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Volumn 357, Issue 1, 2016, Pages 36-44

Ligand-independent adenosine A2B receptor constitutive activity as a promoter of prostate cancer cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE DEAMINASE; CYCLIC AMP; INOSITOL PHOSPHATE; LIGAND; PSB603; SULFONAMIDE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; XANTHINE DERIVATIVE;

EID: 84962520344     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.230003     Document Type: Article
Times cited : (53)

References (46)
  • 1
    • 0028180127 scopus 로고
    • Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands
    • Barker EL, Westphal RS, Schmidt D, and Sanders-Bush E (1994) Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem 269:11687-11690.
    • (1994) J Biol Chem , vol.269 , pp. 11687-11690
    • Barker, E.L.1    Westphal, R.S.2    Schmidt, D.3    Sanders-Bush, E.4
  • 3
    • 31844446495 scopus 로고    scopus 로고
    • Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
    • Bond RA and IJzerman AP (2006) Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol Sci 27:92-96.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 92-96
    • Bond, R.A.1    Ijzerman, A.P.2
  • 4
    • 67649946387 scopus 로고    scopus 로고
    • 1-alkyl-8-(piperazine-1-sulfonyl) phenylxanthines: Development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity
    • Borrmann T, Hinz S, Bertarelli DCG, Li W, Florin NC, Scheiff AB, and Müller CE (2009) 1-alkyl-8-(piperazine-1-sulfonyl) phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem 52:3994-4006.
    • (2009) J Med Chem , vol.52 , pp. 3994-4006
    • Borrmann, T.1    Hinz, S.2    Bertarelli, D.C.G.3    Li, W.4    Florin, N.C.5    Scheiff, A.B.6    Müller, C.E.7
  • 5
    • 0031037633 scopus 로고    scopus 로고
    • Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins
    • Burstein ES, Spalding TA, and Brann MR (1997) Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol Pharmacol 51:312-319.
    • (1997) Mol Pharmacol , vol.51 , pp. 312-319
    • Burstein, E.S.1    Spalding, T.A.2    Brann, M.R.3
  • 7
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael J, De Graff WG, Gazdar AF, Minna JD, and Mitchell JB (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47:936-942.
    • (1987) Cancer Res , vol.47 , pp. 936-942
    • Carmichael, J.1    De Graff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 8
    • 84855408091 scopus 로고    scopus 로고
    • Adenosine A2B receptor blockade slows growth of bladder and breast tumors
    • Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, and Linden J (2012) Adenosine A2B receptor blockade slows growth of bladder and breast tumors. J Immunol 188:198-205.
    • (2012) J Immunol , vol.188 , pp. 198-205
    • Cekic, C.1    Sag, D.2    Li, Y.3    Theodorescu, D.4    Strieter, R.M.5    Linden, J.6
  • 9
    • 0036688175 scopus 로고    scopus 로고
    • The use of constitutively active GPCRs in drug discovery and functional genomics
    • Chalmers DT and Behan DP (2002) The use of constitutively active GPCRs in drug discovery and functional genomics. Nat Rev Drug Discov 1:599-608.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 599-608
    • Chalmers, D.T.1    Behan, D.P.2
  • 10
    • 84893370052 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury
    • Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, and Colgan SP, et al. (2014) Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192:1249-1256.
    • (2014) J Immunol , vol.192 , pp. 1249-1256
    • Eckle, T.1    Kewley, E.M.2    Brodsky, K.S.3    Tak, E.4    Bonney, S.5    Gobel, M.6    Anderson, D.7    Glover, L.E.8    Riegel, A.K.9    Colgan, S.P.10
  • 12
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, and Linden J (2001a) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
    • (2001) Pharmacol Rev , vol.53 , pp. 527-552
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 13
    • 0035865444 scopus 로고    scopus 로고
    • Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells
    • Fredholm BB, Irenius E, Kull B, and Schulte G (2001b) Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol 61:443-448.
    • (2001) Biochem Pharmacol , vol.61 , pp. 443-448
    • Fredholm, B.B.1    Irenius, E.2    Kull, B.3    Schulte, G.4
  • 14
    • 77951223981 scopus 로고    scopus 로고
    • Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
    • Gregory KJ, Hall NE, Tobin AB, Sexton PM, and Christopoulos A (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285:7459-7474.
