Gender and racial disparities in adherence to statin therapy: A meta-analysis

American Heart Journal

Volumn 165, Issue 5, 2013, Pages

  Lewey, Jennifer ^a,b   Shrank, William H ^a   Bowry, Ashna D K ^c   Kilabuk, Elaine ^a   Brennan, Troyen A ^d   Choudhry, Niteesh K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d CVS Caremark   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CAUCASIAN; DEMOGRAPHY; ETHNIC OR RACIAL ASPECTS; GEOGRAPHY; HUMAN; META ANALYSIS; PATIENT COMPLIANCE; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; SAMPLE SIZE; SECONDARY PREVENTION; SEX DIFFERENCE; TREATMENT DURATION; TREATMENT REFUSAL;

EID: 84876807908     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2013.02.011     Document Type: Review

References (93)

1. D. Lloyd-Jones, R.J. Adams, and T.M. Brown Heart disease and stroke statistics - 2010 update: a report from the American Heart Association Circulation 121 2010 e46 e215
2. I. Popescu, M.S. Vaughan-Sarrazin, and G.E. Rosenthal Differences in mortality and use of revascularization in black and white patients with acute MI admitted to hospitals with and without revascularization services JAMA 297 2007 2489 2495
3. V. Vaccarino, L. Parsons, and E.D. Peterson Sex differences in mortality after acute myocardial infarction: changes from 1994 to 2006 Arch Intern Med 169 2009 1767 1774
4. S.E. Sheifer, J.J. Escarce, and K.A. Schulman Race and sex differences in the management of coronary artery disease Am Heart J 139 2000 848 857
5. A.F. Sonel, C.B. Good, and J. Mulgund Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?) Circulation 111 2005 1225 1232
6. E.H. Bradley, J. Herrin, and Y. Wang Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction JAMA 292 2004 1563 1572
7. E.D. Peterson, L.K. Shaw, and E.R. DeLong Racial variation in the use of coronary-revascularization procedures. Are the differences real? Do they matter? N Engl J Med 336 1997 480 486
8. J.S. Benner, R.J. Glynn, and H. Mogun Long-term persistence in use of statin therapy in elderly patients JAMA 288 2002 455 461
9. R.H. Chapman, J.S. Benner, and A.A. Petrilla Predictors of adherence with antihypertensive and lipid-lowering therapy Arch Intern Med 165 2005 1147 1152
10. P.M. Ho, J.S. Rumsfeld, and F.A. Masoudi Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus Arch Intern Med 166 2006 1836 1841
11. P.M. Ho, J.A. Spertus, and F.A. Masoudi Impact of medication therapy discontinuation on mortality after myocardial infarction Arch Intern Med 166 2006 1842 1847
12. L. Osterberg, and T. Blaschke Adherence to medication N Engl J Med 353 2005 487 497
13. M.C. Sokol, K.A. McGuigan, and R.R. Verbrugge Impact of medication adherence on hospitalization risk and healthcare cost Med Care 43 2005 521 530
14. E.S. Ford, U.A. Ajani, and J.B. Croft Explaining the decrease in U.S. deaths from coronary disease, 1980-2000 N Engl J Med 356 2007 2388 2398
15. J.C. LaRosa, J. He, and S. Vupputuri Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials JAMA 282 1999 2340 2346
16. Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses.
