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Volumn 48, Issue 5, 2016, Pages 500-509

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(51)  Fujimoto, Akihiro a   Furuta, Mayuko a   Totoki, Yasushi b   Tsunoda, Tatsuhiko a,c,d   Kato, Mamoru b,d   Shiraishi, Yuichi e   Tanaka, Hiroko e   Taniguchi, Hiroaki a   Kawakami, Yoshiiku f   Ueno, Masaki g   Gotoh, Kunihito h   Ariizumi, Shun Ichi i   Wardell, Christopher P a   Hayami, Shinya g   Nakamura, Toru j   Aikata, Hiroshi f   Arihiro, Koji f   Boroevich, Keith A a   Abe, Tetsuo a   Nakano, Kaoru a   more..


Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ASH1L PROTEIN; CCND1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MACROD2 PROTEIN; MALAT1 PROTEIN; NCOR1 PROTEIN; NEAT1 PROTEIN; PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR CTCF; UNCLASSIFIED DRUG; DNA; TUMOR PROTEIN;

EID: 84963588792     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3547     Document Type: Article
Times cited : (580)

References (63)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag H.B, & Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 132, 2557-2576 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 80052271807 scopus 로고    scopus 로고
    • Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
    • Li M, et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat. Genet. 43, 828-829 (2011).
    • (2011) Nat. Genet , vol.43 , pp. 828-829
    • Li, M.1
  • 3
    • 85027927831 scopus 로고    scopus 로고
    • High-resolution characterization of a hepatocellular carcinoma genome
    • Totoki Y, et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat. Genet. 43, 464-469 (2011).
    • (2011) Nat. Genet , vol.43 , pp. 464-469
    • Totoki, Y.1
  • 4
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto A, et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat. Genet. 44, 760-764 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 760-764
    • Fujimoto, A.1
  • 5
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard C, et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 44, 694-698 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 694-698
    • Guichard, C.1
  • 6
    • 84883718528 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
    • Kan Z, et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 23, 1422-1433 (2013).
    • (2013) Genome Res , vol.23 , pp. 1422-1433
    • Kan, Z.1
  • 7
    • 84922551107 scopus 로고    scopus 로고
    • Trans-Ancestry mutational landscape of hepatocellular carcinoma genomes
    • Totoki Y, et al. Trans-Ancestry mutational landscape of hepatocellular carcinoma genomes. Nat. Genet. 46, 1267-1273 (2014).
    • (2014) Nat. Genet , vol.46 , pp. 1267-1273
    • Totoki, Y.1
  • 8
    • 84866868120 scopus 로고    scopus 로고
    • Exome sequencing of hepatitis B virus-Associated hepatocellular carcinoma
    • Huang J, et al. Exome sequencing of hepatitis B virus-Associated hepatocellular carcinoma. Nat. Genet. 44, 1117-1121 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 1117-1121
    • Huang, J.1
  • 9
    • 84862999344 scopus 로고    scopus 로고
    • Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
    • Sung W.K, et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat. Genet. 44, 765-769 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 765-769
    • Sung, W.K.1
  • 10
    • 84859553856 scopus 로고    scopus 로고
    • The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
    • Jiang Z, et al. The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res. 22, 593-601 (2012).
    • (2012) Genome Res , vol.22 , pp. 593-601
    • Jiang, Z.1
  • 11
    • 84964313795 scopus 로고    scopus 로고
    • Diverse modes of genomic alteration in hepatocellular carcinoma
    • Jhunjhunwala S, et al. Diverse modes of genomic alteration in hepatocellular carcinoma. Genome Biol. 15, 436 (2014).
    • (2014) Genome Biol , vol.15 , pp. 436
    • Jhunjhunwala, S.1
  • 12
    • 84929129284 scopus 로고    scopus 로고
    • Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
    • Schulze K, et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat. Genet. 47, 505-511 (2015).
    • (2015) Nat. Genet , vol.47 , pp. 505-511
    • Schulze, K.1
  • 13
    • 84908894973 scopus 로고    scopus 로고
    • Genome-wide analysis of noncoding regulatory mutations in cancer
    • Weinhold N, Jacobsen A, Schultz N, Sander C, & Lee W. Genome-wide analysis of noncoding regulatory mutations in cancer. Nat. Genet. 46, 1160-1165 (2014).
