Tissue distribution of aryl hydrocarbon receptor in the intestine: Implication of putative roles in tumor suppression

Experimental Cell Research

Volumn 343, Issue 2, 2016, Pages 126-134

  Ikuta, Togo ^a   Kurosumi, Masafumi ^a   Yatsuoka, Toshimasa ^a   Nishimura, Yoji ^a  

^a SAITAMA CANCER CENTER   (Japan)

Author keywords

Aryl Hydrocarbon receptor; Colon cancer; Gut immunity; Tumor suppression

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INTESTINE; INTESTINE TUMOR; LAMINA PROPRIA; LYMPH FOLLICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECTUM TUMOR; TISSUE DISTRIBUTION; ANIMAL; C57BL MOUSE; CARCINOGENESIS; CELL PROLIFERATION; CYTOLOGY; GENETICS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CARCINOGENESIS; CELL PROLIFERATION; HCT116 CELLS; HT29 CELLS; HUMANS; INTESTINAL NEOPLASMS; INTESTINES; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ARYL HYDROCARBON; RECTAL NEOPLASMS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84962603441     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2016.03.012     Document Type: Article

References (34)

1. Medema J.P., Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011, 474(7351):318-326.
2. Bersten D.C., Sullivan A.E., Peet D.J., Whitelaw M.L. bHLH-PAS proteins in cancer. Nat. Rev. Cancer 2013, 13(12):827-841.
3. Shimizu Y., Nakatsuru Y., Ichinose M., Takahashi Y., Kume H., Mimura J., et al. Benzo[a]pyrene carcinogenecity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA 2000, 97(2):779-782.
4. Andersson P.A., McGuire J., Rubio C., Gradin K., Whitelaw M.L., Pettersson S., et al. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc. Natl. Acad. Sci. USA 2002, 99(15):9990-9995.
5. Opitz C.A., Litzenburger U.M., Sahm F., Ott M., Tritscher I., Trump S., et al. An endogenous tumor-promoting ligand of human aryl hydrocarbon receptor. Nature 2011, 478(7368):197-203.
6. Lin P., Chang H., Wu M.H., Liao Y.S., Chen J.T., Su J.M. Overexpression of aryl hydrocarbon receptor in human lung carcinoma. Toxicol. Pathol. 2003, 31(1):22-30.
7. Richmond O., Ghotbaddini M., Allen C., Walker A., Zahir S., Powell J.B. The aryl hydrocarbon receptor is constitutively active in prostate cancer cells. PLoS One 2014, 9(4):e95058.
8. Koliopanos A., Kleeff J., Xiao Y., Safe S., Zimmermann A., Buchler M., et al. Increased aryl hydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene 2002, 21(39):6059-6070.
9. Qiu J., Heller J.J., Guo X., Chen Z.M., Fish K., Fu Y.X., et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2011, 36(1):92-104.
10. Li Y., Innocentin S., Withers D.R., Roberts N.A., Gallagher A.R., Grigorieva E.F., et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011, 147(3):629-640.
11. Qiu J., Guo X., Chen Z.E., He L., Sonnenberg G.F., Artis D., et al. 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013, 39(2):386-399.
12. Hooper L.V., Macpherson A.J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 2010, 10(3):159-169.
13. Hill D.A., Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Ann. Rev. Immunol. 2010, 28:623-667.
14. Oshima H., Nakayama M., Han T.-S., Naoi K., Ju X., Maeda Y., et al. Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. Cancer Res. 2015, 75(4):766-776.
15. Ma X., Aoki T., Tsuruyama T., Narumiya S. Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth. Cancer Res. 2015, 75(14):2822-2832.
16. Maloy K.J., Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011, 474(7351):298-306.
17. H17-cell-mediated autoimmunity to environmental toxins. Nature 2008, 453(7191):106-109.
18. H17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008, 453(7191):65-71.
19. Nam T.N., Hazama H., Nakahama T., Kishimoto T. The roles of aryl hydrocarbon receptor in immune responses. Int. Immunol. 2013, 25(6):335-343.
20. Min/+mice with natural ligands. Proc. Natl. Acad. Sci. USA 2009, 106(32):13481-13486.
21. Kimura A., Naka T., Nakahama T., Chinen I., Masuda K., Nohara K., et al. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J. Exp. Med. 2009, 206(9):2027-2035.
22. Ikuta T., Kobayashi Y., Kitazawa M., Shiizaki K., Itano N., Noda T., et al. ASC-mediated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. Carcinogenesis 2013, 34(7):1620-1627.
23. Kim Y.H., Kwon H.-S., Kim D.H., Shin E.K., Kang Y.-H., Park J.H., et al. 3,3'diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Inflamm. Bowel Dis. 2009, 15(8):1164-1173.
24. Mimura J., Yamashita K., Nakamura K., Morita M., Takagi T.N., Nakao K., et al. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes. Cells 1997, 2(10):645-654.
25. Murray I.A., Patterson A.D., Perdew G.H. Ah receptor ligands in cancer: Friend and foe. Nat. Rev. Can. 2014, 14(12):801-814.
26. Kiss E.A., Vonarbourg C., Kopfmann S., Hobeike E., Finke D., Esser C., Diefenbach A. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 2011, 334(6062):1561-1565.
27. Sekine H., Mimura J., Oshima M., Okawa H., Kanno J., Igarashi K., et al. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol. Cell. Biol. 2009, 29(24):6391-6400.
28. Zhu C., Yi W., Zhao Q., Xu X., Zheng M., et al. Tryptophane derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat. Commun. 2015, 6:7209.
29. Pabst C., Krosl J., Fares I., Boucher G., Rurel R., Marinier A., et al. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nat. Meth. 2014, 11:436-442.
30. Boitano A.E., Wang J., Romeo R., Bouchez L.C., Parker A.E., Sutton S.E., et al. Aryl hydrocarbon receptor agonists promote the expansion of human hematopoietic stem cells. Science 2010, 329(5997):1345-1348.
31. Faust D., Kletting S., Ueberham E., Dietrich C. Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells. Toxicol. Lett. 2013, 223(1):73-80.
32. Zhao S., Ohara S., Kanno Y., Midorikawa Y., Nakayama M., Makimura M., et al. HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett. 2013, 330(1):41-48.
33. Cip1 expression. Mol. Pharm. 2014, 85(4):533-541.
34. Kolluri S.K., Weiss C., Koff A., Gottlicher M. p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes. Dev. 1999, 13(13):1742-1753.