In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1s

Journal of Pharmacology and Experimental Therapeutics

Volumn 357, Issue 1, 2016, Pages 134-144

  Simmler, Linda D ^a   Buchy, Danièle ^b   Chaboz, Sylvie ^b   Hoener, Marius C ^b   Liechti, Matthias E ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; PHENETHYLAMINE DERIVATIVE; PSYCHOTROPIC AGENT; TRACE AMINE-ASSOCIATED RECEPTOR 1; TRYPTAMINE; TRYPTAMINE DERIVATIVE; TYRAMINE;

AGONISTS; ANIMAL; COMPARATIVE STUDY; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; MOUSE; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

AMPHETAMINES; ANIMALS; HEK293 CELLS; HUMANS; MICE; PHENETHYLAMINES; PSYCHOTROPIC DRUGS; RATS; RECEPTORS, G-PROTEIN-COUPLED; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTAMINES; TYRAMINE;

EID: 84962602169     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.229765     Document Type: Article

References (39)

1. Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, and Miller GM (2012) Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav 101:201-207.
2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, and Pathirana S, et al. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98:8966-8971.
3. Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, Wettstein JG, Pinard A, Buchy D, Gassmann M, and Hoener MC, et al. (2009) The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci USA 106:20081-20086.
4. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, and Kennedy JL, et al. (2001) Amphetamine, 3, 4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60:1181-1188.
5. Cichero E, Espinoza S, Franchini S, Guariento S, Brasili L, Gainetdinov RR, and Fossa P (2014) Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach. Chem Biol Drug Des 84:712-720.
6. Cichero E, Espinoza S, Gainetdinov RR, Brasili L, and Fossa P (2013) Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modelling and docking studies. Chem Biol Drug Des 81:509-516.
7. Cisneros IE and Ghorpade A (2014) Methamphetamine and HIV-1-induced neuro-toxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology 85:499-507.
8. Cotter R, Pei Y, Mus L, Harmeier A, Gainetdinov RR, Hoener MC, and Canales JJ (2015) The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects. Front Neurosci 9:39.
9. Di Cara B, Maggio R, Aloisi G, Rivet JM, Lundius EG, Yoshitake T, Svenningsson P, Brocco M, Gobert A, and De Groote L, et al. (2011) Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA). J Neurosci 31:16928-16940.
10. Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, and Harmeier A, et al. (2015) TAAR1 modulates cortical glutamate NMDA receptor function. Neuropsychopharmacology 40:2217-2227.
11. Harkness JH, Shi X, Janowsky A, and Phillips TJ (2015) Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits. Neuro-psychopharmacology 40:2175-2184.
12. Jing L and Li JX (2015) Trace amine-associated receptor 1: a promising target for the treatment of psychostimulant addiction. Eur J Pharmacol 761:345-352.
13. Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, and Porter RH, et al. (2011) G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey. Curr Top Med Chem 11:1902-1924.
14. Lewin AH, Miller GM, and Gilmour B (2011) Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorg Med Chem 19:7044-7048.
15. Lewin AH, Navarro HA, and Mascarella SW (2008) Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1. Bioorg Med Chem 16:7415-7423.
16. Liechti M (2015) Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling. Swiss Med Wkly 145:w14043.
17. Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, Bluethmann H, Bettler B, Wettstein JG, Borroni E, and Moreau JL, et al. (2008) Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther 324:948-956.
18. Lynch LJ, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, and Miller GM (2013) Trace amine associated receptor 1 modulates behavioral effects of ethanol. Subst Abuse 7:117-126.
19. Miller GM (2011) The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem 116:164-176.
20. Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, and Canales JJ (2014) Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuro-psychopharmacology 39:2299-2308.
21. Pei Y, Mortas P, Hoener MC, and Canales JJ (2015) Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry 63:70-75.
22. Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, and Grandy DK (2007) Trace amine-associated receptor 1 displays species-dependent stereoselectivity for iso-mers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther 321:178-186.
23. Reese EA, Norimatsu Y, Grandy MS, Suchland KL, Bunzow JR, and Grandy DK (2014) Exploring the determinants of trace amine-associated receptor 1's functional selectivity for the stereoisomers of amphetamine and methamphetamine. J Med Chem 57:378-390.
24. Revel FG, Meyer CA, Bradaia A, Jeanneau K, Calcagno E, André CB, Haenggi M, Miss MT, Galley G, and Norcross RD, et al. (2012a) Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine. Neuropsychopharmacology 37:2580-2592.
25. Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, and Meyer CA, et al. (2011) TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypo-glutamatergic activity. Proc Natl Acad Sci USA 108:8485-8490.
26. Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, and Norcross RD, et al. (2012b) Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry 72:934-942.
27. Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, and Galley G, et al. (2013) A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry 18:543-556.
28. Rickli A, Hoener MC, and Liechti ME (2015a) Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. Eur Neuropsychopharmacol 25:365-376.
29. Rickli A, Kopf S, Hoener MC, and Liechti ME (2015b) Pharmacological profile of novel psychoactive benzofurans. Br J Pharmacol 172:3412-3425.
30. Rickli A, Luethi D, Reinisch J, Buchy D, Hoener MC, and Liechti ME (2015c) Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2, 5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology 99:546-553.
31. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, and Ronca-Testoni S, et al. (2004) 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med 10:638-642.
32. Simmler LD, Buser TA, Donzelli M, Schramm Y, Dieu LH, Huwyler J, Chaboz S, Hoener MC, and Liechti ME (2013) Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol 168:458-470.
33. Simmler LD, Rickli A, Hoener MC, and Liechti ME (2014a) Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuro-pharmacology 79:152-160.
34. Simmler LD, Rickli A, Schramm Y, Hoener MC, and Liechti ME (2014b) Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochem Pharmacol 88:237-244.
35. Wainscott DB, Little SP, Yin T, Tu Y, Rocco VP, He JX, and Nelson DL (2007) Pharmacologic characterization of the cloned human trace amine-associated re-ceptor1 (TAAR1) and evidence for species differences with the rat TAAR1. J Pharmacol Exp Ther 320:475-485.
36. Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, and Gerald CP (2007) The trace amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav 6:628-639.
37. Xie Z and Miller GM (2007) Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther 321:128-136.
38. Zaczek R, Culp S, and De Souza EB (1991) Interactions of [3H]amphetamine with rat brain synaptosomes. II. Active transport. J Pharmacol Exp Ther 257:830-835.
39. Zucchi R, Chiellini G, Scanlan TS, and Grandy DK (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol 149:967-978.