17. J. Avorn, J. Monette, and A. Lacour Persistence of use of lipid-lowering medications: a cross-national study JAMA 279 1998 1458 1462
18. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539 1558
19. I. Abraha, A. Montedori, and F. Stracci Statin compliance in the Umbrian population Eur J Clin Pharmacol 59 2003 659 661
20. A.P. Amin, E. Mukhopadhyay, and S. Nathan Association of medical noncompliance and long-term adverse outcomes, after myocardial infarction in a minority and uninsured population Transl Res 154 2009 78 89
21. H.A. Batal, M.J. Krantz, and R.A. Dale Impact of prescription size on statin adherence and cholesterol levels BMC Health Serv Res 7 2007 175
22. J.S. Benner, M.F. Pollack, and T.W. Smith Association between short-term effectiveness of statins and long-term adherence to lipid-lowering therapy Am J Health Syst Pharm 62 2005 1468 1475
23. J.S. Benner, J.C. Tierce, and C.M. Ballantyne Follow-up lipid tests and physician visits are associated with improved adherence to statin therapy Pharmacoeconomics 22 Suppl. 3 2004 13 23
24. D.F. Blackburn, R.T. Dobson, and J.L. Blackburn Adherence to statins, beta-blockers and angiotensin-converting enzyme inhibitors following a first cardiovascular event: a retrospective cohort study Can J Cardiol 21 2005 485 488
25. E. Bruckert, C. Simonetta, and P. Giral Compliance with fluvastatin treatment characterization of the noncompliant population within a population of 3845 patients with hyperlipidemia. CREOLE Study Team J Clin Epidemiol 52 1999 589 594
26. H. Caspard, A.K. Chan, and A.M. Walker Compliance with a statin treatment in a usual-care setting: retrospective database analysis over 3 years after treatment initiation in health maintenance organization enrollees with dyslipidemia Clin Ther 27 2005 1639 1646
27. R.H. Chapman, A.A. Petrilla, and J.S. Benner Predictors of adherence to concomitant antihypertensive and lipid-lowering medications in older adults: a retrospective, cohort study Drugs Aging 25 2008 885 892
28. C.W. Cheng, K.S. Woo, and J.C. Chan Association between adherence to statin therapy and lipid control in Hong Kong Chinese patients at high risk of coronary heart disease Br J Clin Pharmacol 58 2004 528 535
29. G. Chodick, V. Shalev, and Y. Gerber Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel Clin Ther 30 2008 2167 2179
30. G. Corrao, V. Conti, and L. Merlino Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy Clin Ther 32 2010 300 310
31. L.A. Donnelly, A.S. Doney, and A.D. Morris Long-term adherence to statin treatment in diabetes Diabet Med 25 2008 850 855
32. K.A. Eagle, E. Kline-Rogers, and S.G. Goodman Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study Am J Med 117 2004 73 81
33. J.J. Ellis, S.R. Erickson, and J.G. Stevenson Suboptimal statin adherence and discontinuation in primary and secondary prevention populations J Gen Intern Med 19 2004 638 645
34. J.M. Foody, A.T. Joyce, and A.E. Rudolph Persistence of atorvastatin and simvastatin among patients with and without prior cardiovascular diseases: a US managed care study Curr Med Res Opin 24 2008 1987 2000
35. T.B. Gibson, T.L. Mark, and K. Axelsen Impact of statin copayments on adherence and medical care utilization and expenditures Am J Manag Care 12 Spec no. 2006 SP11 SP19
36. A. Helin-Salmivaara, P. Lavikainen, and M.J. Korhonen Long-term persistence with statin therapy: a nationwide register study in Finland Clin Ther 30 Pt 2 2008 2228 2240
37. I. Holme, M. Szarek, and N.B. Cater Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study Eur J Cardiovasc Prev Rehabil 16 2009 315 320
38. M. Hudson, H. Richard, and L. Pilote Parabolas of medication use and discontinuation after myocardial infarction - are we closing the treatment gap? Pharmacoepidemiol Drug Saf 16 2007 773 785
39. C.A. Jackevicius, P. Li, and J.V. Tu Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction Circulation 117 2008 1028 1036
40. C.A. Jackevicius, M. Mamdani, and J.V. Tu Adherence with statin therapy in elderly patients with and without acute coronary syndromes JAMA 288 2002 462 467
41. R.C. Kaplan, N.C. Bhalodkar, and E.J. Brown Jr. Race, ethnicity, and sociocultural characteristics predict noncompliance with lipid-lowering medications Prev Med 39 2004 1249 1255
