Regulated protein depletion by the auxin-inducible degradation system in Drosophila melanogaster

Fly

Volumn 10, Issue 1, 2016, Pages 35-46

  Trost, Martina ^a   Blattner, Ariane C ^a   Lehner, Christian F ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Auxin; Auxin dependent degron; Auxin inducible degradation; IAA17; Inducible degradation; Protein degradation; Protein depletion; Roughex; TIR1

Indexed keywords

F BOX PROTEIN; INDOLEACETIC ACID DERIVATIVE; UBIQUITIN PROTEIN LIGASE;

ANIMAL; DROSOPHILA MELANOGASTER; GROWTH, DEVELOPMENT AND AGING; IMAGINAL DISC; METABOLISM; PROCEDURES; PROTEIN DEGRADATION; PROTEOMICS; WING;

ANIMALS; DROSOPHILA MELANOGASTER; F-BOX PROTEINS; IMAGINAL DISCS; INDOLEACETIC ACIDS; PROTEOLYSIS; PROTEOMICS; UBIQUITIN-PROTEIN LIGASES; WINGS, ANIMAL;

EID: 84963555248     PISSN: 19336934     EISSN: 19336942     Source Type: Journal    
DOI: 10.1080/19336934.2016.1168552     Document Type: Article

References (38)

