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Volumn 13, Issue 1, 2016, Pages

Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection

Author keywords

Gastrointestinal barrier; Microbial translocation; Microbiota; Mucosal immunity

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 22;

EID: 84962920643     PISSN: None     EISSN: 17426405     Source Type: Journal    
DOI: 10.1186/s12981-016-0103-1     Document Type: Review
Times cited : (114)

References (76)
  • 1
    • 0029924570 scopus 로고    scopus 로고
    • Elevated relative fluorescence intensity of CD38 antigen expression on CD8+T cells is a marker of poor prognosis in HIV infection: results of 6years of follow-up
    • Liu Z, Hultin LE, Cumberland WG, et al. Elevated relative fluorescence intensity of CD38 antigen expression on CD8+T cells is a marker of poor prognosis in HIV infection: results of 6years of follow-up. Cytometry. 1996;26:1-7.
    • (1996) Cytometry , vol.26 , pp. 1-7
    • Liu, Z.1    Hultin, L.E.2    Cumberland, W.G.3
  • 2
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis. 1999;179:859-70.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3
  • 3
    • 3843056825 scopus 로고    scopus 로고
    • Immune activation set point during early HIV infection predicts subsequent CD4+T-cell changes independent of viral load
    • Deeks SG, Kitchen CM, Liu L, et al. Immune activation set point during early HIV infection predicts subsequent CD4+T-cell changes independent of viral load. Blood. 2004;104:942-7.
    • (2004) Blood , vol.104 , pp. 942-947
    • Deeks, S.G.1    Kitchen, C.M.2    Liu, L.3
  • 4
    • 53549129725 scopus 로고    scopus 로고
    • Microbial translocation is associated with sustained failure in CD4+T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
    • Marchetti G, Bellistrì GM, Borghi E, et al. Microbial translocation is associated with sustained failure in CD4+T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. AIDS. 2008;22:2035-8.
    • (2008) AIDS , vol.22 , pp. 2035-2038
    • Marchetti, G.1    Bellistrì, G.M.2    Borghi, E.3
  • 5
    • 77958083540 scopus 로고    scopus 로고
    • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    • Estes JD, Harris LD, Klatt NR, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog. 2010;6:e1001052.
    • (2010) PLoS Pathog , vol.6 , pp. e1001052
    • Estes, J.D.1    Harris, L.D.2    Klatt, N.R.3
  • 6
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-71.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 7
    • 79952335046 scopus 로고    scopus 로고
    • Plasma levels of soluble CD14 independently predict mortality in HIV infection
    • Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis. 2011;203:780-90.
    • (2011) J Infect Dis , vol.203 , pp. 780-790
    • Sandler, N.G.1    Wand, H.2    Roque, A.3
  • 8
    • 85027956964 scopus 로고    scopus 로고
    • Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+cell count
    • Marchetti G, Cozzi-Lepri A, Merlini E, et al. Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+cell count. AIDS. 2011;25:1385-94.
    • (2011) AIDS , vol.25 , pp. 1385-1394
    • Marchetti, G.1    Cozzi-Lepri, A.2    Merlini, E.3
  • 9
    • 84937938856 scopus 로고    scopus 로고
    • Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients
    • León A, Leal L, Torres B, et al. Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients. AIDS. 2015;29:675-81.
    • (2015) AIDS , vol.29 , pp. 675-681
    • León, A.1    Leal, L.2    Torres, B.3
  • 10
    • 84902281875 scopus 로고    scopus 로고
    • Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
    • Hunt PW, Sinclair E, Rodriguez B, et al. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis. 2014;210:1228-38.
    • (2014) J Infect Dis , vol.210 , pp. 1228-1238
    • Hunt, P.W.1    Sinclair, E.2    Rodriguez, B.3
  • 11
    • 84910010874 scopus 로고    scopus 로고
    • Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment
    • Tenorio AR, Zheng Y, Bosch RJ, et al. Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment. J Infect Dis. 2014;210:1248-59.
    • (2014) J Infect Dis , vol.210 , pp. 1248-1259
    • Tenorio, A.R.1    Zheng, Y.2    Bosch, R.J.3
  • 12
    • 84925555310 scopus 로고    scopus 로고
    • Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions
    • Kim CJ, Kovacs C, Chun TW, et al. Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions. J Acquir Immune Defic Syndr. 2014;67:514-8.
