CREB pathway links PGE2 signaling with macrophage polarization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 51, 2015, Pages 15642-15647

  Luan, Bing ^a,b   Yoon, Young Sil ^a   Lay, John Le ^c   Kaestner, Klaus H ^c   Hedrick, Susan ^a   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CAMP; CREB CRTC; Insulin resistance; M2 macrophage

Indexed keywords

ALPHA TUBULIN; CAMP REGULATED COACTIVATOR 2; CAMP REGULATED COACTIVATOR 3; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; HISTONE DEACETYLASE 4; INSULIN; INTERLEUKIN 4; KRUPPEL LIKE FACTOR 4; LEPTIN; PROSTAGLANDIN E2; STAT6 PROTEIN; UNCLASSIFIED DRUG; CRTC2 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; DOWN REGULATION; GENE EXPRESSION; GLUCOSE TOLERANCE; HEK293 CELL LINE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; CELL POLARITY; HUMAN; PHYSIOLOGY;

ANIMALS; CELL POLARITY; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DINOPROSTONE; HUMANS; INSULIN RESISTANCE; INTERLEUKIN-4; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MACROPHAGES; MICE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84952701152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519644112     Document Type: Article

References (26)

1. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444(7121):860-867.
2. Arkan MC, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191-198.
3. Hirosumi J, et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420(6913):333-336.
4. Han MS, et al. (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339(6116):218-222.
5. Lawrence T, Natoli G (2011) Transcriptional regulation of macrophage polarization: Enabling diversity with identity. Nat Rev Immunol 11(11):750-761.
6. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: In vivo veritas. J Clin Invest 122(3):787-795.
7. Dalmas E, Clément K, Guerre-Millo M (2011) Defining macrophage phenotype and function in adipose tissue. Trends Immunol 32(7):307-314.
8. Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M (2005) Cutting edge: Macrophage inhibition by cyclic AMP (cAMP): Differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J Immunol 174(2):595-599.
9. Altarejos JY, Montminy M (2011) CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12(3):141-151.
10. Clark K, et al. (2012) Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci USA 109(42):16986-16991.
11. Avni D, Ernst O, Philosoph A, Zor T (2010) Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages. Mol Immunol 47(7-8):1396-1403.
12. Nguyen KD, et al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480(7375):104-108.
13. Liao X, et al. (2011) Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest 121(7):2736-2749.
14. Luan B, et al. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab 19(6):1058-1065.
15. Shibuya I, et al. (2002) Regulation of catecholamine synthesis by leptin. Ann N Y Acad Sci 971:522-527.
16. Wang B, et al. (2011) A hormone-dependent module regulating energy balance. Cell 145(4):596-606.
17. Mihaylova MM, et al. (2011) Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145(4):607-621.
18. Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246.
19. Ruffell D, et al. (2009) A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci USA 106(41):17475-17480.
20. Qin H, et al. (2012) SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol 189(7):3439-3448.
21. Weischenfeldt J, Porse B (2008) Bone marrow-derived macrophages (BMM): Isolation and applications. CSH Protoc 2008: pdb prot5080.
22. Blanchet E, et al. (2015) Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Reports 10(7):1149-1157.
23. Screaton RA, et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119(1):61-74.
24. Altarejos JY, et al. (2008) The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 14(10):1112-1117.
25. Liu Y, et al. (2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456(7219):269-273.
26. Wang W, et al. (2013) Effect of normal lung definition on lung dosimetry and lung toxicity prediction in radiation therapy treatment planning. Int J Radiat Oncol Biol Phys 86(5):956-963.