    • (2014) Nat. Genet , vol.46 , pp. 1160-1165
    • Weinhold, N.1    Jacobsen, A.2    Schultz, N.3    Sander, C.4    Lee, W.5
  • 14
    • 84881436148 scopus 로고    scopus 로고
    • High frequency of telomerase reverse-Transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    • Nault J.C, et al. High frequency of telomerase reverse-Transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat. Commun. 4, 2218 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 2218
    • Nault, J.C.1
  • 15
    • 84938132350 scopus 로고    scopus 로고
    • Comprehensive genomic profiles of small cell lung cancer
    • George J, et al. Comprehensive genomic profiles of small cell lung cancer. Nature. 524, 47-53 (2015).
    • (2015) Nature , vol.524 , pp. 47-53
    • George, J.1
  • 16
    • 84924056345 scopus 로고    scopus 로고
    • Whole genomes redefine the mutational landscape of pancreatic cancer
    • Waddell N, et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature. 518, 495-501 (2015).
    • (2015) Nature , vol.518 , pp. 495-501
    • Waddell, N.1
  • 17
    • 84904816744 scopus 로고    scopus 로고
    • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
    • Northcott P.A, et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 511, 428-434 (2014).
    • (2014) Nature , vol.511 , pp. 428-434
    • Northcott, P.A.1
  • 18
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens P.J, et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 144, 27-40 (2011).
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1
  • 19
    • 84943272498 scopus 로고    scopus 로고
    • Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
    • Fujimoto A, et al. Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. Nat. Commun. 6, 6120 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 6120
    • Fujimoto, A.1
  • 20
    • 84873441292 scopus 로고    scopus 로고
    • Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
    • Tomasetti C, Vogelstein B, & Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc. Natl. Acad. Sci. USA. 110, 1999-2004 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 1999-2004
    • Tomasetti, C.1    Vogelstein, B.2    Parmigiani, G.3
  • 21
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
  • 22
    • 84866067741 scopus 로고    scopus 로고
    • DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes
    • Woo Y.H, & Li W.H. DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes. Nat. Commun. 3, 1004 (2012).
    • (2012) Nat. Commun , vol.3 , pp. 1004
    • Woo, Y.H.1    Li, W.H.2
  • 23
    • 84923358817 scopus 로고    scopus 로고
    • Cell-of-origin chromatin organization shapes the mutational landscape of cancer
    • Polak P, et al. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 518, 360-364 (2015).
    • (2015) Nature , vol.518 , pp. 360-364
    • Polak, P.1
  • 24
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov L.B, et al. Signatures of mutational processes in human cancer. Nature. 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 25
    • 0348047592 scopus 로고    scopus 로고
    • Classifying hepatitis B virus genotypes
    • Miyakawa Y, & Mizokami M. Classifying hepatitis B virus genotypes. Intervirology. 46, 329-338 (2003).
    • (2003) Intervirology , vol.46 , pp. 329-338
    • Miyakawa, Y.1    Mizokami, M.2
  • 26
    • 3342946559 scopus 로고    scopus 로고
    • Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration
    • Bill C.A, & Summers J. Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc. Natl. Acad. Sci. USA. 101, 11135-11140 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11135-11140
    • Bill, C.A.1    Summers, J.2
  • 27
    • 84942905508 scopus 로고    scopus 로고
    • Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
    • Nault J.C, et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat. Genet. 47, 1187-1193 (2015).
    • (2015) Nat. Genet , vol.47 , pp. 1187-1193
    • Nault, J.C.1
  • 28
    • 79953056443 scopus 로고    scopus 로고
    • The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
    • Ceol C.J, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471, 513-517 (2011).
    • (2011) Nature , vol.471 , pp. 513-517
    • Ceol, C.J.1
  • 29
    • 84866002800 scopus 로고    scopus 로고
    • Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism
    • Liu Q, et al. Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proc. Natl. Acad. Sci. USA. 109, 14568-14573 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 14568-14573
    • Liu, Q.1
  • 30
    • 76249102739 scopus 로고    scopus 로고
    • Organogenesis and development of the liver
    • Si-Tayeb K, Lemaigre F.P, & Duncan S.A. Organogenesis and development of the liver. Dev. Cell. 18, 175-189 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 175-189
    • Si-Tayeb, K.1    Lemaigre, F.P.2    Duncan, S.A.3
  • 31
    • 84865760395 scopus 로고    scopus 로고
    • Gencode: The reference human genome annotation for the encode project
    • Harrow J, et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 22, 1760-1774 (2012).