    • (2014) J Acquir Immune Defic Syndr , vol.67 , pp. 514-518
    • Kim, C.J.1    Kovacs, C.2    Chun, T.W.3
  • 13
    • 84962829217 scopus 로고    scopus 로고
    • Pre-cART pro-inflammatory milieu, microbial translocation (MT) and risk of disease progression in HIV-infected patients starting their first cART: data from the Icona foundation cohort
    • European AIDS Clinical Society (EACS), Barcelona
    • Marchetti G, Cozzi-Lepri A, Merlini E, et al. Pre-cART pro-inflammatory milieu, microbial translocation (MT) and risk of disease progression in HIV-infected patients starting their first cART: data from the Icona foundation cohort. In: European AIDS Clinical Society (EACS), Barcelona; 2015.
    • (2015)
    • Marchetti, G.1    Cozzi-Lepri, A.2    Merlini, E.3
  • 14
    • 77954059792 scopus 로고    scopus 로고
    • Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    • Nazli A, Chan O, Dobson-Belaire WN, et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog. 2010;6:e1000852.
    • (2010) PLoS Pathog , vol.6 , pp. e1000852
    • Nazli, A.1    Chan, O.2    Dobson-Belaire, W.N.3
  • 15
    • 84902124658 scopus 로고    scopus 로고
    • Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication
    • Kristoff J, Haret-Richter G, Ma D, et al. Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. J Clin Invest. 2014;124:2802-6.
    • (2014) J Clin Invest , vol.124 , pp. 2802-2806
    • Kristoff, J.1    Haret-Richter, G.2    Ma, D.3
  • 16
    • 78049291281 scopus 로고    scopus 로고
    • A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection
    • Smith AJ, Schacker TW, Reilly CS, Haase AT. A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. J Acquir Immune Defic Syndr. 2010;55:306-15.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 306-315
    • Smith, A.J.1    Schacker, T.W.2    Reilly, C.S.3    Haase, A.T.4
  • 17
    • 84939620580 scopus 로고    scopus 로고
    • The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals
    • Perkins MR, Bartha I, Timmer JK, et al. The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals. J Infect Dis. 2015;212:578-84.
    • (2015) J Infect Dis , vol.212 , pp. 578-584
    • Perkins, M.R.1    Bartha, I.2    Timmer, J.K.3
  • 18
    • 0038701685 scopus 로고    scopus 로고
    • T cell activation is associated with lower CD4+T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187:1534-43.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 19
    • 33748052966 scopus 로고    scopus 로고
    • Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    • Marchetti G, Gori A, Casabianca A, et al. Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART. AIDS. 2006;20:1727-36.
    • (2006) AIDS , vol.20 , pp. 1727-1736
    • Marchetti, G.1    Gori, A.2    Casabianca, A.3
  • 20
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis. 2009;199:1177-85.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 21
    • 84879520476 scopus 로고    scopus 로고
    • The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation
    • Chevalier MF, Petitjean G, Dunyach-Rémy C, et al. The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation. PLoS Pathog. 2013;9:e1003453.
    • (2013) PLoS Pathog , vol.9 , pp. e1003453
    • Chevalier, M.F.1    Petitjean, G.2    Dunyach-Rémy, C.3
  • 22
    • 84936810525 scopus 로고    scopus 로고
    • Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection
    • Jenabian MA, El-Far M, Vyboh K, et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J Infect Dis. 2015;212:355-66.
    • (2015) J Infect Dis , vol.212 , pp. 355-366
    • Jenabian, M.A.1    El-Far, M.2    Vyboh, K.3
  • 23
    • 79955972414 scopus 로고    scopus 로고
    • Epithelial adhesion molecules can inhibit HIV-1-specific CD8+T-cell functions
    • Streeck H, Kwon DS, Pyo A, et al. Epithelial adhesion molecules can inhibit HIV-1-specific CD8+T-cell functions. Blood. 2011;117:5112-22.