42. U. Khanderia, K.A. Townsend, and S.R. Erickson Medication adherence following coronary artery bypass graft surgery: assessment of beliefs and attitudes Ann Pharmacother 42 2008 192 199
43. S.P. Kulkarni, K.P. Alexander, and B. Lytle Long-term adherence with cardiovascular drug regimens Am Heart J 151 2006 185 191
44. J. Ma, R. Vaillancourt, and C. Bennett Adherence to lipid-lowering drug therapy among members of the Canadian Forces Mil Med 173 2008 666 670
45. B. McGinnis, K.L. Olson, and D. Magid Factors related to adherence to statin therapy Ann Pharmacother 41 2007 1805 1811
46. B.D. McGinnis, K.L. Olson, and T.M. Delate Statin adherence and mortality in patients enrolled in a secondary prevention program Am J Manag Care 15 2009 689 695
47. C. Melloni, K.P. Alexander, and F.S. Ou Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome Am J Cardiol 104 2009 175 181
48. A. Pedan, L. Varasteh, and S. Schneeweiss Analysis of factors associated with statin adherence in a hierarchical model considering physician, pharmacy, patient, and prescription characteristics J Manag Care Pharm 13 2007 487 496
49. S. Perreault, L. Blais, and A. Dragomir Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular disease Eur J Clin Pharmacol 61 2005 667 674
50. S. Perreault, L. Blais, and D. Lamarre Persistence and determinants of statin therapy among middle-aged patients for primary and secondary prevention Br J Clin Pharmacol 59 2005 564 573
51. S. Perreault, A. Dragomir, and L. Blais Impact of better adherence to statin agents in the primary prevention of coronary artery disease Eur J Clin Pharmacol 65 2009 1013 1024
52. E. Poluzzi, P. Strahinja, and M. Lanzoni Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy Eur J Clin Pharmacol 64 2008 425 432
53. J.N. Rasmussen, A. Chong, and D.A. Alter Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction JAMA 297 2007 177 186
54. S. Schneeweiss, A.R. Patrick, and M. Maclure Adherence to statin therapy under drug cost sharing in patients with and without acute myocardial infarction: a population-based natural experiment Circulation 115 2007 2128 2135
55. J.S. Schultz, J.C. O'Donnell, and K.L. McDonough Determinants of compliance with statin therapy and low-density lipoprotein cholesterol goal attainment in a managed care population Am J Manag Care 11 2005 306 312
56. N.D. Shah, S.M. Dunlay, and H.H. Ting Long-term medication adherence after myocardial infarction: experience of a community Am J Med 122 2009 961 e7-13
57. J.C. Sung, M.B. Nichol, and F. Venturini Factors affecting patient compliance with antihyperlipidemic medications in an HMO population Am J Manag Care 4 1998 1421 1430
58. S. Vinker, M. Shani, and T. Baevsky Adherence with statins over 8 years in a usual care setting Am J Manag Care 14 2008 388 392
59. L. Wei, T.M. MacDonald, and A.D. Watson Effectiveness of two statin prescribing strategies with respect to adherence and cardiovascular outcomes: observational study Pharmacoepidemiol Drug Saf 16 2007 385 392
60. C.C. Yang, S.S. Jick, and M.A. Testa Discontinuation and switching of therapy after initiation of lipid-lowering drugs: the effects of comorbidities and patient characteristics Br J Clin Pharmacol 56 2003 84 91
61. X. Ye, C.R. Gross, and J. Schommer Association between copayment and adherence to statin treatment initiated after coronary heart disease hospitalization: a longitudinal, retrospective, cohort study Clin Ther 29 2007 2748 2757
62. J. Yeaw, J.S. Benner, and J.G. Walt Comparing adherence and persistence across 6 chronic medication classes J Manag Care Pharm 15 2009 728 740
63. A.P. Yu, Y.F. Yu, and M.B. Nichol Delay in filling the initial prescription for a statin: a potential early indicator of medication nonpersistence Clin Ther 30 2008 761 774 [discussion 16]
64. S.J. Shalansky, and A.R. Levy Effect of number of medications on cardiovascular therapy adherence Ann Pharmacother 36 2002 1532 1539
65. Y. Yang, V. Thumula, and P.F. Pace Predictors of medication nonadherence among patients with diabetes in Medicare Part D programs: a retrospective cohort study Clin Ther 31 2009 2178 2188 [discussion 50-1]
66. D.C. Chan, W.H. Shrank, and D. Cutler Patient, physician, and payment predictors of statin adherence Med Care 48 2010 196 202
