Hypercholesterolaemia and risk of coronary heart disease in the elderly: Impact of age. The Copenhagen City Heart Study

European Journal of Internal Medicine

Volumn 20, Issue 2, 2009, Pages 139-144

  Iversen, Allan ^a,b   Jensen, Jan Skov ^a,b   Scharling, Henrik ^a   Schnohr, Peter ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Coronary heart disease; Elderly; Hypercholesterolaemia; Lipid lowering

Indexed keywords

CHOLESTEROL;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HEALTH SURVEY; HUMAN; HYPERCHOLESTEROLEMIA; INCIDENCE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; AGING; CHOLESTEROL; CORONARY DISEASE; DENMARK; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INCIDENCE; MALE; MIDDLE AGED; RISK FACTORS;

EID: 62649093499     PISSN: 09536205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejim.2008.06.003     Document Type: Article

References (37)

1. Keys A., Fidanza F., Scardi V., and Bergami G. The trend of serum-cholesterol levels with age. Lancet 2 6727 (August 2 1952) 209-210
2. Keys A. The age trend of serum concentrations of cholesterol and of Sf 10-20 ("G") substances in adults. J Gerontol 7 2 (April 1952) 201-206
3. Keys A. Coronary heart disease in seven countries. Circulation 41 Suppl 1 (1970)
4. Kannel W.B., Dawber T.R., Kagan A., Revotkie N., and Stokes III J. Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann Intern Med 55 (July 1961) 33-50
5. Kronmal R.A., Cain K.C., Ye Z., and Omenn G.S. Total serum cholesterol levels and mortality risk as a function of age. A report based on the Framingham data. Arch Intern Med 153 9 (May 10 1993) 1065-1073
6. Downs J.R., Clearfield M., Weis S., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 279 20 (May 27 1998) 1615-1622
7. Pedersen T.R., Kjekshus J., and Berg K. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344 8934 (November 19 1994) 1383-1389
8. Schnohr P., Jensen J.S., Scharling H., and Nordestgaard B.G. Coronary heart disease risk factors ranked by importance for the individual and community. A 21 year follow-up of 12 000 men and women from The Copenhagen City Heart Study. Eur Heart J 23 8 (April 2002) 620-626
9. Shepherd J., Cobbe S.M., Ford I., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333 20 (November 16 1995) 1301-1307
10. Shepherd J., Blauw G.J., Murphy M.B., et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360 9346 (November 23 2002) 1623-1630
11. Law M.R., Wald N.J., and Thompson S.G. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ 308 6925 (February 5 1994) 367-372
12. Weverling-Rijnsburger A.W., Blauw G.J., Lagaay A.M., Knook D.L., Meinders A.E., and Westendorp R.G. Total cholesterol and risk of mortality in the oldest old. Lancet 350 9085 (October 18 1997) 1119-1123
13. Simons L.A., McCallum J., Friedlander Y., and Simons J. Predictors of mortality in the prospective Dubbo study of Australian elderly. Aust N Z J Med 26 1 (February 1996) 40-48
14. Anderson K.M., Castelli W.P., and Levy D. Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA 257 16 (April 24 1987) 2176-2180
15. Krumholz H.M., Seeman T.E., Merrill S.S., Mendes de Leon C.F., Vaccarino V., Silverman D.I., et al. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 272 17 (November 2 1994) 1335-1340
16. Benfante R., and Reed D. Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly?. JAMA 263 3 (January 19 1990) 393-396
17. Rubin S.M., Sidney S., Black D.M., Browner W.S., Hulley S.B., and Cummings S.R. High blood cholesterol in elderly men and the excess risk for coronary heart disease. Ann Intern Med 113 12 (December 15 1990) 916-920
18. Corti M.C., Guralnik J.M., Salive M.E., Harris T., Ferrucci L., Glynn R.J., et al. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann Intern Med 126 10 (May 15 1997) 753-760
19. Hansen A.T. In: Jensen G., Schnohr P., Nyboe J., and Appleyard M. (Eds). The Copenhagen City Heart Study. A book of tables with data from the first examination (1976-78) and a five year follow-up (1981-83) (2008) Ref Type: Generic
20. Nordestgaard B.G., Benn M., Schnohr P., and Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298 3 (July 18 2007) 299-308
21. Conroy R.M., Pyorala K., Fitzgerald A.P., et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 24 11 (June 2003) 987-1003
22. Simons L.A., Simons J., Friedlander Y., and McCallum J. Cholesterol and other lipids predict coronary heart disease and ischaemic stroke in the elderly, but only in those below 70 years. Atherosclerosis 159 1 (November 2001) 201-208
23. Sever P.S., Dahlof B., Poulter N.R., et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 361 9364 (April 5 2003) 1149-1158
24. Anum E.A., and Adera T. Hypercholesterolemia and coronary heart disease in the elderly: a meta-analysis. Ann Epidemiol 14 9 (October 2004) 705-721
25. Horiuchi H., Kita T., Mabuchi H., et al. Primary cardiovascular events and serum lipid levels in elderly Japanese with hypercholesterolemia undergoing 6-year simvastatin treatment: a subanalysis of the Japan lipid intervention trial. J Am Geriatr Soc 52 12 (December 2004) 1981-1987
26. Iwashita M., Matsushita Y., Sasaki J., Arakawa K., and Kono S. Relation of serum total cholesterol and other risk factors to risk of coronary events in middle-aged and elderly Japanese men with hypercholesterolemia: the Kyushu Lipid Intervention Study. Circ J 68 5 (May 2004) 405-409
27. Cui R., Iso H., Toyoshima H., et al. Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: the JACC study. Atherosclerosis 194 2 (October 2007) 415-420
28. Jensen J.S. Renal and systemic transvascular albumin leakage in severe atherosclerosis. Arterioscler Thromb Vasc Biol 15 9 (September 1995) 1324-1329
29. Damsgaard E.M., Froland A., Jorgensen O.D., and Mogensen C.E. Microalbuminuria as predictor of increased mortality in elderly people. BMJ 300 6720 (February 3 1990) 297-300
30. Kornerup K., Nordestgaard B.G., Jensen T.K., Feldt-Rasmussen B., Eiberg J.P., and Jensen J.S. Transendothelial exchange of low-density lipoprotein is unaffected by the presence of severe atherosclerosis. Cardiovasc Res 64 2 (November 1 2004) 337-345
31. Thorogood M. Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group. BMJ 303 6807 (October 12 1991) 893-896
32. Humphries S.E., Whittall R.A., Hubbart C.S., et al. Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet 43 12 (December 2006) 943-949
33. Neil H.A., Hammond T., Huxley R., Matthews D.R., and Humphries S.E. Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study. BMJ 321 7254 (July 15 2000) 148
34. Lin C.P., Chen Y.H., Lin W.T., Leu H.B., Liu T.Z., Huang S.L., et al. Direct effect of statins on homocysteine-induced endothelial adhesiveness: potential impact to human atherosclerosis. Eur J Clin Invest 38 2 (February 2008) 106-116
35. Nanda N., Bobby Z., Hamide A., Koner B.C., and Sridhar M.G. Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index. Metabolism 56 10 (October 2007) 1350-1355
36. Pucci E., Chiovato L., and Pinchera A. Thyroid and lipid metabolism. Int J Obes Relat Metab Disord 24 Suppl 2 (June 2000) S109-S112
37. Kabir Z., Bennett K., Shelley E., et al. Life-years-gained from population risk factor changes and modern cardiology treatments in Ireland. Eur J Public Health 17 2 (April 2007) 193-198