    • (2011) Blood , vol.117 , pp. 5112-5122
    • Streeck, H.1    Kwon, D.S.2    Pyo, A.3
  • 24
    • 84903473239 scopus 로고    scopus 로고
    • Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+individuals
    • Chung CY, Alden SL, Funderburg NT, Fu P, Levine AD. Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+individuals. PLoS Pathog. 2014;10:e1004198.
    • (2014) PLoS Pathog , vol.10 , pp. e1004198
    • Chung, C.Y.1    Alden, S.L.2    Funderburg, N.T.3    Fu, P.4    Levine, A.D.5
  • 25
    • 84926519274 scopus 로고    scopus 로고
    • HIV-associated mucosal gene expression: region-specific alterations
    • Voigt RM, Keshavarzian A, Losurdo J, et al. HIV-associated mucosal gene expression: region-specific alterations. AIDS. 2015;29:537-46.
    • (2015) AIDS , vol.29 , pp. 537-546
    • Voigt, R.M.1    Keshavarzian, A.2    Losurdo, J.3
  • 26
    • 84954489957 scopus 로고    scopus 로고
    • Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+T-cell recovery upon virologically-suppressive cART
    • Tincati C, Merlini E, Braidotti P, et al. Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+T-cell recovery upon virologically-suppressive cART. AIDS. 2016;30(7):991-1003. doi: 10.1097/QAD.0000000000001015.
    • (2016) AIDS , vol.30 , Issue.7 , pp. 991-1003
    • Tincati, C.1    Merlini, E.2    Braidotti, P.3
  • 27
    • 84928078278 scopus 로고    scopus 로고
    • Gut epithelial barrier and systemic inflammation during chronic HIV infection
    • Somsouk M, Estes JD, Deleage C, et al. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015;29:43-51.
    • (2015) AIDS , vol.29 , pp. 43-51
    • Somsouk, M.1    Estes, J.D.2    Deleage, C.3
  • 28
    • 84919665923 scopus 로고    scopus 로고
    • Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation
    • Schuetz A, Deleage C, Sereti I, et al. Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog. 2014;10:e1004543.
    • (2014) PLoS Pathog , vol.10 , pp. e1004543
    • Schuetz, A.1    Deleage, C.2    Sereti, I.3
  • 29
    • 0037007670 scopus 로고    scopus 로고
    • HIV preferentially infects HIV-specific CD4+T cells
    • Douek DC, Brenchley JM, Betts MR, et al. HIV preferentially infects HIV-specific CD4+T cells. Nature. 2002;417:95-8.
    • (2002) Nature , vol.417 , pp. 95-98
    • Douek, D.C.1    Brenchley, J.M.2    Betts, M.R.3
  • 30
    • 77949320175 scopus 로고    scopus 로고
    • Peripheral blood CCR4+CCR6+and CXCR3+CCR6+CD4+T cells are highly permissive to HIV-1 infection
    • Gosselin A, Monteiro P, Chomont N, et al. Peripheral blood CCR4+CCR6+and CXCR3+CCR6+CD4+T cells are highly permissive to HIV-1 infection. J Immunol. 2010;184:1604-16.
    • (2010) J Immunol , vol.184 , pp. 1604-1616
    • Gosselin, A.1    Monteiro, P.2    Chomont, N.3
  • 31
    • 84859068534 scopus 로고    scopus 로고
    • The colocalization potential of HIV-specific CD8+and CD4+T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
    • Wacleche VS, Chomont N, Gosselin A, et al. The colocalization potential of HIV-specific CD8+and CD4+T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid. PLoS ONE. 2012;7:e32964.
    • (2012) PLoS ONE , vol.7 , pp. e32964
    • Wacleche, V.S.1    Chomont, N.2    Gosselin, A.3
  • 32
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+T cells in multiple tissues during acute SIV infection
    • Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+T cells in multiple tissues during acute SIV infection. Nature. 2005;434:1093-7.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 33
    • 4644342929 scopus 로고    scopus 로고
    • CD4+T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley JM, Schacker TW, Ruff LE, et al. CD4+T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-59.
    • (2004) J Exp Med , vol.200 , pp. 749-759
    • Brenchley, J.M.1    Schacker, T.W.2    Ruff, L.E.3
  • 34
    • 84867955049 scopus 로고    scopus 로고
    • Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity?