67. H. Charles, C.B. Good, and B.H. Hanusa Racial differences in adherence to cardiac medications J Natl Med Assoc 95 2003 17 27
68. M.U. Yood, B.D. McCarthy, and J. Kempf Racial differences in reaching target low-density lipoprotein goal among individuals treated with prescription statin therapy Am Heart J 152 2006 777 784
69. Institute of Medicine Unequal treatment: confronting racial and ethnic disparities in health care 2003 National Academies Proceedings Washington DC
70. D.M. Mann, M. Woodward, and P. Muntner Predictors of nonadherence to statins: a systematic review and meta-analysis Ann Pharmacother 44 2010 1410 1421
71. C.M. Trinacty, A.S. Adams, and S.B. Soumerai Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study BMC Health Serv Res 9 2009 24
72. P.J. McDonnell, and M.R. Jacobs Hospital admissions resulting from preventable adverse drug reactions Ann Pharmacother 36 2002 1331 1336
73. V. Vaccarino, S.S. Rathore, and N.K. Wenger Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002 N Engl J Med 353 2005 671 682
74. M. Chernew, T.B. Gibson, and K. Yu-Isenberg Effects of increased patient cost sharing on socioeconomic disparities in health care J Gen Intern Med 23 2008 1131 1136
75. M. Lillie-Blanton, and C. Hoffman The role of health insurance coverage in reducing racial/ethnic disparities in health care Health Aff (Millwood) 24 2005 398 408
76. L. Mosca, H. Mochari-Greenberger, and R.J. Dolor Twelve-year follow-up of American women's awareness of cardiovascular disease risk and barriers to heart health Circ Cardiovasc Qual Outcomes 3 2010 120 127
77. J.L. Jarvie, and J.M. Foody Recognizing and improving health care disparities in the prevention of cardiovascular disease in women Curr Cardiol Rep 12 2010 488 496
78. N. Cherry, and K. Shalansky Efficacy of intradialytic parenteral nutrition in malnourished hemodialysis patients Am J Health Syst Pharm 59 2002 1736 1741
79. M. Lillie-Blanton, R.M. Martinez, and A. Salganicoff Site of medical care: do racial and ethnic differences persist? Yale J Health Policy Law Ethics 1 2001 15 32
80. K.L. Kahn, M.L. Pearson, and E.R. Harrison Health care for black and poor hospitalized Medicare patients JAMA 271 1994 1169 1174
81. K.E. Joynt, E.J. Orav, and A.K. Jha Thirty-day readmission rates for Medicare beneficiaries by race and site of care JAMA 305 2011 675 681
82. S. Sathasivam, and B. Lecky Statin induced myopathy BMJ 337 2008 a2286
83. J. Hippisley-Cox, and C. Coupland Individualising the risks of statins in men and women in England and Wales: population-based cohort study Heart 96 2010 939 947
84. A. Schedlbauer, P. Davies, and T. Fahey Interventions to improve adherence to lipid lowering medication Cochrane Database Syst Rev 2010 CD004371
85. S.L. Cutrona, N.K. Choudhry, and M.A. Fischer Modes of delivery for interventions to improve cardiovascular medication adherence Am J Manag Care 16 2010 929 942
86. A.J. Claxton, J. Cramer, and C. Pierce A systematic review of the associations between dose regimens and medication compliance Clin Ther 23 2001 1296 1310
87. N.K. Choudhry, M.A. Fischer, and J. Avorn At Pitney Bowes, value-based insurance design cut copayments and increased drug adherence Health Aff (Millwood) 29 2010 1995 2001
88. N.K. Choudhry, M.A. Fischer, and J. Avorn The implications of therapeutic complexity on adherence to cardiovascular medications Arch Intern Med 171 2011 814 822
89. A.S. Misono, S.L. Cutrona, and N.K. Choudhry Healthcare information technology interventions to improve cardiovascular and diabetes medication adherence Am J Manag Care 16 2010 SP82 SP92
90. D.M. Cutler, and W. Everett Thinking outside the pillbox - medication adherence as a priority for health care reform N Engl J Med 362 2010 1553 1555
91. A.N. Trivedi, A.M. Zaslavsky, and E.C. Schneider Trends in the quality of care and racial disparities in Medicare managed care N Engl J Med 353 2005 692 700
92. J.M. McWilliams, E. Meara, and A.M. Zaslavsky Differences in control of cardiovascular disease and diabetes by race, ethnicity, and education: U.S. trends from 1999 to 2006 and effects of medicare coverage Ann Intern Med 150 2009 505 515
93. C.W. Yancy, T.Y. Wang, and H.O. Ventura The coalition to reduce racial and ethnic disparities in cardiovascular disease outcomes (credo): why credo matters to cardiologists J Am Coll Cardiol 57 2011 245 252