Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes

Current Biology

Volumn 9, Issue 23, 1999, Pages 1392-1402

  Foley, Edan ^a   O'Farrell, Patrick H ^b   Sprenger, Frank ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033518316     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)80084-6     Document Type: Article

References (43)

1. Morgan DO: Principles of CDK regulation. Nature 1995, 374:131-134.
2. Peter M, Herskowitz I: Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 1994, 79:181-184.
3. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995, 9:1149-1163.
4. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707.
5. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, et al.: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 1994, 8:2939-2952.
6. Toyoshima H, Hunter T: P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994, 78:67-74.
7. Blain SW, Montalvo E, Massague J: Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J Biol Chem 1997, 272:25863-25872.
8. Lane ME, Sauer K, Wallace K, Jan YN, Lehner CF, Vaessin H: Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 1996, 87:1225-1235.
9. de Nooij JC, Letendre MA, Hariharan IK: A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 1996, 87:1237-1247.
10. Sprenger F, Yakubovich N, O'Farrell PH: S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol 1997,7:488-499.
11. Thomas BJ, Gunning DA, Cho J, Zipursky L: Cell cycle progression in the developing Drosophila eye: Roughex encodes a novel protein required for the establishment of G1. Cell 1994, 77:1003-1014.
12. Gönczy P, Thomas BJ, DiNardo S: Roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis. Cell 1994, 77:1015-1025.
13. Thomas BJ, Zavitz KH, Dong X, Lane ME, Weigmann K, Finley RL Jr, et al.: Roughex down-regulates G2 cyclins in G1. Genes Dev 1997, 11:1289-1298.
14. Lehner CF, O'Farrell PH: Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 1989, 56:957-968.
15. Huang J, Raff JW: The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J 1999, 18:2184-2195.
16. Edgar BA, O'Farrell PH: The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell 1990, 62:469-480.
17. Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell PH: Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev 1994, 8:440-452.
18. Draetta GF: Cell cycle: Will the real Cdk-activating kinase please stand up. Curr Biol 1997, 7:R50-R52.
19. Campbell SD, Sprenger F, Edgar BA, O'Farrell PH: Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol Biol Cell 1995, 6:1333-1347.
20. Larochelle S, Pandur J, Fisher RP, Salz HK, Suter B: Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev 1998, 12:370-381.
21. Thuret JY, Valay JG, Faye G, Mann C: Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 1996, 86:565-576.
22. Kaldis P, Russo AA, Chou HS, Pavletich NP, Solomon MJ: Human and yeast Cdk-activating kinases (CAKs) display distinct substrate specificities. Mol Biol Cell 1998, 9:2545-2560.
23. Espinoza FH, Farrell A, Erdjument-Bromage H, Tempst P, Morgan DO: A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 1996, 273:1 714-1717.
24. Adams PD, Sellers WR, Sharma SK, Wu AD, Nalin CM, Kaelin WG, Jr: Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol 1996, 16:6623-6633.
25. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A: The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 1998, 2:709-718.
26. Solomon MJ, Lee T, Kirschner MW: Role of phosphorylation in p34cdc2 activation: Identification of an activating kinase. Mol Biol Cell 1992, 3:13-27.
27. Kaldis P, Sutton A, Solomon MJ: The Cdk-activating kinase (CAK) from budding yeast Cell 1996, 86:553-564.
28. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994, 78:59-66.
29. Kato JY, Matsuoka M, Polyak K, Massague J, Sherr CJ: Cyclic AMP- Induced G1 phase arrest mediated by an inhibitor p27Kip1 of cyclin-dependent kinase 4 activation. Cell 1994, 79:487-496.
30. Aprelikova O, Xiong Y, Liu ET: Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem 1995, 270:1 8195-18197.
31. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, et al.: New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997, 11:847-862.
32. Zhang H, Hannon GJ, Beach D: P21-containing cyclin kinases exist in both active and inactive states. Genes Dev 1994, 8:1750-1758.
33. Sigrist SJ, Lehner CF: Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 1997, 90:671-681.
34. Jaspersen SL, Charles JF, Morgan DO: Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 1999, 9:227-236.
35. Schwob E, Bohm T, Mendenhall MD, Nasmyth K: The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 1994, 79:233-244.
36. Correa-Bordes J, Nurse P: p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell 1995, 83:1001-1009.
37. Sanchez-Diaz A, Gonzalez I, Arellano M, Moreno S: The cdk inhibitors p25rum1 and p40Sic1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast J Cell Sci 1998,111:843-851.
38. Knoblich JA, Lehner CF: Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J 1993, 12:65-74.
39. Sprenger F, Nüsslein-Volhard C: Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg. Cell 1992, 71:987-1001.
40. Richardson H, O'Keefe LV, Marty T, Saint R: Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 1995,121:3371-3379.
41. Lehner CF, O'Farrell PH: Drosophila cdc2 homologs: A functional homolog is coexpressed with a cognate variant EMBO J 1990, 9:3573-3581.
42. Knoblich JA, Sauer K, Jones L, Richardson H, Saint R, Lehner CF: Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 1994, 77:107-120.
43. Görlich D, Mattaj IW: Nucleocytoplasmic transport. Science 1996, 271:1513-1518.