    • Costiniuk CT, Angel JB. Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity? Mucosal Immunol. 2012;5:596-604.
    • (2012) Mucosal Immunol , vol.5 , pp. 596-604
    • Costiniuk, C.T.1    Angel, J.B.2
  • 35
    • 84953329705 scopus 로고    scopus 로고
    • The effect of timing of antiretroviral therapy on CD4(+) T-cell reconstitution in the intestine of HIV-infected patients
    • Allers K, Puyskens A, Epple HJ, et al. The effect of timing of antiretroviral therapy on CD4(+) T-cell reconstitution in the intestine of HIV-infected patients. Mucosal Immunol. 2015;9(1):265-74.
    • (2015) Mucosal Immunol , vol.9 , Issue.1 , pp. 265-274
    • Allers, K.1    Puyskens, A.2    Epple, H.J.3
  • 36
    • 0037442137 scopus 로고    scopus 로고
    • IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    • Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol. 2003;170:2106-12.
    • (2003) J Immunol , vol.170 , pp. 2106-2112
    • Ferretti, S.1    Bonneau, O.2    Dubois, G.R.3    Jones, C.E.4    Trifilieff, A.5
  • 37
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto K, Ogawa A, Mizoguchi E, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest. 2008;118:534-44.
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3
  • 38
    • 84866555781 scopus 로고    scopus 로고
    • Loss of mucosal CD103+DCs and IL-17+and IL-22+lymphocytes is associated with mucosal damage in SIV infection
    • Klatt NR, Estes JD, Sun X, et al. Loss of mucosal CD103+DCs and IL-17+and IL-22+lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57.
    • (2012) Mucosal Immunol , vol.5 , pp. 646-657
    • Klatt, N.R.1    Estes, J.D.2    Sun, X.3
  • 39
    • 84922010883 scopus 로고    scopus 로고
    • Loss of Th22 cells is associated with increased immune activation and IDO-1 activity in HIV-1 infection
    • Page EE, Greathead L, Metcalf R, et al. Loss of Th22 cells is associated with increased immune activation and IDO-1 activity in HIV-1 infection. J Acquir Immune Defic Syndr. 2014;67:227-35.
    • (2014) J Acquir Immune Defic Syndr , vol.67 , pp. 227-235
    • Page, E.E.1    Greathead, L.2    Metcalf, R.3
  • 40
    • 84927590232 scopus 로고    scopus 로고
    • Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients
    • Kök A, Hocqueloux L, Hocini H, et al. Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients. Mucosal Immunol. 2015;8:127-40.
    • (2015) Mucosal Immunol , vol.8 , pp. 127-140
    • Kök, A.1    Hocqueloux, L.2    Hocini, H.3
  • 41
    • 84908406134 scopus 로고    scopus 로고
    • Reconstitution of intestinal CD4 and Th17 T cells in antiretroviral therapy suppressed HIV-infected subjects: implication for residual immune activation from the results of a clinical trial
    • d'Ettorre G, Baroncelli S, Micci L, et al. Reconstitution of intestinal CD4 and Th17 T cells in antiretroviral therapy suppressed HIV-infected subjects: implication for residual immune activation from the results of a clinical trial. PLoS ONE. 2014;9:e109791.
    • (2014) PLoS ONE , vol.9 , pp. e109791
    • d'Ettorre, G.1    Baroncelli, S.2    Micci, L.3
  • 42
    • 84883417251 scopus 로고    scopus 로고
    • Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation
    • Kim CJ, McKinnon LR, Kovacs C, et al. Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation. J Immunol. 2013;191:2164-73.
    • (2013) J Immunol , vol.191 , pp. 2164-2173
    • Kim, C.J.1    McKinnon, L.R.2    Kovacs, C.3
  • 43
    • 79955027908 scopus 로고    scopus 로고
    • Memory CCR6+CD4+T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    • Monteiro P, Gosselin A, Wacleche VS, et al. Memory CCR6+CD4+T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7. J Immunol. 2011;186:4618-30.