    • (2010) J Biol Chem , vol.285 , pp. 7459-7474
    • Gregory, K.J.1    Hall, N.E.2    Tobin, A.B.3    Sexton, P.M.4    Christopoulos, A.5
  • 15
  • 16
    • 0033812008 scopus 로고    scopus 로고
    • Non-competitive antagonism of b (2) - Agonist-mediated cyclic AMP accumulation by ICI 118551 in BC3H1 cells endogenously expressing constitutively active β (2)-adrenoceptors
    • Hopkinson HE, Latif ML, and Hill SJ (2000) Non-competitive antagonism of b (2) - agonist-mediated cyclic AMP accumulation by ICI 118551 in BC3H1 cells endogenously expressing constitutively active β (2)-adrenoceptors. Br J Pharmacol 131:124-130.
    • (2000) Br J Pharmacol , vol.131 , pp. 124-130
    • Hopkinson, H.E.1    Latif, M.L.2    Hill, S.J.3
  • 17
    • 84891612009 scopus 로고    scopus 로고
    • Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma
    • Iannone R, Miele L, Maiolino P, Pinto A, and Morello S (2013) Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia 15:1400-1409.
    • (2013) Neoplasia , vol.15 , pp. 1400-1409
    • Iannone, R.1    Miele, L.2    Maiolino, P.3    Pinto, A.4    Morello, S.5
  • 20
    • 77956249652 scopus 로고    scopus 로고
    • Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening
    • Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, and Sexton PM (2010) Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Mol Pharmacol 78:456-465.
    • (2010) Mol Pharmacol , vol.78 , pp. 456-465
    • Koole, C.1    Wootten, D.2    Simms, J.3    Valant, C.4    Sridhar, R.5    Woodman, O.L.6    Miller, L.J.7    Summers, R.J.8    Christopoulos, A.9    Sexton, P.M.10
  • 22
    • 0028950255 scopus 로고
    • The two-state model of receptor activation
    • Leff P (1995) The two-state model of receptor activation. Trends Pharmacol Sci 16:89-97.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 89-97
    • Leff, P.1
  • 23
    • 0027297275 scopus 로고
    • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
    • Lefkowitz RJ, Cotecchia S, Samama P, and Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14:303-307.
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 303-307
    • Lefkowitz, R.J.1    Cotecchia, S.2    Samama, P.3    Costa, T.4
  • 24
    • 33644662506 scopus 로고    scopus 로고
    • Overexpression of G protein-coupled receptors in cancer cells: Involvement in tumor progression
    • Li S, Huang S, and Peng S-B (2005) Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int J Oncol 27:1329-1339.
    • (2005) Int J Oncol , vol.27 , pp. 1329-1339
    • Li, S.1    Huang, S.2    Peng, S.-B.3
  • 25
    • 0028985447 scopus 로고
    • Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation
    • Liang BT and Haltiwanger B (1995) Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ Res 76:242-251.
    • (1995) Circ Res , vol.76 , pp. 242-251
    • Liang, B.T.1    Haltiwanger, B.2
  • 26
    • 0032836645 scopus 로고    scopus 로고
    • Characterization of human A (2B) adenosine receptors: Radioligand binding, western blotting, and coupling to G (q) in human embryonic kidney 293 cells and HMC-1 mast cells
    • Linden J, Thai T, Figler H, Jin X, and Robeva AS (1999) Characterization of human A (2B) adenosine receptors: radioligand binding, western blotting, and coupling to G (q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 56:705-713.
    • (1999) Mol Pharmacol , vol.56 , pp. 705-713
    • Linden, J.1    Thai, T.2    Figler, H.3    Jin, X.4    Robeva, A.S.5
  • 27
    • 0033518280 scopus 로고    scopus 로고
    • Leydigcell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor
    • Liu G, Duranteau L, Carel J-C, Monroe J, Doyle DA, and Shenker A (1999) Leydigcell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N Engl J Med 341:1731-1736.
    • (1999) N Engl J Med , vol.341 , pp. 1731-1736
    • Liu, G.1    Duranteau, L.2    Carel, J.-C.3    Monroe, J.4    Doyle, D.A.5    Shenker, A.6
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method
    • Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0347627709 scopus 로고    scopus 로고
    • Constitutive activity and inverse agonists of G protein-coupled receptors: A current perspective
    • Milligan G (2003) Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective. Mol Pharmacol 64:1271-1276.
    • (2003) Mol Pharmacol , vol.64 , pp. 1271-1276
    • Milligan, G.1
  • 32
    • 0034306612 scopus 로고    scopus 로고
    • Stochastic multidimensional hypercubes and inverse agonism
    • Milligan G and IJzerman AP (2000) Stochastic multidimensional hypercubes and inverse agonism. Trends Pharmacol Sci 21:362-363.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 362-363
    • Milligan, G.1    Ijzerman, A.P.2
  • 33
    • 84926517252 scopus 로고    scopus 로고
    • Expression of adenosine receptor subclasses in malignant and adjacent normal human prostate tissues
    • Mousavi S, Panjehpour M, Izadpanahi MH, and Aghaei M (2015) Expression of adenosine receptor subclasses in malignant and adjacent normal human prostate tissues. Prostate 75:735-747.