    • (2012) Genome Res , vol.22 , pp. 1760-1774
    • Harrow, J.1
  • 32
    • 84880677334 scopus 로고    scopus 로고
    • Stat5 outcompetes stat3 to regulate the expression of the oncogenic transcriptional modulator bcl6
    • Walker S.R, et al. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol. Cell. Biol. 33, 2879-2890 (2013).
    • (2013) Mol. Cell. Biol , vol.33 , pp. 2879-2890
    • Walker, S.R.1
  • 33
    • 34248664108 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma
    • Wong C.M, et al. Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. Hepatology. 45, 1129-1138 (2007).
    • (2007) Hepatology , vol.45 , pp. 1129-1138
    • Wong, C.M.1
  • 34
    • 84874941057 scopus 로고    scopus 로고
    • Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer
    • Xu C, et al. Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer. BMC Cancer. 13, 118 (2013).
    • (2013) BMC Cancer , vol.13 , pp. 118
    • Xu, C.1
  • 35
    • 84891800602 scopus 로고    scopus 로고
    • Neat1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
    • Hirose T, et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol. Biol. Cell. 25, 169-183 (2014).
    • (2014) Mol. Biol. Cell , vol.25 , pp. 169-183
    • Hirose, T.1
  • 36
    • 84944453326 scopus 로고    scopus 로고
    • NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer
    • Li Y, et al. NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer. Oncotarget. 6, 27641-27650 (2015).
    • (2015) Oncotarget , vol.6 , pp. 27641-27650
    • Li, Y.1
  • 37
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA
    • Jopling C.L, Yi M, Lancaster A.M, Lemon S.M, & Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science. 309, 1577-1581 (2005).
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 38
    • 66149114383 scopus 로고    scopus 로고
    • MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
    • Tsai W.C, et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology. 49, 1571-1582 (2009).
    • (2009) Hepatology , vol.49 , pp. 1571-1582
    • Tsai, W.C.1
  • 39
    • 84913537605 scopus 로고    scopus 로고
    • Genome-wide map of regulatory interactions in the human genome
    • Heidari N, et al. Genome-wide map of regulatory interactions in the human genome. Genome Res. 24, 1905-1917 (2014).
    • (2014) Genome Res , vol.24 , pp. 1905-1917
    • Heidari, N.1
  • 40
    • 83255189766 scopus 로고    scopus 로고
    • DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes
    • De S, & Michor F. DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes. Nat. Biotechnol. 29, 1103-1108 (2011).
    • (2011) Nat. Biotechnol , vol.29 , pp. 1103-1108
    • De, S.1    Michor, F.2
  • 41
    • 84861541343 scopus 로고    scopus 로고
    • Mutational processes molding the genomes of 21 breast cancers
    • Nik-Zainal S, et al. Mutational processes molding the genomes of 21 breast cancers. Cell. 149, 979-993 (2012).
    • (2012) Cell , vol.149 , pp. 979-993
    • Nik-Zainal, S.1
  • 42
    • 84880753657 scopus 로고    scopus 로고
    • Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer
    • Ni S, et al. Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer. Cancer Sci. 104, 817-825 (2013).
    • (2013) Cancer Sci , vol.104 , pp. 817-825
    • Ni, S.1
  • 43
    • 84896893831 scopus 로고    scopus 로고
    • Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer
    • Pitkänen E, et al. Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer. Oncotarget. 5, 853-859 (2014).
    • (2014) Oncotarget , vol.5 , pp. 853-859
    • Pitkänen, E.1
  • 44
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 45
    • 77249123407 scopus 로고    scopus 로고
    • Signatures of mutation and selection in the cancer genome
    • Bignell G.R, et al. Signatures of mutation and selection in the cancer genome. Nature. 463, 893-898 (2010).
    • (2010) Nature , vol.463 , pp. 893-898
    • Bignell, G.R.1
  • 46
    • 84876186940 scopus 로고    scopus 로고
    • A family of macrodomain proteins reverses cellular mono-ADP-ribosylation
    • Jankevicius G, et al. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat. Struct. Mol. Biol. 20, 508-514 (2013).