    • (2011) J Immunol , vol.186 , pp. 4618-4630
    • Monteiro, P.1    Gosselin, A.2    Wacleche, V.S.3
  • 44
    • 84929398355 scopus 로고    scopus 로고
    • Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART
    • DaFonseca S, Niessl J, Pouvreau S, et al. Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART. Retrovirology. 2015;12:38.
    • (2015) Retrovirology , vol.12 , pp. 38
    • DaFonseca, S.1    Niessl, J.2    Pouvreau, S.3
  • 45
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, Mold J, Hunt PW, et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med. 2010;2:ra3632.
    • (2010) Sci Transl Med , vol.2 , pp. ra3632
    • Favre, D.1    Mold, J.2    Hunt, P.W.3
  • 46
    • 84944452585 scopus 로고    scopus 로고
    • Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up
    • Gaardbo JC, Trøsied M, Stiksrud B, et al. Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up. J Acquir Immune Defic Syndr. 2015;70:228-35.
    • (2015) J Acquir Immune Defic Syndr , vol.70 , pp. 228-235
    • Gaardbo, J.C.1    Trøsied, M.2    Stiksrud, B.3
  • 47
    • 84904314814 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan catabolism, CD4+T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy
    • Byakwaga H, Boum Y, Huang Y, et al. The kynurenine pathway of tryptophan catabolism, CD4+T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. J Infect Dis. 2014;210:383-91.
    • (2014) J Infect Dis , vol.210 , pp. 383-391
    • Byakwaga, H.1    Boum, Y.2    Huang, Y.3
  • 48
    • 84903731105 scopus 로고    scopus 로고
    • Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients
    • Chen J, Shao J, Cai R, et al. Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients. PLoS ONE. 2014;9:e100446.
    • (2014) PLoS ONE , vol.9 , pp. e100446
    • Chen, J.1    Shao, J.2    Cai, R.3
  • 49
    • 84958841613 scopus 로고    scopus 로고
    • The gut microbiota and host health: a new clinical frontier
    • Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2015;65(2):330-9.
    • (2015) Gut , vol.65 , Issue.2 , pp. 330-339
    • Marchesi, J.R.1    Adams, D.H.2    Fava, F.3
  • 50
    • 38949134533 scopus 로고    scopus 로고
    • Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
    • Gori A, Tincati C, Rizzardini G, et al. Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis. J Clin Microbiol. 2008;46:757-8.
    • (2008) J Clin Microbiol , vol.46 , pp. 757-758
    • Gori, A.1    Tincati, C.2    Rizzardini, G.3
  • 51
    • 80051552856 scopus 로고    scopus 로고
    • Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation
    • Ellis CL, Ma ZM, Mann SK, et al. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr. 2011;57:363-70.
    • (2011) J Acquir Immune Defic Syndr , vol.57 , pp. 363-370
    • Ellis, C.L.1    Ma, Z.M.2    Mann, S.K.3
  • 52
    • 79954536349 scopus 로고    scopus 로고
    • Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy
    • Merlini E, Bai F, Bellistrì GM, Tincati C, d' Arminio Monforte A, Marchetti G. Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy. PLoS ONE. 2011;6:e18580.
    • (2011) PLoS ONE , vol.6 , pp. e18580
    • Merlini, E.1    Bai, F.2    Bellistrì, G.M.3    Tincati, C.4    d' Arminio Monforte, A.5    Marchetti, G.6
  • 53
    • 84880540665 scopus 로고    scopus 로고
    • Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
    • 193ra91
    • Vujkovic-Cvijin I, Dunham RM, Iwai S, et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013;5:193ra91.
    • (2013) Sci Transl Med , vol.5
    • Vujkovic-Cvijin, I.1    Dunham, R.M.2    Iwai, S.3
  • 54
    • 84900493012 scopus 로고    scopus 로고
    • An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
    • Dillon SM, Lee EJ, Kotter CV, et al. An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. Mucosal Immunol. 2014;7:983-94.
    • (2014) Mucosal Immunol , vol.7 , pp. 983-994
    • Dillon, S.M.1    Lee, E.J.2    Kotter, C.V.3
  • 55
    • 84895733084 scopus 로고    scopus 로고
    • A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    • Mutlu EA, Keshavarzian A, Losurdo J, et al. A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects. PLoS Pathog. 2014;10:e1003829.
