Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates

Tetrahedron Letters

Volumn 51, Issue 1, 2010, Pages 125-128

  Nakano, Chiaki ^a   Hoshino, Tsutomu ^a   Sato, Tsutomu ^a   Toyomasu, Tomonobu ^b   Dairi, Tohru ^c   Sassa, Takeshi ^b  

^a Graduate School of Science and Technology   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Biformene; Diterpenes; Enzymatic synthesis; Sclarene; Unnatural natural product

Indexed keywords

1,3 BUTADIENE; BACTERIAL ENZYME; COPALYL DIPHOSPHATE; COPALYL DIPHOSPHATE SYNTHASE; DITERPENE; GERANYLGERANYL PYROPHOSPHATE; PHOSPHATE; PROTEIN CYC2; SCLARENE; SYNTHETASE; TUBERCULOSINYL DIPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CYCLIZATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EUBACTERIUM; KITASATOSPORA GRISEOLA; NONHUMAN; PH; TEMPERATURE;

KITASATOSPORA GRISEOLA;

EID: 70649115507     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.10.110     Document Type: Article

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