    • (2015) Prostate , vol.75 , pp. 735-747
    • Mousavi, S.1    Panjehpour, M.2    Izadpanahi, M.H.3    Aghaei, M.4
  • 34
    • 16544368069 scopus 로고    scopus 로고
    • Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human beta2-adrenoceptor
    • Nakahara T, Maruko T, Sakamoto K, and Ishii K (2004) Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human beta2-adrenoceptor. Biol Pharm Bull 27:239-241.
    • (2004) Biol Pharm Bull , vol.27 , pp. 239-241
    • Nakahara, T.1    Maruko, T.2    Sakamoto, K.3    Ishii, K.4
  • 35
    • 0032749031 scopus 로고    scopus 로고
    • Constitutive activity of the d-opioid receptor expressed in C6 glioma cells: Identification of non-peptide d-inverse agonists
    • Neilan CL, Akil H, Woods JH, and Traynor JR (1999) Constitutive activity of the d-opioid receptor expressed in C6 glioma cells: identification of non-peptide d-inverse agonists. Br J Pharmacol 128:556-562.
    • (1999) Br J Pharmacol , vol.128 , pp. 556-562
    • Neilan, C.L.1    Akil, H.2    Woods, J.H.3    Traynor, J.R.4
  • 36
    • 33947259630 scopus 로고    scopus 로고
    • Inverse agonism: From curiosity to accepted dogma, but is it clinically relevant?
    • Parra S and Bond RA (2007) Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant? Curr Opin Pharmacol 7:146-150.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 146-150
    • Parra, S.1    Bond, R.A.2
  • 37
    • 70349174810 scopus 로고    scopus 로고
    • Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease
    • Polosa R and Blackburn MR (2009) Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease. Trends Pharmacol Sci 30:528-535.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 528-535
    • Polosa, R.1    Blackburn, M.R.2
  • 39
    • 0036033424 scopus 로고    scopus 로고
    • Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
    • Seifert R and Wenzel-Seifert K (2002) Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch Pharmacol 366:381-416.
    • (2002) Naunyn Schmiedebergs Arch Pharmacol , vol.366 , pp. 381-416
    • Seifert, R.1    Wenzel-Seifert, K.2
  • 40
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza GL (2000) Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35:71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 41
    • 0033807967 scopus 로고    scopus 로고
    • Adenosine and cardioprotection during ischaemia and reperfusion-an overview
    • Sommerschild HT and Kirkebøen KA (2000) Adenosine and cardioprotection during ischaemia and reperfusion-an overview. Acta Anaesthesiol Scand 44:1038-1055.
    • (2000) Acta Anaesthesiol Scand , vol.44 , pp. 1038-1055
    • Sommerschild, H.T.1    Kirkebøen, K.A.2
  • 42
    • 0036468505 scopus 로고    scopus 로고
    • Mechanisms of inverse agonism at G-protein-coupled receptors
    • Strange PG (2002) Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol Sci 23:89-95.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 89-95
    • Strange, P.G.1
  • 43
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • Subarsky P and Hill RP (2003) The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20:237-250.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 45
    • 33748648816 scopus 로고    scopus 로고
    • Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: Xanthines modified at position 3 and related pyrimido[1, 2, 3-cd] purinediones
    • Weyler S, Fülle F, Diekmann M, Schumacher B, Hinz S, Klotz K-N, and Müller CE (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1, 2, 3-cd] purinediones. ChemMedChem 1:891-902.
    • (2006) ChemMedChem , vol.1 , pp. 891-902
    • Weyler, S.1    Fülle, F.2    Diekmann, M.3    Schumacher, B.4    Hinz, S.5    Klotz, K.-N.6    Müller, C.E.7
  • 46
    • 67651204566 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the k-opioid receptor
    • Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, and Zjawiony JK, et al. (2009) Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the k-opioid receptor. Biochemistry 48:6898-6908.
    • (2009) Biochemistry , vol.48 , pp. 6898-6908
    • Yan, F.1    Bikbulatov, R.V.2    Mocanu, V.3    Dicheva, N.4    Parker, C.E.5    Wetsel, W.C.6    Mosier, P.D.7    Westkaemper, R.B.8    Allen, J.A.9    Zjawiony, J.K.10


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