Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis

Atherosclerosis

Volumn 248, Issue , 2016, Pages 123-131

  Peters, Sanne A E ^a   Singhateh, Yankuba ^b   Mackay, Diana ^b   Huxley, Rachel R ^b,c   Woodward, Mark ^a,d,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Coronary heart disease; Men; Meta analysis; Stroke; Systematic review; Total cholesterol; Women

Indexed keywords

CHOLESTEROL;

ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; FEMALE; FOLLOW UP; HUMAN; ISCHEMIC HEART DISEASE; MALE; META ANALYSIS; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SYSTEMATIC REVIEW; ADULT; AGED; ALGORITHM; BLOOD; CORONARY DISEASE; MIDDLE AGED; STROKE; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; CHOLESTEROL; CORONARY DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SEX FACTORS; STROKE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84962580040     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2016.03.016     Document Type: Article

References (65)

1. World Health Organization Cardiovascular Diseases (CVDs) - Fact Sheet No 317 2015, (accessed 18.11.15). http://www.who.int/mediacentre/factsheets/fs317/en/.
2. Huxley R.R., Peters S.A., Mishra G.D., Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. Lancet Diab. Endocrinol. 2015, 3(3):198-206.
3. Peters S.A., Huxley R.R., Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia 2014, 57(8):1542-1551.
4. Peters S.A., Huxley R.R., Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet Lond. Engl. 2014, 383(9933):1973-1980.
5. Huxley R.R., Woodward M. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet Lond. Engl. 2011, 378(9799):1297-1305.
6. Peters S.A., Huxley R.R., Woodward M. Comparison of the sex-specific associations between systolic blood pressure and the risk of cardiovascular disease: a systematic review and meta-analysis of 124 cohort studies, including 1.2 million individuals. Stroke J. Cereb. Circ. 2013, 44(9):2394-2401.
7. Mongraw-Chaffin M.L., Peters S.A., Huxley R.R., Woodward M. The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1.2 million participants. Lancet Diab. Endocrinol. 2015, 3(6):437-449.
8. Higgins M., Keller J.B. Cholesterol, coronary heart disease, and total mortality in middle-aged and elderly men and women in Tecumseh. Ann. Epidemiol. 1992, 2(1-2):69-76.
9. Houterman S., Verschuren W.M., Hofman A., Witteman J.C. Serum cholesterol is a risk factor for myocardial infarction in elderly men and women: the Rotterdam Study. J. Intern. Med. 1999, 246(1):25-33.
10. Ingelsson E., Schaefer E.J., Contois J.H., et al. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Jama 2007, 298(7):776-785.
11. Jonsdottir L.S., Sigfusson N., Gudnason V., Sigvaldason H., Thorgeirsson G. Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. J. Cardiovasc. Risk 2002, 9(2):67-76.
12. Madssen E., Laugsand L.E., Wiseth R., et al. Risk of acute myocardial infarction: dyslipidemia more detrimental for men than women. Epidemiol. Camb. Mass) 2013, 24(5):637-642.
13. Nagasawa S.Y., Okamura T., Iso H., et al. Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group: a pooled analysis of 65 594 individuals from 10 cohort studies in Japan. J. Am. Heart Assoc. 2012, 1(5):e001974.
14. Ulmer H., Kelleher C., Diem G., Concin H. Why Eve is not Adam: prospective follow-up in 149650 women and men of cholesterol and other risk factors related to cardiovascular and all-cause mortality. J. Women's Health (2002) 2004, 13(1):41-53.
15. Verschuren W.M.M., Kromhout D. Total cholesterol concentration and mortality at a relatively young age: do men and women differ?. BMJ Clin. Res. Ed. 1995, 311(7008):779-783.
16. von Muhlen D., Langer R.D., Barrett-Connor E. Sex and time differences in the associations of non-high-density lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study). Am. J. Cardiol. 2003, 91(11):1311-1315.
17. Weijenberg M.P., Feskens E.J., Bowles C.H., Kromhout D. Serum total cholesterol and systolic blood pressure as risk factors for mortality from ischemic heart disease among elderly men and women. J. Clin. Epidemiol. 1994, 47(2):197-205.
