Long non-coding RNA HOTTIP promotes tumor growth and inhibits cell apoptosis in lung cancer

Cellular and Molecular Biology

Volumn 61, Issue 4, 2015, Pages 34-40

  Deng, H P ^a   Chen, L ^a   Fan, T ^a   Zhang, B ^a   Xu, Y ^a   Geng, Qing ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Cell cycle; LncRNA HOTTIP; Lung cancer; Tumor growth; apoptosis

Indexed keywords

CASPASE 3; CDC25C PROTEIN; CYCLIN B1; CYCLIN D1; CYCLINE; HOTTIP LONG NON-CODING RNA; LONG UNTRANSLATED RNA; PROTEIN; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG; CCNB1 PROTEIN, HUMAN; CCND1 PROTEIN, HUMAN; CDC25C PROTEIN, HUMAN; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; APOPTOSIS; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; CYCLIN D1; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84963676474     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2015.61.4.6     Document Type: Article

References (26)

1. Wen, X.P., Ma, H.L., Zhao, L.Y., Zhang, W., Dang, C.X. Mir-3a suppresses non-small cell lung cancer progression through AKT signaling pathway by targeting IGF1R. Cell Mol Biol (Noisy-le-grand), 2015, 61: 78-85.
2. Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D. Global cancer statistics. CA Cancer J Clin, 2011, 61:69-90. doi: 10.3322/caac.20107
3. Devesa, S.S., Bray, F., Vizcaino, A.P., Parkin, D.M. International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer, 2005, 117:294-299, doi: 10.1002/ijc.21183
4. Moldvay, J., Rokszin, G., Abonyi-Toth, Z., Katona, L., Fabian, K., Kovacs, G. Lung cancer drug therapy in Hungary-3-year experience. Onco Targets Ther, 2015, 8:1031-1038, doi: 10.2147/OTT.S65794
5. Hsu, T.I., Wang, M.C., Chen, S.Y., Yeh, Y.M., Su, W.C., Chang, W.C. et al. Sp1 expression regulates lung tumor progression. Oncogene, 2012, 31:3973-3988, doi:10.1038/onc.2011.568
6. Li, L., Gao, P., Li, Y., Shen, Y., Xie, J., Sun, D. et al. JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3. Breast Cancer Res Treat, 2013, 147:487-500, doi: 10.1007/s10549-014-3083-7
7. Flynn, R.A., Chang, H.Y. Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell, 2014, 14: 752-761, doi: http://dx.doi.org/10.1016/j.stem.2014.05.014
8. Rinn, J.L., Chang, H.Y. Genome regulation by long noncoding RNAs. Annu Rev Biochem, 2012, 81:145-166, doi: 10.1146/annurev-biochem-051410-092902
9. Wang, K.C., Chang, H.Y. Molecular mechanisms of long noncoding RNAs. Mol Cell, 2011, 43:904-914, doi: http://dx.doi.org/10.1016/j.molcel.2011.08.018
10. Gupta, R.A., Shah, N., Wang, K.C., Kim, J., Horlings, H.M., Wong, D.J. et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature, 2010, 464:1071-1076, doi:10.1038/nature08975
11. Tsai, M.C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J.K., Lan, F. et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science, 2010, 329:689-693, doi: 10.1126/science.1192002
12. Rinn, J.L., Kertesz, M., Wang, J.K., Squazzo, S.L., Xu, X., Brugmann, S.A. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell, 2007, 129:1311-1323, doi:10.1016/j.cell.2007.05.022
13. Yang, Z., Zhou, L., Wu, L.M., Lai, M.C., Xie, H.Y., Zhang, F. et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol, 2010, 18:1243-1250, doi: 10.1245/s10434-011-1581-y
14. Svoboda, M., Slyskova, J., Schneiderova, M., Makovicky, P., Bielik, L., Levy, M. et al. HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis, 2014, 35:1510-1515, doi: 10.1093/carcin/bgu055
15. Kogo, R., Shimamura, T., Mimori, K., Kawahara, K., Imoto, S., Sudo, T. et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res,2011, 71:6320-6326, doi: 10.1158/0008-5472.CAN-11-1021
16. Kim, K., Jutooru, I., Chadalapaka, G., Johnson, G., Frank, J., Burghardt, R. et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene, 2013, 32:1616-1625, doi:10.1038/onc.2012.193
17. Li, X., Wu, Z., Mei, Q., Li, X., Guo, M., Fu, X. et al. Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer, 2013, 109:2266-2278, doi: 10.1038/bjc.2013.548
18. Wang, K.C., Yang, Y.W., Liu, B., Sanyal, A., Corces-Zimmerman, R., Chen, Y. et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature, 2011, 472:120-124, doi:10.1038/nature09819
19. Quagliata, L., Matter, M.S., Piscuoglio, S., Arabi, L., Ruiz, C., Procino, A. et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology, 2014, 59:911-923, doi: 10.1002/hep.26740
20. Li, Z., Zhao, X., Zhou, Y., Liu, Y., Zhou, Q., Ye, H. et al. The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. J Transl Med, 2015, 13:84, doi:10.1186/s12967-015-0442-z
21. Cheng, Y., Jutooru, I., Chadalapaka, G., Corton, J.C., Safe, S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget, 2015, 6:10840-10850.
22. Li, L.L., Xue, A.M., Li, B.X., Shen, Y.W., Li, Y.H., Luo, C.L. et al. JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI. Breast Cancer Res, 2014, 16: R56, doi: 10.1186/bcr3667
23. Morgensztern, D., Ng, S.H., Gao, F., Govindan, R. Trends in stage distribution for patients with non-small cell lung cancer: a National Cancer Database survey. J Thorac Oncol, 2010, 5: 29-33, doi: 10.1097/JTO.0b013e3181c5920c
24. Masuda, Y., Itoh, T., Shin, W., Kato, K. SnO2 Nanosheet/Nanoparticle Detector for the Sensing of 1-Nonanal Gas Produced by Lung Cancer. Sci Rep, 2015, 5:10122, doi:10.1038/srep10122
25. Singh, S.V., Herman-Antosiewicz, A., Singh, A.V., Lew, K.L., Srivastava, S.K., Kamath, R. et al. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem, 2004, 279:25813-25822
26. Li, Y.Y., Popivanova, B.K., Nagai, Y., Ishikura, H., Fujii, C., Mukaida, N. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res, 2006, 66:6741-6747