Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7044-7048

  Lewin, Anita H ^a   Miller, Gregory M ^b   Gilmour, Brian ^a  

^a RTI INTERNATIONAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Amphetamine; Binding site; Phenylisopropylamine; Stereoselective; TAAR1

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 4 METHOXYAMPHETAMINE; AMPHETAMINE; AMPHETAMINE DERIVATIVE; BROLAMFETAMINE; G PROTEIN COUPLED RECEPTOR; HYDROXYAMPHETAMINE; METHAMPHETAMINE; NORFENFLURAMINE; TRACE AMINE ASSOCIATED RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; WILD TYPE;

AMPHETAMINES; ANIMALS; BINDING SITES; CELL LINE; HUMANS; MACACA MULATTA; MICE; RATS; RECEPTORS, G-PROTEIN-COUPLED; TRANSFECTION;

MACACA MULATTA; PRIMATES; RATTUS;

EID: 80655136953     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.007     Document Type: Article

References (42)

1. A.T. Shulgin, T. Sargent, and C. Naranjo Nature 221 1969 537
2. R.A. Glennon, and R. Young Pharm. Biochem. Behav. 72 2002 307
3. T. Branchek, N. Adham, M. Macchi, H.T. Kao, and P.R. Hartig Mol. Pharmacol. 38 1990 604
4. S. Leonhardt, and M. Titeler J. Neurochem. 53 1989 316
5. P.A. Pierce, and S.J. Peroutka J. Neurochem. 52 1989 656
6. T.H. McLean, J.C. Parrish, M.R. Braden, D. Marona-Lewicka, A. Gallardo-Godoy, and D.E. Nichols J. Med. Chem. 49 2006 5794
7. R.B. Rothman, N. Vu, J.S. Partilla, B.L. Roth, S.J. Hufeisen, B.A. Compton-Toth, J. Birkes, R. Young, and R.A. Glennon J. Pharmacol. Exp. Ther. 307 2003 138
8. D.C. U'Prichard, D.A. Greenberg, and S.H. Snyder Mol. Pharmacol. 13 1977 454
9. R.L. Hauger, B. Hulihan-Giblin, P. Skolnick, and S.M. Paul Life Sci. 34 1984 771
10. R. Zaczek, S. Culp, H. Goldberg, D.J. McCann, and E.B. De Souza J. Pharmacol. Exp. Ther. 257 1991 820
11. R. Zaczek, S. Culp, and E.B. De Souza J. Pharmacol. Exp. Ther. 257 1991 830
12. J.R. Bunzow, M.S. Sonders, S. Arttmagangkul, l.M. Harrison, G. Zhamg, D.I. Quigley, T. Darland, K.L. Suchland, S. Pasumamula, J.L. Kennedy, S.B. Olson, R.E. Magenis, S.G. Amara, and D.K. Grandy Mol. Pharmacol. 60 2001 1181
13. G.M. Miller, C. Verrico, A. Jassen, M. Konar, H. Yang, H. Panas, B. Mary, R. Johnson, and B.K. Madras J. Pharmacol. Exp. Ther. 313 2005 983
14. E.A. Reese, J.R. Bunzow, S. Arttamangkul, M.S. Sonders, and D.K. Grandy J. Pharmacol. Exp. Ther. 321 2007 178
15. D.B. Wainscott, S.P. Little, T. Yin, Y. Tu, V.P. Rocco, J.X. He, and D.L. Nelson J. Pharmacol. Exp. Ther. 320 2007 475
16. T.D. Wolinsky, C.J. Swanson, K.E. Smith, H. Zhong, S. Borowsky, P. Seeman, T. Branhek, and C.P. Gerald Genes Brain Behav. 6 2007 628
17. A.H. Lewin, H.A. Navarro, and S.W. Mascarella Bioorg. Med. Chem. 16 2008 7415
18. R. Zucchi, G. Chiellini, T.S. Scanlan, and D.K. Grandy Br. J. Pharmacol. 149 2006 967
19. S.A. Burchett, and T.P. Hicks Prog. Neurobiol. 79 2006 223
20. H.A. Navarro, B.P. Gilmour, and A.H. Lewin J. Biomol. Screen. 11 2006 688