    • (2014) PLoS Pathog , vol.10 , pp. e1003829
    • Mutlu, E.A.1    Keshavarzian, A.2    Losurdo, J.3
  • 56
    • 84922414182 scopus 로고    scopus 로고
    • Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection
    • Dinh DM, Volpe GE, Duffalo C, et al. Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis. 2015;211:19-27.
    • (2015) J Infect Dis , vol.211 , pp. 19-27
    • Dinh, D.M.1    Volpe, G.E.2    Duffalo, C.3
  • 57
    • 84884379881 scopus 로고    scopus 로고
    • Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection
    • Pérez-Santiago J, Gianella S, Massanella M, et al. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013;27:1921-31.
    • (2013) AIDS , vol.27 , pp. 1921-1931
    • Pérez-Santiago, J.1    Gianella, S.2    Massanella, M.3
  • 58
    • 84929633864 scopus 로고    scopus 로고
    • Dysbiotic bacteria translocate in progressive SIV infection
    • Klase Z, Ortiz A, Deleage C, et al. Dysbiotic bacteria translocate in progressive SIV infection. Mucosal Immunol. 2015;8:1009-20.
    • (2015) Mucosal Immunol , vol.8 , pp. 1009-1020
    • Klase, Z.1    Ortiz, A.2    Deleage, C.3
  • 59
    • 84902595278 scopus 로고    scopus 로고
    • HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota
    • McHardy IH, Li X, Tong M, et al. HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota. Microbiome. 2013;1:26.
    • (2013) Microbiome , vol.1 , pp. 26
    • McHardy, I.H.1    Li, X.2    Tong, M.3
  • 60
    • 84932619244 scopus 로고    scopus 로고
    • Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals
    • Vázquez-Castellanos JF, Serrano-Villar S, Latorre A, et al. Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunol. 2015;8:760-72.
    • (2015) Mucosal Immunol , vol.8 , pp. 760-772
    • Vázquez-Castellanos, J.F.1    Serrano-Villar, S.2    Latorre, A.3
  • 61
    • 84860390171 scopus 로고    scopus 로고
    • Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial
    • Gori A, Rizzardini G, Van't Land B, et al. Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011;4:554-63.
    • (2011) Mucosal Immunol , vol.4 , pp. 554-563
    • Gori, A.1    Rizzardini, G.2    Van't Land, B.3
  • 62
    • 84878875269 scopus 로고    scopus 로고
    • The immunomodulatory nutritional intervention NR100157 reduced CD4+T-cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study)
    • Cahn P, Ruxrungtham K, Gazzard B, et al. The immunomodulatory nutritional intervention NR100157 reduced CD4+T-cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study). Clin Infect Dis. 2013;57:139-46.
    • (2013) Clin Infect Dis , vol.57 , pp. 139-146
    • Cahn, P.1    Ruxrungtham, K.2    Gazzard, B.3
  • 63
    • 84873369889 scopus 로고    scopus 로고
    • Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    • Klatt NR, Canary LA, Sun X, et al. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. J Clin Invest. 2013;123:903-7.
    • (2013) J Clin Invest , vol.123 , pp. 903-907
    • Klatt, N.R.1    Canary, L.A.2    Sun, X.3
  • 64
    • 84952872945 scopus 로고    scopus 로고
    • Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques
    • Vujkovic-Cvijin I, Swainson LA, Chu SN, et al. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Rep. 2015;13(8):1589-97.
    • (2015) Cell Rep , vol.13 , Issue.8 , pp. 1589-1597
    • Vujkovic-Cvijin, I.1    Swainson, L.A.2    Chu, S.N.3
  • 65
    • 84923642248 scopus 로고    scopus 로고
    • Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients: a double-blind, randomized, placebo-controlled trial
    • Villar-García J, Hernández JJ, Güerri-Fernández R, et al. Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients: a double-blind, randomized, placebo-controlled trial. J Acquir Immune Defic Syndr. 2015;68:256-63.