1. M.T.Kanemaki. Frontiers of protein expression control with conditional degrons. Pflugers Arch 2013; 465:419-25; PMID:23271452; http://dx.doi.org/10.1007/s00424-012-1203-y
2. A.Pauli, F.Althoff, R.A.Oliveira, S.Heidmann, O.Schuldiner, C.F.Lehner, B.J.Dickson, K.Nasmyth. Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons. Dev Cell 2008; 14:239-51; PMID:18267092; http://dx.doi.org/10.1016/j.devcel.2007.12.009
3. C.Taxis, M.Knop. TIPI: TEV protease-mediated induction of protein instability. Methods Mol Biol 2012; 832:611-26; PMID:22350916; http://dx.doi.org/10.1007/978-1-61779-474-2_43
4. A.Varshavsky. The N-end rule pathway and regulation by proteolysis. Protein science: a publication of the Protein Society 2011; 20:1298-345; PMID:21633985; http://dx.doi.org/10.1002/pro.666
5. R.J.Dohmen, P.Wu, A.Varshavsky. Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science 1994; 263:1273-6; PMID:8122109; http://dx.doi.org/10.1126/science.8122109
6. S.D.Speese, N.Trotta, C.K.Rodesch, B.Aravamudan, K.Broadie. The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Curr Biol 2003; 13:899-910; PMID:12781128; http://dx.doi.org/10.1016/S0960-9822(03)00338-5
7. S.C.Nicholson, B.N.Nicolay, M.V.Frolov, K.H.Moberg. Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development 2011; 138:251-60; PMID:21148181; http://dx.doi.org/10.1242/dev.054429
8. E.Caussinus, O.Kanca, M.Affolter. Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nat Struct Mol Biol 2011; 19:117-21; PMID:22157958; http://dx.doi.org/10.1038/nsmb.2180
9. N.Raychaudhuri, R.Dubruille, G.A.Orsi, H.C.Bagheri, B.Loppin, C.F.Lehner. Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm. PLoS Biol 2013; 10:e1001434; PMID:NOT_FOUND; http://dx.doi.org/10.1371/journal.pbio.1001434
10. E.Urban, S.Nagarkar-Jaiswal, C.F.Lehner, S.K.Heidmann. The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis. PLoS Genet 2014; 10:e1004540; PMID:25101996; http://dx.doi.org/10.1371/journal.pgen.1004540
11. T.Bätz, D.Förster, S.Luschnig. The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila. Development 2014; 141:899-908; PMID:Can't; http://dx.doi.org/10.1242/dev.102160
12. K.Nishimura, T.Fukagawa, H.Takisawa, T.Kakimoto, M.Kanemaki. An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat Methods 2009; 6:917-22; PMID:19915560; http://dx.doi.org/10.1038/nmeth.1401
13. N.Dharmasiri, S.Dharmasiri, M.Estelle. The F-box protein TIR1 is an auxin receptor. Nature 2005; 435:441-5; PMID:15917797; http://dx.doi.org/10.1038/nature03543
14. S.Kepinski, O.Leyser. The Arabidopsis F-box protein TIR1 is an auxin receptor. Nature 2005; 435:446-51; PMID:15917798; http://dx.doi.org/10.1038/nature03542
15. X.Tan, L.I.Calderon-Villalobos, M.Sharon, C.Zheng, C.V.Robinson, M.Estelle, N.Zheng. Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature 2007; 446:640-5; PMID:17410169; http://dx.doi.org/10.1038/nature05731
16. M.Kanke, K.Nishimura, M.Kanemaki, T.Kakimoto, T.S.Takahashi, T.Nakagawa, H.Masukata. Auxin-inducible protein depletion system in fission yeast. BMC Cell Biol 2011; 12:8; PMID:21314938; http://dx.doi.org/10.1186/1471-2121-12-8
17. A.J.Holland, D.Fachinetti, J.S.Han, D.W.Cleveland. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A 2012; 109:E3350-7; PMID:23150568; http://dx.doi.org/10.1073/pnas.1216880109
18. A.Kreidenweiss, A.V.Hopkins, B.Mordmuller. 2A and the auxin-based degron system facilitate control of protein levels in Plasmodium falciparum. PLoS One 2013; 8:e78661; PMID:24236031; http://dx.doi.org/10.1371/journal.pone.0078661
19. N.Philip, A.P.Waters. Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector. Cell Host Microbe 2015; 18:122-31; PMID:26118994; http://dx.doi.org/10.1016/j.chom.2015.05.018
20. L.Zhang, J.D.Ward, Z.Cheng, A.F.Dernburg. The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans. Development 2015; 142:4374-84; PMID:26552885; http://dx.doi.org/10.1242/dev.129635
21. A.Karadeniz, B.Kaya, B.Savas, S.F.Topcuoglu. Effects of two plant growth regulators, indole-3-acetic acid and beta-naphthoxyacetic acid, on genotoxicity in Drosophila SMART assay and on proliferation and viability of HEK293 cells from the perspective of carcinogenesis. Toxicol Industr Health 2011; 27:840-8; PMID:NOT_FOUND; http://dx.doi.org/10.1177/0748233711399314
22. R.W.Daniels, A.J.Rossano, G.T.Macleod, B.Ganetzky. Expression of multiple transgenes from a single construct using viral 2A peptides in Drosophila. PLoS One 2014; 9:e100637; PMID:24945148; http://dx.doi.org/10.1371/journal.pone.0100637
23. B.J.Thomas, K.H.Zavitz, X.Z.Dong, M.E.Lane, K.Weigmann, R.L.Finley, R.Brent, C.F.Lehner, S.L.Zipursky. roughex down-regulates G2 cyclins in G1. Genes Dev 1997; 11:1289-98; PMID:9171373; http://dx.doi.org/10.1101/gad.11.10.1289
24. E.Foley, P.H.O'Farrell, F.Sprenger. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol 1999; 9:1392-402; PMID:10607563; http://dx.doi.org/10.1016/S0960-9822(00)80084-6
25. K.Weigmann, S.M.Cohen, C.F.Lehner. Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase. Development 1997; 124:3555-63; PMID:9342048
26. T.A.Bunch, Y.Grinblat, L.S.Goldstein. Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res 1988; 16:1043-61; PMID:3125519; http://dx.doi.org/10.1093/nar/16.3.1043
27. A.H.Brand, N.Perrimon. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993; 118:401-15; PMID:8223268
28. M.M.Metzstein, M.A.Krasnow. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet 2006; 2:e180; PMID:17196039; http://dx.doi.org/10.1371/journal.pgen.0020180
29. D.J.Hazelett, M.Bourouis, U.Walldorf, J.E.Treisman. decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc. Development 1998; 125:3741-51; PMID:9716539
30. M.Freeman. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 1996; 87:651-60; PMID:8929534; http://dx.doi.org/10.1016/S0092-8674(00)81385-9
31. J.Capdevila, I.Guerrero. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J 1994; 13:4459-68; PMID:7925288
32. S.E.McGuire, P.T.Le, A.J.Osborn, K.Matsumoto, R.L.Davis. Spatiotemporal rescue of memory dysfunction in Drosophila. Science 2003; 302:1765-8; PMID:14657498; http://dx.doi.org/10.1126/science.1089035
33. T.Le, Z.Liang, H.Patel, M.H.Yu, G.Sivasubramaniam, M.Slovitt, G.Tanentzapf, N.Mohanty, S.M.Paul, V.M.Wu, et al. A new family of Drosophila balancer chromosomes with a w- dfd-GMR yellow fluorescent protein marker. Genetics 2006; 174:2255-7; PMID:17057238; http://dx.doi.org/10.1534/genetics.106.063461
34. J.A.Fischer, E.Giniger, T.Maniatis, M.Ptashne. GAL4 activates transcription in Drosophila. Nature 1988; 332:853-6; PMID:3128741; http://dx.doi.org/10.1038/332853a0
35. G.Gasque, S.Conway, J.Huang, Y.Rao, L.B.Vosshall. Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Scientific reports 2013; 3:srep02120; PMID:23817146; http://dx.doi.org/10.1038/srep02120
36. P.V.Lidsky, F.Sprenger, C.F.Lehner. Distinct modes of centromere protein dynamics during cell cycle progression in Drosophila S2R+ cells. J Cell Sci 2013; 126:4782-93; PMID:23943877; http://dx.doi.org/10.1242/jcs.134122
37. B.Handke, J.Szabad, P.V.Lidsky, E.Hafen, C.F.Lehner. Towards long term cultivation of Drosophila wing imaginal discs in vitro. PLoS One 2014; 9:e107333; PMID:25203426; http://dx.doi.org/10.1371/journal.pone.0107333
38. F.Sprenger, N.Yakubovich, P.H.O'Farrell. S phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol 1997; 7:488-99; PMID:9210381; http://dx.doi.org/10.1016/S0960-9822(06)00220-X