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 508-514
    • Jankevicius, G.1
  • 47
    • 0344405718 scopus 로고    scopus 로고
    • Purification and functional characterization of the human n-cor complex: The roles of hdac3 tbl1 and tblr1
    • Yoon H.G, et al. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 22, 1336-1346 (2003).
    • (2003) EMBO J. , vol.22 , pp. 1336-1346
    • Yoon, H.G.1
  • 48
    • 84872506987 scopus 로고    scopus 로고
    • Phenotypic impact of genomic structural variation: Insights from and for human disease
    • Weischenfeldt J, Symmons O, Spitz F, & Korbel J.O. Phenotypic impact of genomic structural variation: insights from and for human disease. Nat. Rev. Genet. 14, 125-138 (2013).
    • (2013) Nat. Rev. Genet , vol.14 , pp. 125-138
    • Weischenfeldt, J.1    Symmons, O.2    Spitz, F.3    Korbel, J.O.4
  • 49
    • 4644256597 scopus 로고    scopus 로고
    • Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers
    • Kaneda A, et al. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res. 64, 6410-6415 (2004).
    • (2004) Cancer Res , vol.64 , pp. 6410-6415
    • Kaneda, A.1
  • 51
    • 0242582958 scopus 로고    scopus 로고
    • Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA
    • Song S, Wheeler L.J, & Mathews C.K. Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA. J. Biol. Chem. 278, 43893-43896 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 43893-43896
    • Song, S.1    Wheeler, L.J.2    Mathews, C.K.3
  • 52
    • 84944275594 scopus 로고    scopus 로고
    • Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer
    • Guo T, Chen T, Gu C, Li B, & Xu C. Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer. Tumour Biol. 36, 7649-7658 (2015).
    • (2015) Tumour Biol , vol.36 , pp. 7649-7658
    • Guo, T.1    Chen, T.2    Gu, C.3    Li, B.4    Xu, C.5
  • 53
    • 84923284989 scopus 로고    scopus 로고
    • The oestrogen receptor a-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
    • Chakravarty D, et al. The oestrogen receptor a-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat. Commun. 5, 5383 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 5383
    • Chakravarty, D.1
  • 54
    • 84939778620 scopus 로고    scopus 로고
    • Tumor hypoxia induces nuclear paraspeckle formation through HIF-2a dependent transcriptional activation of NEAT1 leading to cancer cell survival
    • Choudhry H, et al. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2a dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 34, 4482-4490 (2015).
    • (2015) Oncogene , vol.34 , pp. 4482-4490
    • Choudhry, H.1
  • 55
    • 84929466810 scopus 로고    scopus 로고
    • SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies
    • Kawaguchi T, et al. SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. Proc. Natl. Acad. Sci. USA. 112, 4304-4309 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 4304-4309
    • Kawaguchi, T.1
  • 56
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • International Cancer Genome Consortium
    • International Cancer Genome Consortium. International network of cancer genome projects. Nature. 464, 993-998 (2010).
    • (2010) Nature , vol.464 , pp. 993-998
  • 57
    • 84867164956 scopus 로고    scopus 로고
    • Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
    • Ha G, et al. Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer. Genome Res. 22, 1995-2007 (2012).
    • (2012) Genome Res , vol.22 , pp. 1995-2007
    • Ha, G.1
  • 58
    • 84919686143 scopus 로고    scopus 로고
    • Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers
    • Shiraishi Y, et al. Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PLoS One 9, e114263 (2014).
    • (2014) PLoS One , vol.9 , pp. e114263
    • Shiraishi, Y.1
  • 59
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, & Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B. 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. B. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 60
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang W, Sherman B.T, & Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13 (2009).
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 61
    • 75249087100 scopus 로고    scopus 로고
    • Edger: A Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson M.D, McCarthy D.J, & Smyth G.K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26, 139-140 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 63
    • 76749134818 scopus 로고    scopus 로고
    • Associating genes and protein complexes with disease via network propagation
    • Vanunu O, Magger O, Ruppin E, Shlomi T, & Sharan R. Associating genes and protein complexes with disease via network propagation. PLoS Comput. Biol. 6, e1000641 (2010).
    • (2010) PLoS Comput. Biol , vol.6 , pp. e1000641
    • Vanunu, O.1    Magger, O.2    Ruppin, E.3    Shlomi, T.4    Sharan, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.