18. Woodward M., Barzi F., Martiniuk A., et al. Cohort profile: the Asia Pacific cohort studies collaboration. Int. J. Epidemiol. 2006, 35(6):1412-1416.
19. The atherosclerosis risk in communities (ARIC) study: design and objectives. The ARIC investigators. Am. J. Epidemiol. 1989, 129(4):687-702.
20. Ezzati T.M., Massey J.T., Waksberg J., Chu A., Maurer K.R. Sample design: third national health and nutrition examination survey. Vital Health Stat. Ser. 2 Data Eval. Methods Res. 1992, 113:1-35.
21. Woodward M., Brindle P., Tunstall-Pedoe H. Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC). Heart Br. Card. Soc. 2007, 93(2):172-176.
22. Wells G.A., Shea B., O'Connell D., et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses 2015, (accessed 19.11.15). http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
23. World Health Organization Raised Cholesterol: Situation and Trends 2015, (accessed 19.11.15). http://www.who.int/gho/ncd/risk_factors/cholesterol_text/en/.
24. Farzadfar F., Finucane M.M., Danaei G., et al. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants. Lancet Lond. Engl. 2011, 377(9765):578-586.
25. Ray K.K., Kastelein J.J., Boekholdt S.M., et al. The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011. Eur. Heart J. 2014, 35(15):960-968.
26. Mittendorfer B. Sexual dimorphism in human lipid metabolism. J. Nutr. 2005, 135(4):681-686.
27. Magkos F., Mohammed B.S., Mittendorfer B. Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women. Int. J. Obes. (2005) 2008, 32(11):1655-1664.
28. Magkos F., Wang X., Mittendorfer B. Metabolic actions of insulin in men and women. Nutr. Burbank Los Angel. Cty. Calif. 2010, 26(7-8):686-693.
29. Perez-Lopez F.R., Larrad-Mur L., Kallen A., Chedraui P., Taylor H.S. Gender differences in cardiovascular disease: hormonal and biochemical influences. Reprod. Sci. Thousand Oaks Calif. 2010, 17(6):511-531.
30. Peters S.A., Huxley R.R., Woodward M. Smoking as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 81 cohorts, including 3,980,359 individuals and 42,401 strokes. Stroke J. Cereb. Circ. 2013, 44(10):2821-2828.
31. Lewington S., Whitlock G., Clarke R., et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet Lond.Engl. 2007, 370(9602):1829-1839.
32. Fulcher J., O'Connell R., Voysey M., et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet Lond. Engl. 2015, 385(9976):1397-1405.
33. Lewey J., Shrank W.H., Bowry A.D., Kilabuk E., Brennan T.A., Choudhry N.K. Gender and racial disparities in adherence to statin therapy: a meta-analysis. Am. Heart J. 2013, 165(5):665-678. 78.e1.
34. Chowdhury R., Khan H., Heydon E., et al. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur. Heart J. 2013, 34(38):2940-2948.
35. Mosca L., Benjamin E.J., Berra K., et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: a guideline from the American Heart Association. J. Am. Coll. Cardiol. 2011, 57(12):1404-1423.
36. Mosca L., Linfante A.H., Benjamin E.J., et al. National study of physician awareness and adherence to cardiovascular disease prevention guidelines. Circulation 2005, 111(4):499-510.
37. Mosca L., Barrett-Connor E., Wenger N.K. Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation 2011, 124(19):2145-2154.
38. Soldin O.P., Mattison D.R. Sex differences in pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 2009, 48(3):143-157.
39. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat. Rev. Drug Discov. 2006, 5(5):425-438.
40. Sattar N., Preiss D., Murray H.M., et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet Lond. Engl. 2010, 375(9716):735-742.
41. Goodarzi M.O., Li X., Krauss R.M., Rotter J.I., Chen Y.D. Relationship of sex to diabetes risk in statin trials. Diabetes Care 2013, 36(7):e100-e101.
42. Keil J.E., Sutherland S.E., Knapp R.G., Gazes P.C. Serum cholesterol-risk factor for coronary disease mortality in younger and older blacks and whites. The Charleston Heart Study, 1960-1988. Ann. Epidemiol. 1992, 2(1-2):93-99.
43. Lowe L.P., Greenland P., Ruth K.J., Dyer A.R., Stamler R., Stamler J. Impact of major cardiovascular disease risk factors, particularly in combination, on 22-year mortality in women and men. Arch. Intern. Med. 1998, 158(18):2007-2014.