    • (2015) J Acquir Immune Defic Syndr , vol.68 , pp. 256-263
    • Villar-García, J.1    Hernández, J.J.2    Güerri-Fernández, R.3
  • 66
    • 84945545407 scopus 로고    scopus 로고
    • Probiotics reduce inflammation in antiretroviral treated, HIV-infected individuals: results of the "Probio-HIV" clinical trial
    • d'Ettorre G, Ceccarelli G, Giustini N, et al. Probiotics reduce inflammation in antiretroviral treated, HIV-infected individuals: results of the "Probio-HIV" clinical trial. PLoS ONE. 2015;10:e0137200.
    • (2015) PLoS ONE , vol.10 , pp. e0137200
    • d'Ettorre, G.1    Ceccarelli, G.2    Giustini, N.3
  • 67
    • 84945897500 scopus 로고    scopus 로고
    • Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART
    • Stiksrud B, Nowak P, Nwosu FC, et al. Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART. J Acquir Immune Defic Syndr. 2015;70:329-37.
    • (2015) J Acquir Immune Defic Syndr , vol.70 , pp. 329-337
    • Stiksrud, B.1    Nowak, P.2    Nwosu, F.C.3
  • 68
    • 84893792899 scopus 로고    scopus 로고
    • Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration
    • Sereti I, Estes JD, Thompson WL, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 2014;10:e1003890.
    • (2014) PLoS Pathog , vol.10 , pp. e1003890
    • Sereti, I.1    Estes, J.D.2    Thompson, W.L.3
  • 69
    • 84884780138 scopus 로고    scopus 로고
    • Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21
    • Pallikkuth S, Micci L, Ende ZS, et al. Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. PLoS Pathog. 2013;9:e1003471.
    • (2013) PLoS Pathog , vol.9 , pp. e1003471
    • Pallikkuth, S.1    Micci, L.2    Ende, Z.S.3
  • 70
    • 84961806957 scopus 로고    scopus 로고
    • IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques
    • Ortiz AM, Klase ZA, DiNapoli SR, et al. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol. 2015;9(2):458-67.
    • (2015) Mucosal Immunol , vol.9 , Issue.2 , pp. 458-467
    • Ortiz, A.M.1    Klase, Z.A.2    DiNapoli, S.R.3
  • 71
    • 84948807352 scopus 로고    scopus 로고
    • Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques
    • Micci L, Ryan ES, Fromentin R, et al. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J Clin Invest. 2015;125:4497-513.
    • (2015) J Clin Invest , vol.125 , pp. 4497-4513
    • Micci, L.1    Ryan, E.S.2    Fromentin, R.3
  • 72
    • 84912144937 scopus 로고    scopus 로고
    • Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection
    • Sandler NG, Zhang X, Bosch RJ, et al. Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection. J Infect Dis. 2014;210:1549-54.
    • (2014) J Infect Dis , vol.210 , pp. 1549-1554
    • Sandler, N.G.1    Zhang, X.2    Bosch, R.J.3
  • 73
    • 84919952238 scopus 로고    scopus 로고
    • The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+T cell recovery: a randomized crossover trial
    • Somsouk M, Dunham RM, Cohen M, et al. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+T cell recovery: a randomized crossover trial. PLoS ONE. 2014;9:e116306.
    • (2014) PLoS ONE , vol.9 , pp. e116306
    • Somsouk, M.1    Dunham, R.M.2    Cohen, M.3
  • 74
    • 84939509426 scopus 로고    scopus 로고
    • Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune non-responders to antiretroviral therapy-ACTG A5286
    • Tenorio AR, Chan ES, Bosch RJ, et al. Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune non-responders to antiretroviral therapy-ACTG A5286. J Infect Dis. 2014;211(5):780-90.
    • (2014) J Infect Dis , vol.211 , Issue.5 , pp. 780-790
    • Tenorio, A.R.1    Chan, E.S.2    Bosch, R.J.3
  • 75
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008;5:e203.
    • (2008) PLoS Med , vol.5 , pp. e203
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3
  • 76
    • 84935914891 scopus 로고    scopus 로고
    • Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS
    • Savarino A, Shytaj IL. Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS. Retrovirology. 2015;12:51.
    • (2015) Retrovirology , vol.12 , pp. 51
    • Savarino, A.1    Shytaj, I.L.2


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