     EISSN: 20059256     Source Type: Journal    
DOI: 10.4143/crt.2015.102     Document Type: Article

References (25)

1. Jung KW, Won YJ, Kong HJ, Oh CM, Lee DH, Lee JS. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2011. Cancer Res Treat. 2014;46:109-23
2. Takes RP, Rinaldo A, Silver CE, Haigentz M Jr, Woolgar JA, Triantafyllou A, et al. Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol. 2012;48:775-9
3. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012; 75:311-35
4. Gerwick WH, Moore BS. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol. 2012;19:85-98
5. Shin HA, Shin YS, Kang SU, Kim JH, Oh YT, Park KH, et al. Radioprotective effect of epicatechin in cultured human fibroblasts and zebrafish. J Radiat Res. 2014;55:32-40
6. Lee BS, Kang S, Kim KA, Song YJ, Cheong KH, Cha HY, et al. Met degradation by SAIT301, a Met monoclonal antibody, reduces the invasion and migration of nasopharyngeal cancer cells via inhibition of EGR-1 expression. Cell Death Dis. 2014; 5:e1159
7. Thomas TR, Kavlekar DP, LokaBharathi PA. Marine drugs from sponge-microbe association: a review. Mar Drugs. 2010;8: 1417-68
8. Proksch P, Edrada RA, Ebel R. Drugs from the seas: current status and microbiological implications. Appl Microbiol Biotechnol. 2002;59:125-34
9. Taylor MW, Radax R, Steger D, Wagner M. Sponge-associated microorganisms: evolution, ecology, and biotechnological potential. Microbiol Mol Biol Rev. 2007;71:295-347
10. Wang G. Diversity and biotechnological potential of the sponge-associated microbial consortia. J Ind Microbiol Biotechnol. 2006;33:545-51
11. Naruse N, Kageyama-Kawase R, Funahashi Y, Wakabayashi T. Luminacins: a family of capillary tube formation inhibitors from Streptomyces sp. I. Taxomony, fermentation, isolation, physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 2000;53:579-90
12. Wakabayashi T, Kageyama-Kawase R, Naruse N, Funahashi Y, Yoshimatsu K. Luminacins: a family of capillary tube formation inhibitors from Streptomyces sp. II. Biological activities. J Antibiot (Tokyo). 2000;53:591-6
13. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002;417:141-7
14. Atatreh N, Barraclough J, Welman A, Cawthorne C, Bryce RA, Dive C, et al. Difluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells. J Enzyme Inhib Med Chem. 2007;22:638-46
15. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23:2891-906
16. Li X, Wu D, Shen J, Zhou M, Lu Y. Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl-2 and Bax. Oncol Lett. 2013;5:167-72
17. Ding ZB, Hui B, Shi YH, Zhou J, Peng YF, Gu CY, et al. Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation. Clin Cancer Res. 2011;17:6229-38
18. Shi Y, Tang B, Yu PW, Tang B, Hao YX, Lei X, et al. Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS One. 2012;7:e51076
19. Sishi BJ, Loos B, van Rooyen J, Engelbrecht AM. Autophagy upregulation promotes survival and attenuates doxorubicininduced cardiotoxicity. Biochem Pharmacol. 2013;85:124-34
20. Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, et al. Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy. 2008;4:457-66
21. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005;4:988-1004
22. Lin C, Tsai SC, Tseng MT, Peng SF, Kuo SC, Lin MW, et al. AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells. Int J Oncol. 2013;42:993-1000
23. Zhou H, Shen T, Shang C, Luo Y, Liu L, Yan J, et al. Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway. Oncotarget. 2014;5: 10140-50
24. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000;103:239-52
25. Zhao Z, Han F, Yang S, Wu J, Zhan W. Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the AktmTOR signaling pathway. Cancer Lett. 2015;358:17-26