Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 2978-2983

  Layre, Emilie ^a   Lee, Ho Jun ^b   Young, David C ^a   Martinot, Amanda Jezek ^c   Buter, Jeffrey ^d   Minnaard, Adriaan J ^d   Annand, John W ^a   Fortune, Sarah M ^c   Snider, Barry B ^e   Matsunaga, Isamu ^f,g   Rubin, Eric J ^c   Alber, Tom ^b   Moody, D Branch ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e BRANDEIS UNIVERSITY   (United States)

^f KYOTO UNIVERSITY   (Japan)

^g Okatani Hospital   (Japan)

Author keywords

TbAd; Terpenyl transferase

Indexed keywords

ADENOSINE; BACTERIAL ENZYME; DIMETHYLALLYLTRANSFERASE; DITERPENE; ISOPRENOID; RECOMBINANT PROTEIN; SULFATIDE; TUBERCULOSINYL NUCLEOSIDE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; BINDING SITE; BIOSYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE TRANSFER; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIPIDOMICS; LIPOGENESIS; MASS SPECTROMETRY; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; NUCLEOPHILICITY; PRENYLATION; PRIORITY JOURNAL; SPONTANEOUS MUTATION;

TBAD; TERPENYL TRANSFERASE;

ALKYL AND ARYL TRANSFERASES; BACTERIAL PROTEINS; CHROMATOGRAPHY, ION EXCHANGE; DIMERIZATION; LIPIDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; VIRULENCE;

EID: 84896847440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315883111     Document Type: Article

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