44. Iversen A., Jensen J.S., Scharling H., Schnohr P. Hypercholesterolaemia and risk of coronary heart disease in the elderly: impact of age: the Copenhagen City Heart Study. Eur. J. Intern. Med. 2009, 20(2):139-144.
45. Varbo A., Nordestgaard B.G., Tybjaerg-Hansen A., Schnohr P., Jensen G.B., Benn M. Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population. Ann. Neurol. 2011, 69(4):628-634.
46. Bae J.M., Yang Y.J., Li Z.M., Ahn Y.O. Low cholesterol is associated with mortality from cardiovascular diseases: a dynamic cohort study in Korean adults. J. Korean Med. Sci. 2012, 27(1):58-63.
47. Corti M.C., Guralnik J.M., Salive M.E., et al. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann. Intern. Med. 1997, 126(10):753-760.
48. Qiao Q., Laatikainen T., Zethelius B., et al. Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in Finnish and Swedish cohorts. Stroke J. Cereb. Circ. 2009, 40(2):337-343.
49. Njolstad I., Arnesen E., Lund-Larsen P.G. Body height, cardiovascular risk factors, and risk of stroke in middle-aged men and women. A 14-year follow-up of the Finnmark Study. Circulation 1996, 94(11):2877-2882.
50. Wilson P.W., D'Agostino R.B., Levy D., Belanger A.M., Silbershatz H., Kannel W.B. Prediction of coronary heart disease using risk factor categories. Circulation 1998, 97(18):1837-1847.
51. Petursson H., Sigurdsson J.A., Bengtsson C., Nilsen T.I., Getz L. Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study. J. Eval. Clin. Pract. 2012, 18(1):159-168.
52. Iso H., Sato S., Kitamura A., et al. Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke J. Cereb. Circ. 2007, 38(6):1744-1751.
53. Tanabe N., Iso H., Okada K., et al. Serum total and non-high-density lipoprotein cholesterol and the risk prediction of cardiovascular events - the JALS-ECC. Circ. J. Off. J. Jpn. Circ. Soc. 2010, 74(7):1346-1356.
54. Nago N., Ishikawa S., Goto T., Kayaba K. Low cholesterol is associated with mortality from stroke, heart disease, and cancer: the Jichi Medical School Cohort Study. J. Epidemiol. Japan Epidemiol. Assoc. 2011, 21(1):67-74.
55. Cui R., Iso H., Yamagishi K., et al. High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: the JPHC study. Atherosclerosis 2012, 221(2):565-569.
56. Tamosiunas A., Luksiene D., Baceviciene M., et al. Health factors and risk of all-cause, cardiovascular, and coronary heart disease mortality: findings from the MONICA and HAPIEE studies in Lithuania. PloS One 2014, 9(12):e114283.
57. Gillum R.F., Mussolino M.E., Madans J.H. Coronary heart disease risk factors and attributable risks in African-American women and men: NHANES I epidemiologic follow-up study. Am. J. Public Health 1998, 88(6):913-917.
58. Okamura T., Tanaka H., Miyamatsu N., et al. The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort. Atherosclerosis 2007, 190(1):216-223.
59. Hart C.L., Hole D.J., Smith G.D. Comparison of risk factors for stroke incidence and stroke mortality in 20 years of follow-up in men and women in the Renfrew/Paisley Study in Scotland. Stroke J. Cereb. Circ. 2000, 31(8):1893-1896.
60. Isles C.G., Hole D.J., Gillis C.R., Hawthorne V.M., Lever A.F. Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey. BMJ Clin. Res. Ed. 1989, 298(6678):920-924.
61. Wang C., Hou X., Bao Y., et al. The metabolic syndrome increased risk of cardiovascular events in Chinese-a community based study. Int. J. Cardiol. 2010, 139(2):159-165.
62. Tohidi M., Mohebi R., Cheraghi L., et al. Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in tehran lipid and glucose study. Clin. Biochem. 2013, 46(9):716-721.
63. Zhang Y., Tuomilehto J., Jousilahti P., Wang Y., Antikainen R., Hu G. Total and high-density lipoprotein cholesterol and stroke risk. Stroke J. Cereb. Circ. 2012, 43(7):1768-1774.
64. Jousilahti P., Vartiainen E., Tuomilehto J., Puska P. Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation 1999, 99(9):1165-1172.
65. Marin A., Medrano M.J., Gonzalez J., et al. Risk of ischaemic heart disease and acute myocardial infarction in a Spanish population: observational prospective study in a primary-care setting. BMC Public Health 2006, 6:38.