MTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Cell Reports

Volumn 15, Issue 1, 2016, Pages 86-95

  Costa, Veronica ^a   Aigner, Stefan ^a,f   Vukcevic, Mirko ^c   Sauter, Evelyn ^a,g   Behr, Katharina ^c   Ebeling, Martin ^a   Dunkley, Tom ^a   Friedlein, Arno ^a   Zoffmann, Sannah ^a   Meyer, Claas A ^a   Knoflach, Frédéric ^a   Lugert, Sebastian ^a   Patsch, Christoph ^a   Fjeldskaar, Fatiha ^a   Chicha Gaudimier, Laurie ^b   Kiialainen, Anna ^a   Piraino, Paolo ^d   Bedoucha, Marc ^a   Graf, Martin ^a   Jessberger, Sebastian ^e   Ghosh, Anirvan ^a   Bischofberger, Josef ^c   Jagasia, Ravi ^a   more..

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Pvalue Research SRL   (Italy)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

Autism spectrum disorder; Human pluripotent stem cells; MTORC1; Neuronal differentiation; Synaptogenesis; Tuberous sclerosis

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLINE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NESTIN; NEUROGENIN 3; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POTASSIUM CHLORIDE COTRANSPORTER 2; PROTEIN ZO1; S6 KINASE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; SOMATOMEDIN; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; TUBERIN; ZINC FINGER NUCLEASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; AUTISM; BRAIN MALFORMATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; GABAERGIC SYSTEM; GENE; GENE AMPLIFICATION; GENE DELETION; GENE DISRUPTION; GENE DOSAGE; GENE LOCUS; GENE TARGETING; GENETIC ENGINEERING; GENOTYPE; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; HUMAN CELL; MENTAL DISEASE; MOUSE EMBRYONIC STEM CELL; NEGATIVE FEEDBACK; NERVE CELL EXCITABILITY; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ROSETTE FORMATION; SOMATIC MUTATION; STEM CELL; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; TSC2 GENE; TUBEROUS SCLEROSIS; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; EMBRYONIC STEM CELL; GENETICS; METABOLISM; NEURAL STEM CELL; PHYSIOLOGY; SYNAPSE;

CELL LINE; EMBRYONIC STEM CELLS; HUMANS; MULTIPROTEIN COMPLEXES; NEURAL STEM CELLS; NEUROGENESIS; SYNAPSES; SYNAPTIC TRANSMISSION; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 84963543184     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.02.090     Document Type: Article

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