PGE2 induced in and released by dying cells functions as an inhibitory DAMP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 14, 2016, Pages 3844-3849

  Hangai, Sho ^a,b   Ao, Tomoka ^a   Kimura, Yoshitaka ^a   Matsuki, Kosuke ^a   Kawamura, Takeshi ^c   Negishi, Hideo ^a,b   Nishio, Junko ^a,b   Kodama, Tatsuhiko ^c   Taniguchi, Tadatsugu ^a,b   Yanai, Hideyuki ^a,b  

^a INSTITUTE OF INDUSTRIAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cell death; DAMP; Inflammation; PGE2; Tumor regulation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CELECOXIB; CISPLATIN; COLONY STIMULATING FACTOR 1; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; ETOPOSIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRHL1 PROTEIN; INDOMETACIN; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MIR133B PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; PARACETAMOL; POLYINOSINIC POLYCYTIDYLIC ACID; PROSTAGLANDIN E2; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALARMIN; PTGS2 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CELL GROWTH; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FREEZE THAWING; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; LUCIFERASE ASSAY; LUNG METASTASIS; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIZE EXCLUSION CHROMATOGRAPHY; SUPERNATANT; TRANSCRIPTION INITIATION; TUMOR GROWTH; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; HELA CELL LINE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; TOXIC HEPATITIS; TUMOR CELL LINE;

ACETAMINOPHEN; ALARMINS; ANIMALS; CELL DEATH; CELL LINE, TUMOR; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYCLOOXYGENASE 2; DINOPROSTONE; HELA CELLS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL;

EID: 84962760417     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602023113     Document Type: Article

References (47)

1. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436-444.
2. Kotas ME, Medzhitov R (2015) Homeostasis, inflammation, and disease susceptibility. Cell 160(5):816-827.
3. Janeway CA, Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20(2):197-216.
4. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783-801.
5. Krysko DV, et al. (2012) Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer 12(12):860-875.
6. Garg AD, Krysko DV, Vandenabeele P, Agostinis P (2011) DAMPs and PDT-mediated photo-oxidative stress: Exploring the unknown. Photochem Photobiol Sci 10(5): 670-680.
7. Bianchi ME (2007) DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 81(1):1-5.
8. Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 28:367-388.
9. Amor S, Puentes F, Baker D, van der Valk P (2010) Inflammation in neurodegenerative diseases. Immunology 129(2):154-169.
10. Sugimoto Y, Narumiya S (2007) Prostaglandin E receptors. J Biol Chem 282(16): 11613-11617.
11. Wang D, Dubois RN (2010) Eicosanoids and cancer. Nat Rev Cancer 10(3):181-193.
12. Rodríguez M, et al. (2014) Polarization of the innate immune response by prostaglandin E2: A puzzle of receptors and signals. Mol Pharmacol 85(1):187-197.
13. Dannenberg AJ, Subbaramaiah K (2003) Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise. Cancer Cell 4(6):431-436.
14. Xu XJ, Reichner JS, Mastrofrancesco B, Henry WL, Jr, Albina JE (2008) Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production. J Immunol 180(4): 2125-2131.
15. Wall EA, et al. (2009) Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci Signal 2(75):ra28.
16. Koga K, et al. (2009) Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity 30(3): 372-383.
17. Eigenbrod T, Park J-H, Harder J, Iwakura Y, Núñez G (2008) Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J Immunol 181(12):8194-8198.
18. Le Feuvre RA, Brough D, Iwakura Y, Takeda K, Rothwell NJ (2002) Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem 277(5): 3210-3218.
19. Kochel TJ, Fulton AM (2015) Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15- PGDH) as determinants of PGE2 levels in cancer. Prostaglandins Other Lipid Mediat 116-117:99-103.
20. Sakaguchi S, et al. (2003) Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem Biophys Res Commun 306(4):860-866.
21. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418(6894):191-195.
22. González-Domínguez É, et al. (2015) CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo. J Leukoc Biol 98(4):453-466.
23. Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117(1):175-184.
24. Vacchelli E, et al. (2015) Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350(6263):972-978.
25. Fabian J, et al. (2014) GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. Cancer Res 74(9):2604-2616.
26. Jaeschke H, Williams CD, Ramachandran A, Bajt ML (2012) Acetaminophen hepatotoxicity and repair: The role of sterile inflammation and innate immunity. Liver Int 32(1):8-20.
27. 2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2. Toxicol Appl Pharmacol 251(3):173-180.
28. Hiraoka N, et al. (2010) Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation. Br J Cancer 103(7):1057-1065.
29. Vaupel P, Mayer A (2007) Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev 26(2):225-239.
30. Kargman SL, et al. (1995) Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res 55(12):2556-2559.
31. Soslow RA, et al. (2000) COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 89(12):2637-2645.
32. Luan B, et al. (2015) CREB pathway links PGE2 signaling with macrophage polarization. Proc Natl Acad Sci USA 112(51):15642-15647.
33. Kang R, Zhang Q, Zeh HJ, 3rd, Lotze MT, Tang D (2013) HMGB1 in cancer: Good, bad, or both? Clin Cancer Res 19(15):4046-4057.
34. Chen G-Y, Tang J, Zheng P, Liu Y (2009) CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 323(5922):1722-1725.
35. Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147(4):742-758.
36. Morham SG, et al. (1995) Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83(3):473-482.
37. Zelenay S, et al. (2015) Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell 162(6):1257-1270.
38. Edelman MJ, et al. (2008) Eicosanoid modulation in advanced lung cancer: Cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy-Cancer and leukemia group B trial 30203. J Clin Oncol 26(6):848-855.
39. Rothwell PM, et al. (2010) Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376(9754): 1741-1750.
40. Schultz RM, Altom MG (1990) Protective activity of recombinant murine tumor necrosis factor-alpha and interferon-gamma against experimental murine lung carcinoma metastases. J Interferon Res 10(2):229-236.
41. Gajewski TF, Schreiber H, Fu Y-X (2013) Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 14(10):1014-1022.
42. Kee J-Y, et al. (2014) CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer 14:949.
43. Mantovani A, et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25(12):677-686.
44. Yanai H, et al. (2013) Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci USA 110(51): 20699-20704.
45. Takaoka A, et al. (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434(7030):243-249.
46. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37(8):911-917.
47. Honda K, et al. (2004) Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci USA 101(43):15416-15421.