21. Z. Xie, and G.M. Miller J. Pharmacol. Exp. Ther. 321 2007 128
22. M.E. Hart, K.L. Suchland, M. Miyakawa, J.R. Bunzow, D.K. Grandy, and T.S. Scanlan J. Med. Chem. 49 2006 1101
23. T.S. Scanlan, K.L. Suchland, M.E. Hart, G. Chiellini, Y. Huang, P.J. Kruzich, S. Frascarelli, D.A. Crossley, J.R. Bunzow, S. Ronca-Testoni, E.T. Lin, D. Hatton, R. Zucchi, and D.K. Grandy Nat. Med. 10 2004 638
24. E.S. Tan, M. Miyakawa, J.R. Bunzow, D.K. Grandy, and T.S. Scanlan J. Med. Chem. 50 2007 2787
25. E.S. Tan, J.C. Naylor, E.S. Groban, J.R. Bunzow, M.P. Jacobson, D.K. Grandy, and T.S. Scanlan ACS Chem. Biol. 4 2009 209
26. L. Lindemann, M. Ebeling, N.A. Kratochwil, J.R. Bunzow, D.K. Grandy, and M.C. Hoener Genomics 85 2005 372
27. B. Borowsky, N. Adham, K.A. Jones, R. Raddatz, R. Arymshym, K.L. Ogozalek, M.M. Durkin, P.P. Laklani, J.A. Bonini, S. Pathirana, N. Boyle, X. Po, E. Kouranova, H. Lichtblau, F.Y. Ochoa, T.A. Branchek, and C. Gerald Proc. Natl. Acad. Sci. U.S.A. 98 2001 8966
28. Miller, G. M.; Madras, B. K. Poster Presentation: A Trace Amine Receptor (TAR1) is a Novel Amphetamine Receptor in Primate Brain, Bal Harbour, FL, 2003.
29. A.H. Lewin Drug Addiction from Basic Research to Therapy R.S. Rapaka, W. Sadee, 2008 Springer New York 327
30. L.S. Barak, A. Salahpour, X. Zhang, B. Masri, T.D. Sotnikova, A.J. Ramsey, J.D. Violin, R.J. Lefkowitz, M.G. Caron, and R.R. Gainetdinov Mol. Pharmacol. 74 2008 585
31. Z. Xie, and G.M. Miller Biochem. Pharmacol. 78 2009 1095
32. Z. Xie, and G.M. Miller J. Pharmacol. Exp. Ther. 330 2009 316
33. D. Gilbert, and S.J. Cooper Eur. J. Pharmacol. 95 1983 311
34. F.A.B. Aldous, B.C. Barrass, K. Brewster, D.A. Buxton, D.M. Green, R.M. Pinder, P. Rich, M. Skeels, and K.J. Tutt J. Med. Chem. 17 1974 1100
35. R.A. Glennon, R. Young, M. Dukat, and Y. Cheng Pharmacol. Biochem. Behav. 57 1997 151
36. K.S. Murnane, W.E. Fantegrossi, J.R. Godfrey, M.L. Banks, and L.L. Howell J. Pharmacol. Exp. Ther. 334 2010 642
37. Shulgin, A.; Shulgin, A. PIHKAL: Phenethylamines I Have Known and Loved: A Chemical Love Story; online version: http://www.erowid.org/library/books- online/pihkal/pihkal.shtml, 2010.
38. R.A. Glennon, R. Young, and A.E. Hauck Pharmacol. Biochem. Behav. 22 1985 723
39. R.A. Glennon, R. Young, M. Dukat, J. Chang-Fong, and M. El-Zahabi Pharmacol. Biochem. Behav. 86 2007 477
40. S.H. Snyder, S. Unger, R. Blatchley, and C.F. Barfknecht Arch. Gen. Psychiatry 31 1974 103
41. C. Bendotti, F. Borsini, M.G. Zanini, R. Samanin, and S. Garattini Pharmacol. Res. Commun. 12 1980 567
42. F.G. Revel, J.L. Moreau, R.R. Gainetdinov, A. Bradaia, T.D. Sotnikova, R. Mory, S. Durkin, K.G. Zbinden, R. Norcross, C.A. Meyer, V. Metzler, S. Chaboz, L. Ozmen, G. Trube, B. Pouzet, B. Bettler, M.G. Caron, J.G. Wettstein, and M.C. Hoener Proc. Natl. Acad. Sci. U.S.A. 108 2011 8485